LOCUS       NM_213659               4520 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus signal transducer and activator of transcription 3
            (Stat3), transcript variant 1, mRNA.
ACCESSION   NM_213659
VERSION     NM_213659.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4520)
  AUTHORS   Li,X., Wang,J., Liao,C., Yang,X., Zhao,Z., Liu,Y., Xue,Q., Luo,Y.,
            Liu,X. and Liu,Z.
  TITLE     The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated
            microglial hyperalgesia during inflammatory pain
  JOURNAL   FASEB J 38 (8), e23590 (2024)
   PUBMED   38656553
  REMARK    GeneRIF: The binding of PKCepsilon and MEG2 to STAT3 regulates
            IL-6-mediated microglial hyperalgesia during inflammatory pain.
REFERENCE   2  (bases 1 to 4520)
  AUTHORS   Huang,X., Guo,J., Ning,A., Zhang,N. and Sun,Y.
  TITLE     BAG3 promotes proliferation and migration of arterial smooth muscle
            cells by regulating STAT3 phosphorylation in diabetic vascular
            remodeling
  JOURNAL   Cardiovasc Diabetol 23 (1), 140 (2024)
   PUBMED   38664681
  REMARK    GeneRIF: BAG3 promotes proliferation and migration of arterial
            smooth muscle cells by regulating STAT3 phosphorylation in diabetic
            vascular remodeling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4520)
  AUTHORS   Tang,J., Zhang,J., Zhang,G., Peng,W., Ling,N., Zhou,Y., Xu,H.,
            Ren,H. and Chen,M.
  TITLE     Stat3 activation-triggered transcriptional networks govern the
            early stage of HBV-induced hepatic inflammation
  JOURNAL   mBio 15 (4), e0306823 (2024)
   PUBMED   38440978
  REMARK    GeneRIF: Stat3 activation-triggered transcriptional networks govern
            the early stage of HBV-induced hepatic inflammation.
REFERENCE   4  (bases 1 to 4520)
  AUTHORS   Qiu,Y., Pei,D., Wang,M., Wang,Q., Duan,W., Wang,L., Liu,K., Guo,Y.,
            Luo,L., Guo,Z., Guan,F., Wang,Z., Xing,A., Liu,Z., Ma,Z., Jiang,G.,
            Yan,D., Liu,X., Zhang,Z. and Wang,W.
  TITLE     Nuclear autoantigenic sperm protein facilitates glioblastoma
            progression and radioresistance by regulating the ANXA2/STAT3 axis
  JOURNAL   CNS Neurosci Ther 30 (4), e14709 (2024)
   PUBMED   38605477
  REMARK    GeneRIF: Nuclear autoantigenic sperm protein facilitates
            glioblastoma progression and radioresistance by regulating the
            ANXA2/STAT3 axis.
REFERENCE   5  (bases 1 to 4520)
  AUTHORS   Hu,K., Liu,L., Tang,S., Zhang,X., Chang,H., Chen,W., Fan,T.,
            Zhang,L., Shen,B. and Zhang,Q.
  TITLE     MicroRNA-221-3p inhibits the inflammatory response of keratinocytes
            by regulating the DYRK1A/STAT3 signaling pathway to promote wound
            healing in diabetes
  JOURNAL   Commun Biol 7 (1), 300 (2024)
   PUBMED   38461326
  REMARK    GeneRIF: MicroRNA-221-3p inhibits the inflammatory response of
            keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to
            promote wound healing in diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4520)
  AUTHORS   Schaefer,T.S., Sanders,L.K. and Nathans,D.
  TITLE     Cooperative transcriptional activity of Jun and Stat3 beta, a short
            form of Stat3
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9097-9101 (1995)
   PUBMED   7568080
REFERENCE   7  (bases 1 to 4520)
  AUTHORS   Wen,Z., Zhong,Z. and Darnell,J.E. Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   8  (bases 1 to 4520)
  AUTHORS   Raz,R., Durbin,J.E. and Levy,D.E.
