LOCUS       NM_019963               4476 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus signal transducer and activator of transcription 2
            (Stat2), mRNA.
ACCESSION   NM_019963 XM_990913
VERSION     NM_019963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4476)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   2  (bases 1 to 4476)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4476)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Gunther,C., Gonzalez-Acera,M., Atreya,R.,
            Stolzer,I., Wittner,L., Dressel,A., Schickedanz,L.,
            Gamez-Belmonte,R., Erkert,L., Hundorfean,G., Zundler,S., Rath,T.,
            Vetrano,S., Danese,S., Sturm,G., Trajanoski,Z., Kuhl,A.A.,
            Siegmund,B., Hartmann,A., Wirtz,S., Siebler,J., Finotto,S.,
            Becker,C. and Neurath,M.F.
  TITLE     IL-20 controls resolution of experimental colitis by regulating
            epithelial IFN/STAT2 signalling
  JOURNAL   Gut 73 (2), 282-297 (2024)
   PUBMED   37884352
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4476)
  AUTHORS   Chiriac,M.T., Hracsko,Z., Becker,C. and Neurath,M.F.
  TITLE     STAT2 Controls Colorectal Tumorigenesis and Resistance to
            Anti-Cancer Drugs
  JOURNAL   Cancers (Basel) 15 (22), 5423 (2023)
   PUBMED   38001683
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4476)
  AUTHORS   Reynoso,G.V., Gordon,D.N., Kalia,A., Aguilar,C.C., Malo,C.S.,
            Aleshnick,M., Dowd,K.A., Cherry,C.R., Shannon,J.P., Vrba,S.M.,
            Holmes,A.C., Alippe,Y., Maciejewski,S., Asano,K., Diamond,M.S.,
            Pierson,T.C. and Hickman,H.D.
  TITLE     Zika virus spreads through infection of lymph node-resident
            macrophages
  JOURNAL   Cell Rep 42 (2), 112126 (2023)
   PUBMED   36795561
REFERENCE   6  (bases 1 to 4476)
  AUTHORS   Svaren,J., Apel,E.D., Simburger,K.S., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.A. and Milbrandt,J.
  TITLE     The Nab2 and Stat6 genes share a common transcription termination
            region
  JOURNAL   Genomics 41 (1), 33-39 (1997)
   PUBMED   9126479
REFERENCE   7  (bases 1 to 4476)
  AUTHORS   Sugiyama,T., Nishio,Y., Kishimoto,T. and Akira,S.
  TITLE     Identification of alternative splicing form of Stat2
  JOURNAL   FEBS Lett 381 (3), 191-194 (1996)
   PUBMED   8601453
REFERENCE   8  (bases 1 to 4476)
  AUTHORS   Stancato,L.F., David,M., Carter-Su,C., Larner,A.C. and Pratt,W.B.
  TITLE     Preassociation of STAT1 with STAT2 and STAT3 in separate signalling
            complexes prior to cytokine stimulation
  JOURNAL   J Biol Chem 271 (8), 4134-4137 (1996)
   PUBMED   8626752
REFERENCE   9  (bases 1 to 4476)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Schindler,C., Zhong,Z., Wen,Z.,
            Darnell,J.E. Jr., Mui,A.L., Miyajima,A., Quelle,F.W., Ihle,J.N. et
            al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   10 (bases 1 to 4476)
  AUTHORS   Takeuchi,T., Yamazaki,Y., Katoh-Fukui,Y., Tsuchiya,R., Kondo,S.,
            Motoyama,J. and Higashinakagawa,T.
  TITLE     Gene trap capture of a novel mouse gene, jumonji, required for
            neural tube formation
  JOURNAL   Genes Dev 9 (10), 1211-1222 (1995)
   PUBMED   7758946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135859.4.
