LOCUS       NP_647469                373 aa            linear   ROD 28-JAN-2025
DEFINITION  stAR-related lipid transfer protein 7, mitochondrial isoform 1
            precursor [Mus musculus].
ACCESSION   NP_647469
VERSION     NP_647469.2
DBSOURCE    REFSEQ: accession NM_139308.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Rojas,M.L., Munoz,J.P., Flores-Martin,J.,
            Sanchez-Fernandez-de-Landa,P., Cruz Del Puerto,M.,
            Genti-Raimondi,S. and Zorzano,A.
  TITLE     StarD7 deficiency switches on glycolysis and promotes mitophagy
            flux in C2C12 myoblasts
  JOURNAL   FEBS J 291 (2), 338-357 (2024)
   PUBMED   37846201
  REMARK    GeneRIF: StarD7 deficiency switches on glycolysis and promotes
            mitophagy flux in C2C12 myoblasts.
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Deshwal,S., Onishi,M., Tatsuta,T., Bartsch,T., Cors,E., Ried,K.,
            Lemke,K., Nolte,H., Giavalisco,P. and Langer,T.
  TITLE     Mitochondria regulate intracellular coenzyme Q transport and
            ferroptotic resistance via STARD7
  JOURNAL   Nat Cell Biol 25 (2), 246-257 (2023)
   PUBMED   36658222
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Horibata,Y., Mitsuhashi,S., Shimizu,H., Maejima,S., Sakamoto,H.,
            Aoyama,C., Ando,H. and Sugimoto,H.
  TITLE     The phosphatidylcholine transfer protein StarD7 is important for
            myogenic differentiation in mouse myoblast C2C12 cells and human
            primary skeletal myoblasts
  JOURNAL   Sci Rep 10 (1), 2845 (2020)
   PUBMED   32071354
  REMARK    GeneRIF: The phosphatidylcholine transfer protein StarD7 is
            important for myogenic differentiation in mouse myoblast C2C12
            cells and human primary skeletal myoblasts.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Yang,L., Na,C.L., Luo,S., Wu,D., Hogan,S., Huang,T. and Weaver,T.E.
  TITLE     The Phosphatidylcholine Transfer Protein Stard7 is Required for
            Mitochondrial and Epithelial Cell Homeostasis
  JOURNAL   Sci Rep 7, 46416 (2017)
   PUBMED   28401922
  REMARK    GeneRIF: Stard7 deficiency was associated with altered
            mitochondrial size and membrane organization both in vitro and in
            vivo.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 373)
  AUTHORS   Yang,L., Lewkowich,I., Apsley,K., Fritz,J.M., Wills-Karp,M. and
            Weaver,T.E.
  TITLE     Haploinsufficiency for Stard7 is associated with enhanced allergic
            responses in lung and skin
  JOURNAL   J Immunol 194 (12), 5635-5643 (2015)
   PUBMED   25980009
  REMARK    GeneRIF: these data suggest that Stard7 is an important component
            of a novel protective pathway in tissues exposed to the
            extracellular environment.
REFERENCE   7  (residues 1 to 373)
  AUTHORS   Ryder,E., Wong,K., Gleeson,D., Keane,T.M., Sethi,D., Vyas,S.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Harvey,N., Adams,D.J. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genomic analysis of a novel spontaneous albino C57BL/6N mouse
            strain
  JOURNAL   Genesis 51 (7), 523-528 (2013)
   PUBMED   23620107
REFERENCE   8  (residues 1 to 373)
  AUTHORS   Angeletti,S., Rena,V., Nores,R., Fretes,R., Panzetta-Dutari,G.M.
            and Genti-Raimondi,S.
  TITLE     Expression and localization of StarD7 in trophoblast cells
  JOURNAL   Placenta 29 (5), 396-404 (2008)
   PUBMED   18378304
REFERENCE   9  (residues 1 to 373)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (residues 1 to 373)
  AUTHORS   Thomas,J.W. and Green,E.D.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845368.6.
            
            On Jul 6, 2007 this sequence version replaced NP_647469.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017524.1, AK143699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.88 cM"
     Protein         1..373
                     /product="stAR-related lipid transfer protein 7,
                     mitochondrial isoform 1 precursor"
                     /note="stAR-related lipid transfer protein 7,
                     mitochondrial; START domain-containing protein 7; START
                     domain containing 7"
                     /calculated_mol_wt=36501
     transit_peptide 1..61
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q8R1R3.2)"
                     /calculated_mol_wt=6662
     mat_peptide     62..373
                     /product="StAR-related lipid transfer protein 7,
                     mitochondrial. /id=PRO_0000220675"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1R3.2)"
                     /calculated_mol_wt=36501
     Site            80..81
                     /site_type="cleavage"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q9NQZ5; propagated from
                     UniProtKB/Swiss-Prot (Q8R1R3.2)"
     Region          118..141
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1R3.2)"
     Region          139..328
                     /region_name="START_STARD7-like"
                     /note="Lipid-binding START domain of mammalian STARD7 and
                     related proteins; cd08911"
                     /db_xref="CDD:176920"
     Site            order(147..148,155,168,170,182,186,192,198,218,220,222,
                     231,233,270,272,274,289,291,293,308..310,314,317..318,321)
                     /site_type="active"
                     /note="putative PtdCho binding site [active]"
                     /db_xref="CDD:176920"
     Region          347..373
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1R3.2)"
     CDS             1..373
                     /gene="Stard7"
                     /coded_by="NM_139308.3:354..1475"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS16698.2"
                     /db_xref="GeneID:99138"
                     /db_xref="MGI:MGI:2139090"
ORIGIN      
        1 mfprrppatl aawlagargg gllsalanqc rfvtglrvrr aqqiaqlygr lysessrcal
       61 lgrfwrrlrg rpghasvlma alsgvfvwde eriqeeelqr sinemkrlee msnifqssgv
      121 enyppepksp aggnekskdk eepwemvmdk khfklwrrpi tgthlyqyrv fgtytdvtpr
      181 qffnvqldte yrkkwdalvi klevierdav sgsevlhwvt hfpypmysrd yvyvrrysvd
      241 qennvmvlvs ravehpsvpe spefvrvrsy esqmvirphk sfdengfdyl ltysdnpqtv
      301 fprycvswmv ssgmpdflek lhmatlkakn meikvkdyis akplemssea katapsperk
      361 negscgpari eya
//
