LOCUS       NM_011488               3910 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus signal transducer and activator of transcription 5A
            (Stat5a), transcript variant 1, mRNA.
ACCESSION   NM_011488
VERSION     NM_011488.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Lin,J.X., Ge,M., Liu,C.Y., Holewinski,R., Andresson,T., Yu,Z.X.,
            Gebregiorgis,T., Spolski,R., Li,P. and Leonard,W.J.
  TITLE     Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for
            maximal IL-2 signaling and T cell proliferation
  JOURNAL   Nat Commun 15 (1), 7372 (2024)
   PUBMED   39191751
  REMARK    GeneRIF: Tyrosine phosphorylation of both STAT5A and STAT5B is
            necessary for maximal IL-2 signaling and T cell proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Le Menn,G., Pikkarainen,K., Mennerich,D., Miroszewska,D.,
            Kietzmann,T. and Chen,Z.
  TITLE     USP28 protects development of inflammation in mouse intestine by
            regulating STAT5 phosphorylation and IL22 production in T
            lymphocytes
  JOURNAL   Front Immunol 15, 1401949 (2024)
   PUBMED   39076972
  REMARK    GeneRIF: USP28 protects development of inflammation in mouse
            intestine by regulating STAT5 phosphorylation and IL22 production
            in T lymphocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Qiu,F., Jiang,P., Zhang,G., An,J., Ruan,K., Lyu,X., Zhou,J. and
            Sheng,W.
  TITLE     Priming with LSD1 inhibitors promotes the persistence and antitumor
            effect of adoptively transferred T cells
  JOURNAL   Nat Commun 15 (1), 4327 (2024)
   PUBMED   38773088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Rodrigues de Oliveira,B., Iansavitchous,J., Rysan,H., Wang,W.C.,
            Sams,M.P., Knight,D., Xu,L.S., Jeong,J., Qu,T.P., Zorzi,A.P. and
            DeKoter,R.P.
  TITLE     IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell
            leukemia results in altered DNA binding and altered STAT5-dependent
            gene expression
  JOURNAL   Gene 900, 148131 (2024)
   PUBMED   38216003
  REMARK    GeneRIF: IKZF3/Aiolos H195Y mutation identified in a mouse model of
            B cell leukemia results in altered DNA binding and altered
            STAT5-dependent gene expression.
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Lin,J.X., Mietz,J., Modi,W.S., John,S. and Leonard,W.J.
  TITLE     Cloning of human Stat5B. Reconstitution of interleukin-2-induced
            Stat5A and Stat5B DNA binding activity in COS-7 cells
  JOURNAL   J Biol Chem 271 (18), 10738-10744 (1996)
   PUBMED   8631883
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Liu,X., Robinson,G.W., Gouilleux,F., Groner,B. and Hennighausen,L.
  TITLE     Cloning and expression of Stat5 and an additional homologue
            (Stat5b) involved in prolactin signal transduction in mouse mammary
            tissue
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8831-8835 (1995)
   PUBMED   7568026
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Azam,M., Erdjument-Bromage,H., Kreider,B.L., Xia,M., Quelle,F.,
            Basu,R., Saris,C., Tempst,P., Ihle,J.N. and Schindler,C.
  TITLE     Interleukin-3 signals through multiple isoforms of Stat5
  JOURNAL   EMBO J 14 (7), 1402-1411 (1995)
   PUBMED   7537213
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Mui,A.L., Wakao,H., O'Farrell,A.M., Harada,N. and Miyajima,A.
  TITLE     Interleukin-3, granulocyte-macrophage colony stimulating factor and
            interleukin-5 transduce signals through two STAT5 homologs
  JOURNAL   EMBO J 14 (6), 1166-1175 (1995)
   PUBMED   7720707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277646.1, AY299491.1, AK134012.1 and AA718536.1.
