LOCUS       NM_025303               2890 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus staufen double-stranded RNA binding protein 2 (Stau2),
            transcript variant 3, mRNA.
ACCESSION   NM_025303 NM_001111271
VERSION     NM_025303.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2890)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2890)
  AUTHORS   Yang,H., Zhu,Y., Li,X., Jiang,Z. and Dai,W.
  TITLE     RNF216 affects the stability of STAU2 in the hypothalamus
  JOURNAL   Dev Growth Differ 65 (7), 408-417 (2023)
   PUBMED   37439148
  REMARK    GeneRIF: RNF216 affects the stability of STAU2 in the hypothalamus.
REFERENCE   3  (bases 1 to 2890)
  AUTHORS   Kuc,C.A., Brott,J.T., Thorpe,H.H.A., Smart,A. and Vessey,J.P.
  TITLE     Staufen 1 is expressed by neural precursor cells in the developing
            murine cortex but is dispensable for NPC self-renewal and neuronal
            differentiation in vitro
  JOURNAL   Brain Res 1773, 147700 (2021)
   PUBMED   34678304
REFERENCE   4  (bases 1 to 2890)
  AUTHORS   Chowdhury,R., Wang,Y., Campbell,M., Goderie,S.K., Doyle,F.,
            Tenenbaum,S.A., Kusek,G., Kiehl,T.R., Ansari,S.A., Boles,N.C. and
            Temple,S.
  TITLE     STAU2 binds a complex RNA cargo that changes temporally with
            production of diverse intermediate progenitor cells during mouse
            corticogenesis
  JOURNAL   Development 148 (15) (2021)
   PUBMED   34345913
  REMARK    GeneRIF: STAU2 binds a complex RNA cargo that changes temporally
            with production of diverse intermediate progenitor cells during
            mouse corticogenesis.
REFERENCE   5  (bases 1 to 2890)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2890)
  AUTHORS   Belanger,G., Stocksley,M.A., Vandromme,M., Schaeffer,L., Furic,L.,
            DesGroseillers,L. and Jasmin,B.J.
  TITLE     Localization of the RNA-binding proteins Staufen1 and Staufen2 at
            the mammalian neuromuscular junction
  JOURNAL   J Neurochem 86 (3), 669-677 (2003)
   PUBMED   12859680
REFERENCE   7  (bases 1 to 2890)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2890)
  AUTHORS   Duchaine,T.F., Hemraj,I., Furic,L., Deitinghoff,A., Kiebler,M.A.
            and DesGroseillers,L.
  TITLE     Staufen2 isoforms localize to the somatodendritic domain of neurons
            and interact with different organelles
  JOURNAL   J Cell Sci 115 (Pt 16), 3285-3295 (2002)
   PUBMED   12140260
  REMARK    GeneRIF: Data show that Stau2 is localized to the neuronal soma and
            dendrites, but it does not colocalize with Stau1-containing
            particles.
REFERENCE   9  (bases 1 to 2890)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 2890)
  AUTHORS   Buchner,G., Bassi,M.T., Andolfi,G., Ballabio,A. and Franco,B.
  TITLE     Identification of a novel homolog of the Drosophila staufen protein
            in the chromosome 8q13-q21.1 region
  JOURNAL   Genomics 62 (1), 113-118 (1999)
   PUBMED   10585778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162448.10, AC115952.11, AC116695.12 and AC167117.5.
            
            On or before Jul 22, 2008 this sequence version replaced
            NM_001111271.1, NM_025303.2.
