LOCUS       NM_011487               3000 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus signal transducer and activator of transcription 4
            (Stat4), transcript variant 1, mRNA.
ACCESSION   NM_011487 XM_983876
VERSION     NM_011487.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Mangani,D., Subramanian,A., Huang,L., Cheng,H., Krovi,S.H., Wu,Y.,
            Yang,D., Moreira,T.G., Escobar,G., Schnell,A., Dixon,K.O.,
            Krishnan,R.K., Singh,V., Sobel,R.A., Weiner,H.L., Kuchroo,V.K. and
            Anderson,A.C.
  TITLE     Transcription factor TCF1 binds to RORgammat and orchestrates a
            regulatory network that determines homeostatic Th17 cell state
  JOURNAL   Immunity 57 (11), 2565-2582 (2024)
   PUBMED   39447575
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Farrokhi,A., Atre,T., Salitra,S., Aletaha,M., Marquez,A.C.,
            Gynn,M., Fidanza,M., Jo,S., Rolf,N., Simmons,K., Duque-Afonso,J.,
            Cleary,M.L., Seif,A.E., Kollmann,T., Gantt,S. and Reid,G.S.D.
  TITLE     Early-life infection depletes preleukemic cells in a mouse model of
            hyperdiploid B-cell acute lymphoblastic leukemia
  JOURNAL   Blood 144 (8), 809-821 (2024)
   PUBMED   38875504
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Liang,Y., Pan,H.F. and Ye,D.Q.
  TITLE     Therapeutic potential of STAT4 in autoimmunity
  JOURNAL   Expert Opin Ther Targets 18 (8), 945-960 (2014)
   PUBMED   24844303
  REMARK    Review article
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Wang,Y., Feng,D., Wang,H., Xu,M.J., Park,O., Li,Y. and Gao,B.
  TITLE     STAT4 knockout mice are more susceptible to concanavalin A-induced
            T-cell hepatitis
  JOURNAL   Am J Pathol 184 (6), 1785-1794 (2014)
   PUBMED   24731448
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Yamamoto,K., Quelle,F.W., Thierfelder,W.E., Kreider,B.L.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Silvennoinen,O. and
            Ihle,J.N.
  TITLE     Stat4, a novel gamma interferon activation site-binding protein
            expressed in early myeloid differentiation
  JOURNAL   Mol Cell Biol 14 (7), 4342-4349 (1994)
   PUBMED   8007943
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3: a STAT family member activated by tyrosine phosphorylation
            in response to epidermal growth factor and interleukin-6
  JOURNAL   Science 264 (5155), 95-98 (1994)
   PUBMED   8140422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY097735.1, AC108840.13,
            BY750146.1, AK132675.1 and BF020635.1.
            
            On Apr 28, 2015 this sequence version replaced NM_011487.4.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. Homozygous knockout mice for this gene
            exhibit reduced inflammation and cytokine production in response to
            immune challenge. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09351.1, BC098499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               BY097735.1         10-376
            368-462             AC108840.13        73210-73304         c
            463-489             BY750146.1         1-27
            490-2989            AK132675.1         163-2662
            2990-3000           BF020635.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.67 cM"
     gene            1..3000
                     /gene="Stat4"
                     /note="signal transducer and activator of transcription 4"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
     exon            1..489
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..618
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2737
                     /gene="Stat4"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     4"
                     /protein_id="NP_035617.1"
                     /db_xref="CCDS:CCDS14943.1"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
                     /translation="MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWE
                     VASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVA
                     VVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQD
                     TKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNSLDFKRKEALSKMTQ
                     IVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQL
                     EKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVL
                     KTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSN
                     GSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLP
                     VVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGR
                     GLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHIL
                     PLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHS
                     VEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV
                     SRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETA
                     MNSPYSAE"
     exon            619..763
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..862
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            863..955
