LOCUS       NM_001308266            2672 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus signal transducer and activator of transcription 4
            (Stat4), transcript variant 2, mRNA.
ACCESSION   NM_001308266
VERSION     NM_001308266.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Mangani,D., Subramanian,A., Huang,L., Cheng,H., Krovi,S.H., Wu,Y.,
            Yang,D., Moreira,T.G., Escobar,G., Schnell,A., Dixon,K.O.,
            Krishnan,R.K., Singh,V., Sobel,R.A., Weiner,H.L., Kuchroo,V.K. and
            Anderson,A.C.
  TITLE     Transcription factor TCF1 binds to RORgammat and orchestrates a
            regulatory network that determines homeostatic Th17 cell state
  JOURNAL   Immunity 57 (11), 2565-2582 (2024)
   PUBMED   39447575
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Farrokhi,A., Atre,T., Salitra,S., Aletaha,M., Marquez,A.C.,
            Gynn,M., Fidanza,M., Jo,S., Rolf,N., Simmons,K., Duque-Afonso,J.,
            Cleary,M.L., Seif,A.E., Kollmann,T., Gantt,S. and Reid,G.S.D.
  TITLE     Early-life infection depletes preleukemic cells in a mouse model of
            hyperdiploid B-cell acute lymphoblastic leukemia
  JOURNAL   Blood 144 (8), 809-821 (2024)
   PUBMED   38875504
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Liang,Y., Pan,H.F. and Ye,D.Q.
  TITLE     Therapeutic potential of STAT4 in autoimmunity
  JOURNAL   Expert Opin Ther Targets 18 (8), 945-960 (2014)
   PUBMED   24844303
  REMARK    Review article
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Wang,Y., Feng,D., Wang,H., Xu,M.J., Park,O., Li,Y. and Gao,B.
  TITLE     STAT4 knockout mice are more susceptible to concanavalin A-induced
            T-cell hepatitis
  JOURNAL   Am J Pathol 184 (6), 1785-1794 (2014)
   PUBMED   24731448
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Yamamoto,K., Quelle,F.W., Thierfelder,W.E., Kreider,B.L.,
            Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Silvennoinen,O. and
            Ihle,J.N.
  TITLE     Stat4, a novel gamma interferon activation site-binding protein
            expressed in early myeloid differentiation
  JOURNAL   Mol Cell Biol 14 (7), 4342-4349 (1994)
   PUBMED   8007943
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3: a STAT family member activated by tyrosine phosphorylation
            in response to epidermal growth factor and interleukin-6
  JOURNAL   Science 264 (5155), 95-98 (1994)
   PUBMED   8140422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132675.1 and BF020635.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. Homozygous knockout mice for this gene
            exhibit reduced inflammation and cytokine production in response to
            immune challenge. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2661              AK132675.1         2-2662
            2662-2672           BF020635.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.67 cM"
     gene            1..2672
                     /gene="Stat4"
                     /note="signal transducer and activator of transcription 4"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
     exon            1..73
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            74..161
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            162..290
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2409
                     /gene="Stat4"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     4"
                     /protein_id="NP_001295195.1"
                     /db_xref="CCDS:CCDS14943.1"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
                     /translation="MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWE
                     VASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVA
                     VVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQD
                     TKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNSLDFKRKEALSKMTQ
                     IVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQL
                     EKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVL
                     KTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSN
                     GSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLP
                     VVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGR
                     GLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHIL
                     PLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHS
                     VEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV
                     SRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETA
                     MNSPYSAE"
     exon            291..435
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            436..534
