LOCUS       NM_019667               4180 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus signal transducing adaptor molecule (SH3 domain and
            ITAM motif) 2 (Stam2), transcript variant 1, mRNA.
ACCESSION   NM_019667
VERSION     NM_019667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Zagore,L.L., Grabinski,S.E., Sweet,T.J., Hannigan,M.M.,
            Sramkoski,R.M., Li,Q. and Licatalosi,D.D.
  TITLE     RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell
            Development
  JOURNAL   Mol Cell Biol 35 (23), 4030-4042 (2015)
   PUBMED   26391954
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Kapuralin,K., Curlin,M., Mitrecic,D., Kosi,N., Schwarzer,C.,
            Glavan,G. and Gajovic,S.
  TITLE     STAM2, a member of the endosome-associated complex ESCRT-0 is
            highly expressed in neurons
  JOURNAL   Mol Cell Neurosci 67, 104-115 (2015)
   PUBMED   26101075
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Curlin,M., Kapuralin,K., Muro,A.F., Baralle,F.E., Chowdhury,K. and
            Gajovic,S.
  TITLE     Stam2 expression pattern during embryo development
  JOURNAL   Gene Expr Patterns 12 (1-2), 68-76 (2012)
   PUBMED   22143071
  REMARK    GeneRIF: Stam2 is expressed in the nervous tissue, heart, digestive
            and endocrine system during embryo development.
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Kapuralin,K., Van Ginneken,C., Curlin,M., Timmermans,J.P. and
            Gajovic,S.
  TITLE     Neurons and a subset of interstitial cells of Cajal in the enteric
            nervous system highly express Stam2 gene
  JOURNAL   Anat Rec (Hoboken) 295 (1), 113-120 (2012)
   PUBMED   22140097
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Bache,K.G., Raiborg,C., Mehlum,A. and Stenmark,H.
  TITLE     STAM and Hrs are subunits of a multivalent ubiquitin-binding
            complex on early endosomes
  JOURNAL   J Biol Chem 278 (14), 12513-12521 (2003)
   PUBMED   12551915
  REMARK    GeneRIF: STAM proteins function in a multivalent complex that sorts
            ubiquitinated proteins into the multivesicular body pathway.
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Yamada,M., Ishii,N., Asao,H., Murata,K., Kanazawa,C., Sasaki,H. and
            Sugamura,K.
  TITLE     Signal-transducing adaptor molecules STAM1 and STAM2 are required
            for T-cell development and survival
  JOURNAL   Mol Cell Biol 22 (24), 8648-8658 (2002)
   PUBMED   12446783
  REMARK    GeneRIF: These results demonstrate that the STAMs are indispensably
            involved in T-cell development and survival in the thymus through
            the prevention of apoptosis but are dispensable for the proximal
            signaling of TCR and cytokine receptors.
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Kato,M., Miyazawa,K. and Kitamura,N.
  TITLE     A deubiquitinating enzyme UBPY interacts with the Src homology 3
            domain of Hrs-binding protein via a novel binding motif
            PX(V/I)(D/N)RXXKP
  JOURNAL   J Biol Chem 275 (48), 37481-37487 (2000)
   PUBMED   10982817
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Takata,H., Kato,M., Denda,K. and Kitamura,N.
  TITLE     A hrs binding protein having a Src homology 3 domain is involved in
            intracellular degradation of growth factors and their receptors
  JOURNAL   Genes Cells 5 (1), 57-69 (2000)
   PUBMED   10651905
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Gajovic,S., Chowdhury,K. and Gruss,P.
  TITLE     Genes expressed after retinoic acid-mediated differentiation of
            embryoid bodies are likely to be expressed during embryo
            development
  JOURNAL   Exp Cell Res 242 (1), 138-143 (1998)
   PUBMED   9665811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928960.25.