            
            On Aug 12, 2009 this sequence version replaced NM_011488.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013274.1, SRR1660817.123890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               BY277646.1         1-299
            300-2816            AY299491.1         48-2564
            2817-3886           AK134012.1         936-2005
            3887-3910           AA718536.1         432-455
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.77 cM"
     gene            1..3910
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /note="signal transducer and activator of transcription
                     5A"
                     /db_xref="GeneID:20850"
                     /db_xref="MGI:MGI:103036"
     exon            1..230
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            231..323
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            324..461
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            462..618
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..708
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            709..883
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1014
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1166
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1322
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1502
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1590
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1713
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1806
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2013
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2108
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2239
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2395
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2447
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2552
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..3888
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3853..3858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /note="hexamer: AATAAA"
     polyA_site      3888
                     /gene="Stat5a"
                     /gene_synonym="STAT5"
                     /note="major polyA site"
ORIGIN      
        1 atgccaactt ccaggcagag aggaggccca gaggagaggg aagctgggca aaggggatgg
       61 cagacttcca gcctggcctt gtccaacccc tgggccttga ggggaactct tcgggatggg
      121 gactatgatc caggcaaagc tccagggagc aggtctgctg cccggcaaag tctgcaggca
      181 gatgtgaagt tagaaagtgc cggctacccc ttcctgcgcc tgtttagaag taacagcctc
      241 caccgccgcc gccgtcaaga gccgtcagga gccgtcagaa gccccggcct ggagcgacag
      301 ccgcaggcgc tccgcagcac caggtaaaca gccatggcgg gctggattca ggcccagcag
      361 cttcagggag atgccctgcg ccagatgcaa gtgttgtatg ggcagcattt ccccatcgag
      421 gtccggcact acctggccca gtggatcgag agccagccgt gggatgctat tgacttggat
      481 aatccccagg accgaggtca ggccacccaa ctcctggagg gcctggtgca ggagctgcag
      541 aagaaggcgg agcaccaggt gggggaagat gggtttttgc tgaagatcaa gctggggcac
      601 tatgccacac agctccagaa cacgtatgac cgctgtccca tggagctggt tcgctgtatc
      661 cgtcacattc tgtacaacga acagaggctg gttcgcgaag ccaacaattg cagctcccct
      721 gctggtgtcc tggttgacgc catgtcccag aagcaccttc agatcaacca aaggtttgag
      781 gagctgcgcc tgatcacaca ggacacggag aacgagctga agaagctgca gcagacccaa
      841 gagtacttca tcatccagta ccaggagagc ctgcggatcc aagctcagtt tgcccagctg
      901 ggccagctga acccccagga gcgcatgagc agggagacgg ccctccagca gaagcaagtg
      961 tccctggaga cctggctgca gcgagaggca cagacactgc agcagtaccg agtggagctg
     1021 gctgagaagc accagaagac cctgcagctg ctgcggaagc agcagaccat catcctggac
