LOCUS       NM_009284               3805 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus signal transducer and activator of transcription 6
            (Stat6), mRNA.
ACCESSION   NM_009284
VERSION     NM_009284.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Kabil,A., Nayyar,N., Brassard,J., Li,Y., Chopra,S., Hughes,M.R. and
            McNagny,K.M.
  TITLE     Microbial intestinal dysbiosis drives long-term allergic
            susceptibility by sculpting an ILC2-B1 cell-innate IgE axis
  JOURNAL   J Allergy Clin Immunol 154 (5), 1260-1276 (2024)
   PUBMED   39134158
REFERENCE   2  (bases 1 to 3805)
  AUTHORS   Farrokhi,A., Atre,T., Salitra,S., Aletaha,M., Marquez,A.C.,
            Gynn,M., Fidanza,M., Jo,S., Rolf,N., Simmons,K., Duque-Afonso,J.,
            Cleary,M.L., Seif,A.E., Kollmann,T., Gantt,S. and Reid,G.S.D.
  TITLE     Early-life infection depletes preleukemic cells in a mouse model of
            hyperdiploid B-cell acute lymphoblastic leukemia
  JOURNAL   Blood 144 (8), 809-821 (2024)
   PUBMED   38875504
REFERENCE   3  (bases 1 to 3805)
  AUTHORS   Liu,X., Wang,J., Jin,J., Hu,Q., Zhao,T., Wang,J., Gao,J. and Man,J.
  TITLE     S100A9 deletion in microglia/macrophages ameliorates brain injury
            through the STAT6/PPARgamma pathway in ischemic stroke
  JOURNAL   CNS Neurosci Ther 30 (8), e14881 (2024)
   PUBMED   39107960
  REMARK    GeneRIF: S100A9 deletion in microglia/macrophages ameliorates brain
            injury through the STAT6/PPARgamma pathway in ischemic stroke.
REFERENCE   4  (bases 1 to 3805)
  AUTHORS   Ferguson,A.A., Rossi,H.L. and Herbert,D.R.
  TITLE     The Secretome of Adult Murine Hookworms Is Shaped by Host
            Expression of STAT6
  JOURNAL   Parasite Immunol 46 (7), e13056 (2024)
   PUBMED   39073185
  REMARK    GeneRIF: The Secretome of Adult Murine Hookworms Is Shaped by Host
            Expression of STAT6.
REFERENCE   5  (bases 1 to 3805)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   6  (bases 1 to 3805)
  AUTHORS   Shimoda,K., van Deursen,J., Sangster,M.Y., Sarawar,S.R.,
            Carson,R.T., Tripp,R.A., Chu,C., Quelle,F.W., Nosaka,T.,
            Vignali,D.A., Doherty,P.C., Grosveld,G., Paul,W.E. and Ihle,J.N.
  TITLE     Lack of IL-4-induced Th2 response and IgE class switching in mice
            with disrupted Stat6 gene
  JOURNAL   Nature 380 (6575), 630-633 (1996)
   PUBMED   8602264
REFERENCE   7  (bases 1 to 3805)
  AUTHORS   Takeda,K., Tanaka,T., Shi,W., Matsumoto,M., Minami,M.,
            Kashiwamura,S., Nakanishi,K., Yoshida,N., Kishimoto,T. and Akira,S.
  TITLE     Essential role of Stat6 in IL-4 signalling
  JOURNAL   Nature 380 (6575), 627-630 (1996)
   PUBMED   8602263
REFERENCE   8  (bases 1 to 3805)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   9  (bases 1 to 3805)
  AUTHORS   Quelle,F.W., Shimoda,K., Thierfelder,W., Fischer,C., Kim,A.,
            Ruben,S.M., Cleveland,J.L., Pierce,J.H., Keegan,A.D., Nelms,K. et
            al.
  TITLE     Cloning of murine Stat6 and human Stat6, Stat proteins that are
            tyrosine phosphorylated in responses to IL-4 and IL-3 but are not
            required for mitogenesis
  JOURNAL   Mol Cell Biol 15 (6), 3336-3343 (1995)
   PUBMED   7760829
REFERENCE   10 (bases 1 to 3805)
  AUTHORS   Hou,J., Schindler,U., Henzel,W.J., Ho,T.C., Brasseur,M. and
            McKnight,S.L.
  TITLE     An interleukin-4-induced transcription factor: IL-4 Stat
  JOURNAL   Science 265 (5179), 1701-1706 (1994)
   PUBMED   8085155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163053.1, AK149563.1 and BM122652.2.
