LOCUS       NM_009285               3743 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus stanniocalcin 1 (Stc1), mRNA.
ACCESSION   NM_009285
VERSION     NM_009285.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3743)
  AUTHORS   Cao,R., Liu,Y., Wei,K., Jin,N., Liang,Y., Ao,R., Pan,W., Wang,X.,
            Wang,X., Zhang,L. and Xie,J.
  TITLE     Genes related to neural tube defects and glioblastoma
  JOURNAL   Sci Rep 15 (1), 3777 (2025)
   PUBMED   39885289
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3743)
  AUTHORS   Chan,K.K., Hon,T.C., Au,K.Y., Choi,H.L., Wong,D.K., Chan,A.C.,
            Yuen,M.F., Lai,C.L. and Lo,R.C.
  TITLE     Stanniocalcin 1 is a serum biomarker and potential therapeutic
            target for HBV-associated liver fibrosis
  JOURNAL   J Pathol 257 (2), 227-238 (2022)
   PUBMED   35122667
  REMARK    GeneRIF: Stanniocalcin 1 is a serum biomarker and potential
            therapeutic target for HBV-associated liver fibrosis.
REFERENCE   3  (bases 1 to 3743)
  AUTHORS   Avalle,L., Raggi,L., Monteleone,E., Savino,A., Viavattene,D.,
            Statello,L., Camperi,A., Stabile,S.A., Salemme,V., De Marzo,N.,
            Marino,F., Guglielmi,C., Lobascio,A., Zanini,C., Forni,M.,
            Incarnato,D., Defilippi,P., Oliviero,S. and Poli,V.
  TITLE     STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1
            secretion by cancer associated fibroblasts
  JOURNAL   Oncogene 41 (10), 1456-1467 (2022)
   PUBMED   35042959
  REMARK    GeneRIF: STAT3 induces breast cancer growth via ANGPTL4, MMP13 and
            STC1 secretion by cancer associated fibroblasts.
REFERENCE   4  (bases 1 to 3743)
  AUTHORS   Sun,B., He,S., Liu,B., Xu,G., Guoji,E., Feng,L., Xu,L., Chen,D.,
            Zhao,W., Chen,J., Gao,Y. and Zhang,E.
  TITLE     Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through
            the AMPK Pathway
  JOURNAL   Neurochem Res 46 (11), 2948-2957 (2021)
   PUBMED   34268656
  REMARK    GeneRIF: Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage
            Through the AMPK Pathway.
REFERENCE   5  (bases 1 to 3743)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3743)
  AUTHORS   Stasko,S.E. and Wagner,G.F.
  TITLE     Stanniocalcin gene expression during mouse urogenital development:
            a possible role in mesenchymal-epithelial signalling
  JOURNAL   Dev Dyn 220 (1), 49-59 (2001)
   PUBMED   11146507
REFERENCE   7  (bases 1 to 3743)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 3743)
  AUTHORS   Jiang,W.Q., Chang,A.C., Satoh,M., Furuichi,Y., Tam,P.P. and
            Reddel,R.R.
  TITLE     The distribution of stanniocalcin 1 protein in fetal mouse tissues
            suggests a role in bone and muscle development
  JOURNAL   J Endocrinol 165 (2), 457-466 (2000)
   PUBMED   10810309
REFERENCE   9  (bases 1 to 3743)
  AUTHORS   Varghese,R., Wong,C.K., Deol,H., Wagner,G.F. and DiMattia,G.E.
  TITLE     Comparative analysis of mammalian stanniocalcin genes
  JOURNAL   Endocrinology 139 (11), 4714-4725 (1998)
   PUBMED   9794484
REFERENCE   10 (bases 1 to 3743)
  AUTHORS   Chang,A.C., Dunham,M.A., Jeffrey,K.J. and Reddel,R.R.
  TITLE     Molecular cloning and characterization of mouse stanniocalcin cDNA
  JOURNAL   Mol Cell Endocrinol 124 (1-2), 185-187 (1996)
   PUBMED   9027337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134260.1, AK149293.1 and BB551439.1.
