LOCUS       NM_009283               5183 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus signal transducer and activator of transcription 1
            (Stat1), transcript variant 2, mRNA.
ACCESSION   NM_009283
VERSION     NM_009283.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5183)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (bases 1 to 5183)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   3  (bases 1 to 5183)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   4  (bases 1 to 5183)
  AUTHORS   Kaji,S., Berghoff,S.A., Spieth,L., Schlaphoff,L., Sasmita,A.O.,
            Vitale,S., Buschgens,L., Kedia,S., Zirngibl,M., Nazarenko,T.,
            Damkou,A., Hosang,L., Depp,C., Kamp,F., Scholz,P., Ewers,D.,
            Giera,M., Ischebeck,T., Wurst,W., Wefers,B., Schifferer,M.,
            Willem,M., Nave,K.A., Haass,C., Arzberger,T., Jakel,S., Wirths,O.,
            Saher,G. and Simons,M.
  TITLE     Apolipoprotein E aggregation in microglia initiates Alzheimer's
            disease pathology by seeding beta-amyloidosis
  JOURNAL   Immunity 57 (11), 2651-2668 (2024)
   PUBMED   39419029
  REMARK    Erratum:[Immunity. 2025 Jan 14;58(1):263. doi:
            10.1016/j.immuni.2024.11.024.. PMID: 39637851]
REFERENCE   5  (bases 1 to 5183)
  AUTHORS   Denz,P.J., Speaks,S., Kenney,A.D., Eddy,A.C., Papa,J.L.,
            Roettger,J., Scace,S.C., Rubrum,A., Hemann,E.A., Forero,A.,
            Webby,R.J., Bowman,A.S. and Yount,J.S.
  TITLE     Innate immune control of influenza virus interspecies adaptation
            via IFITM3
  JOURNAL   Nat Commun 15 (1), 9375 (2024)
   PUBMED   39477971
  REMARK    Erratum:[Nat Commun. 2024 Dec 11;15(1):10671. doi:
            10.1038/s41467-024-54981-w.. PMID: 39663387]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5183)
  AUTHORS   Novak,U., Harpur,A.G., Paradiso,L., Kanagasundaram,V.,
            Jaworowski,A., Wilks,A.F. and Hamilton,J.A.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (bases 1 to 5183)
  AUTHORS   Finidori,J. and Kelly,P.A.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (bases 1 to 5183)
  AUTHORS   Harroch,S., Gothelf,Y., Revel,M. and Chebath,J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (bases 1 to 5183)
  AUTHORS   Matsuda,T. and Hirano,T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (bases 1 to 5183)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039458.1, AK082706.1, AC123752.8, BC042551.1 and BX513160.1.
            
            On Apr 14, 2011 this sequence version replaced NM_009283.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform 2),
            compared to isoform 1. Variants 2, 3, and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082706.1, AK159887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK039458.1         2-20
            20-1290             AK082706.1         2-1272
            1291-1291           AC123752.8         126745-126745       c
            1292-2582           AK082706.1         1274-2564
            2583-2583           AC123752.8         110014-110014       c
            2584-4266           AK082706.1         2566-4248
            4267-5166           BC042551.1         2399-3298
            5167-5183           BX513160.1         400-416
FEATURES             Location/Qualifiers
     source          1..5183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     gene            1..5183
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="signal transducer and activator of transcription 1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
     exon            1..186
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            187..347
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            348..478
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2600
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /protein_id="NP_033309.3"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
                     /translation="MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWE
                     HAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMS
                     MIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEI
                     KTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIR
                     ELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAETLQQIRQQ
                     LKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLV
