LOCUS       NM_027399               1216 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus six transmembrane epithelial antigen of the prostate 1
            (Steap1), mRNA.
ACCESSION   NM_027399
VERSION     NM_027399.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Zou,X., Liu,C., Huang,Z., Xiang,S., Li,K., Yuan,Y., Hao,Y. and
            Zhou,F.
  TITLE     Inhibition of STEAP1 ameliorates inflammation and ferroptosis of
            acute lung injury caused by sepsis in LPS-induced human pulmonary
            microvascular endothelial cells
  JOURNAL   Mol Biol Rep 50 (7), 5667-5674 (2023)
   PUBMED   37209327
  REMARK    GeneRIF: Inhibition of STEAP1 ameliorates inflammation and
            ferroptosis of acute lung injury caused by sepsis in LPS-induced
            human pulmonary microvascular endothelial cells.
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Chen,X., Wang,R., Chen,A., Wang,Y., Wang,Y., Zhou,J. and Cao,R.
  TITLE     Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the
            fusion protein of HSP65 & STEAP1 186-193
  JOURNAL   Biomed Pharmacother 111, 1124-1131 (2019)
   PUBMED   30841425
  REMARK    GeneRIF: HSP65 and STEAP1 186-193 can significantly inhibit the
            growth of mouse RM-1 prostate cancer.
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Lavado,A., He,Y., Pare,J., Neale,G., Olson,E.N., Giovannini,M. and
            Cao,X.
  TITLE     Tumor suppressor Nf2 limits expansion of the neural progenitor pool
            by inhibiting Yap/Taz transcriptional coactivators
  JOURNAL   Development 140 (16), 3323-3334 (2013)
   PUBMED   23863479
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Vaghjiani,R.J., Talma,S. and Murphy,C.L.
  TITLE     Six-transmembrane epithelial antigen of the prostate (STEAP1 and
            STEAP2)-differentially expressed by murine and human mesenchymal
            stem cells
  JOURNAL   Tissue Eng Part A 15 (8), 2073-2083 (2009)
   PUBMED   19196137
  REMARK    GeneRIF: STEAPs may represent novel markers of mesenchymal stem
            cells in man as well as mice.
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Porkka,K.P., Helenius,M.A. and Visakorpi,T.
  TITLE     Cloning and characterization of a novel six-transmembrane protein
            STEAP2, expressed in normal and malignant prostate
  JOURNAL   Lab Invest 82 (11), 1573-1582 (2002)
   PUBMED   12429817
REFERENCE   7  (bases 1 to 1216)
  AUTHORS   Yang,D., Holt,G.E., Velders,M.P., Kwon,E.D. and Kast,W.M.
  TITLE     Murine six-transmembrane epithelial antigen of the prostate,
            prostate stem cell antigen, and prostate-specific membrane antigen:
            prostate-specific cell-surface antigens highly expressed in
            prostate cancer of transgenic adenocarcinoma mouse prostate mice
  JOURNAL   Cancer Res 61 (15), 5857-5860 (2001)
   PUBMED   11479226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN176485.1, AK144312.1 and AK010437.1.
            
            On Jul 22, 2009 this sequence version replaced NM_027399.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010437.1, BC061023.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DN176485.1         1-46
            47-765              AK144312.1         2-720
            766-1216            AK010437.1         761-1211
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.2 cM"
     gene            1..1216
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /note="six transmembrane epithelial antigen of the
                     prostate 1"
                     /db_xref="GeneID:70358"
                     /db_xref="MGI:MGI:1917608"
     exon            1..71
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            72..186
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1122
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /note="metalloreductase STEAP1; six-transmembrane
                     epithelial antigen of prostate 1"
                     /codon_start=1
                     /product="STEAP1 protein"
                     /protein_id="NP_081675.2"
                     /db_xref="CCDS:CCDS19077.1"
                     /db_xref="GeneID:70358"
                     /db_xref="MGI:MGI:1917608"
                     /translation="MEISDDVTNPEQLWKMKPKGNLEDDSYSTKDSGETSMLKRPGLS
                     HLQHAVHVDAFDCPSELQHTQEFFPNWRLPVKVAAIISSLTFLYTLLREIIYPLVTSR
                     EQYFYKIPILVINKVLPMVAITLLALVYLPGELAAVVQLRNGTKYKKFPPWLDRWMLA
                     RKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYKQVQQNKEDAWVEHDVWRMEI
                     YVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHALVFAWNK
                     WVDVSQFVWYMPPTFMIAVFLPTLVLICKIALCLPCLRKKILKIRCGWEDVSKINRTE
                     MASRL"
     exon            187..699
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            700..864
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1216
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="Steap1"
                     /gene_synonym="2410007B19Rik; Prss24; Steap"
                     /note="major polyA site"
ORIGIN      
        1 cgggctccgc gtgggactgg gagtccgtcc gggcagcgag cgcctcgccg tcgggtccca
       61 cggagaagcc ggtggctgaa gccgtactat tttatagcag tcatggagat cagtgacgat
      121 gttacaaacc cagaacaact ttggaaaatg aagccaaagg gaaacctgga agatgacagt
      181 tactcgacta aggactcggg agagacgagc atgctgaaaa gaccggggct ctcgcacttg
      241 cagcacgcgg tccacgtcga tgcctttgac tgcccctccg agcttcagca cacgcaggaa
      301 ttctttccaa actggcgctt gccagtgaaa gtcgctgcca tcatatcatc cctgactttc
      361 ctgtacacac ttctgaggga aatcatctac ccgttagtaa cttcccgtga acaatatttt
      421 tataaaattc caatcctggt tattaacaaa gtcttgccaa tggtcgccat taccctcttg
      481 gcactggtct atttgccagg agagttagcg gcagttgtac agcttcgcaa tggaaccaag
      541 tacaagaagt tcccaccctg gttagataga tggatgctgg ccaggaagca gtttggtctc
      601 ctcagcttct tttttgctgt gctgcacgct gtttacagtc tctcataccc aatgaggaga
      661 tcctacagat acaagctact caactgggct tacaaacagg ttcaacaaaa caaagaggat
      721 gcctgggtag agcatgatgt ctggagaatg gagatttatg tgtccctggg gattgtgggg
      781 ctggccatct tggctctctt ggctgtgaca tctattccat ctgtgagcga ctctttaacc
      841 tggagagaat ttcactatat tcagagcaaa ctaggaattg tctctcttct tctgggcaca
      901 gtacacgctt tggtttttgc ctggaataaa tgggtagatg tcagtcaatt tgtatggtac
      961 atgcctccga cttttatgat agctgttttc cttccaactc ttgtcctgat atgtaaaatc
     1021 gccctgtgcc tgccctgtct gaggaagaag atactgaaga ttagatgtgg ttgggaagat
     1081 gtcagcaaaa ttaacaggac tgagatggcc tccaggttgt agaactactg tttgcacata
     1141 tttgcttgtt attgatgtcc tatcataagc atttcaaatt tgtgtttgtt aataaaatga
     1201 atactttggg atcgtt
//
