LOCUS       NM_011491               1793 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus stanniocalcin 2 (Stc2), mRNA.
ACCESSION   NM_011491
VERSION     NM_011491.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Patil,N.Y., Rus,I. and Joshi,A.D.
  TITLE     Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin
            2-Mediated Protection against Alcohol-Induced Apoptosis
  JOURNAL   J Pharmacol Exp Ther 387 (1), 111-120 (2023)
   PUBMED   37562971
  REMARK    GeneRIF: Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven
            Stanniocalcin 2-Mediated Protection against Alcohol-Induced
            Apoptosis.
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Lionikas,A., Hernandez Cordero,A.I., Kilikevicius,A., Carroll,A.M.,
            Bewick,G.S., Bunger,L., Ratkevicius,A., Heisler,L.K., Harboe,M. and
            Oxvig,C.
  TITLE     Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated
            in functional overload-induced hypertrophy
  JOURNAL   Physiol Rep 11 (15), e15793 (2023)
   PUBMED   37568262
  REMARK    GeneRIF: Stanniocalcin-2 inhibits skeletal muscle growth and is
            upregulated in functional overload-induced hypertrophy.
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Zhang,L., He,X., Xiong,Y., Ran,Q., Xiong,A., Wang,J., Wu,D., Niu,B.
            and Li,G.
  TITLE     Transcriptome-wide profiling discover: PM2.5 aggravates airway
            dysfunction through epithelial barrier damage regulated by
            Stanniocalcin 2 in an OVA-induced model
  JOURNAL   Ecotoxicol Environ Saf 220, 112408 (2021)
   PUBMED   34111662
  REMARK    GeneRIF: Transcriptome-wide profiling discover: PM2.5 aggravates
            airway dysfunction through epithelial barrier damage regulated by
            Stanniocalcin 2 in an OVA-induced model.
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Jeon,Y., Shin,J.E., Kwon,M., Cho,E., Cavalli,V. and Cho,Y.
  TITLE     In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic
            Nerves
  JOURNAL   Mol Neurobiol 58 (2), 750-760 (2021)
   PUBMED   33011858
  REMARK    GeneRIF: In Vivo Gene Delivery of STC2 Promotes Axon Regeneration
            in Sciatic Nerves.
REFERENCE   5  (bases 1 to 1793)
  AUTHORS   Hernandez Cordero,A.I., Gonzales,N.M., Parker,C.C., Sokolof,G.,
            Vandenbergh,D.J., Cheng,R., Abney,M., Sko,A., Douglas,A.,
            Palmer,A.A., Gregory,J.S. and Lionikas,A.
  TITLE     Genome-wide Associations Reveal Human-Mouse Genetic Convergence and
            Modifiers of Myogenesis, CPNE1 and STC2
  JOURNAL   Am J Hum Genet 105 (6), 1222-1236 (2019)
   PUBMED   31761296
  REMARK    Erratum:[Am J Hum Genet. 2020 Jan 2;106(1):138. doi:
            10.1016/j.ajhg.2019.12.008.. PMID: 31901248]
REFERENCE   6  (bases 1 to 1793)
  AUTHORS   Ito,D., Walker,J.R., Thompson,C.S., Moroz,I., Lin,W.,
            Veselits,M.L., Hakim,A.M., Fienberg,A.A. and Thinakaran,G.
  TITLE     Characterization of stanniocalcin 2, a novel target of the
            mammalian unfolded protein response with cytoprotective properties
  JOURNAL   Mol Cell Biol 24 (21), 9456-9469 (2004)
   PUBMED   15485913
  REMARK    GeneRIF: induced STC2 expression is an essential feature of
            survival component of the unfolded-protein response
REFERENCE   7  (bases 1 to 1793)
  AUTHORS   Yadav,N., Lee,J., Kim,J., Shen,J., Hu,M.C., Aldaz,C.M. and
            Bedford,M.T.
  TITLE     Specific protein methylation defects and gene expression
            perturbations in coactivator-associated arginine methyltransferase
            1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (11), 6464-6468 (2003)
   PUBMED   12756295
REFERENCE   8  (bases 1 to 1793)
  AUTHORS   Moore,E.E., Kuestner,R.E., Conklin,D.C., Whitmore,T.E., Downey,W.,
            Buddle,M.M., Adams,R.L., Bell,L.A., Thompson,D.L., Wolf,A.,
            Chen,L., Stamm,M.R., Grant,F.J., Lok,S., Ren,H. and De Jongh,K.S.
  TITLE     Stanniocalcin 2: characterization of the protein and its
            localization to human pancreatic alpha cells
  JOURNAL   Horm Metab Res 31 (7), 406-414 (1999)
   PUBMED   10450831
REFERENCE   9  (bases 1 to 1793)
  AUTHORS   Ishibashi,K., Miyamoto,K., Taketani,Y., Morita,K., Takeda,E.,
            Sasaki,S. and Imai,M.
  TITLE     Molecular cloning of a second human stanniocalcin homologue (STC2)
  JOURNAL   Biochem Biophys Res Commun 250 (2), 252-258 (1998)
   PUBMED   9753616
REFERENCE   10 (bases 1 to 1793)
  AUTHORS   Chang,A.C. and Reddel,R.R.
