LOCUS       NM_001163493            5638 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus StAR related lipid transfer domain containing 13
            (Stard13), transcript variant 1, mRNA.
ACCESSION   NM_001163493
VERSION     NM_001163493.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5638)
  AUTHORS   Youlten SE, Kemp JP, Logan JG, Ghirardello EJ, Sergio CM, Dack MRG,
            Guilfoyle SE, Leitch VD, Butterfield NC, Komla-Ebri D, Chai RC,
            Corr AP, Smith JT, Mohanty ST, Morris JA, McDonald MM, Quinn JMW,
            McGlade AR, Bartonicek N, Jansson M, Hatzikotoulas K, Irving MD,
            Beleza-Meireles A, Rivadeneira F, Duncan E, Richards JB, Adams DJ,
            Lelliott CJ, Brink R, Phan TG, Eisman JA, Evans DM, Zeggini E,
            Baldock PA, Bassett JHD, Williams GR and Croucher PI.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5638)
  AUTHORS   Muller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen
            J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P,
            Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L,
            Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P,
            Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP,
            Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E and Rocks O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   3  (bases 1 to 5638)
  AUTHORS   Wong SSC, Lee UM, Wang XM, Chung SK and Cheung CW.
  TITLE     Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory
            pain in mice
  JOURNAL   Neurosci Lett 709, 134379 (2019)
   PUBMED   31323253
  REMARK    GeneRIF: Role of DLC2 and RhoA/ROCK pathway in formalin induced
            inflammatory pain in mice.
REFERENCE   4  (bases 1 to 5638)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5638)
  AUTHORS   Naumann H, Rathjen T, Poy MN and Spagnoli FM.
  TITLE     The RhoGAP Stard13 controls insulin secretion through F-actin
            remodeling
  JOURNAL   Mol Metab 8, 96-105 (2018)
   PUBMED   29310936
  REMARK    GeneRIF: Stard13 regulates insulin secretion in response to glucose
            via actin cytoskeleton remodeling.
REFERENCE   6  (bases 1 to 5638)
  AUTHORS   Lin Y, Chen NT, Shih YP, Liao YC, Xue L and Lo SH.
  TITLE     DLC2 modulates angiogenic responses in vascular endothelial cells
            by regulating cell attachment and migration
  JOURNAL   Oncogene 29 (20), 3010-3016 (2010)
   PUBMED   20208559
REFERENCE   7  (bases 1 to 5638)
  AUTHORS   Yau TO, Leung TH, Lam S, Cheung OF, Tung EK, Khong PL, Lam A, Chung
            S and Ng IO.
  TITLE     Deleted in liver cancer 2 (DLC2) was dispensable for development
            and its deficiency did not aggravate hepatocarcinogenesis
  JOURNAL   PLoS One 4 (8), e6566 (2009)
   PUBMED   19668331
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5638)
  AUTHORS   Kawai K, Seike J, Iino T, Kiyota M, Iwamae Y, Nishitani H and
            Yagisawa H.
  TITLE     START-GAP2/DLC2 is localized in focal adhesions via its N-terminal
            region
  JOURNAL   Biochem Biophys Res Commun 380 (4), 736-741 (2009)
   PUBMED   19250640
  REMARK    GeneRIF: START-GAP2 is localized in focal adhesions through a 'FAT
            (focal adhesion targeting)' region in the N-terminal half.
REFERENCE   9  (bases 1 to 5638)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 5638)
  AUTHORS   Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY and Ng IO.
  TITLE     Deleted in liver cancer 2 (DLC2) suppresses cell transformation by
            means of inhibition of RhoA activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15207-15212 (2005)
   PUBMED   16217026
  REMARK    GeneRIF: Results suggest that DLC2 exhibits its tumor suppressor
            functions in vivo as a GAP specific for RhoA, exerting its effects
            in suppression of cytoskeleton reorganization, cell growth, cell
            migration, and transformation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050259.1, AK136202.1 and AC163219.3.