            
            On Mar 10, 2007 this sequence version replaced NM_009284.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.125115.1, AK149563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AK163053.1         2-1035
            1035-1097           AK149563.1         995-1057
            1098-3286           AK163053.1         1099-3287
            3287-3449           AK149563.1         3248-3410
            3450-3805           BM122652.2         1-356               c
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.59 cM"
     gene            1..3805
                     /gene="Stat6"
                     /note="signal transducer and activator of transcription 6"
                     /db_xref="GeneID:20852"
                     /db_xref="MGI:MGI:103034"
     exon            1..264
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            265..401
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2799
                     /gene="Stat6"
                     /codon_start=1
                     /product="signal transducer and transcription activator 6"
                     /protein_id="NP_033310.2"
                     /db_xref="CCDS:CCDS36082.1"
                     /db_xref="GeneID:20852"
                     /db_xref="MGI:MGI:103034"
                     /translation="MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVG
                     SDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQI
                     LQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQV
                     SLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFE
                     ESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVE
                     KQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGV
                     ESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSF
                     TLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEK
                     MCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILL
                     GRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDS
                     EIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEA
                     FRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQL
                     SSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQS
                     QEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLL
                     ENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW"
     exon            402..540
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            541..624
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            625..763
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            764..816
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            817..965
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1097
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1286
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1374
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1497
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1590
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1797
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1892
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2029
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2176
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2240
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2345
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2417
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2483
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2612
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..3805
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat6"
                     /note="hexamer: CATAAA"
     polyA_site      3545
                     /gene="Stat6"
     regulatory      3749..3754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat6"
                     /note="hexamer: AATAAA"
     regulatory      3774..3779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat6"
                     /note="hexamer: AATAAA"
     polyA_site      3775
                     /gene="Stat6"
                     /note="major polyA site"
     regulatory      3778..3783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat6"
                     /note="hexamer: AATAAT"
     polyA_site      3791
                     /gene="Stat6"
     polyA_site      3804
                     /gene="Stat6"
ORIGIN      
        1 gagaagccgg aaacagcagg ccggggcagc cagggtttac agtgaagaag gcccggagac
       61 gagtgcgtgc gtgcctgtgt gtgtgtttgt gtgtgtgtgc gcgcgctcga gcgtgtgcgc
