LOCUS       NM_001379355            2826 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus STEAP family member 3 (Steap3), transcript variant 4,
            mRNA.
ACCESSION   NM_001379355 XM_006529846
VERSION     NM_001379355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Li,P.L., Liu,H., Chen,G.P., Li,L., Shi,H.J., Nie,H.Y., Liu,Z.,
            Hu,Y.F., Yang,J., Zhang,P., Zhang,X.J., She,Z.G., Li,H., Huang,Z.
            and Zhu,L.
  TITLE     STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3)
            Inhibits Pathological Cardiac Hypertrophy
  JOURNAL   Hypertension 76 (4), 1219-1230 (2020)
   PUBMED   32862709
  REMARK    GeneRIF: STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate
            3) Inhibits Pathological Cardiac Hypertrophy.
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Guo,W.Z., Fang,H.B., Cao,S.L., Chen,S.Y., Li,J., Shi,J.H.,
            Tang,H.W., Zhang,Y., Wen,P.H., Zhang,J.K., Wang,Z.H., Shi,X.Y.,
            Pang,C., Yang,H., Hu,B.W. and Zhang,S.J.
  TITLE     Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency
            in Hepatocytes Protects the Liver Against Ischemia-Reperfusion
            Injury by Suppressing Transforming Growth Factor-beta-Activated
            Kinase 1
  JOURNAL   Hepatology 71 (3), 1037-1054 (2020)
   PUBMED   31393024
  REMARK    GeneRIF: Six-Transmembrane Epithelial Antigen of the Prostate 3
            Deficiency in Hepatocytes Protects the Liver Against
            Ischemia-Reperfusion Injury by Suppressing Transforming Growth
            Factor-beta-Activated Kinase 1.
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Howie,H.L., Hay,A.M., de Wolski,K., Waterman,H., Lebedev,J., Fu,X.,
            Culp-Hill,R., D'Alessandro,A., Gorham,J.D., Ranson,M.S.,
            Roback,J.D., Thomson,P.C. and Zimring,J.C.
  TITLE     Differences in Steap3 expression are a mechanism of genetic
            variation of RBC storage and oxidative damage in mice
  JOURNAL   Blood Adv 3 (15), 2272-2285 (2019)
   PUBMED   31350307
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Sikkeland,J., Sheng,X., Jin,Y. and Saatcioglu,F.
  TITLE     STAMPing at the crossroads of normal physiology and disease states
  JOURNAL   Mol Cell Endocrinol 425, 26-36 (2016)
   PUBMED   26911931
  REMARK    Review article
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Ohgami,R.S., Campagna,D.R., Greer,E.L., Antiochos,B., McDonald,A.,
            Chen,J., Sharp,J.J., Fujiwara,Y., Barker,J.E. and Fleming,M.D.
  TITLE     Identification of a ferrireductase required for efficient
            transferrin-dependent iron uptake in erythroid cells
  JOURNAL   Nat Genet 37 (11), 1264-1269 (2005)
   PUBMED   16227996
REFERENCE   7  (bases 1 to 2826)
  AUTHORS   Amzallag,N., Passer,B.J., Allanic,D., Segura,E., Thery,C., Goud,B.,
            Amson,R. and Telerman,A.
  TITLE     TSAP6 facilitates the secretion of translationally controlled tumor
            protein/histamine-releasing factor via a nonclassical pathway
  JOURNAL   J Biol Chem 279 (44), 46104-46112 (2004)
   PUBMED   15319436
REFERENCE   8  (bases 1 to 2826)
  AUTHORS   Passer,B.J., Nancy-Portebois,V., Amzallag,N., Prieur,S., Cans,C.,
            Roborel de Climens,A., Fiucci,G., Bouvard,V., Tuynder,M.,
            Susini,L., Morchoisne,S., Crible,V., Lespagnol,A., Dausset,J.,
            Oren,M., Amson,R. and Telerman,A.
  TITLE     The p53-inducible TSAP6 gene product regulates apoptosis and the
            cell cycle and interacts with Nix and the Myt1 kinase
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2284-2289 (2003)
   PUBMED   12606722
  REMARK    GeneRIF: TSAP6 may augment Myt1 activity and act downstream to p53
            to interface apoptosis and cell-cycle progression
REFERENCE   9  (bases 1 to 2826)
  AUTHORS   Porkka,K.P., Helenius,M.A. and Visakorpi,T.
