LOCUS       NM_023377               2500 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus StAR related lipid transfer domain containing 5
            (Stard5), mRNA.
ACCESSION   NM_023377
VERSION     NM_023377.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Kakiyama,G., Minoiwa,K., Bai-Kamara,N., Hashiguchi,T., Pandak,W.M.
            and Rodriguez-Agudo,D.
  TITLE     StarD5 levels of expression correlate with onset and progression of
            steatosis and liver fibrosis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (6), G747-G761 (2024)
   PUBMED   38591148
  REMARK    GeneRIF: StarD5 levels of expression correlate with onset and
            progression of steatosis and liver fibrosis.
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Rodriguez-Agudo,D., Malacrida,L., Kakiyama,G., Sparrer,T.,
            Fortes,C., Maceyka,M., Subler,M.A., Windle,J.J., Gratton,E.,
            Pandak,W.M. and Gil,G.
  TITLE     StarD5: an ER stress protein regulates plasma membrane and
            intracellular cholesterol homeostasis
  JOURNAL   J Lipid Res 60 (6), 1087-1098 (2019)
   PUBMED   31015253
  REMARK    GeneRIF: The studies show that StarD5 is a stress-responsive
            protein that regulates PM cholesterol and intracellular cholesterol
            homeostasis.
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   6  (bases 1 to 2500)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   7  (bases 1 to 2500)
  AUTHORS   Soccio,R.E., Adams,R.M., Maxwell,K.N. and Breslow,J.L.
  TITLE     Differential gene regulation of StarD4 and StarD5 cholesterol
            transfer proteins. Activation of StarD4 by sterol regulatory
            element-binding protein-2 and StarD5 by endoplasmic reticulum
            stress
  JOURNAL   J Biol Chem 280 (19), 19410-19418 (2005)
   PUBMED   15760897
  REMARK    GeneRIF: StarD4 is regulated by sterols via SREBP-2, and StarD5 is
            activated by ER stress cholesterol metabolism; they serve different
            functions
REFERENCE   8  (bases 1 to 2500)
  AUTHORS   Romanowski,M.J., Soccio,R.E., Breslow,J.L. and Burley,S.K.
  TITLE     Crystal structure of the Mus musculus cholesterol-regulated START
            protein 4 (StarD4) containing a StAR-related lipid transfer domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6949-6954 (2002)
   PUBMED   12011453
REFERENCE   9  (bases 1 to 2500)
  AUTHORS   Soccio,R.E., Adams,R.M., Romanowski,M.J., Sehayek,E., Burley,S.K.
            and Breslow,J.L.
  TITLE     The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
            transfer protein with two closely related homologues, StarD5 and
            StarD6
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6943-6948 (2002)
   PUBMED   12011452
REFERENCE   10 (bases 1 to 2500)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058226.1.
            
            On Dec 20, 2003 this sequence version replaced NM_023377.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058226.1, AK142503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 47.43 cM"
     gene            1..2500
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /note="StAR related lipid transfer domain containing 5"
                     /db_xref="GeneID:170460"
                     /db_xref="MGI:MGI:2156765"
     exon            1..123
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..666
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /note="18B7-T7(GS); StAR-related protein 1-4E;
                     StAR-related protein p3-15E/p3-16E; START
                     domain-containing protein 5; StAR-related lipid transfer
                     (START) domain containing 5"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 5"
                     /protein_id="NP_075866.2"
                     /db_xref="CCDS:CCDS21411.1"
                     /db_xref="GeneID:170460"
                     /db_xref="MGI:MGI:2156765"
                     /translation="MDPSWATQESEAVAEKVLRYRRDASGWKKCREGNGVSISWRPSE