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..627
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            628..706
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..792
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            793..944
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1103
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1196
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1256
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1274
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1368
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1413
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1497
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1596
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1732
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1782
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1877
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2014
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2206
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2273
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2382
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2662
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat4"
                     /note="hexamer: AATATA"
     polyA_site      2660
                     /gene="Stat4"
                     /note="major polyA site"
ORIGIN      
        1 aatattccac ctgacgcaga gctgtcccct tcaaatggca tttgtttgct tcctggaccc
       61 attcgttcaa gcgtgtcctg gcacttcccc agtcctccag gaaatgttaa acagctgtta
      121 ctctgcagag aagtcaacca cttcagcaag tgttctgtaa acatgtctca gtggaatcaa
      181 gtccaacaat tagaaatcaa gtttttggag caagtagatc agttctatga tgacaacttt
      241 cctatggaaa tccggcatct gctagctcag tggattgaga ctcaagactg ggaagtagct
      301 tctaacaatg aaactatggc aacaattctg cttcaaaact tactaataca attggatgaa
      361 cagttggggc gtgtttccaa agaaaaaaat ctgctattga ttcacaatct aaagagaatt
      421 agaaaagttc ttcagggcaa gtttcatgga aatccaatgc atgtagctgt ggtaatttca
      481 aattgcttaa gggaagagag gagaatattg gctgcagcca acatgcctat ccagggacct
      541 ctggagaaat ccttacagag ttcttcagtt tctgaaagac aaaggaatgt ggaacacaaa
      601 gtgtctgcca ttaaaaacag tgtgcagatg acagaacaag ataccaaata cttagaagac
      661 ctgcaagatg agtttgacta caggtataaa acaattcaga caatggatca gggtgacaaa
      721 aacagtatcc tggtgaacca ggaagttttg acgctgcaag aaatgcttaa tagtctggac
      781 ttcaagagaa aggaagcact cagtaagatg acgcagatag tgaacgagac agacctgctc
      841 atgaacagca tgcttctaga agagctgcag gactggaaaa agcggcagca gattgcctgc
      901 attggtggcc cgctccacaa tgggctggac cagcttcaga actgctttac cctactggca
      961 gagagtcttt tccaactcag acagcaactg gagaaactac aggagcaatc tactaaaatg
     1021 acctatgaag gggatcccat ccctgctcaa agagcacacc tcctggaaag agctaccttc
     1081 ctgatctaca accttttcaa gaactcattt gtggtcgagc gacagccatg catgccaacg
     1141 caccctcaga ggccgatggt acttaaaacc ctcattcagt tcactgtaaa actgagatta
     1201 ctaataaaat tgccggaact aaactatcag gtgaaagtaa aggcgtccat tgacaagaat
     1261 gtttcaactc taagcaatag aagatttgtg ctttgtggaa ctcacgtcaa agctatgtcc
     1321 agtgaggaat cttccaatgg gagcctctca gtggagttta gacatttgca acccaaggag
     1381 atgaagtgca gtactgggag taaaggaaac gagggctgcc acatggtgac agaggagttg
     1441 cattccataa cctttgagac ccagatctgc ctctatggcc tcaccattaa cctagagacc
     1501 agctcattac ctgtcgtgat gatttctaat gtcagccaac tacctaatgc atgggcatcc
     1561 atcatttggt acaatgtatc aactaacgac tcccagaact tggttttctt taataaccct
     1621 ccatctgtca ctttgggcca actcctggaa gtgatgagct ggcaattttc atcctatgtc
     1681 ggtcgtggcc ttaattcaga gcagctcaac atgctggcag agaagctcac agttcagtct
     1741 aactacaatg atggtcacct cacctgggcc aagttctgca aggaacattt gcctggcaaa
     1801 acatttacct tctggacttg gcttgaagca atattggacc taattaaaaa acatattctt
     1861 cccctctgga ttgatgggta catcatggga tttgttagta aagagaagga acggcttctg
     1921 ctcaaagata aaatgcctgg gacatttttg ttaagattca gtgagagcca tcttggaggg
     1981 ataaccttca cctgggtgga ccaatctgaa aatggagaag tgagattcca ctctgtagaa
     2041 ccctacaaca aagggagact gtcggctctg ccgttcgctg acatcctgcg agactacaag
     2101 gttatcatgg ctgaaaacat ccctgaaaac cctctgaagt acctctaccc tgacattccc
     2161 aaagacaaag cctttggcaa acactacagc tcccagccgt gcgaagtctc aagaccaacc
     2221 gaacggggag acaagggtta cgtcccctct gtttttatcc ccatttcaac aatccgaagc
     2281 gattccacgg agccacaatc tccttcagac cttctcccca tgtctccaag tgcatatgct
     2341 gtgctgagag aaaacctgag cccaacgaca attgaaactg caatgaattc cccatattct
     2401 gctgaatgac ggtgcaaacg gacactttaa agaaggaagc agatgaaact ggagagtgtt
     2461 ctttaccata gatcacaatt tatttcttcg gctttgtaaa taccagtttc tagaaaatgg
     2521 taggaagttg gaagctctct tctcacttgg tgccactccc agcaaggagc gctgtgacta
     2581 aaatgctaaa aaacctgcaa gaaaagacag ctttaagaaa ccagtgttgg taacaatata
     2641 acagaggact cctttgaaaa caaaaaaaaa aa
//
