LOCUS       NM_001103156           10341 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus six transmembrane epithelial antigen of prostate 2
            (Steap2), transcript variant 3, mRNA.
ACCESSION   NM_001103156
VERSION     NM_001103156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10341)
  AUTHORS   Wang,Y., Chen,S., Chen,S. and Jiang,J.
  TITLE     Unveiling the role of copper metabolism and STEAP2 in idiopathic
            pulmonary fibrosis molecular landscape
  JOURNAL   J Cell Mol Med 28 (11), e18414 (2024)
   PUBMED   38872435
  REMARK    GeneRIF: Unveiling the role of copper metabolism and STEAP2 in
            idiopathic pulmonary fibrosis molecular landscape.
REFERENCE   2  (bases 1 to 10341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 10341)
  AUTHORS   Ji,L., Shi,X., Wang,G., Wu,H. and Hu,Z.
  TITLE     Overexpressing six-transmembrane protein of prostate 2 (STAMP2)
            alleviates sepsis-induced acute lung injury probably by hindering
            M1 macrophage polarization via the NF-kappaB pathway
  JOURNAL   Folia Histochem Cytobiol 61 (1), 34-46 (2023)
   PUBMED   36583372
  REMARK    GeneRIF: Overexpressing six-transmembrane protein of prostate 2
            (STAMP2) alleviates sepsis-induced acute lung injury probably by
            hindering M1 macrophage polarization via the NF-kappaB pathway.
REFERENCE   4  (bases 1 to 10341)
  AUTHORS   Hasegawa,H., Li,C., Alba,B.M., Penny,D.M., Xia,Z., Dayao,M.R.,
            Li,P., Zhang,J., Zhou,J., Lim,D., Murawsky,C.M. and Lim,A.C.
  TITLE     Membrane cholesterol modulates STEAP2 conformation during dynamic
            intracellular trafficking processes leading to broad subcellular
            distribution
  JOURNAL   Exp Cell Res 370 (2), 208-226 (2018)
   PUBMED   29940176
  REMARK    GeneRIF: The conformational modulation of STEAP2 by the local
            membrane cholesterol content can therefore serve as a potential
            mechanism to modulate STEAP2 function in a compartment-restricted
            manner
REFERENCE   5  (bases 1 to 10341)
  AUTHORS   Sikkeland,J., Sheng,X., Jin,Y. and Saatcioglu,F.
  TITLE     STAMPing at the crossroads of normal physiology and disease states
  JOURNAL   Mol Cell Endocrinol 425, 26-36 (2016)
   PUBMED   26911931
  REMARK    Review article
REFERENCE   6  (bases 1 to 10341)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 10341)
  AUTHORS   Sikkeland,J. and Saatcioglu,F.
  TITLE     Differential expression and function of stamp family proteins in
            adipocyte differentiation
  JOURNAL   PLoS One 8 (7), e68249 (2013)
   PUBMED   23874564
  REMARK    GeneRIF: Stamp1 and Stamp2 play critical roles in adipogenesis, but
            through different mechanisms.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 10341)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 10341)
  AUTHORS   Vaghjiani,R.J., Talma,S. and Murphy,C.L.
  TITLE     Six-transmembrane epithelial antigen of the prostate (STEAP1 and
            STEAP2)-differentially expressed by murine and human mesenchymal
            stem cells
  JOURNAL   Tissue Eng Part A 15 (8), 2073-2083 (2009)
   PUBMED   19196137
  REMARK    GeneRIF: STEAPs may represent novel markers of mesenchymal stem
            cells in man as well as mice.
REFERENCE   10 (bases 1 to 10341)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ122203.1, AK052981.1, AK015015.1 and AC092404.2.