  TITLE     Cloning and characterization of a novel six-transmembrane protein
            STEAP2, expressed in normal and malignant prostate
  JOURNAL   Lab Invest 82 (11), 1573-1582 (2002)
   PUBMED   12429817
REFERENCE   10 (bases 1 to 2826)
  AUTHORS   Amson,R.B., Nemani,M., Roperch,J.P., Israeli,D., Bougueleret,L., Le
            Gall,I., Medhioub,M., Linares-Cruz,G., Lethrosne,F., Pasturaud,P.,
            Piouffre,L., Prieur,S., Susini,L., Alvaro,V., Millasseau,P.,
            Guidicelli,C., Bui,H., Massart,C., Cazes,L., Dufour,F.,
            Bruzzoni-Giovanelli,H., Owadi,H., Hennion,C., Charpak,G.,
            Telerman,A. et al.
  TITLE     Isolation of 10 differentially expressed cDNAs in p53-induced
            apoptosis: activation of the vertebrate homologue of the drosophila
            seven in absentia gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 3953-3957 (1996)
   PUBMED   8632996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084310.16 and AC139867.4.
            
            On Mar 31, 2020 this sequence version replaced XM_006529846.4.
            
            Transcript Variant: This variant (4) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.4891230.1,
                                           SRR5189676.140056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC084310.16        147936-148053
            119-618             AC139867.4         223645-224144       c
            619-1146            AC139867.4         221309-221836       c
            1147-1311           AC139867.4         214119-214283       c
            1312-2826           AC139867.4         206291-207805       c
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.66 cM"
     gene            1..2826
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /note="STEAP family member 3"
                     /db_xref="GeneID:68428"
                     /db_xref="MGI:MGI:1915678"
     exon            1..118
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1593
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /note="isoform a is encoded by transcript variant 4;
                     metalloreductase STEAP3; dudulin 2; protein nm1054; tumor
                     suppressor-activated pathway protein 6; six-transmembrane
                     epithelial antigen of prostate 3"
                     /codon_start=1
                     /product="metalloreductase STEAP3 isoform a"
                     /protein_id="NP_001366284.1"
                     /db_xref="GeneID:68428"
                     /db_xref="MGI:MGI:1915678"
                     /translation="MAQSPVAGTAMSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGIL
                     GSGDFARSLATRLVGSGFSVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVF
                     REHYSSLCSLADQLAGKILVDVSNPTEKEHLQHRQSNAEYLASLFPACTVVKAFNVIS
                     AWALQAGPRDGNRQVLICSDQPEAKRTISEMARAMGFTPLDMGSLASAREVEAIPLRL
                     LPSWKVPTLLALGLFVCFYTYNFIRDVLQPYIRKDENKFYKMPLSVVNTTLPCVAYVL
                     LSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLP
                     LRRSHRYDLVNLAVKQVLANKSRLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSI
                     ANSLNWKEFSFVQSTLGFVALILSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPC
                     VIILAKGLFLLPCLNRRLTKIRRGWEKDGAVKFMLPGDHTQGEKTSHV"
     exon            119..618
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1146
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1311
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2826
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /note="hexamer: ATTAAA"
     polyA_site      2590
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
     regulatory      2818..2823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /note="hexamer: ATTACA"