            
            On Sep 28, 2017 this sequence version replaced NM_019963.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF206162.1, AK150070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC135859.4         36759-36978         c
            221-358             AC135859.4         30853-30990         c
            359-509             AC135859.4         30578-30728         c
            510-605             AC135859.4         30258-30353         c
            606-695             AC135859.4         29743-29832         c
            696-771             AC135859.4         29579-29654         c
            772-857             AC135859.4         29106-29191         c
            858-1009            AC135859.4         28659-28810         c
            1010-1168           AC135859.4         26236-26394         c
            1169-1261           AC135859.4         26034-26126         c
            1262-1321           AC135859.4         25768-25827         c
            1322-1339           AC135859.4         25357-25374         c
            1340-1433           AC135859.4         24671-24764         c
            1434-1478           AC135859.4         24319-24363         c
            1479-1562           AC135859.4         24160-24243         c
            1563-1661           AC135859.4         23894-23992         c
            1662-1797           AC135859.4         23657-23792         c
            1798-1850           AC135859.4         23497-23549         c
            1851-1945           AC135859.4         23284-23378         c
            1946-2082           AC135859.4         22393-22529         c
            2083-2265           AC135859.4         22022-22204         c
            2266-2323           AC135859.4         21758-21815         c
            2324-2850           AC135859.4         16446-16972         c
            2851-4476           AC135859.4         14623-16248         c
FEATURES             Location/Qualifiers
     source          1..4476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.5 cM"
     gene            1..4476
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /note="signal transducer and activator of transcription 2"
                     /db_xref="GeneID:20847"
                     /db_xref="MGI:MGI:103039"
     exon            1..220
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            221..358
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2996
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     2"
                     /protein_id="NP_064347.1"
                     /db_xref="CCDS:CCDS24269.1"
                     /db_xref="GeneID:20847"
                     /db_xref="MGI:MGI:103039"
                     /translation="MAQWEMLQNLDSLFLDQLHQVYSQSILPMDVRQHLATWIEDQNW
                     REAALGSDDAKANMLYFSILDQLNQWDHYSSDSNHFLLQHNLRKFSRDIQTFPNGPTQ
                     LAEMIFNLLLEEQRILNQAQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVR
                     SIRQLKDEQDVFSFRYTVFSLKKTSSSDPHQSQQAQLVQATANKVDRMRKEVLDISKG
                     LVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPELQLEQLEQWLTAGAKFLFHLRQLL
                     KQLKEMSHMLRYKGDMFGQGVDLQNAQVMELLQRLLQRSFVVETQPCMPQTLHRPLIL
                     KTGNKFTVRTRLLVRLQEGSESLKAEVSVDRNSDLPGFRKFNILTSNQKTLTPEEGQR
                     QGLIWDFGFLTLVEQRAVGAGKGNKGPLAVTEELHVISFVVEYVYQGLKMKLQTDTLP
                     VVIISNMNQLSIAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSSYVGR
                     GLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHL
                     KDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLRFSETSEGGITCSWVEHQDDDKVEIY
                     SVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPLRFLYPRIPRDEAFGCYYQEKVNF
