LOCUS       NM_139308               3118 bp    mRNA    linear   ROD 06-SEP-2023
DEFINITION  Mus musculus StAR related lipid transfer domain containing 7
            (Stard7), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_139308
VERSION     NM_139308.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama
            C, Ando H and Sugimoto H.
  TITLE     The phosphatidylcholine transfer protein StarD7 is important for
            myogenic differentiation in mouse myoblast C2C12 cells and human
            primary skeletal myoblasts
  JOURNAL   Sci Rep 10 (1), 2845 (2020)
   PUBMED   32071354
  REMARK    GeneRIF: The phosphatidylcholine transfer protein StarD7 is
            important for myogenic differentiation in mouse myoblast C2C12
            cells and human primary skeletal myoblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Yang L, Na CL, Luo S, Wu D, Hogan S, Huang T and Weaver TE.
  TITLE     The Phosphatidylcholine Transfer Protein Stard7 is Required for
            Mitochondrial and Epithelial Cell Homeostasis
  JOURNAL   Sci Rep 7, 46416 (2017)
   PUBMED   28401922
  REMARK    GeneRIF: Stard7 deficiency was associated with altered
            mitochondrial size and membrane organization both in vitro and in
            vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K
            and Sugimoto H.
  TITLE     StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine
            Composition, Respiratory Activity, and Cristae Structure of
            Mitochondria
  JOURNAL   J Biol Chem 291 (48), 24880-24891 (2016)
   PUBMED   27694445
  REMARK    GeneRIF: These findings indicate that StarD7 plays important roles
            in maintaining the proper composition of mitochondrial
            phospholipids as well as mitochondrial function and morphogenesis.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Lin S, Ikegami M, Moon C, Naren AP and Shannon JM.
  TITLE     Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically
            Interacts with Phospholipid Transfer Protein StarD10 to Facilitate
            Surfactant Phospholipid Trafficking in Alveolar Type II Cells
  JOURNAL   J Biol Chem 290 (30), 18559-18574 (2015)
   PUBMED   26048993
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Yang L, Lewkowich I, Apsley K, Fritz JM, Wills-Karp M and Weaver
            TE.
  TITLE     Haploinsufficiency for Stard7 is associated with enhanced allergic
            responses in lung and skin
  JOURNAL   J Immunol 194 (12), 5635-5643 (2015)
   PUBMED   25980009
  REMARK    GeneRIF: these data suggest that Stard7 is an important component
            of a novel protective pathway in tissues exposed to the
            extracellular environment.
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Ryder E, Wong K, Gleeson D, Keane TM, Sethi D, Vyas S, Wardle-Jones
            H, Bussell JN, Houghton R, Salisbury J, Harvey N, Adams DJ and
            Ramirez-Solis R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genomic analysis of a novel spontaneous albino C57BL/6N mouse
            strain
  JOURNAL   Genesis 51 (7), 523-528 (2013)
   PUBMED   23620107
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Angeletti S, Rena V, Nores R, Fretes R, Panzetta-Dutari GM and
            Genti-Raimondi S.
  TITLE     Expression and localization of StarD7 in trophoblast cells
  JOURNAL   Placenta 29 (5), 396-404 (2008)
   PUBMED   18378304
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3118)
  AUTHORS   Thomas JW and Green ED.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845368.6.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_139308.3.
            
            On Nov 6, 2008 this sequence version replaced NM_139308.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017524.1, SRR1660813.148864.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               AL845368.6         75329-75980
            653-861             AL845368.6         89195-89403
            862-911             AL845368.6         89632-89681
            912-1022            AL845368.6         95872-95982
            1023-1105           AL845368.6         96058-96140
            1106-1205           AL845368.6         97251-97350
            1206-1290           AL845368.6         100584-100668
            1291-3118           AL845368.6         102207-104034
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.88 cM"
     gene            1..3118
                     /gene="Stard7"
                     /note="StAR related lipid transfer domain containing 7"
                     /db_xref="GeneID:99138"
                     /db_xref="MGI:MGI:2139090"
     exon            1..652
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1475
                     /gene="Stard7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; stAR-related lipid transfer protein 7,
                     mitochondrial; START domain-containing protein 7; START
                     domain containing 7"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 7,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_647469.2"
                     /db_xref="CCDS:CCDS16698.2"
                     /db_xref="GeneID:99138"
