LOCUS       NM_011485               4046 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus steroidogenic acute regulatory protein (Star), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_011485
VERSION     NM_011485.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4046)
  AUTHORS   Fujiki,J., Maeda,N., Yamaguchi,K., Ohtsuki,Y. and Iwano,H.
  TITLE     DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts
  JOURNAL   Mol Cell Endocrinol 593, 112336 (2024)
   PUBMED   39094930
  REMARK    GeneRIF: DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts.
REFERENCE   2  (bases 1 to 4046)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   3  (bases 1 to 4046)
  AUTHORS   Song,C., Qin,Y., Li,Y., Yang,B., Guo,T., Ma,W., Xu,D., Xu,K.,
            Fu,F., Jin,L., Wu,Y., Tang,S., Chen,X. and Zhang,F.
  TITLE     Deleterious variants in RNF111 impair female fertility and induce
            premature ovarian insufficiency in humans and mice
  JOURNAL   Sci China Life Sci 67 (7), 1325-1337 (2024)
   PUBMED   38874713
REFERENCE   4  (bases 1 to 4046)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   5  (bases 1 to 4046)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4046)
  AUTHORS   Selvaraj,N., Israeli,D. and Amsterdam,A.
  TITLE     Partial sequencing of the rat steroidogenic acute regulatory
            protein message from immortalized granulosa cells: regulation by
            gonadotropins and isoproterenol
  JOURNAL   Mol Cell Endocrinol 123 (2), 171-177 (1996)
   PUBMED   8961254
REFERENCE   7  (bases 1 to 4046)
  AUTHORS   Clark,B.J., Soo,S.C., Caron,K.M., Ikeda,Y., Parker,K.L. and
            Stocco,D.M.
  TITLE     Hormonal and developmental regulation of the steroidogenic acute
            regulatory protein
  JOURNAL   Mol Endocrinol 9 (10), 1346-1355 (1995)
   PUBMED   8544843
REFERENCE   8  (bases 1 to 4046)
  AUTHORS   Clark,B.J. and Stocco,D.M.
  TITLE     Expression of the steroidogenic acute regulatory (StAR) protein: a
            novel LH-induced mitochondrial protein required for the acute
            regulation of steroidogenesis in mouse Leydig tumor cells
  JOURNAL   Endocr Res 21 (1-2), 243-257 (1995)
   PUBMED   7588386
REFERENCE   9  (bases 1 to 4046)
  AUTHORS   Clark,B.J., Wells,J., King,S.R. and Stocco,D.M.
  TITLE     The purification, cloning, and expression of a novel luteinizing
            hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor
            cells. Characterization of the steroidogenic acute regulatory
            protein (StAR)
  JOURNAL   J Biol Chem 269 (45), 28314-28322 (1994)
   PUBMED   7961770
REFERENCE   10 (bases 1 to 4046)
  AUTHORS   Epstein,L.F. and Orme-Johnson,N.R.
  TITLE     Acute action of luteinizing hormone on mouse Leydig cells:
            accumulation of mitochondrial phosphoproteins and stimulation of
            testosterone synthesis
  JOURNAL   Mol Cell Endocrinol 81 (1-3), 113-126 (1991)
   PUBMED   1797581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019725.2, AK136327.1 and AK054470.1.