  TITLE     Acute phase response factor and additional members of the
            interferon-stimulated gene factor 3 family integrate diverse
            signals from cytokines, interferons, and growth factors
  JOURNAL   J Biol Chem 269 (39), 24391-24395 (1994)
   PUBMED   7523373
REFERENCE   9  (bases 1 to 4520)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (bases 1 to 4520)
  AUTHORS   Akira,S., Nishio,Y., Inoue,M., Wang,X.J., Wei,S., Matsusaka,T.,
            Yoshida,K., Sudo,T., Naruto,M. and Kishimoto,T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene factor 3
            p91-related transcription factor involved in the gp130-mediated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591466.8, AK145486.1,
            AA123454.1 and AK153170.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_213659.4.
            
            On Sep 12, 2015 this sequence version replaced NM_213659.2.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. This
            protein is activated through phosphorylation in response to various
            cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,
            LIF and BMP2. This protein mediates the expression of a variety of
            genes in response to cell stimuli, and thus plays a key role in
            many cellular processes such as cell growth and apoptosis. The
            small GTPase Rac1 has been shown to bind and regulate the activity
            of this protein. PIAS3 protein is a specific inhibitor of this
            protein. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153472.1, AK153005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL591466.8         56374-56547
            175-2514            AK145486.1         2-2341
            2515-2515           AL591466.8         106386-106386
            2516-3090           AK145486.1         2343-2917
            3091-3429           AA123454.1         40-378
            3430-4506           AK153170.1         580-1656
            4507-4520           AL591466.8         109095-109108
FEATURES             Location/Qualifiers
     source          1..4520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.82 cM"
     gene            1..4520
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /note="signal transducer and activator of transcription 3"
                     /db_xref="GeneID:20848"
                     /db_xref="MGI:MGI:103038"
     exon            1..285
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            286..436
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2621
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /note="isoform 1 is encoded by transcript variant 1; acute
                     phase response factor"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     3 isoform 1"
                     /protein_id="NP_998824.1"
                     /db_xref="CCDS:CCDS25440.1"
                     /db_xref="GeneID:20848"
                     /db_xref="MGI:MGI:103038"
                     /translation="MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWA
                     YAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIA
                     RIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQ
                     KMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIV
                     SELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQ
                     TRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
                     RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTK
                     VMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
                     KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
                     SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLD
