LOCUS       NM_133774               5314 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus StAR related lipid transfer domain containing 4
            (Stard4), transcript variant 1, mRNA.
ACCESSION   NM_133774
VERSION     NM_133774.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5314)
  AUTHORS   Ferrell,J.M., Boehme,S., Li,F. and Chiang,J.Y.
  TITLE     Cholesterol 7alpha-hydroxylase-deficient mice are protected from
            high-fat/high-cholesterol diet-induced metabolic disorders
  JOURNAL   J Lipid Res 57 (7), 1144-1154 (2016)
   PUBMED   27146480
REFERENCE   2  (bases 1 to 5314)
  AUTHORS   Iaea,D.B., Dikiy,I., Kiburu,I., Eliezer,D. and Maxfield,F.R.
  TITLE     STARD4 Membrane Interactions and Sterol Binding
  JOURNAL   Biochemistry 54 (30), 4623-4636 (2015)
   PUBMED   26168008
  REMARK    GeneRIF: a model of STARD4 membrane interaction and sterol binding
            and release that requires dynamic movement of both the Omega1 loop
            and membrane insertion of the C-terminal alpha-helix.
REFERENCE   3  (bases 1 to 5314)
  AUTHORS   Patra,D., DeLassus,E., Liang,G. and Sandell,L.J.
  TITLE     Cartilage-specific ablation of site-1 protease in mice results in
            the endoplasmic reticulum entrapment of type IIb procollagen and
            down-regulation of cholesterol and lipid homeostasis
  JOURNAL   PLoS One 9 (8), e105674 (2014)
   PUBMED   25147951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5314)
  AUTHORS   Rodriguez-Agudo,D., Calderon-Dominguez,M., Ren,S., Marques,D.,
            Redford,K., Medina-Torres,M.A., Hylemon,P., Gil,G. and Pandak,W.M.
  TITLE     Subcellular localization and regulation of StarD4 protein in
            macrophages and fibroblasts
  JOURNAL   Biochim Biophys Acta 1811 (10), 597-606 (2011)
   PUBMED   21767660
REFERENCE   5  (bases 1 to 5314)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5314)
  AUTHORS   Riegelhaupt,J.J., Waase,M.P., Garbarino,J., Cruz,D.E. and
            Breslow,J.L.
  TITLE     Targeted disruption of steroidogenic acute regulatory protein D4
            leads to modest weight reduction and minor alterations in lipid
            metabolism
  JOURNAL   J Lipid Res 51 (5), 1134-1143 (2010)
   PUBMED   19965609
  REMARK    GeneRIF: StARD4's role can largely be compensated for by other
            intracellular cholesterol transporters.
            Erratum:[J Lipid Res. 2010 Jun;51(6):1618]
REFERENCE   7  (bases 1 to 5314)
  AUTHORS   Rodriguez-Agudo,D., Ren,S., Wong,E., Marques,D., Redford,K.,
            Gil,G., Hylemon,P. and Pandak,W.M.
  TITLE     Intracellular cholesterol transporter StarD4 binds free cholesterol
            and increases cholesteryl ester formation
  JOURNAL   J Lipid Res 49 (7), 1409-1419 (2008)
   PUBMED   18403318
  REMARK    GeneRIF: StarD4 plays an important role as a directional
            cholesterol transporter in the maintenance of cellular cholesterol
            homeostasis
REFERENCE   8  (bases 1 to 5314)
  AUTHORS   Soccio,R.E., Adams,R.M., Maxwell,K.N. and Breslow,J.L.
  TITLE     Differential gene regulation of StarD4 and StarD5 cholesterol
            transfer proteins. Activation of StarD4 by sterol regulatory
            element-binding protein-2 and StarD5 by endoplasmic reticulum
            stress
  JOURNAL   J Biol Chem 280 (19), 19410-19418 (2005)
   PUBMED   15760897
  REMARK    GeneRIF: StarD4 is regulated by sterols via SREBP-2, and StarD5 is
            activated by ER stress cholesterol metabolism; they serve different
            functions
REFERENCE   9  (bases 1 to 5314)
  AUTHORS   Romanowski,M.J., Soccio,R.E., Breslow,J.L. and Burley,S.K.