            
            On Sep 30, 2016 this sequence version replaced NM_011485.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054470.1, AK019725.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               AK019725.2         2-511
            511-1132            AK136327.1         482-1103
            1133-2787           AK019725.2         1134-2788
            2788-4046           AK054470.1         2749-4007
FEATURES             Location/Qualifiers
     source          1..4046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.17 cM"
     gene            1..4046
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /note="steroidogenic acute regulatory protein"
                     /db_xref="GeneID:20845"
                     /db_xref="MGI:MGI:102760"
     exon            1..159
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..950
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /note="steroidogenic acute regulatory protein,
                     mitochondrial; START domain-containing protein 1;
                     luteinizing hormone-induced protein"
                     /codon_start=1
                     /product="steroidogenic acute regulatory protein,
                     mitochondrial precursor"
                     /protein_id="NP_035615.2"
                     /db_xref="CCDS:CCDS22203.1"
                     /db_xref="GeneID:20845"
                     /db_xref="MGI:MGI:102760"
                     /translation="MFLATFKLCAGSSYRHMRNMKGLRHQAVLAIGQELNWRALGDSS
                     PGWMGQVRRRSSLLGSQLEATLYSDQELSYIQQGEVAMQKALGILNNQEGWKKESQQE
                     NGDEVLSKMVPDVGKVFRLEVVVDQPMDRLYEELVDRMEAMGEWNPNVKEIKVLQRIG
                     KDTVITHELAAAAAGNLVGPRDFVSVRCTKRRGSTCVLAGMATHFGEMPEQSGVIRAE
                     HGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKTIINQVLSQTQIEFANHLRKRLEA
                     SPASEAQC"
     exon            160..270
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..398
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..557
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..742
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..836
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..4046
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /note="hexamer: AATAAA"
     polyA_site      1477
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /note="major polyA site"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="Star"
                     /gene_synonym="D8Ertd419e; stARD1"
ORIGIN      
        1 atttaaggca gcgcacttga tctgcgccac agctgcagga ctcaggacct tgaaaggctc
       61 aggaagaaca acccttgagc acctcagcac tcagcatgtt cctcgctacg ttcaagctgt
      121 gtgctggaag ctcctataga catatgcgga atatgaaagg attaaggcac caagctgtgc
      181 tggccattgg ccaagagctc aactggagag cactggggga ttccagtccc gggtggatgg
      241 gtcaagttcg acgtcggagc tctctgcttg gttctcaact ggaagcaaca ctctatagtg
      301 accaggagct gtcctacatc cagcagggag aggtggctat gcagaaggcc ttgggcatac
      361 tcaacaacca ggaaggctgg aagaaggaaa gccagcagga gaacggggac gaagtgctaa
      421 gtaagatggt gccagatgtg ggcaaggtgt ttcgcttgga ggtggtggta gaccagccca
      481 tggacagact ctatgaagaa cttgtggacc gcatggaggc catgggagag tggaacccaa
      541 atgtcaagga gatcaaggtc ctgcagagga ttggaaaaga cacggtcatc actcatgagc
      601 tggctgcggc ggcagcaggc aacctggtgg ggcctcgaga cttcgtgagc gtgcgctgta
      661 ccaagcgcag aggttccacc tgtgtgctgg caggcatggc cacacatttt ggggagatgc
      721 cggagcagag tggtgtcatc agagctgaac acggccccac ctgcatggtg cttcatccac
      781 tggctggaag tccctccaag actaaactca cttggctgct cagtattgac ctgaaggggt
      841 ggctgccgaa gacaatcatc aaccaggtcc tatcgcagac ccagatagag ttcgccaacc
      901 acctgcgcaa gcgcctggaa gccagccctg cctctgaggc ccagtgttaa ggactgtcca
      961 ccacattgac ctgcaaatca ttggaagctc tcacaggaag cctgcaagtc tgtccatctt