            
            On Oct 22, 2013 this sequence version replaced NM_001103156.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166607.1, AK145468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               CJ122203.1         5-136
            133-2787            AK052981.1         192-2846
            2788-3436           AK015015.1         1815-2463
            3437-10341          AC092404.2         192130-199034
FEATURES             Location/Qualifiers
     source          1..10341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.18 cM"
     gene            1..10341
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /note="six transmembrane epithelial antigen of prostate 2"
                     /db_xref="GeneID:74051"
                     /db_xref="MGI:MGI:1921301"
     exon            1..132
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            133..258
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            259..780
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1761
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /note="isoform 1 is encoded by transcript variant 3;
                     metalloreductase STEAP2"
                     /codon_start=1
                     /product="metalloreductase STEAP2 isoform 1"
                     /protein_id="NP_001096626.1"
                     /db_xref="CCDS:CCDS39007.1"
                     /db_xref="GeneID:74051"
                     /db_xref="MGI:MGI:1921301"
                     /translation="MESISMMGSPKSLETFLPNGINGIKDARQVTVGVIGSGDFAKSL
                     TIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWD
                     LRHLLVGKILIDVSNNMRVNQYPESNAEYLASLFPDSLIVKGFNVISAWALQLGPKDA
                     SRQVYICSNNIQARQQVIELARQLNFIPVDLGSLSSAKEIENLPLRLFTLWRGPVVVA
                     ISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLA
                     AAYQLYYGTKYRRFPPWLDTWLQCRKQLGLLSFFFAVVHVAYSLCLPMRRSERYLFLN
                     MAYQQVHANIENAWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSF
                     IQSTLGYVALLITTFHVLIYGWKRAFAEEYYRFYTPPNFVLALVLPSIVILGKMILLL
                     PCISRKLKRIKKGWEKSQFLDEGMGGAVPHLSPERVTVM"
     exon            781..1308
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1473
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..10341
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /note="hexamer: AATAAA"
     polyA_site      3443
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /note="major polyA site"
     regulatory      6616..6621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /note="hexamer: ATTAAA"
     polyA_site      6640
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
ORIGIN      
        1 gcggtccggc tcgggggcag gaggagcttg ggcgggagga gcactccgta ggcccgggag
       61 ctcggcgggc cctcggcgcg ggggagccac ggcgctgcgc tgcgagcgtg gctcggagaa
      121 gagggcgtgg aggccttcct cgctacacat aggcaattcc actgtccagc agcatctgcc
      181 gtgctcttat agaaatgcag cctccagagc ctccctgcag gccctctgag tgagaagcta
      241 caacttaaga tcccccaggt cattcctggt gctcttagac gagtctctac catggaatcc
      301 atctctatga tgggaagccc taagagcctg gagacgtttt tgcctaatgg cataaatggt