                     EFPGNLYRGEGILCGTPEEVWDCIKPVASGLREKWDDNVSSFEIVQSITDMLCVSRTS
                     TPSAAMKLISPRDFVDLVLVKKYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFC
                     EPLPGDPNKTNLVTFFQTDLSGYLPQSVVDSFFPRSMAEFYPNLQKAVRKFHH"
     exon            124..173
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     exon            174..306
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     exon            307..424
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     exon            425..518
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     exon            519..2425
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /note="hexamer: ATTAAA"
     polyA_site      2422
                     /gene="Stard5"
                     /gene_synonym="2310058G22Rik; D7Ertd152e"
                     /note="major polyA site"
ORIGIN      
        1 gctgggagcc tgcacgttgg cggaatggac ccgtcctggg ccacgcaaga gagtgaggcg
       61 gtggcagaga aggtgctccg gtaccggcgg gacgcgtcgg gctggaagaa gtgtcgggaa
      121 ggcaatggag tttcaatttc ctggaggcca tctgaggagt ttccagggaa tctgtaccga
      181 ggagaaggga ttctgtgtgg gacaccagaa gaggtgtggg attgcataaa gccagttgct
      241 tcgggcctcc gggagaagtg ggatgataat gtgagcagct ttgaaattgt ccagagcatc
      301 acggatatgc tgtgtgtgag cagaacctcc acgccctcag ctgccatgaa gcttatttct
      361 cccagggact ttgtggactt ggtgctggtg aagaagtatg aggatggcac catcagctcc
      421 aatgctaccc atgtggaaca tccattgtgt cccccaaagc ccggttttgt gagaggattt
      481 aaccatccat gcgggtgctt ctgtgaacca ctgccagggg atcccaacaa aaccaacctg
      541 gtcacattct ttcagacaga cctgagtggc tacctccctc agagtgtggt ggactccttc
      601 ttccctcgaa gcatggctga gttctacccc aaccttcaga aggcagtgag gaagttccat
      661 cactgacagt cgcctattgg cagggattgc ctatggtcct tcaggaactc cagctgttga
      721 gcctcaaagg acacggaaga gctgctgagg ccttttgaga tgccatagtt aacagcaaat
      781 ctcagggttc cattccagag gagcagccca tccccccaca ccaccctccg tcctcttggg
      841 cttggtgtgg aaggagctaa ccactagctt gccgtggtgc acacataggc ctggcaggcc
      901 agggcaagtc cctctatggc cacctgagag atggctcacg tactctttga ttccttgtgg
      961 tccagagccc tgtgtgctgg ttgctgtaag acaccttgtc cctgtgtggg tcttaaagaa
     1021 tcatcatcca ttgtggtcgc taagtcctgc ttcctctggc atctggagtt cccagactcc
     1081 tgtgttccct ttctggatat gcttttgtat acaaattttt agcacaagac tttcactctt
     1141 tacaaaagtg tcaacttgga aaatgatgtt ttaaaccaca ggataagcct taaggaaaaa
     1201 tactttcaat ctaccgtttg tgatctcttc catcagaatc atctctttct atctgtttct
     1261 ccctttgtgg gttaaggttc acatccccat gaaaccggct tgtaactgcc tcaggccagt
     1321 ttgtatcttt gggaaggagt gtgaattctt gtggccccta tgagtgactc taggcagggc
     1381 cagcagttcc tgtgtgcatg ctagactctg gggaggtgag ccccatggca tgtacctcac
     1441 tgtgccctca gtcatcatgg tgaggcaaga atgctgggga ctcctggccc ctcaggcttt
     1501 gctgccatta ggaaggaggg aagaatgtct gctatgctgt gcaagtatgc acgcctattg
     1561 tatctgacac tgaccacaag gtctgccatt cctttaggga caaagggttt ctctttagct
     1621 ttccaaataa atttagatcc ttgctttcca tcagatggag aaaggaaaga tctctgctga
     1681 ctgacactgt cttcagagac acagtaccct cacagtccag ctgctcccct ctagtagctt
     1741 ttaataattt taataattcc cctactctct ctacctttgt tcttctcact gttgttggag
     1801 cagcttggat ttagtcaaag ggctcattag gacacagctt cattttgacg gggcttgttc
     1861 agaatttccc gcaatctcta tagatctgtc aggttttctt gctgctgccc tgttgcctgg
     1921 ggtttggatg ctgatctctt tctgtggttc tctctctctc tctctctctc tctctctctc
     1981 tctctctctg gttttgtctc catattaagc ttactcactt gctataccat tatttaggat
     2041 gtgatccacc ttgggatttt tgagaccagc tttctcattg gcctttgact caccaaatag
     2101 gctagattgg atgaccaaca attccaggga ccagtatctt tctgcttccc caggtctgga
     2161 attacacttt gaatgccacc gcatctggtt cttttctttt tttcctcctt ttcttttctc
     2221 ttcttttctt ttcttttctt tttggttggt tggttgcttg gttggtttta tttatgtttt
     2281 cttcttgtct ctggagatga agttcaggtg accatgcttg catggcaagc attttactta
     2341 ctgacagctg ttccccccgg ccccatacct tctcctgtta gatcaaatgt accttctatt
     2401 aaacctgata gattgatata aatggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
