LOCUS       NM_001113563            4919 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus signal transducer and activator of transcription 5B
            (Stat5b), transcript variant 2, mRNA.
ACCESSION   NM_001113563
VERSION     NM_001113563.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4919)
  AUTHORS   Lin,J.X., Ge,M., Liu,C.Y., Holewinski,R., Andresson,T., Yu,Z.X.,
            Gebregiorgis,T., Spolski,R., Li,P. and Leonard,W.J.
  TITLE     Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for
            maximal IL-2 signaling and T cell proliferation
  JOURNAL   Nat Commun 15 (1), 7372 (2024)
   PUBMED   39191751
  REMARK    GeneRIF: Tyrosine phosphorylation of both STAT5A and STAT5B is
            necessary for maximal IL-2 signaling and T cell proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4919)
  AUTHORS   Murao,N., Matsuda,T., Kadowaki,H., Matsushita,Y., Tanimoto,K.,
            Katagiri,T., Nakashima,K. and Nishitoh,H.
  TITLE     The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal
            neurogenesis
  JOURNAL   EMBO Rep 25 (8), 3678-3706 (2024)
   PUBMED   39080439
  REMARK    GeneRIF: The Derlin-1-Stat5b axis maintains homeostasis of adult
            hippocampal neurogenesis.
REFERENCE   3  (bases 1 to 4919)
  AUTHORS   Ullah Khan,F., Khongorzul,P., Gris,D. and Amrani,A.
  TITLE     Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic
            dendritic cell subset in autoimmune diabetes
  JOURNAL   Int Immunopharmacol 133, 112166 (2024)
   PUBMED   38678673
  REMARK    GeneRIF: Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic
            dendritic cell subset in autoimmune diabetes.
REFERENCE   4  (bases 1 to 4919)
  AUTHORS   Qiu,F., Jiang,P., Zhang,G., An,J., Ruan,K., Lyu,X., Zhou,J. and
            Sheng,W.
  TITLE     Priming with LSD1 inhibitors promotes the persistence and antitumor
            effect of adoptively transferred T cells
  JOURNAL   Nat Commun 15 (1), 4327 (2024)
   PUBMED   38773088
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4919)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   6  (bases 1 to 4919)
  AUTHORS   Lin,J.X., Mietz,J., Modi,W.S., John,S. and Leonard,W.J.
  TITLE     Cloning of human Stat5B. Reconstitution of interleukin-2-induced
            Stat5A and Stat5B DNA binding activity in COS-7 cells
  JOURNAL   J Biol Chem 271 (18), 10738-10744 (1996)
   PUBMED   8631883
REFERENCE   7  (bases 1 to 4919)
  AUTHORS   Liu,X., Robinson,G.W., Gouilleux,F., Groner,B. and Hennighausen,L.
  TITLE     Cloning and expression of Stat5 and an additional homologue
            (Stat5b) involved in prolactin signal transduction in mouse mammary
            tissue
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8831-8835 (1995)
   PUBMED   7568026
REFERENCE   8  (bases 1 to 4919)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   9  (bases 1 to 4919)
  AUTHORS   Azam,M., Erdjument-Bromage,H., Kreider,B.L., Xia,M., Quelle,F.,
            Basu,R., Saris,C., Tempst,P., Ihle,J.N. and Schindler,C.
  TITLE     Interleukin-3 signals through multiple isoforms of Stat5
  JOURNAL   EMBO J 14 (7), 1402-1411 (1995)
   PUBMED   7537213
REFERENCE   10 (bases 1 to 4919)
  AUTHORS   Mui,A.L., Wakao,H., O'Farrell,A.M., Harada,N. and Miyajima,A.
  TITLE     Interleukin-3, granulocyte-macrophage colony stimulating factor and
            interleukin-5 transduce signals through two STAT5 homologs
  JOURNAL   EMBO J 14 (6), 1166-1175 (1995)
   PUBMED   7720707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591466.8, AK150098.1, AK045531.1 and AI414876.1.