  TITLE     Crystal structure of the Mus musculus cholesterol-regulated START
            protein 4 (StarD4) containing a StAR-related lipid transfer domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6949-6954 (2002)
   PUBMED   12011453
REFERENCE   10 (bases 1 to 5314)
  AUTHORS   Soccio,R.E., Adams,R.M., Romanowski,M.J., Sehayek,E., Burley,S.K.
            and Breslow,J.L.
  TITLE     The cholesterol-regulated StarD4 gene encodes a StAR-related lipid
            transfer protein with two closely related homologues, StarD5 and
            StarD6
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6943-6948 (2002)
   PUBMED   12011452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850053.1, AK085331.1 and AC114919.5.
            
            On Dec 2, 2016 this sequence version replaced NM_133774.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085331.1, AK054501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BB850053.1         1-42
            43-2945             AK085331.1         1-2903
            2946-5314           AC114919.5         126111-128479       c
FEATURES             Location/Qualifiers
     source          1..5314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.18 cM"
     gene            1..5314
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /note="StAR related lipid transfer domain containing 4"
                     /db_xref="GeneID:170459"
                     /db_xref="MGI:MGI:2156764"
     exon            1..229
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..866
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     StAR-related lipid transfer protein 4; START
                     domain-containing protein 4; StAR-related lipid transfer
                     (START) domain containing 4"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 4 isoform 1"
                     /protein_id="NP_598535.1"
                     /db_xref="CCDS:CCDS29123.1"
                     /db_xref="GeneID:170459"
                     /db_xref="MGI:MGI:2156764"
                     /translation="MADPESPWSQIGRKIKLEGLSDVASISTKLQNTLIQYHSIEEDE
                     WRVAKKAKDVTVWRKPSEEFNGYLYKAQGVMDDVVNNVIDHIRPGPWRLDWDRLMTSL
                     DVLEHFEENCCVMRYTTAGQLLNIISPREFVDFSYTVGYEEGLLSCGVSVEWSETRPE
                     FVRGYNHPCGWFCVPLKDSPSQSLLTGYIQTDLRGMIPQSAVDTAMASTLANFYSDLR
                     KGLRKA"
     exon            230..344
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..394
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..521
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..636
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..5314
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5161
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /note="major polyA site"
     regulatory      5289..5294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5310
                     /gene="Stard4"
                     /gene_synonym="4632419C16Rik; 9030213J02Rik"
ORIGIN      
        1 ggcgggctgg aaaatatctt gctgaaacgc gcggggttgc aggagtggcg agctaccttt
       61 tcctggagtt gttgaccgcc tgacatcctc tggtacggga caggaaggag ggcggtcggc
      121 cgagtggggt ccagcggggc caaggcgaag ctgagcatct cctggagctg ccccctgtag