            
            On Mar 21, 2023 this sequence version replaced NM_019667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035789.1, AK004604.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL928960.25        189818-189957       c
            141-225             AL928960.25        168641-168725       c
            226-301             AL928960.25        167659-167734       c
            302-400             AL928960.25        167454-167552       c
            401-547             AL928960.25        164182-164328       c
            548-617             AL928960.25        163445-163514       c
            618-804             AL928960.25        162575-162761       c
            805-899             AL928960.25        157353-157447       c
            900-982             AL928960.25        155900-155982       c
            983-1070            AL928960.25        155675-155762       c
            1071-1125           AL928960.25        154156-154210       c
            1126-1276           AL928960.25        150859-151009       c
            1277-1443           AL928960.25        147762-147928       c
            1444-4180           AL928960.25        139958-142694       c
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 30.41 cM"
     gene            1..4180
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="signal transducing adaptor molecule (SH3 domain and
                     ITAM motif) 2"
                     /db_xref="GeneID:56324"
                     /db_xref="MGI:MGI:1929100"
     exon            1..140
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1672
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="isoform a is encoded by transcript variant 1; Hrs
                     binding protein; signal transducing adapter molecule 2;
                     STAM-2; hrs-binding protein"
                     /codon_start=1
                     /product="signal transducing adapter molecule 2 isoform a"
                     /protein_id="NP_062641.1"
                     /db_xref="CCDS:CCDS16037.1"
                     /db_xref="GeneID:56324"
                     /db_xref="MGI:MGI:1929100"
                     /translation="MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAK
                     DCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIKNKAH
                     PKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGVTFPSAGSQTVAAAAKNGTS
                     LNKNKEDEDIAKAIELSLQEQKQQYTETKALYPPAESQLNNKAARRVRALYDFEAVED
                     NELTFKHGELITVLDDSDANWWQGENHRGTGLFPSNFVTTDLSTEVETATVDKLNVID
                     DDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKESKPDSQDLLDLEDVCQQMGPMID
                     EKLEEIDRKHSELSELNVKVLEALDLYNKLVNEAPVYSVYSKLHPAHYPPAAAGVPVQ
                     TYPVQSHGGNYLGHGIHQVSVAQNYNLGPDPMGSLRSLPPNMNSVTAHTVQPPYLSTG
                     QDTVSNPSYMNQSSRLQAAAGTAAYTQPVGMSTDVSSFQNTASGLPQLAGFPVAVPAP
                     VAAQPQASYHQQPLL"
     exon            141..225
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            226..301
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            302..400
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            401..547
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            548..617
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            618..804
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            805..899
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            900..982
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1070
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1125
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1276
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1443
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..4180
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2998..3003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="hexamer: ATTAAA"
     polyA_site      3020
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="major polyA site"
     polyA_site      3768
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
     regulatory      4153..4158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="hexamer: AATAAA"
     polyA_site      4180
                     /gene="Stam2"
                     /gene_synonym="1200004O12Rik; 5730456G07Rik; Hbp"
                     /note="major polyA site"
ORIGIN      
        1 accgctgggc caagccgtct aggaagccgc ggcgggtcgc ccagctgggg cagtcggagt
       61 cccgccagag cgtcgggatt cagctcgggt tgccggcgtg atgcctctgt tcactgccaa
      121 cccgttcgag caagatgtgg aaaaagccac aaatgagtac aacaccacag aagactggag
      181 tctgatcatg gacatctgtg acagggttgg aagcactccc agtggagcaa aagattgcct
      241 aaaagccata atgaaaaggg taaaccataa ggtccctcac gttgctctgc aggcattgac
      301 ccttcttgga gcttgtgtgg caaactgtgg aaagatattt catttagaag tatgttcccg