                     /db_xref="MGI:MGI:2139090"
                     /translation="MFPRRPPATLAAWLAGARGGGLLSALANQCRFVTGLRVRRAQQI
                     AQLYGRLYSESSRCALLGRFWRRLRGRPGHASVLMAALSGVFVWDEERIQEEELQRSI
                     NEMKRLEEMSNIFQSSGVENYPPEPKSPAGGNEKSKDKEEPWEMVMDKKHFKLWRRPI
                     TGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDAVSGSEVLHW
                     VTHFPYPMYSRDYVYVRRYSVDQENNVMVLVSRAVEHPSVPESPEFVRVRSYESQMVI
                     RPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIK
                     VKDYISAKPLEMSSEAKATAPSPERKNEGSCGPARIEYA"
     exon            653..861
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            862..911
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1022
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1105
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1205
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1290
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..3118
                     /gene="Stard7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard7"
     regulatory      3104..3109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard7"
     polyA_site      3117
                     /gene="Stard7"
ORIGIN      
        1 actcggcgcg agaggcggac acaggcgcac gggaccgctt ctgctgtggc ctgggacggc
       61 caccgctttg cttcccgcgc cctggccgcg ggggccccgc gagttcccgc cgtacacaca
      121 gacgggcggg ctgtcgggac cgagagggcc tcgtgcaacg gcgctctcct cggaagccac
      181 gctacctcag ccgcttctgc aaaaaggcat gagggacggc tcctggcttc tggagcgtga
      241 ggtggcctcg gggtcaaccc gttaagggga ctgcgcggac ggcccggcct gccttccccc
      301 agcccttcct ctccggggcc ccgcggcagg cgcgggaatc cacagaggcc gacatgttcc
      361 cgaggaggcc accggccacc ctggccgcct ggctggcggg cgcgcggggc gggggcctgc
      421 tgtccgcgct ggccaatcag tgccgcttcg tgacgggcct gcgcgtgcgg cgagcgcagc
      481 agatcgcgca gctctacggc cgcctgtatt ccgagagctc gcgctgcgcc ctgctcggac
      541 gcttctggcg ccggctgcga ggccgccccg gccatgcctc tgttttgatg gcggcgctct
      601 ccggtgtttt cgtatgggac gaggagagaa tccaggagga ggagttgcag aggtccatta
      661 atgagatgaa acggttggaa gaaatgtcaa atatatttca gagctctgga gttgagaatt
      721 accctcccga accaaagtcc ccagcaggag ggaatgaaaa gtcaaaagac aaggaagaac
      781 cctgggaaat ggtgatggac aagaaacact tcaagctgtg gcgccgccca attacaggca
      841 cccaccttta ccagtaccga gtttttggaa catacacaga tgtgactccc cgacagttct
      901 tcaatgttca gctggataca gagtacagga aaaaatggga tgcccttgtg atcaagctag
      961 aggtgattga gagagatgct gttagtggtt ctgaggttct tcattgggta acccattttc
     1021 cttatccaat gtactctcgt gattatgttt atgttcggcg gtatagtgtg gatcaggaaa
     1081 acaatgtgat ggtcttggtg tcacgtgcgg tggaacaccc cagtgtgcca gagtctccag
     1141 agtttgtcag ggtcagatct tacgaatccc aaatggttat ccgtcctcac aagtcgtttg
     1201 atgagaatgg ctttgactac ttactgacat acagtgacaa tccacagaca gtgttccctc
     1261 gatactgtgt cagttggatg gtttctagtg gcatgccaga tttcttggag aagctgcaca
     1321 tggccactct gaaagccaag aacatggaga tcaaagtgaa agactacatc tcggctaagc
     1381 ctctggaaat gagcagtgag gccaaggcca ctgctccatc ccctgagcgg aagaatgagg
     1441 gtagctgtgg ccctgctcgg attgagtatg cttaaaggcc tttgggataa ggaaagacag
     1501 gcacttccag ccctgccttg ctccttcagc tctgctgcag gacagggaca agtcacacat
     1561 gttagaagac atctgctgta actgtcagtg caagaggatt tagaactgga gttagatttc
     1621 atctggagcc ctattgctct ttaccaaaca gaggagcatg acattgtgga gttgtcatgt
     1681 tctcaggcca gcagttgtga aatccagtat cgtgcttacc tactctggaa caacctctca
     1741 tgttaggcca gaaggagatg actcctatcc gcctcctacg agaagcttcc ttgctgacat
     1801 tccaaatgcc actgttggtt atgcaatgct ctggatatcc ttcagttctg taggtcactt
     1861 ggagagtggt tggcccctgg ttctcactaa gtggtttttt ggagtgctct tggtaacagt
     1921 cctgtggtgg tgtgaacaat tctggctgag ctaagtgcct tgtcctcacc ttgctttatc
     1981 tttaaagaca tgaagtttgt accaagggat ccttccccct gcagactacc atgacattga
     2041 ctcatctggt ggaggcagct ttcatcttaa ctggcctttc tgttttcatg ggctgtgctc
     2101 actgtgtcat ggcctctgcc gtagccttag cccatttgct gggagcacca gagacaaact
     2161 cctctagacg gtagcttcct aaatgatgtc atcagtgttt tgataggatc agtggaagtg
     2221 tgcacaaaac atcttactta aaaatagatt tctttttaac ccttgtagca aatggagtta
     2281 ggtggttgag cacaactctt cccttagtct tgtttgtttt ggcactattt tcccactgca
     2341 gattgactgc gctgtcctgg aaggataaag gtggtagatg gtggttgtgc catttcctca
     2401 gagttttcaa aactgtaagc tgacatatgg gccaacagat ggagtcttgc ccaataccag
     2461 tatggtaggg atggggcttt tgtgacctct tggtcttgta aagcatttct ctccagagct
     2521 gacatagaag taatagacac agtttggata agatcacaac cagatgctag gtgcctggcc
     2581 ttgctggttt ctttatggtg aatagggatc aagtttcaca tccttctctc tcttttcctg
     2641 gaattaatag agctgacatt ttcttttctt gcttgctacc taccctgttg tggtgttaaa
     2701 agagactaaa cccaaggtga acataatctt taaccttctg ttgcctattc agttctgtgc
     2761 caaggaaaca gctaactccc cagtgtttct gtcttttcgg ttgttggcag agcagagagt
     2821 ggcattgaga agccccagtg tctctcagtg agcatttttc ccttcttccc aggacctgac
     2881 aggaaaagaa aaaatcttta tttgacttta acatctgtag ctgactgcct gtgaatctgt
     2941 gagcaagtgt aagcatgtat gtgtgcgtgt gtgtgctggg gctcagggac tgagcagtta
     3001 cgtttaccct ttgttttgtg atttgactct gtacagttaa cttgtgtcat cataatgagt
     3061 ttgctcttaa ctgtgacatt tttatcaaag gtgtgaataa atgcataaag attggtac
//