                     NIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWV
                     EKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEA
                     FGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNN
                     GEGAEPSAGGQFESLTFDMDLTSECATSPM"
     exon            437..581
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            582..680
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            681..776
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            777..858
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            859..953
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1105
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1264
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1357
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1417
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1447
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1541
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1589
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1673
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1772
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1908
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1961
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2056
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2196
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2409
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2452
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2565
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..4520
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4493..4498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /note="hexamer: AATAAA"
     polyA_site      4511
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /note="major polyA site"
ORIGIN      
        1 aattatgcat ggaggcgtgt cttggccagt ggcggctggg tggggattgg ctggaggggc
       61 tgtaattcag cggtttccgg agctgcagtg tagacaggga gggggaacct ggggttccga
      121 cgtcgcggcg gagggaacga gccctaaccg gatcgctgag gtacaacccc gctcggtgtc
      181 gcctgaccgc gtcggctagg agaggccagg cggccctcgg gagcccagca gctcgcgcct
      241 ggagtcagcg caggccggcc agtcgggcct cagccccgga gacagtcgag acccctgact
      301 gcagcaggat ggctcagtgg aaccagctgc agcagctgga cacacgctac ctggagcagc
      361 tgcaccagct gtacagcgac agcttcccca tggagctgcg gcagttcctg gcaccttgga
      421 ttgagagtca agactgggca tatgcagcca gcaaagagtc acatgccacg ttggtgtttc
      481 ataatctctt gggtgaaatt gaccagcaat atagccgatt cctgcaagag tccaatgtcc
      541 tctatcagca caaccttcga agaatcaagc agtttctgca gagcaggtat cttgagaagc
      601 caatggaaat tgcccggatc gtggcccgat gcctgtggga agagtctcgc ctcctccaga
      661 cggcagccac ggcagcccag caagggggcc aggccaacca cccaacagcc gccgtagtga
      721 cagagaagca gcagatgttg gagcagcatc ttcaggatgt ccggaagcga gtgcaggatc
      781 tagaacagaa aatgaaggtg gtggagaacc tccaggacga ctttgatttc aactacaaaa
      841 ccctcaagag ccaaggagac atgcaggatc tgaatggaaa caaccagtct gtgaccagac
      901 agaagatgca gcagctggaa cagatgctca cagccctgga ccagatgcgg agaagcattg
      961 tgagtgagct ggcggggctc ttgtcagcaa tggagtacgt gcagaagaca ctgactgatg
     1021 aagagctggc tgactggaag aggcggcagc agatcgcgtg catcggaggc cctcccaaca
     1081 tctgcctgga ccgtctggaa aactggataa cttcattagc agaatctcaa cttcagaccc
     1141 gccaacaaat taagaaactg gaggagctgc agcagaaagt gtcctacaag ggcgacccta
     1201 tcgtgcagca ccggcccatg ctggaggaga ggatcgtgga gctgttcaga aacttaatga
     1261 agagtgcctt cgtggtggag cggcagccct gcatgcccat gcacccggac cggcccttag
     1321 tcatcaagac tggtgtccag tttaccacga aagtcaggtt gctggtcaaa tttcctgagt
     1381 tgaattatca gcttaaaatt aaagtgtgca ttgataaaga ctctggggat gttgctgccc
     1441 tcagagggtc tcggaaattt aacattctgg gcacgaacac aaaagtgatg aacatggagg
     1501 agtctaacaa cggcagcctg tctgcagagt tcaagcacct gacccttagg gagcagagat