     1081 gacgagctga tccagtggaa gcggagacag cagctggccg ggaacggggg tccccccgag
     1141 ggcagcctgg acgtgctgca gtcctggtgt gagaagctgg ccgagatcat ctggcagaac
     1201 cggcagcaga tccgcagggc tgagcacctg tgccagcagc tgcccatccc aggccccgtg
     1261 gaggagatgc tggctgaggt caacgccacc atcacggaca tcatctcagc tctggtcacc
     1321 agcacgttca tcatcgagaa gcagcctcct caggtcctga agacccagac caagtttgcg
     1381 gccaccgtgc gcctgctggt ggggggaaag ctgaatgtgc acatgaaccc cccgcaggtg
     1441 aaggcgacca tcatcagcga gcagcaggcc aagtccctgc tcaagaatga gaacacccgc
     1501 aatgagtgca gcggcgagat cctgaacaac tgttgcgtca tggagtacca ccaggccact
     1561 ggcacgctca gcgcccactt cagaaacatg tcactgaaaa gaatcaagcg cgccgacagg
     1621 cgtggtgcag agtcggtgac ggaggagaag ttcacagtcc tgtttgagtc tcagttcagc
     1681 gttggcagca acgagctggt gttccaggtg aagaccctgt ccctccctgt ggtcgttatc
     1741 gtccatggca gccaggacca caatgctact gccaccgtgc tgtgggacaa tgcctttgct
     1801 gagccgggca gggtgccatt tgctgtgcct gacaaggtgc tgtggccgca gctgtgtgaa
     1861 gcgctcaaca tgaaattcaa ggctgaagta cagagcaacc ggggcttgac caaagagaac
     1921 ctcgtgttcc tggcacagaa actgttcaac atcagcagca accacctcga ggactacaac
     1981 agcatgtctg tgtcctggtc ccagttcaac cgggagaact tgcccggctg gaactacacc
     2041 ttctggcagt ggttcgacgg ggtgatggag gtgctgaaga agcaccataa gccccattgg
     2101 aatgatgggg ctatcctggg tttcgtgaac aagcaacagg cccacgacct gctcatcaac
     2161 aagccggacg ggaccttcct gctgcgcttc agtgactcgg aaatcggggg catcaccatt
     2221 gcttggaagt ttgactctcc ggaccgaaac ctctggaatc tgaagccatt cacgacgcga
     2281 gatttctcca ttcggtccct ggccgaccgg ctgggggacc tgaactacct tatctacgtg
     2341 ttcccagacc gacccaagga cgaggtcttt gccaagtatt acactcctgt acttgcgaaa
     2401 gcagttgacg gatacgtgaa gccacagatc aagcaagtgg tccctgagtt cgtcaatgca
     2461 tccacagatg ccggagccag cgccacctac atggaccagg ctccttcccc agtcgtgtgc
     2521 cctcaacctc actacaacat gtacccaccc aaccctgacc ctgtccttga ccaagatggc
     2581 gagtttgacc tggatgagag catggatgtt gccaggcacg tggaagaact tttacgccgg
     2641 cccatggaca gtctcgacgc ccgcctctcc ccacctgctg gtctcttcac ctccgctaga
     2701 agctccctgt cctgaacgct ggactccatg cttctcttgg aaaaccacct tcagtgtgag
     2761 gagcccacgt cagttgtagt atctctgttc ataccaacaa tggctttgca cgtttcacag
     2821 ggctaccttg cccacacagt tctgggtttg tggctaaagc ggtggtgacc tttttgttca
     2881 gacctcaagg gcccccaggg cctctcgtgt aagagctgaa cctatcattg ctgacaaacc
     2941 tatttctccg gtgtcctttt tctgtccaat ggccatttca gtgaaattct agaaaaggca
     3001 gggaggcagg tttaggcaac taagttggag ttttactcct aagctagaag cttcgcccag
     3061 accggtgtgc tcctgtcctc gcacaggtgg aagattgggg ttcatcttag tgacccttta
     3121 tacctttgtg tatacatacg ggctgcagac tttgtgattg ctcggtgtgc ttaagctgtt
     3181 cccttcaaca cagcagaggg ctgccacagc cgagtgtcag ttcttgcgcc agggtggatg
     3241 gacgtgagat tcaagtctaa cggccttgtc cacgttccca ccatcccttt tctccattcg
     3301 atatcctcac ccttccagat ggattcatcc ttcttgcttt tttttttttt tttatgtttt
     3361 tgctttgctt ttttgagaca aggtctctcc atatatccca gactatccat gaatgatcct
     3421 cctacctgtt tctagagtgc taggattaca ggcatgcatg accacacgtg gcctcatcct
     3481 ttcttccttt cctgtttgca accttgctta ttatatcaga aaggagggga atactggggg
     3541 tctgggagga ggaaacctgg ggcgaaaaac ctgtagcaca caaaacctgt acacactgtc
     3601 tgaaggaagg gggtggggag cgctcagtct gctccactct gctgggcggc aagacctaga
     3661 acgggccctg cactgtccca ccatgggttg tggtctcaga aatcgcttca gcagctcttc
     3721 cctggaggct gtgacagagc agccaggagg agccgactag gagtcctggc ttccaacctc
     3781 tctgaaggaa gcagagggat gctttttata ttttgtacat agaactcaac atttatgtaa
     3841 acagtgtttt tgaataaagt ttttgttggt ttggtttttg caaatctaaa aaaaaaaaaa
     3901 aaaaaaaaaa
//