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1034
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1120
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1272
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1431
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1524
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1584
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1602
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1696
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1741
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1825
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1924
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2060
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2110
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2205
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2342
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2534
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2601
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2710
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2990
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat4"
                     /note="hexamer: AATATA"
     polyA_site      2988
                     /gene="Stat4"
                     /note="major polyA site"
ORIGIN      
        1 ggtaccaaga caaggtggaa gctggccaga gagggcatac accgagaact tttacacgag
       61 ttgccacaaa cctgtgtaag cctgtcttct cacaagacag cagaccctgc tgttggttgg
      121 tgtgttgatg ctggctccct agaaaggatg gagttatgtc taggaaaaca ggaatcccag
      181 tccttcagtg tgtacctctt actctacaca ccttgggaca atttgcattt gtaagagtgg
      241 ctactaggga tggggcggtg ctctgccaag ggggcttcag cctgactttg taaagcgttt
      301 ctagaataga gtggatagga actgcctaaa gtcccaggga ctcaaacact gacgcacagg
      361 aaagcctcaa gtgggtggag aaatgcaaat cccctagagg aatggcgtca gcggctgtgg
      421 accctgaagg ccgattctga ctttggactt gtgcagtgcc actacctgga cggagagaga
      481 gagagccagc atgtctcagt ggaatcaagt ccaacaatta gaaatcaagt ttttggagca
      541 agtagatcag ttctatgatg acaactttcc tatggaaatc cggcatctgc tagctcagtg
      601 gattgagact caagactggg aagtagcttc taacaatgaa actatggcaa caattctgct
      661 tcaaaactta ctaatacaat tggatgaaca gttggggcgt gtttccaaag aaaaaaatct
      721 gctattgatt cacaatctaa agagaattag aaaagttctt cagggcaagt ttcatggaaa
      781 tccaatgcat gtagctgtgg taatttcaaa ttgcttaagg gaagagagga gaatattggc
      841 tgcagccaac atgcctatcc agggacctct ggagaaatcc ttacagagtt cttcagtttc
      901 tgaaagacaa aggaatgtgg aacacaaagt gtctgccatt aaaaacagtg tgcagatgac
      961 agaacaagat accaaatact tagaagacct gcaagatgag tttgactaca ggtataaaac
     1021 aattcagaca atggatcagg gtgacaaaaa cagtatcctg gtgaaccagg aagttttgac
     1081 gctgcaagaa atgcttaata gtctggactt caagagaaag gaagcactca gtaagatgac
     1141 gcagatagtg aacgagacag acctgctcat gaacagcatg cttctagaag agctgcagga
     1201 ctggaaaaag cggcagcaga ttgcctgcat tggtggcccg ctccacaatg ggctggacca
     1261 gcttcagaac tgctttaccc tactggcaga gagtcttttc caactcagac agcaactgga
     1321 gaaactacag gagcaatcta ctaaaatgac ctatgaaggg gatcccatcc ctgctcaaag
     1381 agcacacctc ctggaaagag ctaccttcct gatctacaac cttttcaaga actcatttgt
     1441 ggtcgagcga cagccatgca tgccaacgca ccctcagagg ccgatggtac ttaaaaccct
     1501 cattcagttc actgtaaaac tgagattact aataaaattg ccggaactaa actatcaggt
     1561 gaaagtaaag gcgtccattg acaagaatgt ttcaactcta agcaatagaa gatttgtgct
     1621 ttgtggaact cacgtcaaag ctatgtccag tgaggaatct tccaatggga gcctctcagt
     1681 ggagtttaga catttgcaac ccaaggagat gaagtgcagt actgggagta aaggaaacga
     1741 gggctgccac atggtgacag aggagttgca ttccataacc tttgagaccc agatctgcct
     1801 ctatggcctc accattaacc tagagaccag ctcattacct gtcgtgatga tttctaatgt
     1861 cagccaacta cctaatgcat gggcatccat catttggtac aatgtatcaa ctaacgactc
     1921 ccagaacttg gttttcttta ataaccctcc atctgtcact ttgggccaac tcctggaagt
     1981 gatgagctgg caattttcat cctatgtcgg tcgtggcctt aattcagagc agctcaacat
     2041 gctggcagag aagctcacag ttcagtctaa ctacaatgat ggtcacctca cctgggccaa
     2101 gttctgcaag gaacatttgc ctggcaaaac atttaccttc tggacttggc ttgaagcaat
     2161 attggaccta attaaaaaac atattcttcc cctctggatt gatgggtaca tcatgggatt
     2221 tgttagtaaa gagaaggaac ggcttctgct caaagataaa atgcctggga catttttgtt
     2281 aagattcagt gagagccatc ttggagggat aaccttcacc tgggtggacc aatctgaaaa
     2341 tggagaagtg agattccact ctgtagaacc ctacaacaaa gggagactgt cggctctgcc
     2401 gttcgctgac atcctgcgag actacaaggt tatcatggct gaaaacatcc ctgaaaaccc
     2461 tctgaagtac ctctaccctg acattcccaa agacaaagcc tttggcaaac actacagctc
     2521 ccagccgtgc gaagtctcaa gaccaaccga acggggagac aagggttacg tcccctctgt
     2581 ttttatcccc atttcaacaa tccgaagcga ttccacggag ccacaatctc cttcagacct
     2641 tctccccatg tctccaagtg catatgctgt gctgagagaa aacctgagcc caacgacaat
     2701 tgaaactgca atgaattccc catattctgc tgaatgacgg tgcaaacgga cactttaaag
     2761 aaggaagcag atgaaactgg agagtgttct ttaccataga tcacaattta tttcttcggc
     2821 tttgtaaata ccagtttcta gaaaatggta ggaagttgga agctctcttc tcacttggtg
     2881 ccactcccag caaggagcgc tgtgactaaa atgctaaaaa acctgcaaga aaagacagct
     2941 ttaagaaacc agtgttggta acaatataac agaggactcc tttgaaaaca aaaaaaaaaa
//
