LOCUS       NM_024239               2157 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus STAM binding protein (Stambp), transcript variant 2,
            mRNA.
ACCESSION   NM_024239
VERSION     NM_024239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Suzuki,S., Tamai,K., Watanabe,M., Kyuuma,M., Ono,M., Sugamura,K.
            and Tanaka,N.
  TITLE     AMSH is required to degrade ubiquitinated proteins in the central
            nervous system
  JOURNAL   Biochem Biophys Res Commun 408 (4), 582-588 (2011)
   PUBMED   21531206
  REMARK    GeneRIF: These data suggest that AMSH plays an important role in
            degrading ubiquitinated proteins and glutamate receptors in vivo
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Mukai,A., Mizuno,E., Kobayashi,K., Matsumoto,M., Nakayama,K.I.,
            Kitamura,N. and Komada,M.
  TITLE     Dynamic regulation of ubiquitylation and deubiquitylation at the
            central spindle during cytokinesis
  JOURNAL   J Cell Sci 121 (Pt 8), 1325-1333 (2008)
   PUBMED   18388320
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 2157)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   7  (bases 1 to 2157)
  AUTHORS   Berry,D.M., Nash,P., Liu,S.K., Pawson,T. and McGlade,C.J.
  TITLE     A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity
            for the interaction between Gads and SLP-76 in T cell signaling
  JOURNAL   Curr Biol 12 (15), 1336-1341 (2002)
   PUBMED   12176364
REFERENCE   8  (bases 1 to 2157)
  AUTHORS   Ishii,N., Owada,Y., Yamada,M., Miura,S., Murata,K., Asao,H.,
            Kondo,H. and Sugamura,K.
  TITLE     Loss of neurons in the hippocampus and cerebral cortex of
            AMSH-deficient mice
  JOURNAL   Mol Cell Biol 21 (24), 8626-8637 (2001)
   PUBMED   11713295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074803.1, AK139391.1 and AB010123.1.
            
            On Dec 9, 2009 this sequence version replaced NM_024239.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010123.1, AK139391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ074803.1         1-26
            27-2139             AK139391.1         2-2114
            2140-2157           AB010123.1         2087-2104
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..2157
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /note="STAM binding protein"
                     /db_xref="GeneID:70527"
                     /db_xref="MGI:MGI:1917777"
     exon            1..94
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            95..311
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1383
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /EC_number="3.1.2.15"
                     /note="associated molecule with the SH3 domain of STAM"
                     /codon_start=1
                     /product="STAM-binding protein"
                     /protein_id="NP_077201.1"
                     /db_xref="CCDS:CCDS20280.1"
                     /db_xref="GeneID:70527"
                     /db_xref="MGI:MGI:1917777"
                     /translation="MSDHGDVSLPPQDRVRILSQLGSAVELNEDIPPRRYYRSGVEII
                     RMASVYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKSVAFPK
                     AEELKTELLRRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQE
                     QFHAFEEMIQRQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPCVDVAPSSPFSPTQT
                     PDCNTGMRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTA
                     KGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWI
                     HTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTDYGLQEISTCRQ
                     KGFHPHGRDPPLFCDCSHVTVKDRIVTITDLR"
     exon            312..387
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            388..483
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            484..850
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            851..975
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1113
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1226
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1326
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..2157
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /note="hexamer: AATAAA"
     polyA_site      2153
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /note="major polyA site"
ORIGIN      
        1 taaatccgtg gagcgtaatt gaaggagtgg cgagagtggg cgtgtcatcg gaggtgacgt
       61 ttccggaagc tctgactgtc atccttcacg aaagaactta tttgtccaat gtctgaccat
      121 ggggatgtga gcctcccacc ccaagaccgg gtgaggattc tgtcccaact tgggagtgca
      181 gttgagttaa atgaagacat tccaccccgt cgctactacc gctccggtgt tgagatcatc
      241 cgcatggcgt ccgtttactc ggaagaaggc aacattgaac atgcctttat cctctacaac
      301 aagtacatca cgctgtttat tgaaaaactt ccgaaacacc gagactacaa atcagctatc
      361 attcctgaga agaaagatgc tgtcaagaaa ttaaagagcg tcgctttccc taaagcggaa
      421 gagctgaaga cagagctctt gagaagatac accaaagaat atgagcagta taaagagcga
      481 aagaaaaagg aagaagagga acttgcccga aatatcgcca tccagcaaga gttggaaaaa
      541 gaaaaacaga gggttgctca gcagaagcag aagcagctag agcaggagca attccatgcc
      601 tttgaggaga tgatccagag gcaggagctg gaaaaagaac ggctgaaaat tgttcaagag
      661 ttcgggaagg tagaccctgg cccctgcggg cctctgctcc ctgatctgga aaagccttgt
      721 gtagatgtgg cccccagctc accgttctcg cccacgcaga ctccagactg taacacaggc
      781 atgaggccag ctaagccacc tgtggtggac aggtccctga aacctggagc gttaagcgtc
      841 atagaaaatg ttcccaccat tgaaggcctg cgccacatcg tggtgccccg taatctgtgc
      901 tcagaatttc tccagcttgc cagtgccaat accgccaaag gcattgaaac ctgtggagtc
      961 ctctgtggaa aactgatgag aaatgaattc acaatcacac atgttctcat ccccagacaa
     1021 aatggtgggc ctgattattg ccacacggag aatgaagaag aaattttctt tatgcaggat
     1081 gaccttggac tcctcactct tggctggatc catactcatc caacccaaac ggcctttctg
     1141 tccagtgtgg atctccacac tcactgctcc taccaaatga tgttaccaga gtccatcgca
     1201 atcgtctgtt ccccaaagtt ccaggaaact ggattcttta agctaactga ctatggtctt
     1261 caagagattt caacctgccg gcagaaaggc tttcaccccc atggcagaga cccaccgctg
     1321 ttctgtgact gcagccatgt cactgtcaag gacagaattg tgacgatcac agaccttcga
     1381 taaatctcaa atcatgaacc agggagatgg atcactgggt aacagcactt gtcaccaagc
     1441 ccaacagccc aggctcagtt cttgggaccc acatggtaga aggagtgtac cgacattccc
     1501 ccaagttgtc ctctaacctc cacatgtgtg ctgtggtatg tgtgttctca cgtgtgtgtg
     1561 cacatacaca cacacacgca tatcaattaa tttaaaaagc gaataaatgt aaattataaa
     1621 aagagtccta cccccctctt aagctgcata tcccgttcag tttattgccc ccatggagtt
     1681 gagtaagctt ttaagacagg ataggaaagg gtcaacacta aggggagact gttgttgttg
     1741 ttgttgttgt tgttgttgtt gtttttcctt aatttgaaat catcttattt tttaagacaa
     1801 atgtgaaaat gaccaaatca caccaagcaa ctaactcaaa aattaggatg caagagaaaa
     1861 tacttctcta gatccaaaca ctggccttct gttcctcttg aaatttacct cccaacttgt
     1921 tcatctctgc ctttggacta aataggggca tctgtgcaaa actgtagaag ccattttgaa
     1981 ggatttggct ttttattgtt tgtggcatta ataagggagc ttaccattct ggtgggatgt
     2041 gcatgaggcg ttcacagccc ccatacatgg atcttgttta aagtgtatta tttaaaaggt
     2101 cagggtgtta ttttcttcta taataaaaca gctcacttgt gttgtgctcc agagtga
//