            
            Transcript Variant: This variant (3) has multiple differences in
            the presence and absence of exons, compared to variant 1. These
            differences produce a unique 5' UTR and cause translation
            initiation at a downstream start codon, compared to variant 1. The
            encoded protein (isoform 3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459099.1, SRR1660817.179894.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC162448.10        77200-77329
            131-197             AC162448.10        87094-87160
            198-328             AC162448.10        110352-110482
            329-488             AC115952.11        8194-8353
            489-624             AC115952.11        30930-31065
            625-784             AC115952.11        77178-77337
            785-892             AC115952.11        78764-78871
            893-1105            AC115952.11        81355-81567
            1106-1243           AC116695.12        12864-13001
            1244-1375           AC116695.12        17789-17920
            1376-1436           AC116695.12        21536-21596
            1437-1744           AC116695.12        41664-41971
            1745-1833           AC167117.5         48510-48598
            1834-2890           AC167117.5         49735-50791
FEATURES             Location/Qualifiers
     source          1..2890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 5.05 cM"
     gene            1..2890
                     /gene="Stau2"
                     /note="staufen double-stranded RNA binding protein 2"
                     /db_xref="GeneID:29819"
                     /db_xref="MGI:MGI:1352508"
     exon            1..130
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..197
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..328
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1927
                     /gene="Stau2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     staufen 2; double-stranded RNA-binding protein Staufen
                     homolog 2; staufen (RNA binding protein) homolog 2"
                     /codon_start=1
                     /product="double-stranded RNA-binding protein Staufen
                     homolog 2 isoform 3"
                     /protein_id="NP_079579.2"
                     /db_xref="CCDS:CCDS14831.2"
                     /db_xref="GeneID:29819"
                     /db_xref="MGI:MGI:1352508"
                     /translation="MANPKEKTPVCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQL
                     SLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNG
                     LAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPMPKIFYVQLTVGNNEFFGE
                     GKTRQAARHNAAMKALQALQNEPIPEKSPQNGESGKEMDDDKDANKSEISLVFEIALK
                     RNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLP
                     PLPVVEKPKLFFKKRPKTIVKAGPDYGQGMNPISRLAQIQQARKEKEPDYILLSERGM
                     PRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDPLDKTGENK
                     GWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHRVTSGTTLSYLSPKDMNQPSSS
                     FFSVSPSSTSSATVARELLMNGTSPTAEAIGLKGSSPTSPCSSVQPSKQLEYLARIQG
                     FQAALSALKQFSEQGLESIDGAVNVEKGSLEKQAKHLREKADNNQAKPASISQDCKKS
                     KSAI"
     exon            329..488
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..624
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..784
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..892
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1105
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1243
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1375
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1436
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1744