                     EEQRKYLKHKLIVISNRQVDELQQPLELKQDSESLEVNAELLLAHDQELPLMMQTGLV
                     LGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVPLEPAPQVLLEPAPQVLLEPAPQVL
                     LEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLLELAPQVQLEPAHLLQQP
                     SESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGDETSIPYHSHFDADGL
                     LGWTLDTF"
     exon            359..509
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..605
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..695
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..771
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..857
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1009
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1168
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1261
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1321
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1339
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1433
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1478
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1562
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1661
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1797
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1850
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1945
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2082
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2265
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2323
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2850
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..4476
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4448..4453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4475
                     /gene="Stat2"
                     /gene_synonym="1600010G07Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggggaggg cgtggctaag ctttcggtcg ccccaccgat cccggaacgc cgagcgtcca
       61 cagccgggtg atccattccg ccagccgggt gacccattcc gctgttcgct atcttggtcc
      121 gccggagtcg ggggagggtg gaaaacgggt ccttgaaccg cttggagaat tggaagttgc
      181 agcgagagca ctggaaggag cggcactgga ccctcagaag agtccaaatg gcgcagtggg
      241 agatgttgca gaaccttgac agcctgttcc tggaccagtt acaccaggtc tactcacaga
      301 gcatcctgcc aatggacgtt cgacagcatt tggctacctg gattgaagac cagaactgga
      361 gggaagctgc gctgggcagt gatgacgcca aggccaacat gctatacttc agcatcctgg
      421 accaactgaa ccagtgggac cactacagct cagactccaa tcacttttta ttacagcata
      481 acttgcgaaa attcagccgg gatattcaga cctttcccaa tggccctacc cagttggctg
      541 agatgatctt taatcttctt ctggaagagc aaaggattct gaatcaggct caaagagctc
      601 aagaggtgca gcccccacca gcccccgaag cagttgtgga gagccagcag cttgagattg
      661 aaaatcgaat ccagggttta catgtggaca ttgagttctt ggtgagatcc atcaggcagc
      721 tgaaggacga acaggatgtc ttcagcttca gatacacagt tttcagtctg aagaagacgt
      781 cgtcttcaga cccccatcag agccaacagg cgcagcttgt gcaggcaaca gccaacaaag
      841 tcgacagaat gagaaaggag gtgctggaca tctccaaagg actggttggc cgattaacca
      901 ccctggtcga cctattgctg cccaagctgg acgagtggaa ggtgcagcag cagaagtcct
      961 gcattggagc cccgcccccc gagctgcagc tggaacagct ggaacagtgg ttgacggctg
     1021 gagcaaagtt cttgttccac cttcggcagc tactgaagca gctgaaggag atgagtcaca
     1081 tgcttcggta taagggtgac atgtttggcc aaggggtgga cctgcagaat gcccaagtca
     1141 tggagttact tcagcgtctg ctccaaaggt cctttgtagt agaaacccag ccctgcatgc
     1201 cccagactct ccaccgaccc ctcatcctga agactgggaa caagttcacc gtccgaacaa
     1261 gacttctggt gagactccag gaaggcagcg aatcactcaa agcagaagtc tctgtcgaca
     1321 ggaattcaga cttaccaggc ttccggaagt tcaacattct gacctcaaac caaaaaacct
     1381 tgaccccgga ggagggccag agacagggct taatttggga cttcggcttc ttgactctgg
     1441 tggagcaacg cgctgtgggt gcaggaaagg gcaacaaggg gccgctggca gtgacagagg