            
            [WARNING] On Oct 4, 2023 this sequence was replaced by
            NM_001163493.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050259.1, SRR10223969.6210.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3278              AK050259.1         2-3279
            3279-4441           AK136202.1         1805-2967
            4442-5638           AC163219.3         128953-130149       c
FEATURES             Location/Qualifiers
     source          1..5638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.82 cM"
     gene            1..5638
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /note="StAR related lipid transfer domain containing 13"
                     /db_xref="GeneID:243362"
                     /db_xref="MGI:MGI:2385331"
     exon            1..268
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3498
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serologically defined colon cancer antigen 28;
                     StAR-related lipid transfer (START) domain containing 13;
                     serologically defined colon cancer antigen 13;
                     stAR-related lipid transfer protein 13; START
                     domain-containing protein 13"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 13 isoform
                     1"
                     /protein_id="NP_001156965.1"
                     /db_xref="CCDS:CCDS51710.1"
                     /db_xref="GeneID:243362"
                     /db_xref="MGI:MGI:2385331"
                     /translation="MFSQVPRTPAAGCYYLNPLTPESQEMYLRFDQTARRSPYRMSRI
                     LARHHLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDL
                     VEPLCRRLNTLNKCASMRLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLH
                     TLFPVADRNGSPGGPRMRNTASSESVLTDLSEPEVCSIHSESSGGSDSRSQSGHHSAD
                     STHALEATLVSSSLPQSTREGLNQSFHPKNEKPTRTRAKSFLKRMDTLRVKGALGRHK
                     GPGRTGGLVISRPVLQQEPESFKTMQCVQIPNGDLQTSPPAACRKGLPCSSKSSGESS
                     PLENSSTVSTPCMKERKCHHEANKRGGMYLEDLDVLAGTALPDTSDQNHMHGFHSQEN
                     LVVHIPKDHKPGTFPKALSIESLSPTDNSNGVNWRTGSISLGRQQGPGMREPRLMSSC
                     HRASRVSIYDNVPSSHLYASTGDLLDLEKDGLLPQLDDILQHVNGIQEVVDDWSKNIL
                     PELQSHSTLAGDPGLSPFPSPNQVTLDFEGNSVSEGRTTPSDVERDRTSLNESEATGV
                     RERRDSGVGASLTRPNRRLRWSSFQLSHQPQPSPATPHISSQTAAQLNLLQRFSLLRL
                     TAIMEKYSMSNKHGWTCLSAQSAPGALHDLVSVNSRSVPKFMKRIKAPDYRDKAVFGV
                     PLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNV
                     SYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLA
                     DENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFHLNLLKKESSPKVIQKKY
                     ATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRDSYLEAEIHVPSLEDL
                     GAQLAESGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGHPLKLW
                     KASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVERLDKQTEIYQYVLNSMVPHPSRD
                     FLVLRTWKTDLPKGMCTLVSLSVEYEEAQLMGGVRAVVMDSQYLIEPCGSGKSRLTHI
                     CRIDLKGHSPEWYSKGFGHLCAAEVTRIRNSFQPLVAEGPETKI"
     exon            269..340
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            341..422
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            423..486
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1847
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2021
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2238
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2437
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2648
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2763
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2985