     1561 gtgggaatgg aggccgtgcc aattgtgatg cctccttgat cgtgactgag gagctgcacc
     1621 tgatcacctt cgagactgag gtgtaccacc aaggcctcaa gattgaccta gagacccact
     1681 ccttgccagt tgtggtgatc tccaacatct gtcagatgcc aaatgcttgg gcatcaatcc
     1741 tgtggtataa catgctgacc aataacccca agaacgtgaa cttcttcact aagccgccaa
     1801 ttggaacctg ggaccaagtg gccgaggtgc tcagctggca gttctcgtcc accaccaagc
     1861 gggggctgag catcgagcag ctgacaacgc tggctgagaa gctcctaggg cctggtgtga
     1921 actactcagg gtgtcagatc acatgggcta aattctgcaa agaaaacatg gctggcaagg
     1981 gcttctcctt ctgggtctgg ctagacaata tcatcgacct tgtgaaaaag tatatcttgg
     2041 ccctttggaa tgaagggtac atcatgggtt tcatcagcaa ggagcgggag cgggccatcc
     2101 taagcacaaa gcccccgggc accttcctac tgcgcttcag cgagagcagc aaagaaggag
     2161 gggtcacttt cacttgggtg gaaaaggaca tcagtggcaa gacccagatc cagtctgtag
     2221 agccatacac caagcagcag ctgaacaaca tgtcatttgc tgaaatcatc atgggctata
     2281 agatcatgga tgcgaccaac atcctggtgt ctccacttgt ctacctctac cccgacattc
     2341 ccaaggagga ggcatttgga aagtactgta ggcccgagag ccaggagcac cccgaagccg
     2401 acccaggtag tgctgccccg tacctgaaga ccaagttcat ctgtgtgaca ccaacgacct
     2461 gcagcaatac cattgacctg ccgatgtccc cccgcacttt agattcattg atgcagtttg
     2521 gaaataacgg tgaaggtgct gagccctcag caggagggca gtttgagtcg ctcacgtttg
     2581 acatggatct gacctcggag tgtgctacct cccccatgtg aggagctgaa accagaagct
     2641 gcagagacgt gacttgagac acctgccccg tgctccaccc ctaagcagcc gaaccccata
     2701 tcgtctgaaa ctcctaactt tgtggttcca gatttttttt tttaatttcc tacttctgct
     2761 atctttgggc aatctgggca ctttttaaaa tagagaaatg agtgagtgtg ggtgataaac
     2821 tgttatgtaa agaggagagc acctctgagt ctggggatgg ggctgagagc agaagggagc
     2881 aaggggaaca cctcctgtcc tgcccgcctg ccctcctttt tcagcagctc ggggttggtt
     2941 gttagacaag tgcctcctgg tgcccatggc atcctgttgc cccactctgt gagctgatac
     3001 cccaggctgg gaactcctgg ctctgcactt tcaaccttgc taatatccac atagaagcta
     3061 ggactaagcc cagaggttcc tctttaaatt aaaaaaaaaa aaaataagaa ttaaagggca
     3121 aaacacactg acacagcata gcctttccat atcaaggaat actcagttaa cagcctctcc
     3181 agcgctgtct tcaggctgat catctatata aaccctggaa tggttgcaga tcaaatctgt
     3241 aaaagagatc cgagagctgt ggcttggcct ctggttcaaa cacaaaggct agagagaacc
     3301 tagatatccc tgggttttgt ttacccagta tgcttgtcgg ttggaggtgt gaggtaggcc
     3361 aagggcactg gaaagccttt gtcatcaccc tactccctcc ccaacccaga ctccagaccc
     3421 tgtttcaggg tcagcctgcc ctgtgggtgc cttactgggc ctagggtcaa cctgccttcc
     3481 tttcccactt gaccttgctg gtagtatgtc cccttcccat gtccaaaggc cctctgtcct
     3541 gcttctattg ggaatccctg cctcaggacc ttgtgtcgag agggattgcc ttacaggttt
     3601 gaacctgcct cagactacag gccctcagca aagctcaggg agtatggtcc ttattctatg
     3661 cgcttggttc ccagggatat ctgtaaccac agggcaaaag ctgacatata ctccaggtct
     3721 gccctcatat gagtggtgta ttcttggcct cccctgagac tggcaactgt ctgctcccca
     3781 ttgggtctcc caggtgaggt ggaacacagt tcctgcacct actgtggcct ccatgtcgct
     3841 tgcttgcttc gctcactcag cttactggaa cactgagtgt tcaaggcaag cctttcctga
     3901 cagaggcatg gctagattca gtgactcaaa gccacctcat tcagctgatc agtgtctgtg
     3961 gaattgtttc cttccagtta accagtgtct gaattaaggg cagtgaggac attgtctcca
     4021 agacgaactg cttgccttga ccaccccagc cttctgcttc gagacagtta ctgctctccc
     4081 accccatcaa tgttctttag ttatacaata agctgaactt ataaactgaa agggtattta
     4141 ggaaggcaag gcttgggcat ttttatggct ttcaatcctg gggacccagg aacaaggtga
     4201 gggcttctct ggggctggtg ttgtacctca ggggctctgg gaagtctgtg tgcctgggtt
     4261 aaccacccat agtgagcccc tggaactgcc cactttccct ctccttggcc ccacttggcc
     4321 ccagcctcac ccagcctgca gactgcttag cctttcagtg cagtggcttg tgttctggcc
     4381 actgcactca gattccaatg taaactttct agtgtaaaaa tttatattat tgtgggttgt
     4441 tttttgttgt tgtttgtttt tgtatattgc tgtaactact ttaacttcca gaaataaaga
     4501 ttatatagga actgtctggc
//