     polyA_site      2826
                     /gene="Steap3"
                     /gene_synonym="1010001D01Rik; pHyde; Tsap6"
                     /note="major polyA site"
ORIGIN      
        1 agtcagactg ccgaaggtgg agactttagt cagaagaggc gacttgcagc ggggttgtct
       61 gggcattcta aaacttcaga cctcccctga ggccagatgg cgcagtcacc tgttgctggc
      121 actgctatgt cgggggagat ggacaagccg ctgatcagcc gccgcctagt ggacagtgat
      181 ggcagtctgg ctgaggtccc caaggaggcc cccaaagtgg gcatcctggg cagtggggat
      241 tttgcccgtt ccctggccac acgcctggtg ggctctggct tcagtgtggt ggtggggagc
      301 cgtaacccca aacgcacggc tggcctcttc ccctccttag ctcaagtgac tttccaggag
      361 gaagccgtga gctctccaga ggtcatcttt gtggccgtgt tccgggagca ctattcctca
      421 ctgtgcagtc tcgctgacca gttggctggc aagatcctcg tggatgtaag caaccccacg
      481 gagaaggagc atcttcagca ccgccagtct aacgctgagt acctggcctc actctttcct
      541 gcgtgcactg tggtgaaggc cttcaacgtc atctctgcat gggccctaca ggctggccca
      601 agggatggga acaggcaggt gctcatctgc agtgatcagc cagaagccaa gcgcaccatc
      661 tcagagatgg cacgcgccat gggtttcaca cccctggaca tgggatccct ggcctcagcg
      721 agggaggtag aagccatacc cctgcgcctc cttccatcct ggaaggtgcc caccctcctg
      781 gcactggggc tctttgtgtg cttctacacc tacaacttca tccgagacgt tctacagcca
      841 tacattcgga aagatgagaa caagttctac aagatgccct tgtctgtggt caacaccaca
      901 ctaccctgtg tggcttatgt gctgctgtcc ctagtgtacc tgcccggtgt gctggcagct
      961 gcgcttcagc tgcggagggg gaccaagtac cagcgcttcc cagactggct ggaccactgg
     1021 ctgcagcatc gcaagcagat cgggctgctc agcttcttct tcgcgatgct gcacgctctc
     1081 tacagcttct gcctgccgct gcgccgctcc caccgctacg acctggtcaa tctggctgtg
     1141 aagcaggtcc tggccaacaa gagccgcctc tgggctgagg aagaagtctg gaggatggag
     1201 atatacctgt ccctgggtgt gctggccctg ggcatgttgt cgctgctggc tgtcacctcg
     1261 ctcccgtcca ttgctaattc cctcaactgg aaggagttca gcttcgtgca gtccacactg
     1321 ggcttcgtgg ccctgatact cagcacaatg cacacactca cctacggctg gacccgtgcc
     1381 tttgaggaaa accactacaa gttctacctg ccgcccacat tcacactcac gctgctcctg
     1441 ccctgtgtga tcatcctggc caagggcctc ttcctcctgc cctgcctcaa ccgcagactc
     1501 accaagatac gcaggggctg ggagaaagat ggggctgtca agttcatgct gcccggcgac
     1561 cacacacagg gggagaaaac aagccacgtg tgaggccctg gaagtggaga tggcttgtgg
     1621 gggccctgag ctgggttcgg gtctcttttc tggatgctgc acagcgaggt gatgatatat
     1681 gcgtgggtgg ctgagatcct aattcctggg atgcaggtgt aaactgacat actcagaatg
     1741 acaccccata catgtgatat gtacttacat atatttcaca tataataaga tttgctatta
     1801 ttcttactta gctaaaaaaa aaaagtgggt ccctatattt cagcgtaagc atttcaaagc
     1861 aaatgccaca cattgaacag cagatcccac ccttgtggta tctacagagg cagacagaca
     1921 ctctggtata ggagaaactg tctttcgttg gattctctcc tttaatctct atgctcctta
     1981 ttagctgaat cctaaagttg gtgcaaagct ggggcaagaa atgcctctgg tgccgcctac
     2041 ccccatccca gggctaagaa agaagcctcg agtgaacagg gaaccaggtc tggactctgc
     2101 tgcttccctg ggcgtgcgtg gggaggctca gcaagacccc ctgggatcta tgcaggagct
     2161 ttttcaggtc cgtcctttct tcagggaagg gtctgaagct gccccatctg atcctagctg
     2221 agctgagaag attcttcccc accccctgaa agtccagagt caccaccgga gcctgcaaat
     2281 tgatccttct gcgaaggtgt gaagtcaccg cctctccaga gccattaatg aacctggtct
     2341 tcgggaggag gataattgtt tcctctccat taagttgctg gtgacccccc ctttaaatca
     2401 ctgtgccttc tcgccttttc catcattaat ttggacatct ccgtggagtg gacacttgtc
     2461 tgggcagtcc ggggtggggg ggagcattag agattgcaga gaataaccat cgaatcctct
     2521 tcttggggca accctcccct tggatgtgcc ccaggcctgc cttcattaaa ttggtccctg
     2581 aggagaataa tagggaccct tttcatttac cctgtcgcct gtaggcagaa aacctacctt
     2641 ctgagcaccc agaaaacaca gtggccccat gctcttcttc agggggttcc acagccccct
     2701 tccccgtgtt tttgcctccc tccctccttc ctcccctccc tccctccctc actgttacgt
     2761 tcaaccacaa aagtcttcaa atattgtttt tttgaattct taaagagacc tcattttatt
     2821 acaata
//