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3203
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3380
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..5638
                     /gene="Stard13"
                     /gene_synonym="DLC2; GT650"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggtctg tggctctctc ctggggctcc attgactgag gctggagaca gctgcgaaga
       61 gccaccggca gctgaggtgg cagtggaaac tctcccgaga tgttcagcca ggtgcccagg
      121 acgccggctg caggctgcta ctatctaaac cccttgacac ctgagagcca ggagatgtac
      181 ttgcgatttg atcagactgc cagacgctct ccctacagga tgagccggat cctagcacgc
      241 catcacctag tgactaaaat ccagcaagaa attgaggcga aggaagcatg tgactggctc
      301 cgagctgccg ggttcccgca gtacgctcag ctgtatgaag attcgcagtt ccccatcaac
      361 attgcggccg tcaaaaaaga ccatgacttt cttgaaaggg accttgtaga acctctttgc
      421 agacgactta atacgttgaa caagtgtgcc tcaatgagac ttgatgtgaa cttccaaagg
      481 aaaaagggtg acgactcaga tgaggaagac ctgtgcatca gcaacaaatg gactttccag
      541 agaaccagcc gcagatggtc ccgtgtggat gacctgcata cgctgttccc cgtggcagac
      601 agaaacgggt ccccaggagg ccctaggatg agaaacacag ccagcagtga gagcgtgctc
      661 acggatctga gtgagccaga ggtctgctct attcacagcg aaagcagtgg gggcagtgac
      721 agccgcagcc aatcagggca tcattctgct gacagtacgc atgcgctgga ggccaccctg
      781 gtcagtagca gcctcccaca gtctacccga gagggtctca accagtcttt tcaccccaag
      841 aatgagaaac ccaccaggac cagggccaag tcctttctga aacgcatgga taccctgaga
      901 gtgaagggtg cacttgggag gcataagggg ccagggcgga caggaggcct ggtcatcagt
      961 aggcctgtgc tgcagcagga accggagtcc tttaagacca tgcagtgcgt ccagataccc
     1021 aacggagatc tgcagacctc acctccagct gcctgcagga aaggcctccc atgctccagt
     1081 aagtcaagtg gtgagagcag ccccctggag aacagcagca cagtgagcac tccgtgcatg
     1141 aaggaacgca agtgccacca cgaggccaac aagcgcggtg gcatgtacct ggaggacctg
     1201 gatgtgctgg cagggacggc attaccagat acgtcagacc aaaaccacat gcatgggttt
     1261 cactcccaag aaaacttggt ggtccacatt cccaaggatc acaaaccagg aacgttcccc
     1321 aaggcacttt ctatagaaag cctctcaccc acagacaaca gcaatggggt taactggagg
     1381 accgggagta tctccctggg taggcaacag ggccctggca tgagggaacc cagactcatg
     1441 tcttcctgcc acagggccag ccgtgtcagt atctatgaca atgtccccag ctcgcacctg
     1501 tatgccagca caggagatct gttggacctg gagaaagacg gcctccttcc acagctggat
     1561 gacatcctac agcatgtcaa tggcatacaa gaggtagtgg atgactggtc aaaaaacatc
     1621 ttacccgaac tgcaaagtca cagcacattg gcaggggatc ctggtctgtc cccattccca
     1681 tctcccaatc aggtcacttt agattttgaa ggcaactctg tctcagaagg tcggacaaca
     1741 cctagtgatg tggaaaggga caggacttct ctgaatgaat cggaggccac tggggtcaga
     1801 gaaagaaggg attctggtgt gggggcctct ctgaccagac caaacagacg actaaggtgg
     1861 agcagcttcc agctctcaca ccagccccag ccgtctccag ccaccccgca catcagcagc
     1921 cagacggccg cccagctgaa cctgctccag cgcttctccc tacttcgtct tacggccatc
     1981 atggagaagt actctatgtc caacaagcac ggctggacct gcctgtctgc acagagcgcc
     2041 ccaggggcct tgcatgacct ggtttctgtg aattccaggt ccgttccaaa gttcatgaag
     2101 aggatcaaag ctcctgacta ccgagacaag gctgtcttcg gtgttccgct catagtccac
     2161 gttcagagaa caggacagcc cctgcctcag agcatccaac aagcactgag gtatctacgt
     2221 agcaactgtc tggatcaggt gggtcttttc cgcaagtcag gagtgaagtc tcgaatccat
     2281 gccctccgtc agatgaatga gaacttccct gacaatgtga gctatgaaga ccagtctgca
     2341 tacgacgtgg cagatatggt gaagcagttc ttccgggacc tccctgagcc cctgttcacc
     2401 aacaagctca gcgagacctt cctccacatc tatcagtatg tccccaaaga gcagcggctg
     2461 caggccgtgc aggcagccat cctgctgctg gccgacgaga accgggaggc cctgcagact
     2521 ctcctgtgct tcctgcatga cgtagtaaac ttggtggacg agaatcagat gacgcccatg
     2581 aatctggccg tgtgcctggc cccctccctc tttcacctaa acttactgaa gaaagaaagc
     2641 tccccaaaag tcatccagaa gaaatacgcc actgggaagc cagatcagaa ggacctcaat