      361 atcaaagacg caaggcaggt caccgtgggg gtgataggaa gtggggattt tgccaagtct
      421 ctgaccattc ggcttattag atgtggctac cacgtggtca taggaagcag aaatcccaag
      481 tttgcatcag aattttttcc tcacgtggta gacgtcaccc accatgaaga tgctttaaca
      541 aaaacaaata taatattcgt ggctatccat agagaacatt acacctcctt gtgggacctg
      601 agacatctgc ttgtgggcaa aatcctcatt gatgtgagca acaacatgag agtaaaccag
      661 tacccagaat ccaatgcaga gtacctggct tcattattcc cggactcctt gattgtcaaa
      721 ggatttaatg tgatctcagc ttgggcactt cagctaggtc ccaaggatgc cagccgccag
      781 gtttatatat gcagcaacaa tatccaagct cgacagcagg ttatcgagct cgcccgccag
      841 ctgaatttta ttcctgttga cttgggatct ttgtcgtcag ccaaggagat tgaaaactta
      901 cctctgcgac tgtttactct ctggaggggg ccagtggtag tagccataag cttggccaca
      961 tttttctttc tttattcctt tgtcagagat gtgatacatc catatgccag aaaccagcag
     1021 agtgactttt acaagattcc cattgagatt gtgaacaaaa ccttgccgat cgtcgccatc
     1081 accctgctgt ctctggtgta cctggctggc ctcctggcag ctgcgtatca gctttattat
     1141 ggcactaagt accgccgatt tcccccgtgg ctggatactt ggctgcagtg caggaaacag
     1201 ctgggattgc tgagcttctt ctttgcagtt gttcacgtag cctacagcct ctgcttacca
     1261 atgaggaggt cggaaagata cctgttcctc aacatggctt atcagcaggt tcatgccaat
     1321 attgagaacg cgtggaacga ggaggaggtc tggaggattg agatgtacat ttcctttggc
     1381 atcatgagcc tgggcttgtt gtccctgctg gcggtcactt ccatcccatc agtgagcaac
     1441 gctttgaact ggagagagtt cagtttcatc cagtctacgc ttggctacgt cgccctgctc
     1501 atcacgacct tccacgtgtt aatttacgga tggaagcgtg cgtttgcaga agagtactac
     1561 cgcttttaca caccaccaaa cttcgttctt gccctcgttt tgccctccat tgtaattctg
     1621 ggtaagatga tattactcct cccatgcata agccgaaagc taaaacgaat taaaaagggc
     1681 tgggaaaaga gccagtttct agacgaaggc atgggaggag cggttcctca tctgtcccca
     1741 gagagggtca cagtgatgtg atgacaagag gtgctcgcag aagccacaca cacttccatc
     1801 catgccatta ctttaggccc tcgccttggt ccctgtcagc gggctgttga ttggcagtcc
     1861 tgcagtctga aacctgcagt aagttttcag cagaaggaga gattggattc tcttcaagtt
     1921 aatttttata aatgtcatat ttttccaaca tgcaattttg tagtccacat ctattgttac
     1981 aatctagaaa tttcctttgt gcaactgtaa cactgttgtt cttttaacca tattgcatag
     2041 ttgggcacaa atatttgtac ttaataatac agatgagata taatgtttag aacacttggc
     2101 aaaacagcag aattagaagc ttttaacatt actcagtgga catgctcttt ccccaaggct
     2161 aaagatttta attactattc aatttaagga gcagaaatgc ataatcatat attattgaga
     2221 aggggcacat cacattagca tctagggtat gcaggagcaa tcttatgctc tcataaaaat
     2281 gggacaggaa ggatgtcatc cattatacac agcactgtga gtatgtgagc acaaattaaa
     2341 gacaaatgaa aaattgtatt gaatgtgcac tggagataca acataccaat gcataactca
     2401 cgagagcttt agtctctatc acattacaga acccttccat cttcctgttt atgtcaatcg
     2461 ggaaggatct agcaacactt gacctcccaa gcaggtactc tgaatacggt attgtgggcc
     2521 tgtccttagt tacaatgaaa gtaattgtca cacgtcagtc tatatgttac tttggccagt
     2581 caccaccctt cctgtgtgga ttttatcgac atccactgag ggagtatgga atggttgtaa
     2641 acacttgccc aattaatact tacaacaaac ccatgaaata gttatcttca tttcccatat
     2701 ggaaaactga aggacagaag aattaaattt tcctgaggtc acacagtgag cagccatcct
     2761 agggagtcat tcgtcaggac ccacggcttt ataaacatca gtatacacaa cccccgatcc
     2821 atctccatgt actacattct cgacgccagc cttgatggtt cctttctggt agagtcattg