     1021 cagctaacag catcgggagg ggtggtagtc aggagacact aggactgact ggtaaaatca
     1081 ggatcagcaa aatagaaatg aggcttagaa taaaagttct ctagtgtctc ccactgcata
     1141 gctgtgaagg ctaagggata agtagctatg aaacctttca tctaggcttg tatatgctga
     1201 cctaaaagac accagcagct acgaacaggg gatgctaagg atcgggaact gttgtcttac
     1261 cagctccaaa tgtcactacc tgaaggcagt gtgcacacaa agcaaggtct tgcctaggaa
     1321 actctgtaaa agttctcctc tgtaaaaggc cagaacttga atgaaactac ctacaaaggg
     1381 cctttccaga gtattccaac ttttctctga ggagaaatga aaccatcatt gtgccgactt
     1441 ccctactaat cccatgacaa taaagaacat acatgcacac ttcagcctgt acatgtcagg
     1501 tcccagcctg aggaatcaca gcttcagcag aactctgcgc ttaaatctcc tagctcacaa
     1561 aaggggacaa aacgtccgga gatttatgtc atttgactgt ttagattctt tcctaaaaag
     1621 gcaatctcat aattaaaggc acgtgccttt aatcccaaca ctcaagtggc agaggcaggt
     1681 ggattttttc taatactgag gctaacctgg tctacacaga aggatagcca gagctacata
     1741 atgagactgt ctcaaaacca caaaacccag ggattgaaaa gatggctgac ctgttgggag
     1801 cacaagctgc tcttccaagg aatccagggt caatctccag catccacaca gcagctccca
     1861 actctaattc tagtcccagg gaacctgatg ccctcttgtg gccgccatgg ggaccaggta
     1921 tgcaagtggt acatagacat acagatatgt aggctgaaca cccattaaca ttaacaacaa
     1981 aacccttgtc gggcacggtg gctcaacagc tttaatctca acactgcaaa tggtgacacc
     2041 agtgaatcgc tccaagttcc aggccagctt ggaccccagt gagaccgtct cacaaaagca
     2101 ggaacaaaat cttgggagtt ggtagttaag attaacagca tcctggcagg aagattatga
     2161 cgggattttc atttacctat actgatcaaa taatactgac caataatgtt aagataaagt
     2221 gactgttcta ttgtttatag acagattaga tgccagcctg gctcagagct agcagcttcc
     2281 ttatttgaaa aggttaaaat gttatgttac cttctaggaa gacaaatagc tagaagtcag
     2341 tagagctata acattcctgt tccaggattt ggagatatta cactttaagg gtataaattg
     2401 ggagccaggt gacggtggca cacgacttta atcccagtag aggcaggtgg atctcttgag
     2461 tttgaagtca gcctggttta cagagtaagt tccaggaaag tcagggctgt taaatagaga
     2521 aatgctgctc aaaaacataa aaaaataaaa atgacaaaaa tataagtgtg accagcaaaa
     2581 tgactcaggg tgtaagtgct tgccaccaag tctgatgatg gcagaagcca cagagatgga
     2641 aggagagaga tgaaaaacag aggtccttat ggctgcttat ctacactaag taccttacac
     2701 acataaatac tggtatatat tggaattcct ttccgaatgt gttaaggatg aacaattcta
     2761 acaaccgaaa gcttttcatt ctaagcatga aaaaaaaaaa aagtaatgtc tgtgtgagtg
     2821 tgcatgggcc ccagcagaca cgtggaggtc agaggacaac ttcaggagtg tgccttcgac
     2881 ccccacccgg gtcttgggtc ctggattgtt agggtaggca gcaagcactt tcatccgcag
     2941 tgccattttg ctggcccact tttctgtccc ttatcgtgtg ggtaaccccc atcatttgca
     3001 aagaactgag cttatttatg aatagaacaa tgtggaacat gtacttattt attgaagtct
     3061 taagccttca ctgatattta ttgctcacct cggtgcttta aggtgagcga gggcagctgt
     3121 agagtgtttc tgatagaacc atcccgggaa tcagttaaga gagcagccac ttgggtgctg
     3181 aaagacccat gtgtgccggc ctcgagacaa caggctgcca gtggagaagc gccttcagca
     3241 aacactgtgg ctttgattgg attagtgttt gctcctatac acaccgtcac tctatctctg
     3301 ccgtctggga tgtttgaccc atttgtttaa tcttatattt taataaaagc agttgtcact
     3361 ggcattctga tacctataga tgggtagtag ttctttttta atctttcaaa cgaaccttat
     3421 taacacattc aagtttacaa ctgtacacac attttttttt tcttgtttca cttcaattgt
     3481 tcttttgaga caggatcttc tcactcattc tgtagcccaa gatggcctgg aacttatatc
     3541 aacccttctg cctctgcctc tcaagtgctg ggattaatgg tggggcctgc aggcatctgg
     3601 gcattttttt cagacactgc taagtactgt caagcacctt gataacttct aatgcaggaa
     3661 agccaggtac acaaacacgt aggtagacag gagacctggg catggttatg tgccaacacc
     3721 cactcatact tcttccaaga ccatcacttc actttcttca gagtccttcg aacaccgatg
     3781 agctcattct acaagctggc ttgttctttc ttggactagt ccttgcatta gtggttatct
     3841 agcagctggt aggctgtgac cccagcttta aataatgcag acaccccaaa gaaggcatag
     3901 caagacagat ttctgtcagt ttgaagccag tcaggctata tggacagacc ttgcctcaaa
     3961 aaagcaaaaa aagatattca atgtatgaaa gaagtttggg ggattcagca gcagacaagt
     4021 atattaaatt gtgttaatag tcattc
//
