LOCUS       NM_011484               3702 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus signal transducing adaptor molecule (SH3 domain and
            ITAM motif) 1 (Stam), transcript variant 1, mRNA.
ACCESSION   NM_011484
VERSION     NM_011484.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Nam H and Lee S.
  TITLE     Identification of STAM1 as a novel effector of ventral projection
            of spinal motor neurons
  JOURNAL   Development 143 (13), 2334-2343 (2016)
   PUBMED   27161150
  REMARK    GeneRIF: the motor neuron-specific ISL1-LHX3 complex directly
            transactivates the Stam1 gene.
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard
            AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips
            SE, Miller RJ and Wilson SM.
  TITLE     Motor and Sensory Deficits in the teetering Mice Result from
            Mutation of the ESCRT Component HGS
  JOURNAL   PLoS Genet 11 (6), e1005290 (2015)
   PUBMED   26115514
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Kojima K, Amano Y, Yoshino K, Tanaka N, Sugamura K and Takeshita T.
  TITLE     ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase
            substrate (Hrs) is targeted to endosomes independently of
            signal-transducing adaptor molecule (STAM) and the complex
            formation with STAM promotes its endosomal dissociation
  JOURNAL   J Biol Chem 289 (48), 33296-33310 (2014)
   PUBMED   25296754
  REMARK    GeneRIF: ESCRT-0 protein hepatocyte growth factor-regulated
            tyrosine kinase substrate (Hrs) is targeted to endosomes
            independently of signal-transducing adaptor molecule (STAM) and the
            complex formation with STAM promotes its endosomal dissociation.
            Erratum:[J Biol Chem. 2015 Mar 27;290(13):8065-6. PMID: 25819836]
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri
            K, Tak J, Chung ED, Mastromonaco G, Caniggia I and Varmuza S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N
            and Sugamura K.
  TITLE     Hrs, a mammalian master molecule in vesicular transport and protein
            sorting, suppresses the degradation of ESCRT proteins signal
            transducing adaptor molecule 1 and 2
  JOURNAL   J Biol Chem 280 (11), 10468-10477 (2005)
   PUBMED   15640163
  REMARK    GeneRIF: Hrs is a master molecule that controls in part the
            degradation of STAM1 and the accumulation of ubiquitinated proteins
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Yamada M, Ishii N, Asao H, Murata K, Kanazawa C, Sasaki H and
            Sugamura K.
  TITLE     Signal-transducing adaptor molecules STAM1 and STAM2 are required
            for T-cell development and survival
  JOURNAL   Mol Cell Biol 22 (24), 8648-8658 (2002)
   PUBMED   12446783
  REMARK    GeneRIF: These results demonstrate that the STAMs are indispensably
            involved in T-cell development and survival in the thymus through
            the prevention of apoptosis but are dispensable for the proximal
            signaling of TCR and cytokine receptors.
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Yamada M, Takeshita T, Miura S, Murata K, Kimura Y, Ishii N, Nose
            M, Sakagami H, Kondo H, Tashiro F, Miyazaki JI, Sasaki H and
            Sugamura K.
  TITLE     Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1
  JOURNAL   Mol Cell Biol 21 (11), 3807-3819 (2001)
   PUBMED   11340172
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Kato M, Miyazawa K and Kitamura N.
  TITLE     A deubiquitinating enzyme UBPY interacts with the Src homology 3
            domain of Hrs-binding protein via a novel binding motif
            PX(V/I)(D/N)RXXKP
  JOURNAL   J Biol Chem 275 (48), 37481-37487 (2000)
   PUBMED   10982817
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko
            K, Munakata H, Endo Y, Fujita T and Sugamura K.
  TITLE     Cloning of a novel signal-transducing adaptor molecule containing
            an SH3 domain and ITAM
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1035-1039 (1996)
   PUBMED   8780729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087075.1, BC055326.1, AK164191.1 and AL845434.11.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_011484.4.