            
            On Apr 25, 2018 this sequence version replaced NM_001113563.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024319.1, AK154664.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL591466.8         145333-145360
            29-2816             AK150098.1         2-2789
            2817-4158           AK045531.1         2964-4305
            4159-4838           AK150098.1         4133-4812
            4839-4919           AI414876.1         6-86                c
FEATURES             Location/Qualifiers
     source          1..4919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.63 cM"
     gene            1..4919
                     /gene="Stat5b"
                     /note="signal transducer and activator of transcription
                     5B"
                     /db_xref="GeneID:20851"
                     /db_xref="MGI:MGI:103035"
     exon            1..183
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            184..321
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2554
                     /gene="Stat5b"
                     /note="mammary gland factor STAT5B"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     5B"
                     /protein_id="NP_001107035.1"
                     /db_xref="CCDS:CCDS25438.1"
                     /db_xref="GeneID:20851"
                     /db_xref="MGI:MGI:103035"
                     /translation="MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWD
                     SIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCP
                     MELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTEN
                     ELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQRE
                     AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
                     SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
                     EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDY
                     SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSV
                     GGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
                     EALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGR
                     NYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
                     GGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKY
                     YTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYN
                     MYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS"
     exon            322..478
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            479..568
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            569..743
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            744..874
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1026
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1182
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1362
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1450
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1573
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1666
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1873
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1968
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2099
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2270
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2322
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2427
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..4919
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat5b"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="Stat5b"
                     /note="major polyA site"
ORIGIN      
        1 gagagcggcg cgcgcccccg tgggccccgg cgggaggaga gtcggcggcc caagccgtca
       61 ccccgggcgg ggaccgagcg cgggcgacga cgcgcggagg tcctgcacgg ggagggagcg
      121 agcgggcgtg cgagagagcg tgcgggaccg gagagaccgc tggctctggt ggggcagaac
      181 gaggttgtga accatggcta tgtggataca ggctcagcag ctccagggcg atgcccttca
      241 ccagatgcag gccttgtacg gccagcattt ccccatcgag gtgcgacatt atttatcaca
      301 gtggatcgaa agccaagcct gggactcaat agatcttgat aatccacagg agaacattaa
      361 ggccacccag ctcctggagg gcctggtgca ggagctgcag aagaaggcgg agcaccaggt
      421 gggggaagat gggtttttgc tgaagatcaa gctggggcac tatgccacac agctccagag
      481 cacgtacgac cgctgcccca tggagctggt tcgctgtatc cggcacattc tgtacaacga
      541 acagaggctg gttcgcgaag ccaacaacgg cagctctcca gctggaagtc ttgctgacgc
      601 catgtcccag aagcaccttc agatcaacca aacgtttgag gagctgcgcc tgatcacaca
      661 ggacacggag aacgagctga agaagctgca gcagacccaa gagtacttca tcatccagta
      721 ccaggagagc ctgcggatcc aagctcagtt tgcccagctg ggacagctga acccccagga
      781 gcgcatgagc agggagacgg ccctccagca gaagcaagtg tccctggaga cctggctgca
      841 gcgagaggca cagacactgc agcagtaccg agtggagctg gctgagaagc accagaagac
      901 cctgcagctg ctgcggaagc agcagaccat catcctggac gacgagctga tccagtggaa
      961 gcggagacag cagctggccg ggaacggggg tccccccgag ggcagcctgg acgtgctgca
