LOCUS       NP_077201                424 aa            linear   ROD 30-APR-2024
DEFINITION  STAM-binding protein [Mus musculus].
ACCESSION   NP_077201
VERSION     NP_077201.1
DBSOURCE    REFSEQ: accession NM_024239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 424)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (residues 1 to 424)
  AUTHORS   Suzuki,S., Tamai,K., Watanabe,M., Kyuuma,M., Ono,M., Sugamura,K.
            and Tanaka,N.
  TITLE     AMSH is required to degrade ubiquitinated proteins in the central
            nervous system
  JOURNAL   Biochem Biophys Res Commun 408 (4), 582-588 (2011)
   PUBMED   21531206
  REMARK    GeneRIF: These data suggest that AMSH plays an important role in
            degrading ubiquitinated proteins and glutamate receptors in vivo
REFERENCE   4  (residues 1 to 424)
  AUTHORS   Mukai,A., Mizuno,E., Kobayashi,K., Matsumoto,M., Nakayama,K.I.,
            Kitamura,N. and Komada,M.
  TITLE     Dynamic regulation of ubiquitylation and deubiquitylation at the
            central spindle during cytokinesis
  JOURNAL   J Cell Sci 121 (Pt 8), 1325-1333 (2008)
   PUBMED   18388320
REFERENCE   5  (residues 1 to 424)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (residues 1 to 424)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   7  (residues 1 to 424)
  AUTHORS   Berry,D.M., Nash,P., Liu,S.K., Pawson,T. and McGlade,C.J.
  TITLE     A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity
            for the interaction between Gads and SLP-76 in T cell signaling
  JOURNAL   Curr Biol 12 (15), 1336-1341 (2002)
   PUBMED   12176364
REFERENCE   8  (residues 1 to 424)
  AUTHORS   Ishii,N., Owada,Y., Yamada,M., Miura,S., Murata,K., Asao,H.,
            Kondo,H. and Sugamura,K.
  TITLE     Loss of neurons in the hippocampus and cerebral cortex of
            AMSH-deficient mice
  JOURNAL   Mol Cell Biol 21 (24), 8626-8637 (2001)
   PUBMED   11713295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074803.1, AK139391.1 and AB010123.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010123.1, AK139391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     Protein         1..424
                     /product="STAM-binding protein"
                     /EC_number="3.1.2.15"
                     /note="associated molecule with the SH3 domain of STAM"
                     /calculated_mol_wt=48383
     Region          1..127
                     /region_name="Interaction with CHMP3.
                     /evidence=ECO:0000250|UniProtKB:O95630"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95630; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Region          7..117
                     /region_name="USP8_dimer"
                     /note="USP8 dimerization domain; pfam08969"
                     /db_xref="CDD:462647"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95630; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Region          227..231
                     /region_name="Interaction with STAM.
                     /evidence=ECO:0000250|UniProtKB:O95630"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95630; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Region          254..424
                     /region_name="MPN_AMSH_like"
                     /note="Mov34/MPN/PAD-1 family; cd08066"
                     /db_xref="CDD:163697"
     Site            order(280,335,337,345,348)
                     /site_type="active"
                     /note="MPN+ (JAMM) motif [active]"
                     /db_xref="CDD:163697"
     Site            280
                     /site_type="other"
                     /note="Indirect zinc-binding.
                     /evidence=ECO:0000250|UniProtKB:Q96FJ0; propagated from
                     UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Site            order(282..284,309..313,316..317,320,323,329..330,333,335,
                     337,345,347..348,350..351,354..355,357..358,395)
                     /site_type="other"
                     /note="Distal ubiquitin recognition interface [polypeptide
                     binding]"
                     /db_xref="CDD:163697"
     Site            order(309,337,340..341,343,345..346,395..397)
                     /site_type="active"
                     /note="Proximal ubiquitin recognition interface [active]"
                     /db_xref="CDD:163697"
     Region          335..348
                     /region_name="JAMM motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01182"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQ26.1)"
     Site            order(335,337,348)
                     /site_type="other"
                     /note="Zinc-binding site [ion binding]"
                     /db_xref="CDD:163697"
     CDS             1..424
                     /gene="Stambp"
                     /gene_synonym="5330424L14Rik; 5730422L11Rik; Amsh;
                     mKIAA4198"
                     /coded_by="NM_024239.2:109..1383"
                     /db_xref="CCDS:CCDS20280.1"
                     /db_xref="GeneID:70527"
                     /db_xref="MGI:MGI:1917777"
ORIGIN      
        1 msdhgdvslp pqdrvrilsq lgsavelned ipprryyrsg veiirmasvy seegniehaf
       61 ilynkyitlf ieklpkhrdy ksaiipekkd avkklksvaf pkaeelktel lrrytkeyeq
      121 ykerkkkeee elarniaiqq elekekqrva qqkqkqleqe qfhafeemiq rqelekerlk
      181 ivqefgkvdp gpcgpllpdl ekpcvdvaps spfsptqtpd cntgmrpakp pvvdrslkpg
      241 alsvienvpt ieglrhivvp rnlcseflql asantakgie tcgvlcgklm rneftithvl
      301 iprqnggpdy chteneeeif fmqddlgllt lgwihthptq taflssvdlh thcsyqmmlp
      361 esiaivcspk fqetgffklt dyglqeistc rqkgfhphgr dpplfcdcsh vtvkdrivti
      421 tdlr
//
