LOCUS       NP_033310                837 aa            linear   ROD 03-JUN-2025
DEFINITION  signal transducer and transcription activator 6 [Mus musculus].
ACCESSION   NP_033310
VERSION     NP_033310.2
DBSOURCE    REFSEQ: accession NM_009284.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 837)
  AUTHORS   Wang,J., Gao,S., Fu,S., Li,Y., Su,L., Li,X., Wu,G., Jiang,J.,
            Zhao,Z., Yang,C., Wang,X., Cui,K., Sun,X., Qi,X., Wang,C., Sun,H.,
            Shao,S., Tian,Y., Gong,T., Luo,J., Zheng,J., Cui,S., Liao,F.,
            Liu,F., Wang,D., Wong,C.C.L., Yi,M. and Wan,Y.
  TITLE     Irisin reprograms microglia through activation of STAT6 and
            prevents cognitive dysfunction after surgery in mice
  JOURNAL   Brain Behav Immun 125, 68-91 (2025)
   PUBMED   39701329
REFERENCE   2  (residues 1 to 837)
  AUTHORS   Kabil,A., Nayyar,N., Brassard,J., Li,Y., Chopra,S., Hughes,M.R. and
            McNagny,K.M.
  TITLE     Microbial intestinal dysbiosis drives long-term allergic
            susceptibility by sculpting an ILC2-B1 cell-innate IgE axis
  JOURNAL   J Allergy Clin Immunol 154 (5), 1260-1276 (2024)
   PUBMED   39134158
REFERENCE   3  (residues 1 to 837)
  AUTHORS   Desai,P., Karl,C.E., Ying,B., Liang,C.Y., Garcia-Salum,T.,
            Santana,A.C., Ten-Caten,F., Joseph F Urban,Jr., Elbashir,S.M.,
            Edwards,D.K., Ribeiro,S.P., Thackray,L.B., Sekaly,R.P. and
            Diamond,M.S.
  TITLE     Intestinal helminth infection impairs vaccine-induced T cell
            responses and protection against SARS-CoV-2 in mice
  JOURNAL   Sci Transl Med 16 (761), eado1941 (2024)
   PUBMED   39167662
REFERENCE   4  (residues 1 to 837)
  AUTHORS   Liu,X., Wang,J., Jin,J., Hu,Q., Zhao,T., Wang,J., Gao,J. and Man,J.
  TITLE     S100A9 deletion in microglia/macrophages ameliorates brain injury
            through the STAT6/PPARgamma pathway in ischemic stroke
  JOURNAL   CNS Neurosci Ther 30 (8), e14881 (2024)
   PUBMED   39107960
  REMARK    GeneRIF: S100A9 deletion in microglia/macrophages ameliorates brain
            injury through the STAT6/PPARgamma pathway in ischemic stroke.
REFERENCE   5  (residues 1 to 837)
  AUTHORS   Ferguson,A.A., Rossi,H.L. and Herbert,D.R.
  TITLE     The Secretome of Adult Murine Hookworms Is Shaped by Host
            Expression of STAT6
  JOURNAL   Parasite Immunol 46 (7), e13056 (2024)
   PUBMED   39073185
  REMARK    GeneRIF: The Secretome of Adult Murine Hookworms Is Shaped by Host
            Expression of STAT6.
REFERENCE   6  (residues 1 to 837)
  AUTHORS   Shimoda,K., van Deursen,J., Sangster,M.Y., Sarawar,S.R.,
            Carson,R.T., Tripp,R.A., Chu,C., Quelle,F.W., Nosaka,T.,
            Vignali,D.A., Doherty,P.C., Grosveld,G., Paul,W.E. and Ihle,J.N.
  TITLE     Lack of IL-4-induced Th2 response and IgE class switching in mice
            with disrupted Stat6 gene
  JOURNAL   Nature 380 (6575), 630-633 (1996)
   PUBMED   8602264
REFERENCE   7  (residues 1 to 837)
  AUTHORS   Takeda,K., Tanaka,T., Shi,W., Matsumoto,M., Minami,M.,
            Kashiwamura,S., Nakanishi,K., Yoshida,N., Kishimoto,T. and Akira,S.
  TITLE     Essential role of Stat6 in IL-4 signalling
  JOURNAL   Nature 380 (6575), 627-630 (1996)
   PUBMED   8602263
REFERENCE   8  (residues 1 to 837)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   9  (residues 1 to 837)
  AUTHORS   Quelle,F.W., Shimoda,K., Thierfelder,W., Fischer,C., Kim,A.,
            Ruben,S.M., Cleveland,J.L., Pierce,J.H., Keegan,A.D., Nelms,K. et
            al.