     2881 gcagtctttg gagtatgtcg tgtgcatcaa aggatatcta aaagtatctc agtcataatt
     2941 ttattattac ttgtgggtag tccatagttg cctggaaacc catagtagca caaagcctcc
     3001 ccatgcagtg cagaccgagc agggagaagg ctcctaacag tgtggatgaa ctattaagat
     3061 cctgtagctc tttaaaattt tccataaggt ggccatgtcc tttctcctcc tgagaagccc
     3121 ctccctttac tgctgttcat taggaaactg tttttaagca caaaggatat taggacaagt
     3181 ggttaattat aaatctatat gattatgtgt ccctggacac ataattaaca aaatttgtca
     3241 gtgctggtct tccttgtgta aactgcattt tgttcaaaca ttagggtata ttacattttc
     3301 tccatttgtt ccttttttat tacagtaaaa gttctagaca agatgtaatt gtgtgtattc
     3361 ttcctaaaat tgtatcacct ctaaagttac ctactgactt gaatccaacc atcagaaata
     3421 aaaggactct tatttttgtg gaacctatct ttcccaccat tgtctgtttt cctatccttg
     3481 tactgctggc ctggaaaata gcccactact ctttgatgtt gtcttcttgg ccaaatgtaa
     3541 tattgaacac ctcatcttca ttatattaat cataatcaat ttttgtagga attcagtaca
     3601 ttcatgactt ttaacagtaa ataccaacaa gctgggtgtg gtggctcatg cctttagtct
     3661 cagcactcag gaggcagatg caggctgttc tctgtgagtt agagatgagc ctggtccaca
     3721 ctgtgagttc caggccatca ccgcgagaca ctttctaagt acatacatac atgcttacat
     3781 acatacatac acacatacat acataagtac aaagcgagac actaagtaca tacatgcata
     3841 catacataca tatgcagtga gacactgtat agcacataca tacatacata catacataca
     3901 tacatacata cttacatacc ggtactgtca tgaactagtg aaaaatagca atgtgttttt
     3961 aatacttgct tacttcttga actttactgt aaggcaatta aatgtggaaa tacaatgaaa
     4021 tatttctaaa agttagatga ttaaagtaca ttgttatgca tatgatagga agcctgtaat
     4081 ataaaattat tgctaatata catacatggg acctttgaaa atatgaaatt atgtaaaagc
     4141 tatgaattta atttcaaatg acactttttc tttggaatgc taccaaaacg gaatagcttt
     4201 cgtttttaga ataaatgtaa tatagtcctt gcaattctaa gtgctgaaag gcctgacctc
     4261 tgggatggag aagtctgacc cctgggatgg atgtggggtc agagcacgga ctcgttgtcc
     4321 tctgacaagc acactcatgg tctccttcct ccttttctct gtctctgtct ctctgtgtat
     4381 ctctctctgt catacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     4441 cgtcaatgaa atagaattta aagcttttag gggtggagag aaggtaggga gactttaagg
     4501 gagtgaacat gtgtttcctg atgtttgtct tgagtaggac aagagacgaa atgatgggag
     4561 tgtagaaaac agaacccgtc tcagtcctct gtaacgacag ccaaataatt tttcctgagg
     4621 gaaaaaccca tataacatgt atcatgctac ttaacttttg tgcagatttc ttctctcctt
     4681 tattaagaat atttaaaacc acatttaaat aataaatgta tccatccatt ttaagaagat
     4741 acactgaaat ttagctcaga gaatctccat gagctttcta tttaaaattt taaaacatta
     4801 taaagtgtga gtaaattttg attatttatc agagctaatt attttgtaca ttatagaagg
     4861 tgctgatgtg tccatgtgta actgctggat tcttataaat aagcataact tcaagtttga
     4921 ctgaagaatt ttactttcaa aattaattat taatttgata aaaatatatt cctacttaca
     4981 gttaagttat gaaaattatt ttttaaaggg gctccaagca tatattcaac ctggtataca
     5041 tagtgagttc caggatagcc aggactatat atagatagaa accctgcctc aaaaaagaaa
     5101 gaaaaagaga gatagagaaa gagagagaga gagagagaga gagagagaga gagagagaga
     5161 gagagaagag aagagaagag aaaaagaaag aaaagaaaga gagaaagaaa gaaaaggaaa
     5221 atgaatatat tcaattttgc tattatttct ctcttatgta aataacaaaa gtcttacttt
     5281 aaattttata tgtcattaag ctatttagta atatattcta tgatgttccc tccccaaatg