      361 tgattttgca acggaagtac gttctgtgat aaaaaataag gctcatccta aagtatgtga
      421 aaaactaaaa tctctaatgg tggaatggtc agaagaattc cagaaggacc cccaatttag
      481 tctgatatct gcaactatta agtctatgaa agaagaaggg gttacttttc cttccgcagg
      541 ctcccagact gtcgcggctg ctgccaaaaa cgggacatca ttgaacaaaa acaaagaaga
      601 tgaggacata gctaaagcta ttgagttatc gttgcaagag cagaagcagc agtacacgga
      661 gacaaaggct ttgtacccac ccgcagagag tcagctcaat aacaaggctg cacggagagt
      721 cagagcttta tacgactttg aagctgttga ggacaacgag ctcaccttta aacatggtga
      781 gctcattact gttttggatg acagtgacgc caactggtgg caaggagaaa atcacagagg
      841 aacaggactc ttcccctcca actttgtaac gactgactta agcacagagg ttgagacagc
      901 aacggtggac aaattgaatg taattgatga tgatgtggag gaaattaaga aatcagaacc
      961 tgagcctgtt tatatagatg agggtaaaat ggatagagcc ctgcagattc tccagagcat
     1021 agatccaaaa gagtcaaaac ccgactccca agacctcttg gacttggaag atgtttgcca
     1081 acagatgggt ccgatgatag atgaaaaact tgaagagatt gataggaagc attcagaact
     1141 gtctgagttg aacgtaaagg tgctggaagc cctggacctg tacaataagt tggtgaatga
     1201 agcgcctgtg tactcggtct attcaaagct gcatcccgca cattacccac ccgcagcagc
     1261 tggggttcca gtgcagacat atccagtcca gtcgcatggt ggaaactacc tgggccacgg
     1321 cattcaccaa gtatctgttg cccagaacta taacctagga cctgatccta tgggctcgct
     1381 gagatctctg cctccaaata tgaactcggt aacagcacac accgtccaac ctccatactt
     1441 aagcactgga caggacactg tctccaaccc ttcttacatg aaccagagct ctcgtcttca
     1501 ggcagctgct ggtacagctg cttacacaca gcctgtgggg atgtctacag atgtgtcttc
     1561 tttccagaac acagcatccg gtttgcctca gctggctggc tttccagtgg cagttcctgc
     1621 acctgtcgct gcacagccac aagcaagcta ccaccagcag cctctcctgt agagacgcac
     1681 caggacctgc tgaacggctt tgtgggtgtg ctgtttaatc taggggattc taatctgaaa
     1741 tattaaaagt ttcccctctc agtcaaaaag aaccatgaat aaataaagca caaaacccca
     1801 ccttaccctg aaggccataa aaggtttttt tttccagtcc agttggcttg aagttgacct
     1861 tttggtcaaa ggcagcttgg atgttctaag ttagtcgggc tgaactttct gggcccttac
     1921 tgagtagcct tacgacacta catgatatga ggtaggagtg tggaattttc tctttaaaga
     1981 acccgttgtt tcctcttaag atgtgatttt tgaggagcac tgaagacctt gaaacatttt
     2041 ttgtctgcac ttcccccacc ccttgaattt cccacaccct gttattttaa aaggcgagca
     2101 tcttttagtg caagccttta gcttgccagc atatttcctg ttggctcctt aaattacagt
     2161 tgtgtttgca gtactgtcag gtttgctctc agtgtaatgc tgagtagtaa ttagcagata
     2221 cttgtctaca gaagcaagaa caatttggaa ggtacaaaaa tggtttctgt cattaccagt
     2281 gaaaaccatg taaatgcaaa tattgtggag cagttagcca gtcctctgac agacgagggc
     2341 cagggactgc cccaggagat gttagccttc cccagaaagg gcatcctctc atactcgtgt
     2401 ccctggtatt tagaattgtt ttctagtgtc ttttggtgga tgtctaatga aggtgctgtc
     2461 ctttggattt cctgcctgct acatatgcag acactgcact tccttcttag ggattctcag
     2521 tgaatctgag ccaggagaca ctccccataa cctgatgtga taggaaccat catgggtatc
     2581 agtgtgaggt gggcgttcct ttcttacaga aagctgtcat cgtgtgccat tgggaaggga
     2641 ttgtgtgtcc cctagaagta gttgtgagcc tttgcaggag cagcaggcag cggtgtggtg
     2701 gccacaggct gacaggacag cagtcagctg cttgtctgaa gctcctgtct tacgttaggt
     2761 cttagtacag ttccacatac tgtaagagtt ggtggcaaac ccaagggaat tttctcttac
     2821 agctttgcac actactttat tatatcagct ttttacacaa cataaactag aaaacataga
     2881 tgcacaggac tcggatccat gatatttaca ctgggaaatg ttctaaatgg gattttttaa
     2941 aatttaaaat ttttgcatga atgcacttct gtatattttt ttaagccctt aaactttatt
     3001 aaaaatccat tgtgagacaa tttggaaatc ttatcgttta tctgtttacg atacttggtt
     3061 ataagtatgt tttttttcca aagaaactgt attctagaac ctactactgc ataaaatagc
     3121 cagcacagaa gagagcgtgg gccgtccctg caagcctgta tcttgtcagt gtctggttgt
     3181 cagatgcagg accctggaag gcttttcagt ccttagccct caccttctgt gtttcacacg
     3241 gccttctccc ttcagctgga ctcattgagt ccttacaagg atggagtgcg tgcaaaatgg
     3301 taccttactg tttctagaac agccttctgc tcttcaaaga ttaagtaaat aaatgtaaaa
     3361 gtccagagct gcccttgata acgtttgtgt agaggaatgc gtcttccctg cccttccaaa
     3421 ctgtgtttaa taagctcatg ctagtgtttg tgcatttcat gttcagttat tgtctaaatt
     3481 ataaaagctt tatttagtca gtgtaaatac tgcgttctca ttaagtgggg accagccatt
     3541 gaagcttagc cgttttggaa tactaaaata tgccacatga cctgtatata aatagtgtat
     3601 attagtgtct gtgaagttta atatatgtag aaatttcttc ctcctacatt ttattttttt
     3661 ccattcataa atttgtgttg cagagttatt gttagcctaa aatattaaat ctgtattgat
     3721 ctgatttcag tattaatacg atatgtaaag atatatattt tcccatgatc cagttgaact
     3781 gtacttattt taagatgttt gtagctattt attttcagcc aaaggaatag tttaccttca
     3841 gatttctaca ttgggttcat atttaatgtt ttctaacaaa aatttttgaa tttcattttt
     3901 catataaatc ttgatatatt agaaaattct taaaaatata tagaatttta tagtataaaa
     3961 catttccttg ggtgttaagt ggagtatgtt tgaaaagtca acagtcagcc aatgttgtct
     4021 ttttatttgg taatttgctt acaaaattac ctacacatta tctttttgct tagcatttaa
     4081 atatgtattt ccattatgct atttcaagta cttgattttt gactaatgat tgtactgtat
     4141 actgaagatg ataataaagt ttcatccaca ttttgaaaaa
//