  TITLE     Cloning of murine Stat6 and human Stat6, Stat proteins that are
            tyrosine phosphorylated in responses to IL-4 and IL-3 but are not
            required for mitogenesis
  JOURNAL   Mol Cell Biol 15 (6), 3336-3343 (1995)
   PUBMED   7760829
REFERENCE   10 (residues 1 to 837)
  AUTHORS   Hou,J., Schindler,U., Henzel,W.J., Ho,T.C., Brasseur,M. and
            McKnight,S.L.
  TITLE     An interleukin-4-induced transcription factor: IL-4 Stat
  JOURNAL   Science 265 (5179), 1701-1706 (1994)
   PUBMED   8085155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163053.1, AK149563.1 and BM122652.2.
            
            On Mar 10, 2007 this sequence version replaced NP_033310.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.125115.1, AK149563.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.59 cM"
     Protein         1..837
                     /product="signal transducer and transcription activator 6"
                     /calculated_mol_wt=93366
     Region          2..115
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain; cl03749"
                     /db_xref="CDD:470871"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42226; propagated from
                     UniProtKB/Swiss-Prot (P52633.2)"
     Region          105..276
                     /region_name="STAT6_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 6 (STAT6); cd16856"
                     /db_xref="CDD:341081"
     Region          273..432
                     /region_name="STAT6_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 6 (STAT6); cd16850"
                     /db_xref="CDD:341088"
     Site            order(284,287..288,367,370,373..374,378..379,414..415,418)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341088"
     Region          517..646
                     /region_name="SH2_STAT6"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 6
                     proteins; cd10377"
                     /db_xref="CDD:198240"
     Site            order(544,562,588,590)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198240"
     Site            order(589,605)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198240"
     Site            order(599..600,646)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198240"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK.
                     /evidence=ECO:0000250|UniProtKB:P42226; propagated from
                     UniProtKB/Swiss-Prot (P52633.2)"
     Region          655..837
                     /region_name="STAT6_C"
                     /note="STAT6 C-terminal; pfam14596"
                     /db_xref="CDD:291272"
     Region          793..797
                     /region_name="LXXLL motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P52633.2)"
     Region          802..837
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52633.2)"
     CDS             1..837
                     /gene="Stat6"
                     /coded_by="NM_009284.2:286..2799"
                     /db_xref="CCDS:CCDS36082.1"
                     /db_xref="GeneID:20852"
                     /db_xref="MGI:MGI:103034"
ORIGIN      
        1 mslwgliskm speklqrlyv dfpqrlrhll adwlesqpwe flvgsdafcy nmasallsat
       61 vqrlqatage qgkgnsilph istlesiyqr dplklvatir qilqgekkav ieefrhlpgp
      121 fhrkqeelkf ttalgrlqhr vretrllres lqqgaktgqv slqnlidppv ngpgpsedla
      181 tmlqgtvgdl eatqalvlkr iqiwkrqqql agngtpfees laglqerces lveiysqlqq
      241 eigaasgele pktraslisr ldevlrtlvt ssflvekqpp qvlktqtkfq agvrfllglq
      301 flgtsakppm vradmvtekq arelslaqgp gtgvestgei mnntvplens ipsnccsalf
      361 knlllkkikr cerkgtesvt eekcavlfst sftlgpnkll iqlqalslpl vvivhgnqdn
      421 nakatilwdn afsemdrvpf vvaervpwek mcetlnlkfm aevgtsrgll pehflflaqk
      481 ifndnslsve afqhrcvsws qfnkeillgr gftfwqwfdg vldltkrclr sywsdrliig
      541 fiskqyvtsl llnepdgtfl lrfsdseigg itiahvirgq dgssqieniq pfsakdlsir
      601 slgdrirdla qlknlypkkp kdeafrshyk peqmgkdgrg yvsttikmtv erdqplptpe
      661 pqmpamvppy dlgmapdasm qlssdmgypp qsihsfqsle esmsvlpsfq ephlqmppnm
      721 sqitmpfdqp hpqgllqcqs qehavsspep mlcsdvtmve dscltqpvgg fpqgtwvsed
      781 mypplmppte qdltklllen qgeaggslgs qpllqpspyg qsgislshld lrtnpsw
//