                     LKTGVQFTVKLRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGFRKFNILGTHTKVMNM
                     EESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLET
                     TSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSS
                     VTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIK
                     KHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGG
                     EPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYS
                     RPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGP
                     EFDSMMSTV"
     exon            479..623
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..722
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..812
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..891
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            892..983
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1135
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1294
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1387
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1447
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1477
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1571
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1613
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1697
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1796
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1932
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..1982
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2077
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2223
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2409
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2485
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2585
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..5168
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3340
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="major polyA site"
     regulatory      4207..4212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="hexamer: TATAAA"
     polyA_site      4227
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
     regulatory      5147..5152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5166
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
ORIGIN      
        1 aggaggcggg acgccctcta gccttttttc ctgcccggta ctttcggttt tcagcgccga
       61 gtctgtcaaa gctccctgga gacctccggg accgcgcccc tcagacccac ttgggacact
      121 gctgagcggc gcagagagat ttgcccagac tcgagctcct gcgtgcagtg agtgagtgag
      181 agccagtcgt ttcagctctg ctccataccc tgagccggcg ccacgccgcc gcgcatgcaa
      241 ctggcatata acttgctgtg tgtggtgatt gcttgtgttg aatcccgaac ctgcacccgg
      301 agacagccca gtaagtctac gtgggaacgg aagcatttgg aatctcaagg atgtcacagt
      361 ggttcgagct tcagcagctg gactccaagt tcctggagca ggtccaccag ctgtacgatg
      421 acagtttccc catggaaatc agacagtacc tggcccagtg gctggaaaag caagactggg
      481 agcacgctgc ctatgatgtc tcgtttgcga ccatccgctt ccatgacctc ctctcacagc
      541 tggacgacca gtacagccgc ttttctctgg agaataattt cttgttgcag cacaacatac
      601 ggaaaagcaa gcgtaatctc caggataact tccaagaaga tcccgtacag atgtccatga
      661 tcatctacaa ctgtctgaag gaagaaagga agattttgga aaatgcccaa agatttaatc
      721 aggcccagga gggaaatatt cagaacactg tgatgttaga taaacagaag gagctggaca
      781 gtaaagtcag aaatgtgaag gatcaagtca tgtgcataga gcaggaaatc aagaccctag
      841 aagaattaca agatgaatat gactttaaat gcaaaacctc tcagaacaga gaaggtgaag
      901 ccaatggtgt ggcgaagagc gaccaaaaac aggaacagct gctgctccac aagatgtttt
      961 taatgcttga caataagaga aaggagataa ttcacaaaat cagagagttg ctgaattcca
     1021 tcgagctcac tcagaacact ctgattaatg acgagctcgt ggagtggaag cgaaggcagc
     1081 agagcgcctg catcggggga ccgcccaacg cctgcctgga tcagctgcaa agctggttca
     1141 ccattgttgc agagaccctg cagcagatcc gtcagcagct taaaaagctg gaggagttgg
     1201 aacagaaatt cacctatgag cccgacccta ttacaaaaaa caagcaggtg ttgtcagatc
     1261 gaaccttcct cctcttccag cagctcattc agagctcctt cgtggtagaa cgacagccgt
     1321 gcatgcccac tcacccgcag aggcccctgg tcttgaagac tggggtacag ttcactgtca
     1381 agctgagact gttggtgaaa ttgcaagagc tgaactataa cttgaaagtg aaagtctcat
     1441 ttgacaaaga tgtgaacgag aaaaacacag ttaaaggatt tcggaagttc aacatcttgg
     1501 gtacgcacac aaaagtgatg aacatggaag aatccaccaa cggaagtctg gcagctgagt
     1561 tccgacacct gcaactgaag gaacagaaaa acgctgggaa cagaactaat gaggggcctc
     1621 tcattgtcac cgaagaactt cactctctta gctttgaaac ccagttgtgc cagccaggct