     5341 aggcttactt attacaaaat ttagcttttt catatggcat ttaaaatata agtatcataa
     5401 atataattta taatatacta caaacagcta aatatacctg tataaatcta taaaatcctg
     5461 cttttgagat gtgcaagcag actgaaagac agcagaattg ttctgtacat tcgcgacaaa
     5521 gcaatagcac ccacagtgta aggcacccag tccagtgtta tggttctgtg tgatgtcagg
     5581 aacatgaggt gcccaacctt ccactgctct gaattcagca ggacaagttc cagcatctat
     5641 tctgtctttg taattaactc taaatgaaag tgtagccagt ttagtggaaa ctctgttctt
     5701 gtgaacccca ggagtgaaca ggttcttccc tacttatgag tgttataaag tgctcagttt
     5761 ttcaggggtc ctagccatat gataaaacag ggcttctggt taacctgaga tccatactag
     5821 gaattgttgg attgttttta actttacaaa tcactaaatt tccacaatgc aggcaggcta
     5881 ggaatcttcc tggtagctta gggactctcc tgttgactaa acacacaaag caaggcaggt
     5941 gctctgtccg acagttcaca gatgttcgtc cttcacggtc ttttcctcac ccttgagctg
     6001 ctgaggactg gcttcacagt tactcctgga gctaggtgcc cttgggacta atctctgtga
     6061 ctcactgaga ggtgaccctg ggatgagtgc tggtctctga ggactctgct cgaagggaag
     6121 gaacttggta tgtgttcttc gtgggccctc agtctggctg acgaggctgt gggtaaacaa
     6181 ctgtccccag agggtcaggg catcatgctg aaaaggctga ggagagaata gcgaacagac
     6241 aagcctctgc ttctccctgc gtttcaacca ttataaattt aagtttctag gttccgtgaa
     6301 atgtaaattt tagccctgcc agttctttct cgcaatacaa atttaacatt cctgaatagg
     6361 ttagactgta ataatcctga gttttaaaag attttgaagg ataatataca atttatatta
     6421 aaatcaatat tctgttgtta attaattata ctttagtttt atccccatct ttcattagct
     6481 attttgtatt gatgtgtata attttctttg tgtgtattca tttttgctaa aggcctgtat
     6541 cctgcaacaa gttgctgtta aattatacac catgatttta tgtcattctc atagatctgc
     6601 tttataaaca tttcaattaa aagtattatt taatgtttta ttcattctgc ttttctatct
     6661 tactgaataa cttgaatgtt tcatttaata ttttggtctt tgcttttaaa aggacatcca
     6721 gaaagcaatc caactgatag ctttgctagg gtaggggact ctttgttttc acagaagtca
     6781 tttaggaaaa ttctatttaa agactatcat ttcattttat tgagcatgtt ttagatgagg
     6841 gtacctacaa tatttaagct attctgtaag acaggaatat agtgttatgt gttgctaagt
     6901 gtctcatgtc taatacagtt tgttctacag cagatattta aagggacacg gctcatttct
     6961 attgaaaatt ataccattcc tctcttctgt gcctatttct tcctgcctga gcctcacatt
     7021 gctcaccatc actgtcttcc ctttttggct tgcctcctgt ccagtggccc agagctgccc
     7081 tgtcctccta gggaggagtt gctagggtgc tgccatcacc ggtgtcacac tgcttcatgt
     7141 ggaagggtcc catacacaca gcagagcagg agaaatggac tctgcgtgga tctgcatgaa
     7201 gatgcttcag tgtgtatcct gacaaggtta ccagaagagg attctcagtg aaaactgagt
     7261 tacaggcaaa caataaatag ccttttacca tatgtatttt aagaatggga cacatattac
     7321 gtggcctttt tattttccta atatggcatc ccgaaagaaa ggtaaaccct gactgaggag
     7381 acacgacata aaattgcact aggagatcta ccatccattt gtttcctcta gatggaatgt
     7441 tccaaaatgc aattcagcag accttcatgg caatatccta taaatcttac caattagctt
     7501 tacctgttcc aaagccaggt ttagcaacat ctacgctttt tcctttcccc tcctcagaaa
     7561 caacagtccc aaataaagtg atgcccactg tgtgtttatg aagggctcag aaaacaggca
     7621 ggctcaagtg gagctgttga ctggcaaatg gagtatgaaa taaagttatc tttgtggttg
     7681 taggcatctg acctcgcaag ctctaaatcc agattgcgtt gagaggcttg gtgacagatt
     7741 catactgaac aagtgcaaag tagtaggcat taaattaaca tcgcaattta cacactggaa
     7801 attatcagta ttctacaggt gataatacca atcttacttt aactaaacat agtgtattat