      181 aggggagaga gatggctgac cctgagagcc cgtggtcaca gattggcagg aagatcaaac
      241 tggaaggact gtctgatgtt gcctctattt caactaaact tcagaacact ctgatccagt
      301 atcacagcat cgaagaagat gagtggcgag ttgccaaaaa agcgaaagat gtgaccgttt
      361 ggagaaaacc ctcagaagag tttaatgggt atctatataa agctcaagga gttatggatg
      421 acgtggtcaa taatgtaata gaccatatcc gcccagggcc ctggcgcttg gactgggacc
      481 ggttaatgac ctccctggat gttctggagc actttgaaga gaattgttgt gtgatgcgtt
      541 acaccactgc tgggcagctt ttaaatatta tttccccgag agagtttgtt gatttctcct
      601 atactgtggg ctatgaagaa ggacttttat cctgtggtgt gagtgttgag tggagtgaga
      661 cgagaccaga gtttgtccgt ggctataacc atccctgtgg ctggttctgt gttccactca
      721 aagacagtcc aagccagagt cttcttacag gctatattca gacagacctg cgtggcatga
      781 tccctcagtc tgccgtagat acagcaatgg cgagcacgtt agccaacttc tacagtgatt
      841 tgcgaaaagg tctacgcaag gcataacatg ttcaactcct gttgccgtgg tttgcggact
      901 ctgctcctac cctgtcagct ccatgaccta gagaagccat gttcctgcct gctgcggcct
      961 gtggaaacac tggaggtgtt gttggggcca tagtacaatc tcattttcta ttaaaaatac
     1021 atggctatgt aaatagggca tttacaattt cttaaaagtc ttatttgcac cttgtttggt
     1081 tgtgaaatga aataccaaga tttaggtcca ggctaagtgt agtctattca catgggtcaa
     1141 ataggctgct tggaaattac agagtgtgta aactcagtgc tattcatgtt cttctggagc
     1201 tttttgaaca ttttgtaaaa ttatagtggc tcctaatgta aatgtgagtt tctcttgcta
     1261 tgttctctga gtttgccagt agcttggaca aaaggaagtt ctccattgtc tgtataggtg
     1321 agtccactat gggttaactt gtgctattgt aagtattagg aagaccacag ggggcaagaa
     1381 tggcacagtt caatagagtt taattttgat atgtgggcaa cgttcttctg caaagtctat
     1441 aaaaaacata tttgtgtcct tatgtgcatt tattctggga gtgactgaaa acaaccaggt
     1501 atgctctggt gacatcgcat tgagcagtag ctgtcactga ggggaccagc tagtggtgcc
     1561 cctcatcgcc agcaaaaggt cagtgctaaa aagtctggtc tataccgaca tcaacatgaa
     1621 gctacaaact gcatgctgaa aattcagatt tgatgtaact ttgatatgca tttgtagcga
     1681 aagcatcatt tgattcagcc aggaaaagga aacacataag gatgcttaga tgtcctggta
     1741 tgaccagggt gaactatgaa tgaagctgtc tcatgtgaac attacttcat ggctatgaca
     1801 tcccaaatcc ttctctgact tttgaatatc tacctagttt atttgtaaag tggacatgtg
     1861 aggtgactcc gtgtccacac acattttgtg tttgtgtgaa cacgcagcgc tcagtggtgc
     1921 atgccatttc cgtgtgggtt gctgtttctg ctcctcactg gtcttacgtg tttccctttc
     1981 cttcgtttgg ttggttggtg ggaaggtggg tgggtttgtg tttccgtgtt ggcagatctg
     2041 gagtaacgtg agctctggca ataatggcag gcaggcaggt cacacagagg ccttcttcac
     2101 aagtctgtgg tgggtcagct gcatgaagga agggatcaaa ggcaggaagg tctgctcttc
     2161 agtttacatt agtttgtttc tgtaaaaatg taaagtcagt tctttacatc cattttgaca
     2221 gtcaaaaaag ggagactgaa ttttttctct tctaaaattt ttttcttgca actggtgatg
     2281 aagatacaca caggacagag gcgcagggtc agtgttctgg tgggtgagct catagctctt
     2341 ggcttgaaat atcacttcca ggacctgcca gacgcagttc cccccagagg gttgtgttct
     2401 cagtttgttc attgctaagt tcctgtctga ctttattgta acttctgaaa ggctagattt
     2461 cctctctgct cttctcttca gcaataggga aagaaaatgg acttgagagt gtccggtgaa
     2521 ggctgtgaat tgttaactat ccagtgtgtc ttctgtgact ttatctgttt ttattagtga
     2581 gagcagaagg tctcgtgtat cccactagtc tgcccatgat cataaagtga caggagcctg
     2641 ggtaaagact tggtaccaac attggatgct gtcaaggctc tccctggcct gctccgaacg
     2701 ggctctctgc ggatctcaca cttgcccagt gtctcttggc tagacctcca gtgactgatg