            
            On Mar 24, 2007 this sequence version replaced NM_009285.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134260.1, AF099098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2064              AK134260.1         2-2065
            2065-2284           AK149293.1         1948-2167
            2285-3548           AK134260.1         2286-3549
            3549-3549           BB551439.1         134-134
            3550-3740           AK134260.1         3551-3741
            3741-3743           BB551439.1         326-328
FEATURES             Location/Qualifiers
     source          1..3743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 35.98 cM"
     gene            1..3743
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="stanniocalcin 1"
                     /db_xref="GeneID:20855"
                     /db_xref="MGI:MGI:109131"
     exon            1..219
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..845
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="STC-1"
                     /codon_start=1
                     /product="stanniocalcin-1 precursor"
                     /protein_id="NP_033311.3"
                     /db_xref="CCDS:CCDS27236.1"
                     /db_xref="GeneID:20855"
                     /db_xref="MGI:MGI:109131"
                     /translation="MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVR
                     CLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANG
                     ITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYY
                     NRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNE
                     PQKLKVLLRNLRGEGDSPSHIKRTSQESA"
     exon            220..362
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /inference="alignment:Splign:2.1.0"
     exon            363..574
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /inference="alignment:Splign:2.1.0"
     exon            575..3743
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="hexamer: CATAAA"
     polyA_site      1292
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="major polyA site"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="hexamer: ATTAAA"
     polyA_site      3666
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="major polyA site"
     regulatory      3698..3703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="hexamer: AATAAT"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stc1"
                     /gene_synonym="Stc"
                     /note="hexamer: AATAAA"
     polyA_site      3715
                     /gene="Stc1"
                     /gene_synonym="Stc"
     polyA_site      3743
                     /gene="Stc1"
                     /gene_synonym="Stc"
ORIGIN      
        1 agtatatcca gatccacatc ttcactcaag ccgggagagg gaaagaggaa agggggggag
       61 gaaaaaaaaa agccaacaac ttagcggaaa cttctcagag aatgctccaa aactcagcag
      121 tgattctggc gctggtcatc agtgcagctg cagcgcacga ggcggaacaa aatgattctg
      181 tgagccccag aaaatcccgg gtggcggctc aaaattcagc tgaagtggtt cgctgcctca
      241 acagtgccct gcaggttggc tgcggggctt ttgcatgcct ggaaaactcc acatgtgaca
      301 cagatgggat gtacgacatt tgtaaatcct tcttgtacag tgctgctaaa tttgacactc
      361 agggaaaagc atttgtcaaa gagagcttaa agtgcatcgc caatgggatc acctccaagg
      421 tattccttgc cattcggagg tgttcgactt tccagaggat gatcgccgag gtgcaggagg
      481 actgctacag caagcttaac gtttgcagca tcgccaagcg caacccggaa gccatcactg
      541 aagtcataca gctgcccaat cacttctcca acagatacta caacagactt gtccgaagcc
      601 ttctggaatg tgatgaagac acggtcagta caatcagaga cagcctgatg gagaagatcg
      661 ggcccaacat ggccagcctc ttccacatcc tgcagacaga ccactgtgcc cagacacacc
      721 ccagagctga cttcaatagg aggcgcacaa atgagccaca gaagctgaaa gtcctcctca
