LOCUS       NP_001096626             489 aa            linear   ROD 01-OCT-2024
DEFINITION  metalloreductase STEAP2 isoform 1 [Mus musculus].
ACCESSION   NP_001096626
VERSION     NP_001096626.1
DBSOURCE    REFSEQ: accession NM_001103156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Wang,Y., Chen,S., Chen,S. and Jiang,J.
  TITLE     Unveiling the role of copper metabolism and STEAP2 in idiopathic
            pulmonary fibrosis molecular landscape
  JOURNAL   J Cell Mol Med 28 (11), e18414 (2024)
   PUBMED   38872435
  REMARK    GeneRIF: Unveiling the role of copper metabolism and STEAP2 in
            idiopathic pulmonary fibrosis molecular landscape.
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Ji,L., Shi,X., Wang,G., Wu,H. and Hu,Z.
  TITLE     Overexpressing six-transmembrane protein of prostate 2 (STAMP2)
            alleviates sepsis-induced acute lung injury probably by hindering
            M1 macrophage polarization via the NF-kappaB pathway
  JOURNAL   Folia Histochem Cytobiol 61 (1), 34-46 (2023)
   PUBMED   36583372
  REMARK    GeneRIF: Overexpressing six-transmembrane protein of prostate 2
            (STAMP2) alleviates sepsis-induced acute lung injury probably by
            hindering M1 macrophage polarization via the NF-kappaB pathway.
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Hasegawa,H., Li,C., Alba,B.M., Penny,D.M., Xia,Z., Dayao,M.R.,
            Li,P., Zhang,J., Zhou,J., Lim,D., Murawsky,C.M. and Lim,A.C.
  TITLE     Membrane cholesterol modulates STEAP2 conformation during dynamic
            intracellular trafficking processes leading to broad subcellular
            distribution
  JOURNAL   Exp Cell Res 370 (2), 208-226 (2018)
   PUBMED   29940176
  REMARK    GeneRIF: The conformational modulation of STEAP2 by the local
            membrane cholesterol content can therefore serve as a potential
            mechanism to modulate STEAP2 function in a compartment-restricted
            manner
REFERENCE   5  (residues 1 to 489)
  AUTHORS   Sikkeland,J., Sheng,X., Jin,Y. and Saatcioglu,F.
  TITLE     STAMPing at the crossroads of normal physiology and disease states
  JOURNAL   Mol Cell Endocrinol 425, 26-36 (2016)
   PUBMED   26911931
  REMARK    Review article
REFERENCE   6  (residues 1 to 489)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (residues 1 to 489)
  AUTHORS   Sikkeland,J. and Saatcioglu,F.
  TITLE     Differential expression and function of stamp family proteins in
            adipocyte differentiation
  JOURNAL   PLoS One 8 (7), e68249 (2013)
   PUBMED   23874564
  REMARK    GeneRIF: Stamp1 and Stamp2 play critical roles in adipogenesis, but
            through different mechanisms.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 489)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (residues 1 to 489)
  AUTHORS   Vaghjiani,R.J., Talma,S. and Murphy,C.L.
  TITLE     Six-transmembrane epithelial antigen of the prostate (STEAP1 and
            STEAP2)-differentially expressed by murine and human mesenchymal
            stem cells
  JOURNAL   Tissue Eng Part A 15 (8), 2073-2083 (2009)
   PUBMED   19196137
  REMARK    GeneRIF: STEAPs may represent novel markers of mesenchymal stem
            cells in man as well as mice.
REFERENCE   10 (residues 1 to 489)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ122203.1, AK052981.1, AK015015.1 and AC092404.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166607.1, AK145468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.18 cM"
     Protein         1..489
                     /product="metalloreductase STEAP2 isoform 1"
                     /note="metalloreductase STEAP2"
                     /calculated_mol_wt=55629
     Region          32..221
                     /region_name="COG2085"
                     /note="Predicted dinucleotide-binding enzyme [General
                     function prediction only]"
                     /db_xref="CDD:441688"
     Site            207..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Region          258..405
                     /region_name="Ferric_reduct"
                     /note="Ferric reductase like transmembrane component;
                     pfam01794"
                     /db_xref="CDD:426438"
     Site            258..278
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Site            304..324
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Site            358..378
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Site            392..412
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Site            431..451
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWB6.1)"
     Site            482
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BWB6.1)"
     CDS             1..489
                     /gene="Steap2"
                     /gene_synonym="4921538B17Rik; IPCA-1; IPCA1; PCANAP1;
                     STAMP1; STMP"
                     /coded_by="NM_001103156.2:292..1761"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS39007.1"
                     /db_xref="GeneID:74051"
                     /db_xref="MGI:MGI:1921301"
ORIGIN      
        1 mesismmgsp ksletflpng ingikdarqv tvgvigsgdf aksltirlir cgyhvvigsr
       61 npkfaseffp hvvdvthhed altktniifv aihrehytsl wdlrhllvgk ilidvsnnmr
      121 vnqypesnae ylaslfpdsl ivkgfnvisa walqlgpkda srqvyicsnn iqarqqviel
      181 arqlnfipvd lgslssakei enlplrlftl wrgpvvvais latffflysf vrdvihpyar
      241 nqqsdfykip ieivnktlpi vaitllslvy lagllaaayq lyygtkyrrf ppwldtwlqc
      301 rkqlgllsff favvhvaysl clpmrrsery lflnmayqqv hanienawne eevwriemyi
      361 sfgimslgll sllavtsips vsnalnwref sfiqstlgyv allittfhvl iygwkrafae
      421 eyyrfytppn fvlalvlpsi vilgkmilll pcisrklkri kkgweksqfl degmggavph
      481 lspervtvm
//