     1681 tggtgattga cctggagacc acctctcttc ctgtcgtggt gatctccaac gtcagccagc
     1741 tccccagtgg ctgggcgtct atcctgtggt acaacatgct ggtgacagag cccaggaatc
     1801 tctccttctt cctgaacccc ccgtgcgcgt ggtggtccca gctctcagag gtgttgagtt
     1861 ggcagttttc atcagtcacc aagagaggtc tgaacgcaga ccagctgagc atgctgggag
     1921 agaagctgct gggccctaat gctggccctg atggtcttat tccatggaca aggttttgta
     1981 aggaaaatat taatgataaa aatttctcct tctggccttg gattgacacc atcctagagc
     2041 tcattaagaa gcacctgctg tgcctctgga atgatgggtg cattatgggc ttcatcagca
     2101 aggagcgaga acgcgctctg ctcaaggacc agcagccagg gacgttcctg cttagattca
     2161 gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggaacggtcc cagaacggag
     2221 gtgaacctga cttccatgcc gtggagccct acacgaaaaa agaactttca gctgttactt
     2281 tcccagatat tattcgcaac tacaaagtca tggctgccga gaacatacca gagaatcccc
     2341 tgaagtatct gtaccccaat attgacaaag accacgcctt tgggaagtat tattccagac
     2401 caaaggaagc accagaaccg atggagcttg acgaccctaa gcgaactgga tacatcaaga
     2461 ctgagttgat ttctgtgtct gaagtccacc cttctagact tcagaccaca gacaacctgc
     2521 ttcccatgtc tccagaggag tttgatgaga tgtcccggat agtgggcccc gaatttgaca
     2581 gtatgatgag cacagtataa acacgaattt ctctctggcg acattttttt cccatctgtg
     2641 attccttcct gctactgttc cttcatatgc agtatttcta gggaaatgca agaaagaaag
     2701 agcatcacat ttgctgagca ctgctggtag aaagtggata tttctctaat tagaaacctg
     2761 ttactctgaa ggacttcatg catcttactg aaggtgaaat ggaaagtcac ttaacacaaa
     2821 atggattttg taaacaaaga ccaagagatc cacccaagca ccaggactag agtgcgagta
     2881 tttggggcaa ggtgaggaga acggtcactt tagtaatggt ctgtaatcag tgcccaagtg
     2941 ctgcacatca ctggaaagag acatacttat gggggagggg ccttcttgat ggaggaatgt
     3001 ttctgtcccg ggagacattg gcacttcccc tctcctggat ggccggaagt cttccactgt
     3061 tttacatatg gcacagttca aagtcaactt tagatccaat gctctatcaa actatagtgg
     3121 gcatccttca tgtgagtggg aagaaaacaa ccgtgctcct tactgcagct tctgccaagg
     3181 catggttgct ctcctcaggg actagctttg ttggtggcaa tggctacaca aaactaaaca
     3241 ccaacagaag taagaccatt ttcatgagta ctccatcaag ttaaagggtt tttgttgtct
     3301 ttttggtcat ggattgaata aaattgtctt tgcacatcca ttaagggggc cagctttctt
     3361 aaagcaattt ttcttttttt ttaactaaaa ttagatatag gtgaactcat gttttttagt
     3421 gggctgaact tatcggtttt agctggttgt cttaattagc cataaacttg gagaaagcag
     3481 tgacttcttg aatccttagc caaatatgag tatcagataa ttttattatt tttttttcga
     3541 gacagggttt ctctgtgtag ccctggctat tctggaactc actctgtaga tcaggctggc
     3601 ctggaactca gaaatccgcc tgtctctgcc tcccgagtgc tgggattaaa ggtgtgcacc
     3661 accaatgcct ggtgagataa ctttaaagaa ctccctataa atgcatgaga accactgtta
     3721 ctgatgaatg tggttttttg acaactacat tcacaaatgg cctgtcttgt gttttgtcac
     3781 cgttttgagg gatgatgttt tgtggcacgt gtgtgatcac agcctgatgg ttctggtcgt
     3841 gggttggttc ttctgggcca gctttcacag actgctgcgc agctgcacct acagtgctgc
     3901 cccataatac tgtttcactt tggtgaagat cagcccacct tacaccccga gtgcaggtgt
     3961 gaaccacggt aagtgtgcac agtccttagg gaaaacaggg acgcagaggc ctgcctcctc
     4021 tcttttccat gccaaaatga aatgaccaag aaacaaaaca tttaaaaagt tgtttctaaa
     4081 tgctgagacc taaccattgc ttatatactg ttgtctgttg aaacagtttg ttacaatttc
     4141 attctgttga actaggtgag actttaagaa atgttgaaat tatgttaatt tcctattatt
     4201 atttaatata aagatattta aaatgtctag tgttatgagt tggtttaata tatatctcat
     4261 gtatgtatca gtcctatttt aagcgctttt taaaaaagac ttgtttaggt atatatttta
     4321 tgtatatggg tgttttatct gaatgtatgg acaccagaag agagcactgg gtcccatgag
     4381 actacagtca aatgggatca cagtcagatg caattttgag ctgccatgtg ggtgctggga
     4441 tttgaactca gggcctctgg aagaacagcc agtgctttta actgctgaac catctcttgg
     4501 gacgcctatg ggtcctattt taaaggaaga ccgatatttc ccaagtgtca cccttgctta
     4561 ctctactgca gacacaggaa ctatggcagt ttaaggtagg tcagcgggca ggcccagcgg
     4621 tgaggcctct ctgaggtaga ggcctgggga tcaggcgttt agtcattcaa ggccggcagg
     4681 gctccatggg atcacatcca agtcagggca agacatccac ttacactttc aggtagctgc
     4741 ctgttagacg tcaccaagca tgtcctagct taagtatgac gaggatggca ttttctaagt
     4801 acagagcata tatgtagcac ttgggataag ctgatctagg gacttcctga ggcggcagag
     4861 cttaaagtgg actccattga ctgcttggag actactgtgg aatgaaggca tgtctcagta
     4921 aacagaacaa acctgtggca tctgtctgcc tcagggaggc atcagacaaa gctggaaagg
     4981 atttagaaaa ttcttttacc tactctggga gctgggaggc tgtccttcat cccgagggca
     5041 ttatttatct gaaggcatct tttgtttaag attcattcat ttgttcctca aatatgttca
     5101 gtgcctgcct tgcaccaggc actattctag atgcgttgaa ggcactaata aaagaaatgc
     5161 ctcacagtaa aaaaaaaaaa aaa
//