     2701 gaaaatctag ctgcggctca ggggctggcc cacatgatca cggaatgcaa ccgactcttt
     2761 gaggttccac acgagatggt ggcccagtct cgggactcct acttagaggc tgaaatccat
     2821 gtgcccagcc tggaagactt gggagcacag ctggcggaga gcggggcaac ttttcacacg
     2881 tacttggagc atctagtcca aggcctccag aaagaggcta aggagaaatt caagggatgg
     2941 gtcacatgtt ccagccctga caacacagac cttgctttca aaaaggtggg cgatgggcac
     3001 ccgctgaagc tgtggaaagc atctgtggag gtggaggcac caccctccgt ggtgctgaac
     3061 cgtgtgctga gagaacgtca cctgtgggat gaggactttg tgcagtggaa ggtggtggaa
     3121 agattggaca aacaaacgga aatctaccag tacgtgctaa acagcatggt tccacatccc
     3181 tccagagact tcctggtgct caggacctgg aagactgacc tgcccaaagg aatgtgcacc
     3241 ctggtgtccc tgtctgtgga gtacgaagaa gcccagctca tgggtggcgt gagggcggtg
     3301 gtgatggact ctcagtacct gatagaaccc tgcggttctg gcaagtccag gctgacccac
     3361 atctgcagaa tagacctgaa gggccactcc ccagaatggt acagcaaagg ctttggacac
     3421 ctctgtgcgg cagaagttac cagaattagg aactctttcc agcctctcgt tgctgagggt
     3481 ccagaaacaa aaatctaagc tttccccagc atgacatcaa actcagggaa gaagaaggga
     3541 aagaacactc acagcgtggc aagtgcacgc atgtgcagga atgtcgcagt gggatccgga
     3601 gatcgcggag accgtggagc ccgttcctag cctgcctaga gatggctaat ccctactaat
     3661 ataatgtctc ggaactttta tctatactgc ttaaaattaa atgggttatt tcttccgcgt
     3721 tgcctaactt gctatttaaa ggcttctaag aagcgtgtct tagctgtaaa taaatgtact
     3781 gtagcatttg tacatgtatg tatatctccc tttactgtat atatgtaaaa taccagtttt
     3841 atatataatt cagtgtctga ctctgtgagt ctcctcacat ggcacttccc aggttgctgt
     3901 agaccccgtg tcccatcccg acctgtcccg ccagctgagc agagcctgct gacaaacacc
     3961 aaagtgtgaa atgtgtagtc tgtcagcctg cccaggctta cccaaagatt agctaaccaa
     4021 agaaaaatag agttgagagc ttcttccaca ggttggcctc ttatttctga tgtttaaaga
     4081 ctggagcagg atgttgacat aaattgaggg atataatatt tgcttctctt taacgcaaag
     4141 cagcaggtga gaggttattg ccaaatccaa ggctagacct tgcattgcct ctgggccctc
     4201 ttgagattca gttctcatag tgctttttaa ccatctattt gaccagtggc ctatgtggcc
     4261 acagtttttt taacatgttc ttgcactgac cttgactctg gacaccagag tgagatgaca
     4321 gtccatcgag tgtccaggag tcatcacagc ttcagggaat tccacacatg ctatagatga
     4381 tgcttgtaaa atctaagcca ttaaaaatct tgcaatctaa aagacaggat tttaaacaaa
     4441 agaccaaact gtatcattag tttttgttac caatcccatg tttcttcatt acccagcacc
     4501 agcacctggg cgttcgaccc caaccttatt tattattgta tagactgagc aaactggctt
     4561 cccttaacca agtgaggatg gagttgttat tttttttttt attgtgatac aacatctgta
     4621 gagagataac ttagtatgtc tggcctccag gaaagattgt cttaggttgt ctaaacagag
     4681 attgatatcc tgattcagca actggtgtcg gaagacgagg aaaaaaccaa acctatattt
     4741 ccctggtttt tgttgttgtt gtgttatata cttttatctt ttatctgtgg tgtgcaattg
     4801 ttttattggg aggaataaag atgttttctg tatatttggt atagcacagg gaaaaccagg
     4861 gtaagagttt ttcattctcg tgtctacctg ggagaggggc agtcagacca catggtgcct
     4921 cctgggcagc gttctgtgga gtggacaagt tcacttctgc cattacctca tgcctaccat
     4981 gctggatggc tttgtatgtc ttgtcaggac catcagtgga gcttagtgtg gttccacacc
     5041 atctgtctct gtgccagagc cgggtcactg tgcacaggaa aacagatcgg gcgcccgggg
     5101 atggctgggt tgtttgtctc ggggcacact tgtttggcat acactgggaa tcaactaaag
     5161 cctttgttaa caggctccca tccaggccat gtgggtgggc ctggcgttct ggatttctaa
     5221 tgagcctgag ggatgcaggg tgcctcaagg acacactttg agaaacaagg acctaggaaa
     5281 tactaaaact caataaaata tctgatacag ttatattccc cagcaccttt ctcttccaac
     5341 ttagctggct ttctgattgt atgcacatac taatcatatc acttctgcta accacagggc
     5401 gcgtctttaa aataaagggg aggggagggg gagatgatgc attgagcttg tttgtcaaat
     5461 accacagtat tttattcatt gttatcttgc tgatggaaat aaaaaaattg catttaaata
     5521 ttatatttat acctcatgta tatttttacc tcaattgttg gtatcagtca tcagttgtaa
     5581 ataaataatt gccaaggcag ataaatttat atacattaaa tatttcctat tttctata
//