      121 gcgtgcctgt gtgcatatgt gtgtgtgtgt ctgtacacat tgagttttta gggccagccc
      181 aggacccgct ggacagacct acagacccat ggggcttggt agtgccctct gagagaggga
      241 gaagatagca gcggggctgc tgaggcaccc tgtatatccc agatcatgtc tctgtggggc
      301 ctaatttcca agatgtcccc agaaaaactg caacggctct atgttgactt tccacaacgc
      361 ctacggcatc tcctggctga ctggctggag agccagccct gggagttcct ggtcggttca
      421 gatgctttct gttacaacat ggccagtgcc ctactttctg ccacagtcca gcgtcttcag
      481 gccactgctg gagagcaggg gaagggaaac agcatcttgc cgcacatcag caccttggag
      541 agcatctatc agagggaccc cctgaagctg gtggccacca tcagacaaat acttcaaggg
      601 gagaaaaaag ctgttataga agagttccgc cacctgccag ggcccttcca tcggaagcag
      661 gaagaactca agtttactac agccctcgga aggcttcagc atcgagtaag ggagacccgg
      721 cttctccgag aatctctgca gcaaggggct aagactggac aagtgtctct gcagaatttg
      781 atagaccctc ctgtcaatgg tcctggtcca agtgaggacc tggccaccat gctgcagggg
      841 actgtggggg acctggaggc cacccaggcc ctggtgctga aaaggattca gatttggaag
      901 cggcagcaac agctggcagg gaatggcaca ccctttgagg agagcctagc agggctgcag
      961 gagaggtgtg aaagcctggt ggaaatttat tcccagctgc agcaggagat tggggcagcc
     1021 agtggagaac tggaacccaa gacccgggca tcgctgataa gccgtctgga tgaagtcctg
     1081 cgaacccttg tgaccagctc tttcctggtg gagaagcagc ccccgcaggt tctgaagaca
     1141 cagactaagt tccaggctgg ggttcgattc ctgctgggtc tgcagtttct agggacctca
     1201 gccaagcctc caatggtcag agctgacatg gtgacagaga aacaggccag agaactaagc
     1261 ctggcccagg ggcccgggac tggagtggag agcacaggag agatcatgaa caacacggtg
     1321 cccctggaga acagcattcc cagcaactgc tgctccgccc tgttcaagaa cctgctcctg
     1381 aagaaaataa agcgctgtga gcggaagggc acagagtctg tcaccgagga gaagtgtgct
     1441 gtgctcttct ccacgagctt cacattgggc cccaacaaac ttctcatcca gcttcaggcc
     1501 ctgtctctgc ccttggtggt catcgtgcat ggtaaccaag acaacaacgc caaagctacc
     1561 atcctatggg acaatgcctt ctctgagatg gaccgagtgc cctttgtggt ggctgagcga
     1621 gtgccctggg agaagatgtg tgaaacccta aacctcaagt ttatggctga ggtggggacc
     1681 agccggggac tgcttccaga gcacttcctg ttcctcgccc agaagatctt caacgacaac
     1741 agcctcagtg tggaggcctt tcagcaccgc tgtgtgtcct ggtcacagtt caataaggag
     1801 atcctgctgg gccgaggctt cacattttgg cagtggtttg atggtgtcct ggacctcacc
     1861 aaacgctgtc tccggagcta ctggtcagat cggctgatca ttggctttat tagtaagcaa
     1921 tatgtcacta gccttctcct caatgagcca gatgggacct tcctcctccg ctttagcgac
     1981 tctgagatcg ggggcatcac cattgcacac gtcatccggg gtcaggatgg ctcctcacag
     2041 atagagaaca tccagccatt ttctgccaaa gacctgtcca ttcgctcact gggggaccgg
     2101 atccgggatc ttgctcagtt aaaaaacctc taccccaaga aacccaaaga tgaggctttc
     2161 cggagtcact ataagcccga acagatgggg aaggacggga ggggttatgt ctctactact
     2221 atcaagatga ctgtggaaag ggaccagccc cttcctactc cagagcccca gatgcctgcc
     2281 atggtgccac cttatgatct tggaatggcc cctgatgctt ccatgcaact cagctcagat
     2341 atggggtatc ctccacagtc catccactca tttcagagcc tagaagagtc catgagtgta
     2401 ctgccatctt ttcaggagcc tcacctgcaa atgcccccca acatgagcca gataaccatg
     2461 ccctttgacc agcctcaccc ccagggtctg ctgcagtgcc agtcccagga acatgctgtg
     2521 tccagccctg aacccatgct ttgctcagat gtgactatgg tagaggacag ctgcctaact
     2581 cagcctgtgg gaggtttccc ccaaggcacc tgggtcagtg aagacatgta ccctcccctg
     2641 atgcctccca ctgaacagga cctcaccaag cttctcctgg agaaccaagg ggaggcagga
     2701 gggtccttag gaagccagcc cctcctgcaa ccatctcctt atgggcaatc agggatctca
     2761 ctgtcccacc tggacctaag gaccaacccc agctggtgat cccagctgga gaagcccaga
     2821 aacaaagcct cttctgtctc tatggaccag ctctggacac ctgctcatgc aggtgccttc
     2881 cgtctcaact gttccttggt caagagaaaa gaactggctg ggagaccatg tggtgtatgg
     2941 aactgctgtg ctctgtcctt cctgccatat cagggccccc cttttccagc actgggtgca
     3001 aagggatgag tggggtgtta atgctcgaat gtgatacaac tgtatcacaa cacacacgca
     3061 cacacacata cacacacacc agaactgtgt tgagccaggg cctgggactc aacatacaga
     3121 aacatagaga cattgtgcca aagacagagg gcatataggc ctagggcatt gaagctgggc
     3181 tcaggtgact ctgggaggga gaaaaaggaa aaagtgggta tacagtcact ggtgtgagtt
     3241 ctacccagat tttaaaaaac aagactccaa agctccaaat tcttgcaaaa aaagatgcct
     3301 agtgacattt gagactgcat tctaagagct aagcttgtgt atagctgtac caatgtttac
     3361 ccaagacatg ttaacctata gaagtcacac atcactgtat gaccgcacag aacatgtatc
     3421 ttctgctttt gccagtgtga ccttaacata tctgaaaggc tgagacattg tataagacag
     3481 caacccagta tcatttgggg agtaactatg tggctgtgac atgcataaag ctctagcctg
     3541 ggtaacttga tgcttccagt gtttcctaga gcctgggata taagtaggga tgcagacctc
     3601 tctgtgtaaa ctccctgggc gttgaggccc tcaactgctg tctcttgtac ttttctgtcc
     3661 actgccagct ctgcccccct cccccggctc ttacccagtc ctttttccct cactggaggg
     3721 gaagggggcc atggatccta agccataaaa taaattttat tccaaaataa caaaataaat
     3781 aatctactgt acacaatctg aaaag
//