     1501 agttacatgt catcagcttc gtggttgagt acgtgtacca gggtctgaag atgaagctgc
     1561 agacggacac tctccctgtt gtgattattt ctaacatgaa ccaactctcc attgcctggg
     1621 cctccattct ctggttcaac atgctcagcc caaatcccaa gaaccagcag ttcttctgcc
     1681 aagctccgaa agccccctgg agtttgctgg gacctgtgct cagctggcag ttctcctctt
     1741 acgttggccg aggcctcgat tctgagcagc tgggcatgct gagaaccaag ctgtttggaa
     1801 agagctgcaa gatggaggat gcgctgttgt cctgggtaga cttttgcaag cgagagagcc
     1861 cccctggtaa gatccctttc tggacctggc tggacaaaat tctggagctg gtgcacgacc
     1921 acctgaagga tctctggaag gatgggcgca tcatgggctt tgtgagccgc aaccaggaac
     1981 gcagactgct gaagaagatg ttgtctggca ccttcctact gcgcttcagt gaaacttctg
     2041 aagggggcat tacttgttct tgggtggagc accaggatga cgataaagtc gaaatctact
     2101 cagtgcagcc ctacaccaag gaagtgttac agtcactccc actgacagag atcatccgcc
     2161 actaccaggt tcttgccgaa gagaacatcc ccgagaaccc actccgcttc ctctatcccc
     2221 gaatccctcg ggacgaagct tttgggtgtt actaccagga aaaagttaat tttgaagaac
     2281 agaggaaata tttgaaacat aaactcattg tgatctctaa cagacaggtg gacgagctgc
     2341 agcagcctct ggagctcaaa caggattcag agtccttaga agtgaatgca gagctcttgt
     2401 tagcacacga ccaggagttg ccattgatga tgcagactgg gctggttctg ggcacagagc
     2461 tgaaagtgga ccccatactg agtacagccc cacaagtcct gctggagcca gccccacaag
     2521 tcctgctgga gccagcccca caagtcccgc tggagccagc cccacaagtc ctgctggagc
     2581 cagccccaca agtcctgctg gagccagccc cacaagtcct gctggagcca gccccacaag
     2641 tcctgctgga gccagcccca caagtccagc tggagccagc cccacaagtc ctgctggagc
     2701 tagccccaca agtcctgctg gagccagccc cacaagtcct gctggagcta gccccacaag
     2761 tccagctgga gccagcacac ttgctgcagc agccatcaga gtcagatttg cctgaggacc
     2821 tgcagcagat tagcgtggag gatctgaaaa aattaagcaa cccgagtact gaatacatca
     2881 caaccaacga aaacccaatg ttggctggcg agagcagtgg agatgagact tccataccct
     2941 accacagcca ttttgatgcg gatggactct tgggatggac tcttgatacc ttctgaggac
     3001 taggagctat gtttctgttt tgttcctcct aactccaaca tcaagatgtt gcttccgaca
     3061 gtggggatcg gggtcttcta agctggttta catgaacttt ggaataagag gtaaaagcct
     3121 aacatggttt tgaaggtgca ccaaagagtc agaacagaca ctggccataa tctttctagg
     3181 atcctgaggc tacctaccat gctgggagac gcaggggtct tgagggctgg tcaggacatt
     3241 tgcgaggtcc ttagagggtc tggggcagtg gtgtctttca ggttggaacg actttaatgt
     3301 tttgataatt ggctaagttg gtgcaaagca gcatcgggcc tttgtgggga gttcagacat
     3361 gaatggaatt ctgttcttcc tcctccattg ctaccctggg tcctgtcaaa cccagagccc
     3421 tgcccgtggt aggcaaccac ggtggccctg agccatacct gggcccttca gttctctctt
     3481 ccagttacct caggtgtact cccttcgctc ctgactccag ttctataaat ttccttctct
     3541 tcctatagag gctgagcgct gtctgcttca gcccaccatg taaaacagaa ttcatgctag
     3601 cagctccctt gccatgatca attccccacc tacaaagtaa tcctgacact ctcatgaaga
     3661 tgtgaagctc tgctgctcta ggccatgccg tctctacctc ccccagcgct tgagagaatc
     3721 actcctggag gtttgaatgg tttctgagca cttgggaatt actccttata gtactcagta
     3781 gagctgagag cttgaagaga acttagctat tttattattt tatgaataag agggcatcat
     3841 ttcttttgca cagtgttttg ttaacatgaa aggaaaaaaa aaaacccaaa acttctgttc
     3901 cttaggagtg acctaggcaa ggaccaggtt ccttgggtct cagaaccttg aaggtttatc
     3961 agacatcttt atgccttagc cattgttggg gaacccagga ggcaattgcc ttgccgctgc
     4021 tctacggtgt gcttgtggta caacttgtgg gaaacgaatg tgaggacctg cactgtggcc
     4081 gttctctaac ggcgcatcag aacagtccag gaaggggtta ataataactg ggacagggga
     4141 cagcagtgcc atgcccagcc tcaaaggcgg cacgagccaa ccaagaacca aggaggcaga
     4201 caaagaagat acacacagga gcagaagctc aaggagccag aagcaaaagt cgtgagaaaa
     4261 aggtgcccgg ccaacaggtg aaattaagaa attcagcaaa accaaggcac aacagcatag
     4321 tgggaccaag agaatggcac tgcttctttc tgctcctttg taagtccctg gttctctgct
     4381 gtaccatctc tcaccaagct ctgaatagtt agaaagaact gttgtcctga agtccttcgt
     4441 acgtcataat aaacttttgt taaaacaaca acaaag
//
