LOCUS       NM_029019               1496 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus StAR related lipid transfer domain containing 6
            (Stard6), transcript variant 1, mRNA.
ACCESSION   NM_029019
VERSION     NM_029019.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Bose,H.S., Whittal,R.M., Ran,Y., Bose,M., Baker,B.Y. and
            Miller,W.L.
  TITLE     StAR-like activity and molten globule behavior of StARD6, a male
            germ-line protein
  JOURNAL   Biochemistry 47 (8), 2277-2288 (2008)
   PUBMED   18211099
  REMARK    GeneRIF: StARD6, which is expressed only in male germ-line cells,
            thus exhibits biological and biophysical properties that imply a
            role in steroidogenesis.
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Golas,A., Dzieza,A., Kuzniarz,K. and Styrna,J.
  TITLE     Gene mapping of sperm quality parameters in recombinant inbred
            strains of mice
  JOURNAL   Int J Dev Biol 52 (2-3), 287-293 (2008)
   PUBMED   18311719
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Wang,M., Wang,Y., You,M. and Devereux,T.R.
  TITLE     Analysis of the Par2 modifier of pulmonary adenoma formation in
            mice
  JOURNAL   Exp Lung Res 31 (2), 193-204 (2005)
   PUBMED   15828125
  REMARK    Review article
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Hedlund,E., Karsten,S.L., Kudo,L., Geschwind,D.H. and
            Carpenter,E.M.
  TITLE     Identification of a Hoxd10-regulated transcriptional network and
            combinatorial interactions with Hoxa10 during spinal cord
            development
  JOURNAL   J Neurosci Res 75 (3), 307-319 (2004)
   PUBMED   14743444
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Romanowski,M.J., Soccio,R.E., Breslow,J.L. and Burley,S.K.
  TITLE     Crystal structure of the Mus musculus cholesterol-regulated START
            protein 4 (StarD4) containing a StAR-related lipid transfer domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6949-6954 (2002)
   PUBMED   12011453
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Soccio,R.E., Adams,R.M., Romanowski,M.J., Sehayek,E., Burley,S.K.
            and Breslow,J.L.
  TITLE     The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
            transfer protein with two closely related homologues, StarD5 and
            StarD6
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6943-6948 (2002)
   PUBMED   12011452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162297.5, AK014759.1 and BE691268.1.
            
            On Jan 25, 2014 this sequence version replaced NM_029019.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014759.1, SRR11927937.4436427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC162297.5         178267-178357
            92-1493             AK014759.1         3-1404
            1494-1496           BE691268.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 44.44 cM"
     gene            1..1496
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="StAR related lipid transfer domain containing 6"
                     /db_xref="GeneID:170461"
                     /db_xref="MGI:MGI:2156774"
     exon            1..115
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            116..268
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            269..349
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            350..443
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1055
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="START domain containing protein 6; StAR-related
                     lipid transfer (START) domain containing 6"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 6"
                     /protein_id="NP_083295.1"
                     /db_xref="CCDS:CCDS37854.1"
                     /db_xref="GeneID:170461"
                     /db_xref="MGI:MGI:2156774"
                     /translation="MDYKAIAQQTAEQVLAYNQDLSGWKLIKSSKKVTVSSKTSRIFH
                     GNLYRVEGIIPESAAHLSDFLFKHDHRVSWDKSLKGFNVIHKIDSDTLICHTITQSFA
                     MGSISPRDFIDLVHIKHYERNVDIISTKSVDFPGYAPTSTYIRGFNHPSGYVCSPLKE
                     NPAYSKLVIFVQTEMKGKLPASVIEKSMPSNLVSFLLNVKDGVKTYRIPPIRARHSSH
                     SSVHKKKEGHSAIKP"
     exon            444..493
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..620
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..738
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..832
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1496
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1070
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="major polyA site"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1265
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
     regulatory      1467..1472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="hexamer: ATTAAA"
     regulatory      1475..1480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="hexamer: AATAAA"
     regulatory      1479..1484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1484
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
     polyA_site      1492
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
     polyA_site      1496
                     /gene="Stard6"
                     /gene_synonym="1700011K09Rik; 4833424I06Rik;
                     4933429L05Rik"
ORIGIN      
        1 gcgctcgctt tcaaaccgac ccaacatggc gccgggccgc agggcgcatg tgtagtacca
       61 ggcgccggga gggatggggg aggagggtct cgagagcccg gcgaagagtt cagaggctgg
      121 gacaggatat gaagtgggaa gaatcaagtt gcaaccaagt gcaattttca aaaaagatgc
      181 tatctcaaca atggtctgtt tttctgaaga cacccttgct tttcatctga atacatgcat
      241 tctagttcat gcaatgttac atcatcaggt taacagagat ggagatctcc tccaggattt
      301 ggagagtagt atcaatgggc actaaaactc tggactaaat tagataaagg tagatggact
      361 ataaggcaat tgcccaacaa actgctgaac aagttttagc ttacaatcaa gacctatctg
      421 gctggaaact cattaaatct tcaaaaaagg taactgtttc cagcaagacc tctagaatat
      481 tccacggaaa cctataccgc gttgaaggaa taatcccaga atcagcagct catctctctg
      541 acttcctctt caaacatgat cacagagtct catgggacaa atcattgaaa gggttcaatg
      601 tgatacacaa gattgattcg gacacactca tatgccacac cattacacaa agttttgcca
      661 tgggctcaat ttcccctaga gactttatcg acttagtaca catcaagcac tatgaaagga
      721 acgtggacat tatcagtact aaaagtgtgg acttcccagg atatgctcca acttcgactt
      781 atatccgtgg ctttaatcat ccctctggct atgtgtgttc acctctgaag gaaaacccag
      841 cctattccaa gctagtgatt tttgtccaga cagagatgaa aggaaaattg cctgcatcgg
      901 taattgaaaa gtctatgcct tccaacttag taagcttcct cctcaatgtg aaagatggcg
      961 taaagacgta cagaattcca cccatacgtg cccggcacag ttcgcactcc tctgtgcaca
     1021 aaaagaaaga aggacattct gccattaaac cgtagcgatt tcagacagca cagcctacta
     1081 gtaagtggag tttgttcctg cagagtactc ctaagtcaac gtgaataagc ctgttcagtg
     1141 tctctaggca ttaaccttgt acagagtacg taaaatattt tgtcaaagta agaacttcac
     1201 tggacaagaa aagtcaatta aatacagttt ttaagctaac ataacattaa ataatgtgcc
     1261 gttaatacac tttgaccatc tgagcatgct gtgcattcgg atcctaaaga aggagatacc
     1321 gtcagtagtt agcattaatt agaacttaat taaatattca tctggcagtg atggtaagca
     1381 cctgaaatcc ctgccgtgaa gaagctaaaa caggaccagc acaatgacac tagcctgggc
     1441 tactcagaga gaccctatgc caataaatta aataaataaa taaataaata aataaa
//
