LOCUS       NM_019990               1718 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus StAR related lipid transfer domain containing 10
            (Stard10), transcript variant 2, mRNA.
ACCESSION   NM_019990 XM_905743
VERSION     NM_019990.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Carrat,G.R., Haythorne,E., Tomas,A., Haataja,L., Muller,A.,
            Arvan,P., Piunti,A., Cheng,K., Huang,M., Pullen,T.J.,
            Georgiadou,E., Stylianides,T., Amirruddin,N.S., Salem,V.,
            Distaso,W., Cakebread,A., Heesom,K.J., Lewis,P.A., Hodson,D.J.,
            Briant,L.J., Fung,A.C.H., Sessions,R.B., Alpy,F., Kong,A.P.S.,
            Benke,P.I., Torta,F., Teo,A.K.K., Leclerc,I., Solimena,M.,
            Wigley,D.B. and Rutter,G.A.
  TITLE     The type 2 diabetes gene product STARD10 is a
            phosphoinositide-binding protein that controls insulin secretory
            granule biogenesis
  JOURNAL   Mol Metab 40, 101015 (2020)
   PUBMED   32416313
  REMARK    GeneRIF: The type 2 diabetes gene product STARD10 is a
            phosphoinositide-binding protein that controls insulin secretory
            granule biogenesis.
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Floris,A., Luo,J., Frank,J., Zhou,J., Orru,S., Biancolella,M.,
            Pucci,S., Orlandi,A., Campagna,P., Balzano,A., Ramani,K. and
            Tomasi,M.L.
  TITLE     Star-related lipid transfer protein 10 (STARD10): a novel key
            player in alcohol-induced breast cancer progression
  JOURNAL   J Exp Clin Cancer Res 38 (1), 4 (2019)
   PUBMED   30611309
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Carrat,G.R., Hu,M., Nguyen-Tu,M.S., Chabosseau,P., Gaulton,K.J.,
            van de Bunt,M., Siddiq,A., Falchi,M., Thurner,M., Canouil,M.,
            Pattou,F., Leclerc,I., Pullen,T.J., Cane,M.C., Prabhala,P.,
            Greenwald,W., Schulte,A., Marchetti,P., Ibberson,M.,
            MacDonald,P.E., Manning Fox,J.E., Gloyn,A.L., Froguel,P.,
            Solimena,M., McCarthy,M.I. and Rutter,G.A.
  TITLE     Decreased STARD10 Expression Is Associated with Defective Insulin
            Secretion in Humans and Mice
  JOURNAL   Am J Hum Genet 100 (2), 238-256 (2017)
   PUBMED   28132686
  REMARK    GeneRIF: StarD10 is required for normal insulin secretion, though
            its deletion enhances proinsulin processing.
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Ito,M., Yamanashi,Y., Toyoda,Y., Izumi-Nakaseko,H., Oda,S.,
            Sugiyama,A., Kuroda,M., Suzuki,H., Takada,T. and Adachi-Akahane,S.
  TITLE     Disruption of Stard10 gene alters the PPARalpha-mediated bile acid
            homeostasis
  JOURNAL   Biochim Biophys Acta 1831 (2), 459-468 (2013)
   PUBMED   23200860
  REMARK    GeneRIF: results indicate that STARD10 is involved in regulating
            bile acid metabolism through the modulation of PPARalpha-mediated
            mechanism.
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Aksu,S., Koczan,D., Renne,U., Thiesen,H.J. and Brockmann,G.A.
  TITLE     Differentially expressed genes in adipose tissues of high body
            weight-selected (obese) and unselected (lean) mouse lines
  JOURNAL   J Appl Genet 48 (2), 133-143 (2007)
   PUBMED   17495347
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Tabibiazar,R., Wagner,R.A., Liao,A. and Quertermous,T.
  TITLE     Transcriptional profiling of the heart reveals chamber-specific
            gene expression patterns
  JOURNAL   Circ Res 93 (12), 1193-1201 (2003)
   PUBMED   14576202
  REMARK    GeneRIF: Stard10 (Sdccag28) is much more highly transcribed in
            cardiac atria than in cardiac ventricles.
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Yamanaka,M., Koga,M., Tanaka,H., Nakamura,Y., Ohta,H., Yomogida,K.,
            Tsuchida,J., Iguchi,N., Nojima,H., Nozaki,M., Matsumiya,K.,
            Okuyama,A., Toshimori,K. and Nishimune,Y.
  TITLE     Molecular cloning and characterization of phosphatidylcholine
            transfer protein-like protein gene expressed in murine haploid germ
            cells
  JOURNAL   Biol Reprod 62 (6), 1694-1701 (2000)
   PUBMED   10819773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129079.5.