     1021 gtcctggtgt gagaagctgg ccgagatcat ctggcagaac cggcagcaga tccgcagggc
     1081 tgagcacttg tgccagcagc tgcccatccc aggccccgtg gaggagatgc tggctgaggt
     1141 caacgccacc atcacggaca tcatctcagc cctggtcacc agcacgttca tcatcgagaa
     1201 gcagcctcct caggtcctga agacccagac caagtttgca gccaccgtgc gcctgctggt
     1261 gggggggaag ctgaatgtgc acatgaaccc cccgcaggtg aaggcgacca tcatcagcga
     1321 gcagcaggcc aagtccctgc tcaagaatga gaacacccgc aatgattaca gcggcgagat
     1381 cctgaacaac tgttgcgtca tggagtacca ccaggccact ggcacactca gcgcccactt
     1441 cagaaacatg tccctgaaac gaatcaagag gtctgaccgc cgtggggcag agtcagtaac
     1501 ggaagagaag ttcacgatcc tgtttgactc acagttcagc gtcggtggaa acgagctggt
     1561 ctttcaagtc aagaccttgt cgctcccggt ggtggtgatt gttcacggca gccaggacaa
     1621 caatgccaca gccactgtcc tctgggacaa cgcctttgca gagcctggca gggtgccatt
     1681 tgccgtgcct gacaaggtgc tgtggccgca gctgtgtgaa gcgctcaaca tgaaattcaa
     1741 ggctgaagta cagagcaacc ggggcttgac caaggagaac ctcgtgttcc tggcacagaa
     1801 actgttcaac atcagcagca accacctcga ggactacaac agcatgtccg tgtcctggtc
     1861 ccagttcaac cgggagaatt tgccaggacg gaattacact ttctggcagt ggtttgatgg
     1921 cgtgatggaa gtattgaaaa aacatctcaa gcctcactgg aatgatgggg ctatcctggg
     1981 tttcgtgaac aagcaacagg cccacgacct gctcatcaac aagccagacg ggaccttcct
     2041 gctgcgcttc agcgactcgg aaatcggggg catcaccatt gcttggaagt ttgactctca
     2101 ggagagaatg ttttggaatc tgatgccttt taccactaga gacttctcta tccggtccct
     2161 cgctgaccgc ctgggggacc tgaattacct catatatgtg tttcctgatc ggccaaagga
     2221 tgaagtatat tctaagtact acacaccggt cccctgtgag cccgcaactg cgaaagcagc
     2281 tgacggatac gtgaagccac agatcaagca ggtggtcccc gagtttgcaa atgcatccac
     2341 agatgctggg agtggcgcca cctacatgga tcaggctcct tccccagtcg tgtgccctca
     2401 ggctcactac aacatgtacc cacccaaccc ggactccgtc cttgataccg atggggactt
     2461 cgatctggaa gacacgatgg acgtggcgcg gcgcgtggaa gagctcttag gccggcccat
     2521 ggacagtcag tggatccctc acgcacagtc atgaccagac ctcaccacct gcagcttcat
     2581 cgccctcgtg gaggaacttc ctgtggatgt tttaattcca tgaatcgctt ctctttggaa
     2641 acaatactcg taatgtgaag tgttaatact agttgtgact ttagtgtctc tgtgcatagt
     2701 ggcactagtg aagggagtgc gcgtgagtgt gagtgcattt gcacgtcgtg tttttttccc
     2761 cgcccctgct gtccagtcta agccgccacg ccagggcagc ggctgcgctt ttttttacca
     2821 tgtgcaaaaa ggcagttggt tccctgaacc ctggaacctg gccatgtgtc ttcagggtgg
     2881 ctgacccttg acacgtgact atccaagtaa gaaaaggaca gaggaaaaag caccctctct
     2941 ctggggagcc tcggttcctc tgccaggtag tccatagtcc aagcaagcat tgtcattgtc
     3001 tccgcctgtc ttctgagatg tagatgactg tctgatgatg aaagccagta cctcccgtgt
     3061 cccctgtccc ctttgcataa gggacggaaa ggggagctga atcaagggtg atggggcaag
     3121 ggtggtcaca ggtttttgga tggggagtgg ctgtttcccg tttctgccac ttccgccatc
     3181 ttaacactgg ctccttccct ctctgcttgc tcagtctcta tttctagaac tgccactcag
     3241 cttaagtgca agtgtgtgta ctcaagtgga gatgtttaac aaaatagtgg agaggaagcc
     3301 aggccaccca gctctgagcg tacaggttca ggtgatgccc tgtgttcctt ctgtcagggc
     3361 ggtgcgttgt gcccaagtcc tggctccaga cactgggcgt agcctgtctg cgccagcctc
     3421 cccaactctt gtctgtgctg tggccaggcc gcgcctgcgc tatccaaggc ttttctccaa
     3481 gcgtgttgat aatggcttcc tgcaaacgtc cggtggtgtt ttttgtttct aaatcaggtc
     3541 tttttttatg tttttcccat ttgcacccta atttgacatc aaatttcccc cctcctgtat
     3601 caggtcctgg gtcctctgta cccagatcac ttcatctccc ttcagtgtca catagtgccc
     3661 tgaggattag gtggtaggaa tgggacctgc acacggggcc agcctgccaa gcaggcagcc
     3721 agcactgtac agtgctgggt gccgggtggc cgttggggat tggggaaatg cagtcagtca
     3781 gcgggtttcc taggaagctt ggaaaactaa aagcaaagtg aaagcctcag ggtgatttgt
     3841 tccacagtct cctctgtagt gtctccagaa ggaaggaagg ggctgcagtg ggccgtcagg
     3901 gagaggggca agcagagagc ggttaccact caggcttgct gagagccctc cttggcttcc
     3961 tctcccaaac aagggcagaa ccgtgcccag gagaggagcc cccaaaacct tatttttata
     4021 catgcaagta aataaacata ttttttttac aaaaataact tctgaattta tcagtgtttt
     4081 actgttaaaa gaaaatactc ctgtgtagta aattatttat tgggagatga gtttttaaaa
     4141 gctgctgttt gccttgcctt ggttttgtac actgattttt ctatgcctgg cggtagcctc
     4201 tctgcctcag gtgctggccg gatggaggag gtgtgaggcc cctccctggc ccctcagaag
     4261 aaagctggaa ctgccagggg agtccaggct taagggactc gtccccacct gtcatgcgac
     4321 tgtcccagta accctcacga gggtgtggac tcgacaaata tctagatata tggtggacat
     4381 ggccccaagt catggggaga gtagagcagc ctgggccccc ccacccccaa ggttctaagc
     4441 tgactttcaa gttaggttgg agaaaagggt gccaaagaag cgagacttcc acatagtttt
     4501 taagctaccc tggatttact gagggtgtac ctggacatgg gagaggtttt taactggaaa
     4561 gtgtgtcccc tatctgcatg ctggtctctc tctctctctg cccaactctt gcacccaaaa
     4621 atgaggtgag ggcaggtctc cacccacctc ttgcctgctc acagacccac tcgtgagtcg
     4681 ggaaagcctc agctttgggg tgtggggctt tgtagaagtg gaaggagatt tgaagtggct
     4741 atctcctaca acggaaaata tccttttata atttttcttt ttaacgtttt atttcagata
     4801 catattttag tgtcgaggca gattagtata tagccaccaa aaaagtattg tgtataaatt
     4861 gaggcagcca caaaattgtg tattttatgt tacaataaag gcgtctcctt gaaggacaa
//