     2761 aggtcattca ctgctgagca gggacgcact gcaagtaaaa caaccctcgt ggaaatgttt
     2821 tcattgccat tgtgagtttc acagtaggtt cagaagtgac atgtgagctg tctgaaacct
     2881 atgttcatta atgtagagtt cacataatct acagtttacc tgtggtaaaa gtgtgagtgt
     2941 tctttaaaaa aagaaaggaa aataaaaaac aaaacatttg aagagttgtg cagccctcac
     3001 cacagcacag tttagaccgt ttttgtcacc caaaaagatc ctttgtttct gtgtacactg
     3061 tgtattgtca cctaagcagc agttacccaa gttgccagga tagggagagg atgaaaaggg
     3121 cgacaccaga gcttgctagg ttttacttct gagagtagag tggtgtgtgg gggtggggcg
     3181 tgtcggggtg gggcgtgcat gcaggtgcat gtgggtgtgg acgtgcacgt gtgcacattt
     3241 aagctcagga acatttacat gttgtaagtg tgttatctcc attattgtaa cataaaaacg
     3301 atgtgaagtg aggatgatac ttgcatactt agagcggctg cttctggagc agacctattg
     3361 caggaaaacc ctacaagcca tacgtgtaac tcagagtatc ccagcagagg ctgggaggtg
     3421 atggtagtga aagagcgttc tctgctcttg caaaagtacc tggggctggg ggaagggctt
     3481 atagcagtcc atagctccag ttctgaagga tcttgtgccc tctggcctct gcagatgcag
     3541 gcatgtgcac agtgcttata cacacatcca aaaaaaccca ctcattcata gaaagaaaaa
     3601 atacacagct gaaactaatt gtagcaatgt tttctttgac tctatatcca aagtatttca
     3661 gtacacagct gatgtaaaag atattgcgat agctcactgt gtctattaac tcttggaaat
     3721 aaggtgggta ttctgtgctg ggactcgcca tatggcaagc actcattgtc cacaggaggc
     3781 ctgcagctgt tatcatgact cacacaagcc tacagtagct ttcatttgcc ttgctgtaag
     3841 atgaagtgga caattcctga attgttctct tcaccagaat cttttatagc tgagcacttt
     3901 cagtgcttgc tgcacacggt gtctgcttta gaaatgtgca taaataaatt actgatttcc
     3961 agtaaattta aaaattattg cctcaaaatt attttcacta aaagtaactt ttgataggac
     4021 cgtgaaggag aaacagaata accactcaca ttgccgtgca gatgaacatt tcctgtagct
     4081 tacagcttgc tgaggaaatg tgtgtactct ggaaatacgt gccctagtgt cgtgttcagg
     4141 acacactgct cttttaagat gaaattagtt ttatataagt gacattttgg taggaaatac
     4201 tgggttttgc ttaaaaaaaa attcttgcct actcttgaat gactaaagca atactcagca
     4261 aaaaaataat agtagaagta ttcttagatt tctgtgctat aaaccactgg agtattatct
     4321 tataaatacc aggatttctt tcttgttcca tgaacacaat gggtgtattt gaaactgggg
     4381 ggtttcaagt gtaaatctat atcctaggat gtttcccctt tatcttcttg tcttttctac
     4441 ttgaggatca tttgactgat acttagtgag ctaaactaat gtctcaaggt taagactgta
     4501 cccgaggttc tggagaagca gagacaacac cccagtcttt gtcactcatc tctctattag
     4561 gtctgagaaa tcccctttgc tgtggatggc agttttgtat gtttatgaga gcacagtagc
     4621 ccctttagga ccagatgcta aattaaatgg ctgttgtagc tttctagacc aaaaaagaga
     4681 ggctaacaga accagagaag cagatggaaa tctggattta atgaggactc ctttaaaagt
     4741 tacatgaaca cttgtccagg cccttccatc cttccttctt ttcctgtgat accgaggcct
     4801 ggtgcatgct gggactgagc tacacttctg gccccctcag tgagcacatg ggacttgtaa
     4861 gagtatagag tggcaagatc tgagcataga agaagggagt cctcctccta cagtgcaggg
     4921 ctggagttac ggttttgtcg tcactttatt tccagggatt gtataagtac tgctatgtac
     4981 taaataaaaa ttcatctctt gcagtccaac aaatgatgta ttatattaag ataattttta
     5041 gaaagtttat cattttatga atctgtatat ggaattagaa taaaggactg ctgatataaa
     5101 tgagatgtat atttttaaat tacagtggaa tgtatctgaa taaagatttc tagacactct
     5161 ttgtcactgg tcattgacct tgtttgtgta agttacttta accttaagta ctgaccaaat
     5221 gcttatatat ttatatttag agaatgtcat ttaactactt gaactattta acaagtataa
     5281 atctggaaaa taaagctaaa cctatgctaa tctg
//