     7861 tcaggctgtt cataaagttc ttattttaac ttaaaagatg gtgaaattta ttatgggctg
     7921 aattgtgtct tccaaaactt gtatggtaag tcctatcccc caaccgctta aaaaaaaaaa
     7981 aaaaaaaaga ctgtatttgg agactggcct aaagagatca taggggtgag atcaaatggg
     8041 tgaatcttaa tccaatatga ctgacatcct tttaagtaga aaacggacat ggacagccac
     8101 atgacgtaaa gggaagaaaa tagcaagcca agaaaaaagg tctacacaaa gccttggtct
     8161 tgattttcca gccttcagga ctgttagaaa atctttgttt ttaagcattt gttactgcag
     8221 acttcaataa caaatgcaag gactatgcaa tccacagaag tgaggtaatt tatacaactt
     8281 gatgtcatta gaataagcgt atctagtgaa tcctacttta caataaaaac ctgtatctag
     8341 gggccttcat tttgccctct accatgtaag cacagtacat agttgatagt tctaaatgtg
     8401 caggaacgtt ttcacttcat agggatactg ctgtgtcaaa agctaaagag ttgatctggt
     8461 ggaagcaggt cttttgtttg tttttgcttt tttgtctggt gttataaatt tatttcctcc
     8521 gtgactgcat actgcatttg tcctctacat aggaacagtt ccctggcttc acctgcaatc
     8581 tgaattacta tggatacatt tttgatttga gtatctgact tcaggggtag ctgttctact
     8641 tgtcttttct gttccatttg tcatgtataa atttcagagg tgattagttt gtaggctggc
     8701 aactctaagt caatatgaaa aagactgttt aaagtgcatg agtaaattaa attccagcac
     8761 tcttctgcta gaaatttccc caaaagctaa cccactatat taataatatt taatataatg
     8821 ctataaaagt tctctaaaca aactactttg tctcagcagg taataatctt tgtttgaaca
     8881 tttaggacaa gcagcattgg tttagagaga attaaattca catgtaactt aaatacttac
     8941 aaaatgtttg taattcatga taatgaataa gtgcagtttt gctaacttgc taatgaggca
     9001 cggtgaaaaa caaaatggta agaattatat tagtattgaa tttgtttaag tctatgttta
     9061 acttcgttca ttacttctaa atgtacaaat tgtatttagg ttgatatatg aaaactttgt
     9121 tttacatgta caagtgcttc taagaagcac taagtcatat cttcatgatg ctacgttctg
     9181 cgagcggcca atgtattgac gcactgaaac attccgattc cctgggtaga cctgatttct
     9241 cgcgtttctc tattattaat tgatcttttg ttgaagtaat tggacatctc ggtagacatt
     9301 aatcttttta tccatctatg ttcacctgca tcatcataaa cagggatcaa tgaatagtaa
     9361 ttaaaattaa atccacacat ttaaacagtc gaagctcttg aaaacataaa ccttggtgca
     9421 cttctaagga gaaatgctgt gaaacaaata attgtcacca agtccatttg caaatagagg
     9481 aagccccagc cagttccttt ttcttttgag atggctaact ttggtaaaac tgttccaaaa
     9541 caataataac aaaaaactac acatcatgag cttcttagtt tttatatgta cacttgttaa
     9601 aatgggcatt attcacacca ggaggtgcaa agttctgcat tcctgacgag cccctaatgg
     9661 ccacacagtt aggaaaccca tgaaaaccac tttgagtagc aaggatctaa aatgcttaat
     9721 ctagataatt tacaaaattc tttcatttta ccttaaatca aaatctagcc cttgacattt
     9781 tcatgaacac ttattgaaca ccttctatga tattgactag aaggaccaag agtatggcct
     9841 tcagaccaac tacatcagca tcacatggga actcactata aaggcaaact ggaaccagac
     9901 aaggtattca caaacatgcc tacctacatc tccagcatgt cacaggctgg ggacacacag
     9961 ccacaccttc actcagcaag taagcaaatt agtggctatg tacaaatttt taattgcctt
    10021 agtctcagta gcataacatg gttgggctat ttcgtcaata aattccacta actatacagt
    10081 gagcaccaaa aaacaaaaca aaataaaaga caaaaaaaaa agagcatgcc actaagcgtg
    10141 acatctaaaa caacagaaaa aatacaggct tcctgggaaa gatcaggcca gactgtttca
    10201 tagagtgtaa gccttctgaa gatggtagca tgaagtttgt actctatgaa gagatcacaa
    10261 ggcgactgag tatgaagtgc gtgagacttc tgtccctctt gcttctcaac ctactaatga
    10321 ataaaataaa tgctatcgta g
//