      781 ggaacctccg aggtgagggg gactctccct cacacatcaa acgcacctcc caagagagtg
      841 cgtaagcagg gagaggtatt cacagcctca ccaaactaat agcattttag gggtgttgac
      901 acaccaactt tgagtgtact gtgcctggtt tgattttttt taagtagtac ctattttcta
      961 tccccccgtt aaagaaaaat tgcatgaaac taggcttcca taatcaatat cccaacattc
     1021 tgcaatgaca gcattcttac caacagaata catgtgtggt cattctgcct ctcctcaaga
     1081 gagaatgtac cctcttccat cccccctctc tctgaattct tttcccagat ccctatctac
     1141 tctccgcaaa cacaaaccat tcatgtaact acccagtcat tgtaatctga aaatgtagat
     1201 ccctttagaa tggtcacctg gtagagttag ccaatacaaa acaactttat ttaaatgcat
     1261 gtcttaaatg ctcataaata tgttaaatgg aattcgtgtt atgaatctgt gctggccatg
     1321 gacgaatatg aatgtcatgt ttgaattctt gatctctaac gagtcttatg gtctctatcc
     1381 tccaatgtct aatttccttt ctgacatatt taccaaattg ctcaaacctg gttctccaac
     1441 cagactttga gctagcatct tcttgcatct aatgaaaaac aaaaaagcta acatctttat
     1501 gtactgtaac tgctcagagc tttaaaagta tctttaacaa ttgtcttaaa aaacggagaa
     1561 tcttaaggtc taactgtgga atataaatag ctgaaaacta ttgtactgta cataaattcc
     1621 agaggactct gcttaacaga gcagtctata ataactttat tgcatataga tttagttttg
     1681 taccttagct ttattttcct tttcctggga atggaataac tatctcactt ccagatatcc
     1741 acattcatgc tccttgtggc cttttttata actaaggggg tagaagtagt tttaactcaa
     1801 catcagaact taagatgggc ctatacttga caggaaaacc caacaggtta tctgaaggac
     1861 cccaggtaag acgttaatct cccagcccac ctcaacccgg aggctacgtt tgacttagat
     1921 gtatcctgaa acagctctgt cacatccaac tgggaataac aagaatcaaa aagaccatcc
     1981 ctttgggctt ggaccacttg gtgtgacaag gcctactatc cccttggaag tggcagttct
     2041 tggctcatcg ccttccatca gtgcctggca ctctggtaaa tgatggagtg ggatattgtt
     2101 ccactaagcc aatcaggaat gagtcaatca gcctttgggt ctttagtccg ggaaacttgg
     2161 gcttaagggg gtatgaataa ccctgggctg tccagcctta atagactcct cttacatctt
     2221 ttgtcctgta acatgctgcc tgccaaagta gtcctggcag ctggaccatc tctgtaggat
     2281 ctttaaaaaa aaagaaaaaa agaaaaaaaa aagaaaaaat atagagagaa tgaaggaggg
     2341 cataagcgct ggtggtttga tcatttctgc tgtgatgttt acaggatggt agccaccaaa
     2401 gccaaatgat taacctgtct acgaacaaca gtagtttctc agggtcattg tccttgaacc
     2461 caacagcccc aattatgagt gtcactgctc accaaaggtc aatgctgaga gaggaagagg
     2521 gaggggctgc tccaaactca tttgggtaga aactatcggt gcttgactct cactaggcta
     2581 caccccagag ttgaccaaat tgagtgatag ggaccctggt gggaggaggg agggcacctc
     2641 tccagggaaa tcaaaagcaa tacaacttta ccacaaagcc tttaaaacca gtaacatagt
     2701 gctcaaggac caagatcaag cgtagcagct gcagctgcag cagcggcccc aaggctgcag
     2761 cctctgtccc cacacagcct cgaagcgcgc tgacatcaga ttgttaaggg cattttcata
     2821 cttagaactg tcccatcccc aggtcccaaa caaatggaca ctgccttagc ctcttggaaa
     2881 tcaggtagca catattctaa gctagattca cccctctccc ccacccccaa cttcccaccc
     2941 caggcaaggc tgacttcttt gaaccagaaa agctagtcaa gtgtgtgtgt gttgtgcatt
     3001 gttgcaaacc cactaagcca gaagcccaaa gtggcaaata gcttatgaga attcctagta
     3061 caattctctt aagttcagta aactttcttt ctctcttttc tctttttttt tatttttttt
     3121 atttttgctg tgaccttttc aatctgtgat ataccctcct ttctccccac agtgacattg
     3181 gtatatgtac caacaatgca catatctaca catatgaaaa gaagcagttc tcacaacgtt
     3241 gctgggtttt tgttttgttt tgttttttgg tttttgtttt ttgttttttg cttctttttt
     3301 ccccctcccc ctgcccctct ccacctcctt cttgaacttc caaagctttg tctcgtgttt
     3361 gctgcagagc gattcgggga ctgacctaga cctgtttgca tgatctcctc tcttgtgatt
     3421 tggttgcact ttagaacatt tttgtgccgt attatttgca ttatgtattt ataatttaaa
     3481 tgatatttag gtttttggct gagtactgga ataaacagtg agcatatctg gtatatgtca
     3541 ttatttattg ttaaattaca tttttaagct ccatgtgcat ataaaagtta tgaaacatat
     3601 catggtaatg acagatgcaa gttattttat ttgcttattt ttataattaa agatgccata
     3661 gcataatttg aagcctttgg tgaattcctt ctacgataat aataataata ataaagtgtt
     3721 aacgttttat ttgttccccc tcc
//