            
            On Feb 3, 2018 this sequence version replaced NM_019990.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080808.1, BI146399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC129079.5         152634-152873       c
            241-560             AC129079.5         151953-152272       c
            561-708             AC129079.5         131341-131488       c
            709-812             AC129079.5         130699-130802       c
            813-930             AC129079.5         129952-130069       c
            931-983             AC129079.5         128299-128351       c
            984-1718            AC129079.5         127360-128094       c
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.55 cM"
     gene            1..1718
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /note="StAR related lipid transfer domain containing 10"
                     /db_xref="GeneID:56018"
                     /db_xref="MGI:MGI:1860093"
     exon            1..240
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     exon            241..560
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1229
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PCTP-like protein; PCTP-L; START domain-containing protein
                     10; stAR-related lipid transfer protein 10; START domain
                     containing 10; serologically defined colon cancer antigen
                     28 homolog; serologically defined colon cancer antigen 10"
                     /codon_start=1
                     /product="START domain-containing protein 10 isoform 2"
                     /protein_id="NP_064374.1"
                     /db_xref="CCDS:CCDS21509.1"
                     /db_xref="GeneID:56018"
                     /db_xref="MGI:MGI:1860093"
                     /translation="MEKPAASTEPQGSRPALGRESVQVPDDQDFRSFRSECEAEVGWN
                     LTYSKAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIET
                     FDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKD
                     LVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKA
                     CIKYPEWKQKHQPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVTESREERA
                     GGAGGEGSDDDTSLT"
     exon            561..708
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     exon            709..812
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     exon            813..930
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     exon            931..983
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1718
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1378..1383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
                     /note="major polyA site"
     polyA_site      1713
                     /gene="Stard10"
                     /gene_synonym="CGI-52; NY-C0-28; PC-TP2; PCTP2; Pctpl;
                     Sdccag28; SdccagG28; TISP-81"
ORIGIN      
        1 tggaaaatac cgagcgaggc gagcggagcc cgggagcccc gagcctagcg ggagggagga
       61 gggcggaggg ggcgcgcggg gcggggggcg cggagcgggg cggggccggc ggcgggaccc
      121 actgctcctc cccccagggt ccccgcgcgg cccccggtcg cccgggcagc ggaggcagcg
      181 gcggcggcgg aagagctcgc acaccggccc cggcgggccc cggcagagaa gcccgcacag
      241 gtcccaggaa ggtggcgtca gcatctgcag ccgcgtcgac gttgtctgag cctccgcgga
      301 ggacccagga gagtcggact aggaccaggg ccccgggcct ccccacgctc cctatggaaa
      361 agccagctgc ctcaacagaa ccccaagggt ctcggcccgc cttgggccgt gaaagtgtcc
      421 aggtgcccga tgaccaggac ttccgcagtt tccggtcaga gtgtgaggcc gaggtgggct
      481 ggaacctgac ctacagcaag gccggcgtgt ctgtgtgggt gcaggctgtg gagatggatc
      541 gaactctgca caagatcaag tgtcggatgg aatgctgtga cgtgccagct gagacgctct
      601 acgatgtcct gcatgacata gaatacagaa agaagtggga cagtaatgtc attgagactt
      661 tcgacatcgc ccgcttgact gtcaacgctg acgtaggata ttattcctgg aggtgtccca
      721 agcccctgaa gaaccgtgat gtcatcaccc tccgctcctg gctccccatg ggcgctgatt
      781 acatcattat gaactactca gtgaaacacc ctaaataccc acctcggaaa gacttggtcc
      841 gagctgtgtc catccagacg ggctacctca tccagagcac ggggcccaag agctgcgtca
      901 tcacctacct ggcccaagtg gaccccaaag gctccttacc caagtgggtg gtgaataagt
      961 catctcagtt cctggccccc aaggccatga agaagatgta caaggcctgc atcaagtacc
     1021 ccgagtggaa gcagaaacac cagcctcatt tcaagccatg gctgcacccg gagcagagcc
     1081 cattgcccag cctggcgctg tcagagttgt cggtgcaaca tgcagactca ctggagaaca
     1141 tcgatgagag tgcagtgaca gagagccgcg aggagcgggc aggcggtgcg ggaggagagg
     1201 gcagcgacga tgacacctcg ctcacctgag tgaccggctc tctgcaagga ccaagaccag
     1261 actggggtgg aaccctgggg cactgagcct tctgcacttc ctcccttccc ccacctgcct
     1321 tctggggggg cactgggctc ctgcccaggt ggctgcggca tggctggaca tggccccaat
     1381 aaatgaacca cacagcccca gccagctctt tgtgcctgct tctcatctgc tcagccccac
     1441 gctgctctgt tctacagtta ttttccttaa tactcttatt gttcacagga ctgctgtccc
     1501 tataggcgtc ttgtaacgta gggtggagct tgttgccccc tcctttcctg tggttccttt
     1561 cttttcgttc atttgcacat tcatttttct ggtcacaaag gtggtttgct cattttttca
     1621 gggctcttaa gaggagctgg tctaacctga ggtcaggctt ctactgtgtg atggacttct
     1681 ggtccaagct agctttaaac agttgatctg gcatactc
//