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1833
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2890
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcggcg ggagcgcagg gcggcaggcg gaggcggggg gcgggagccg aggagggagc
       61 aggcggcgtc ggcggagctc tggagcgctc gcccatgtgg agccgtctgc cgggcgtccg
      121 tggcccgcag ttttgtggag ctgtgaggga tacggaagtt tgatcaatat tgtcttaaca
      181 tgcttcagat aaatcagctt ctctccacga taaaatggca aaccccaaag agaaaactcc
      241 agtgtgtctg gtaaatgagt tagcccgttt ccatagcatc caaccccagt ataagcttct
      301 gaatgaaagc gggcctgctc attcgaagat gttttcggtg cagctgagtc ttggcgagca
      361 gacatgggaa tccgaaggga gcagtataaa gaaggcccaa caagctgttg ctaacaaagc
      421 tttgactgaa tctacgcttc ccaaaccagt tcagaaacca cctaaaagta atgtcaataa
      481 taacccaggt agtataactc caactgtgga actgaatggg ctcgctatga aaaggggaga
      541 gcctgccatc tacaggccac tagatccaaa gccattccca aattatagag ctaactacaa
      601 cttccggggc atgtacaatc agaggtatca ttgcccaatg cccaagatct tttatgttca
      661 gttaactgta ggaaataatg aattctttgg tgaagggaag actcgacaag ctgccagaca
      721 caatgctgcg atgaaagcgc ttcaagccct acagaatgag ccaattccag aaaagtctcc
      781 ccagaatggt gaatcaggaa aagaaatgga tgacgataaa gatgcaaata aatctgaaat
      841 aagcttagtg tttgagattg cgctgaagag aaatatgcct gtcagttttg aggttattaa
      901 agaaagtgga ccaccacata tgaagagttt tgtaactcgg gtgtcagtgg gagaattttc
      961 tgcagaagga gagggaaata gcaaaaaact ctccaagaag cgtgccgcaa ccactgtctt
     1021 acaggagctt aaaaaactcc cacctcttcc tgtggtagag aagccaaaac tattttttaa
     1081 aaaacgccct aaaacaatag taaaggctgg acccgactat ggtcaaggaa tgaaccccat
     1141 tagccgcctg gctcagatcc agcaagccag aaaggaaaag gagcctgatt acatcctact
     1201 ctcagaacga ggaatgcctc gccgtcgaga gttcgtaatg caggtcaagg taggcaatga
     1261 agttgcgact ggaacaggac ccaataaaaa gatagccaaa aaaaatgctg ctgaagcaat
     1321 gctgttacag cttggctata aagcgtccac cagtcttcag gatccgctcg acaagacagg
     1381 tgaaaacaaa ggatggagtg gtccaaagcc tgggtttcct gaaccaacaa ataacactcc
     1441 aaaaggaatt cttcatcttt ctcctgatgt ttatcaagag atggaagcta gccgccacag
     1501 agtgacctct ggcacaactc taagctactt atctcccaaa gatatgaacc aaccttcaag
     1561 ctctttcttc agtgtgtctc cctcatcaac tagttcagcc acagttgcca gggaactcct
     1621 tatgaatgga acatctccta ctgctgaagc cataggttta aaaggaagtt ctcctacttc
     1681 cccttgttct tcagtacagc cttcaaaaca actggaatat ttagcaagga ttcaaggctt
     1741 tcaggcagcc ttaagtgcct tgaaacagtt ttctgaacaa ggactggaat caattgatgg
     1801 ggcagtgaat gttgaaaagg gttctcttga aaaacaagcc aagcatctgc gggagaaagc
     1861 agacaataac caggcgaagc cggcctccat ctctcaggac tgcaagaaat caaagtcggc
     1921 catctagcag ctcccagaac ccacggctgc cactgcgtcc gtataaacct gtcagcacgc
     1981 acgagggtgt ctgtgttcta ggaaacgaat gactaatagc attatgagtc ttatgtgaag
     2041 acaacactat tctaacacag gagataatgt acttggtact gtttattcaa ctgggggaaa
     2101 ataaaacttt gagcatttcc cttggaactt gagatcagat cataactcac ttgcccagag
     2161 gcagcagaaa tctgatccta ctactggagc ttaaaaataa caattaatga aaagtgttag
     2221 aaacaaggct acagttttaa aatggcttgg ttctgtcctt gcaattgctt tgtcgtggca
     2281 agtgtgttgt tctactctct cttgtttgaa acaatgcttg acaattcaga aattaaccac
     2341 tgatgtgctg tggaatgtga tgcttgtcct catatagtct cagtttctct ttttatgcag
     2401 atatttgtga ccttcatctt gcacatacaa ccaaattatt ttaaggtgca tagcacaaag
     2461 atgtatgcaa acaactgttt taaatcaggt ctgataactg atttaaatat aaataatact
     2521 aggaacaagt agtttccata tatttcggaa cttttaaaaa gacaaaatga aacaaaaccg
     2581 agcagttatg ggttttgttc tataggatgc catcagccat cgagggggcg tcttgcctct
     2641 gcccatcgct ccaggagtct acgctgtcgt ggaaattgtg cccaccccca tctgtgtgtt
     2701 gtagccactc actgttcaca tcgagtgtct ctagtaactg cctctggact cggaacagtg
     2761 agtaggatca aaataaatac tgtacatggt ggggaatgga atgcctgttg gagaagcttc
     2821 tagccaatca cgctctggac cagcatgttg gaatccagtg tggggcaaat gcagtaaaga
     2881 tttgttccgt
//