  TITLE     Identification of a second stanniocalcin cDNA in mouse and human:
            stanniocalcin 2
  JOURNAL   Mol Cell Endocrinol 141 (1-2), 95-99 (1998)
   PUBMED   9723890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF031035.1.
            
            On Jun 19, 2003 this sequence version replaced NM_011491.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031035.1, BC012206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.4 cM"
     gene            1..1793
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /note="stanniocalcin 2"
                     /db_xref="GeneID:20856"
                     /db_xref="MGI:MGI:1316731"
     exon            1..350
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1090
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /codon_start=1
                     /product="stanniocalcin-2 precursor"
                     /protein_id="NP_035621.1"
                     /db_xref="CCDS:CCDS24512.1"
                     /db_xref="GeneID:20856"
                     /db_xref="MGI:MGI:1316731"
                     /translation="MCAERLGQFVTLALVFATLDPAQGTDSTNPPEGPQDRSSQQKGR
                     LSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSF
                     IKDALRCKAHALRHKFGCISRKCPAIREMVFQLQRECYLKHDLCSAAQENVGVIVEMI
                     HFKDLLLHEPYVDLVNLLLTCGEDVKEAVTRSVQAQCEQSWGGLCSILSFCTSNIQRP
                     PTAAPEHQPLADRAQLSRPHHRDTDHHLTANRGAKGERGSKSHPNAHARGRTGGQSAQ
                     GPSGSSEWEDEQSEYSDIRR"
     exon            351..493
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            494..705
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1793
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaacggc ctggtcacat gctctccaga gagctacggg agggcgctgg gtaacctcta
       61 tccgagccgc ggcgaggagg agggaagggg ccagcgagga ggaagagtgg gaggaggggg
      121 aagcggcgga ggaggaagag gaggaggagg ggcgcacaaa gaatccaggt ctccaggcgg
      181 gagggtgata cccagaacca tgtgtgcgga gcggctgggc cagtttgtga ccctggcttt
      241 ggtgtttgcc accttggacc cggcgcaggg gacggactcc acgaaccctc cggaaggtcc
      301 ccaagacagg agctcgcagc agaaaggccg tctgtccctg cagaacacag cggagatcca
      361 gcactgtttg gtcaatgccg gggacgtggg ctgtggtgtg tttgagtgtt tcgagaacaa
      421 ctcttgtgaa atccagggtt tacatgggat ttgcatgacg tttctgcaca acgctggaaa
      481 attcgatgcc cagggaaagt cattcatcaa ggatgccctg aggtgcaagg cccatgccct
      541 gcgtcataaa tttggctgca tcagcaggaa gtgtccagca attagggaaa tggttttcca
      601 gttgcagagg gaatgctatc tgaagcatga cctgtgctcc gcagcccagg agaacgtcgg
      661 tgtgattgtg gagatgattc atttcaagga tctcctgctg catgagccct atgtggacct
      721 tgtgaacctg ctgctgacct gcggggaaga tgtgaaggag gcagtcaccc gcagcgtcca
      781 ggctcagtgt gaacagagct ggggaggcct ctgctccatc ctgagtttct gcacctccaa
      841 tatacagaga cctcccacgg cagccccaga gcatcagccc ctggcagaca gggctcagct
      901 ctccaggcct caccaccggg acacagacca tcacctaaca gccaacagag gtgccaaggg
      961 tgagcgaggg agcaaaagcc acccgaatgc ccatgctcga ggcagaaccg gtggccagag
     1021 cgctcaggga ccctctggaa gcagtgagtg ggaggatgaa cagtctgagt attccgacat
     1081 ccggaggtga aatgaaaacc gggccatgaa agctttcctc caggctgtcc attttcttat
     1141 ctatggacat tccaaaacat ttacattaaa gaggggggat gtcacacgct ggatgtgtgc
     1201 aaattgtgga cttcgtgcag gtgtgtgaac aggtgagatg aagattcccg ggcagcaagg
     1261 tctcgagtgc ctggtgggtt ggcacctgtg taagcttatt ggcgggagtg ttgtattgaa
     1321 tcggccgtgt aactgtctct tcggtctgtg gagttagttg gtggcttaag tatggtctgt
     1381 tggggggagg tcagccgggg agggaagggg ccacaggtgg gtggtaaacc ctcccccaca
     1441 gttcccagta ctgtctgcac agagcagggg ctgggttctg gggtagggct gagtggagat
     1501 acagctgaca aggcagagag agcagagagg aggaagggct tagccccact cagtcccaaa
     1561 ccggaagttt agtgtcgtgc atgggatcta gtgtttcaga gctgctggag gggacatgga
     1621 tggtacattt tctgtgtgtc atttctgagc cattgttctg tctgggggac actgaaggag
     1681 tggccctgtt tgtttatttt tgaccactgt ttcaagtctc cattttactt tttttttttt
     1741 taaatcaact gacatctatg tgtctgtcat ctaaataaat ggctttcaaa cca
//
