LOCUS       NP_473439                470 aa            linear   ROD 15-JUN-2024
DEFINITION  metalloreductase STEAP4 [Mus musculus].
ACCESSION   NP_473439
VERSION     NP_473439.2
DBSOURCE    REFSEQ: accession NM_054098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Zhu,L., Li,B., Chen,D., Chen,N., Xu,L., Li,Q. and Chen,X.
  TITLE     sSTEAP4 regulates cellular homeostasis and improves
            high-fat-diet-caused oxidative stress in hepatocytes
  JOURNAL   Life Sci 296, 120438 (2022)
   PUBMED   35227772
  REMARK    GeneRIF: sSTEAP4 regulates cellular homeostasis and improves
            high-fat-diet-caused oxidative stress in hepatocytes.
REFERENCE   2  (residues 1 to 470)
  AUTHORS   Mollenhauer,M., Bokredenghel,S., Geissen,S., Klinke,A.,
            Morstadt,T., Torun,M., Strauch,S., Schumacher,W., Maass,M.,
            Konradi,J., Peters,V.B.M., Berghausen,E., Vantler,M.,
            Rosenkranz,S., Mehrkens,D., Braumann,S., Nettersheim,F., Hof,A.,
            Simsekyilmaz,S., Winkels,H., Rudolph,V., Baldus,S., Adam,M. and
            Freyhaus,H.T.
  TITLE     Stamp2 Protects From Maladaptive Structural Remodeling and Systolic
            Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil
            Activation
  JOURNAL   Front Immunol 12, 701721 (2021)
   PUBMED   34691017
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Zhao,J., Liao,Y., Miller-Little,W., Xiao,J., Liu,C., Li,X., Li,X.
            and Kang,Z.
  TITLE     STEAP4 expression in CNS resident cells promotes Th17 cell-induced
            autoimmune encephalomyelitis
  JOURNAL   J Neuroinflammation 18 (1), 98 (2021)
   PUBMED   33879167
  REMARK    GeneRIF: STEAP4 expression in CNS resident cells promotes Th17
            cell-induced autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Batool,M., Berghausen,E.M., Zierden,M., Vantler,M., Schermuly,R.T.,
            Baldus,S., Rosenkranz,S. and Ten Freyhaus,H.
  TITLE     The six-transmembrane protein Stamp2 ameliorates pulmonary vascular
            remodeling and pulmonary hypertension in mice
  JOURNAL   Basic Res Cardiol 115 (6), 68 (2020)
   PUBMED   33188479
  REMARK    GeneRIF: The six-transmembrane protein Stamp2 ameliorates pulmonary
            vascular remodeling and pulmonary hypertension in mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Kim,H.Y., Kwon,W.Y., Park,J.B., Lee,M.H., Oh,Y.J., Suh,S.,
            Baek,Y.H., Jeong,J.S. and Yoo,Y.H.
  TITLE     Hepatic STAMP2 mediates recombinant FGF21-induced improvement of
            hepatic iron overload in nonalcoholic fatty liver disease
  JOURNAL   FASEB J 34 (9), 12354-12366 (2020)
   PUBMED   32721044
  REMARK    GeneRIF: Hepatic STAMP2 mediates recombinant FGF21-induced
            improvement of hepatic iron overload in nonalcoholic fatty liver
            disease.
REFERENCE   6  (residues 1 to 470)
  AUTHORS   Yu,X., Bauer,K., Koczan,D., Thiesen,H.J. and Ibrahim,S.M.
  TITLE     Combining global genome and transcriptome approaches to identify
            the candidate genes of small-effect quantitative trait loci in
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 9 (1), R3 (2007)
   PUBMED   17244351
REFERENCE   7  (residues 1 to 470)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
REFERENCE   8  (residues 1 to 470)
  AUTHORS   Fasshauer,M., Kralisch,S., Klier,M., Lossner,U., Bluher,M.,
            Chambaut-Guerin,A.M., Klein,J. and Paschke,R.
  TITLE     Interleukin-6 is a positive regulator of tumor necrosis factor
            alpha-induced adipose-related protein in 3T3-L1 adipocytes
  JOURNAL   FEBS Lett 560 (1-3), 153-157 (2004)
   PUBMED   14988015
  REMARK    GeneRIF: Tiarp is stimulated by tumor necrosis factor-alpha in
            adipocytes.
REFERENCE   9  (residues 1 to 470)
  AUTHORS   Porkka,K.P., Helenius,M.A. and Visakorpi,T.
  TITLE     Cloning and characterization of a novel six-transmembrane protein
            STEAP2, expressed in normal and malignant prostate
  JOURNAL   Lab Invest 82 (11), 1573-1582 (2002)
   PUBMED   12429817
REFERENCE   10 (residues 1 to 470)
  AUTHORS   Moldes,M., Lasnier,F., Gauthereau,X., Klein,C., Pairault,J.,
            Feve,B. and Chambaut-Guerin,A.M.
  TITLE     Tumor necrosis factor-alpha-induced adipose-related protein
            (TIARP), a cell-surface protein that is highly induced by tumor
            necrosis factor-alpha and adipose conversion
  JOURNAL   J Biol Chem 276 (36), 33938-33946 (2001)
   PUBMED   11443137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133514.4.
            
            On Jun 19, 2003 this sequence version replaced NP_473439.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006651.1, AK040760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.37 cM"
     Protein         1..470
                     /product="metalloreductase STEAP4"
                     /EC_number="1.16.1.9"
                     /note="tumor necrosis factor, alpha-induced protein 9;
                     dudulin 4; six-transmembrane epithelial antigen of
                     prostate 4; tumor necrosis factor-alpha-induced
                     adipose-related protein; Tnfa-induced adipose-related
                     protein"
                     /calculated_mol_wt=52863
     Region          24..190
                     /region_name="COG2085"
                     /note="Predicted dinucleotide-binding enzyme [General
                     function prediction only]"
                     /db_xref="CDD:441688"
     Site            202..224
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     Site            236..256
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     Region          249..394
                     /region_name="Ferric_reduct"
                     /note="Ferric reductase like transmembrane component;
                     pfam01794"
                     /db_xref="CDD:426438"
     Site            293..313
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     Site            342..362
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     Site            381..401
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     Site            419..439
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923B6.1)"
     CDS             1..470
                     /gene="Steap4"
                     /gene_synonym="1110021O17Rik; Tiarp; Tnfaip9"
                     /coded_by="NM_054098.4:92..1504"
                     /db_xref="CCDS:CCDS39008.1"
                     /db_xref="GeneID:117167"
                     /db_xref="MGI:MGI:1923560"
ORIGIN      
        1 mekahadefp lttdssekqg vvcifgtgdf gkslglkmlq cgysivfgsr npqvssllpr
       61 gaevlsysea asksdiiila mhrehydslt elvdylkgkv lvdvsnnrki nqypesnaey
      121 laqlepgahv vkafntisaw alqsgtldas rqvfvcgnds kakqrvmdia rtlgltpldq
      181 gslmaaseie nyplqlfpmw rfpfylssvl cvfffvycai reviypyvng ktdatyrlai
      241 sipnrvfpit alillalvyl pgilaailql yrgtkyrrfp nwldhwmlcr kqlglvalgf
      301 aflhviytlv ipiryyvrwr lrnatitqal tnkdspfits yawindsyla lgilgfflfl
      361 llgitslpsv snmvnwrefr fvqsklgylt lvlctahtlv yggkrflsps ilrwslpsay
      421 ilalvipcav lvlkcilimp cidktltrir qgwernskyt qsalngksdi
//