            
            On Sep 29, 2017 this sequence version replaced NM_011484.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044666.1, AK162431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY087075.1         1-66
            67-2892             BC055326.1         1-2826
            2893-3692           AK164191.1         1813-2612
            3693-3702           AL845434.11        40474-40483
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3702
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /note="signal transducing adaptor molecule (SH3 domain and
                     ITAM motif) 1"
                     /db_xref="GeneID:20844"
                     /db_xref="MGI:MGI:1329014"
     exon            1..237
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1844
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal transducing adapter molecule 1; STAM-1"
                     /codon_start=1
                     /product="signal transducing adapter molecule 1 isoform 1"
                     /protein_id="NP_035614.1"
                     /db_xref="CCDS:CCDS15698.1"
                     /db_xref="GeneID:20844"
                     /db_xref="MGI:MGI:1329014"
                     /translation="MPLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPK
                     DCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHP
                     KVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALV
                     AKDPGTVATKKEEEDLAKAIELSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAV
                     YDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIK
                     TEKKTVQFNDDVQIETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEA
                     MCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQQY
                     YLQSSAVSASQVYPGPAQSGTYLVAGSAQMTHLQSYSLPPEQLSSISQGAVPSSANQA
                     LPSQQTQASYPNAMVSSVQGNSYPSQASIYSPPAAAAAAAAAAVVPVPVPADVTIYQN
                     AGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQAYSQKALL"
     exon            238..322
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..398
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..494
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..641
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..732
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..925
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1020
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1109
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1197
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1252
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1406
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1582
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..3702
                     /gene="Stam"
                     /gene_synonym="STAM1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttccgctt ctcggctgtt gccgccgccg ccgcctctgt tgctggggtg ggtgagagga
       61 ggggctgaga gggaccctgc actggcaggc aggcgccctt gctgtgtttg tacctgaggg
      121 gcctcctttc tccgtcaccc ctagagtgcc gcggggtcga ggggcagtcc ccggggacac
      181 ctcggcacgc agcggacatg cctctctttg ccaccaaccc cttcgaccag gatgttgaga
      241 aagcaactag tgagttgaat actgctgagg actggggcct catcttggat atttgtgata
      301 aggttggcca atctcgcaca ggacctaaag attgtcttcg ttccattatg agaagagtga
      361 accataaaga cccccatgtt gctatgcaag ccttaactct tctgggagca tgtgtatcaa
      421 actgtggcaa aatttttcac ttagaagtat gttcaagaga ctttgctagt gaagtaagca
      481 atgtattaaa taagggtcat cctaaagtat gtgaaaaatt aaaggctctt atggttgaat
      541 ggacagatga atttaagaat gatccacagc ttagtctgat atcggcaatg atcaagaacc
      601 ttaaggaaca aggtgtaaca ttcccagcta ttggctctca ggctgcagaa caagcaaaag
      661 caagcccagc tctcgtagcc aaggaccctg ggactgtggc taccaaaaag gaagaagaag
      721 atttagccaa agctattgag ttgtccctga aggagcaaag gcagcagtca gcccccgtgt
      781 ccacgctgta ccccagcaca tctaacctcc tcactaacca ccagcacgaa ggcaggaaag
      841 tccgcgccgt gtacgatttt gaagccgctg aggataatga gcttaccttt aaagctggag
      901 aaatcattac agtccttgat gacagtgatc ccaactggtg gaaaggtgaa acccatcaag
      961 gcgtggggct ttttccttct aattttgtaa ctgcagatct tactgctgaa ccagaaatga
     1021 ttaaaacaga gaagaagacg gtacagttca atgatgatgt tcagatagag acaatagaac
     1081 cagaaccaga accagccttt attgatgagg ataaaatgga ccagttgtta cagatgttgc
     1141 aaagtacaga tcctagtgat aatcagccag acttgccaga gctgcttcat cttgaagcaa
     1201 tgtgtcacca gatgggacct ctcattgatg aaaagctgga agatattgat agaaaacatt
     1261 cagaactgtc agaactaaac gtgaaggtga tggaagctct ctcactgtat acgaagttaa
     1321 tgaatgaaga cccaatgtac tctatgtatg caaaattaca gagtcagcag tactatctgc
     1381 agtcgtcggc tgtctctgct tcccaggtat atccagggcc tgcgcagagc ggtacctacc
     1441 tggttgcagg gagtgcacag atgacccatc tgcagagcta cagccttccc ccagagcagc
     1501 tgtcttctat cagccaagga gcagttccat cctctgcaaa tcaagctctt cctagtcagc
     1561 agacccaggc ttcttacccg aatgcaatgg ttagttctgt tcaaggaaat tcgtatccta
     1621 gccaggcttc aatatatagt cctcctgctg ctgctgctgc tgccgctgct gctgctgtag
     1681 tacctgttcc tgtacctgct gatgtcacca tataccagaa tgcaggacct actatgtccc
     1741 aggtgccaaa ctatacttta acatcatcaa ccctgcctca aacaggaggc agccaacagc
     1801 cacctcagcc acagcaagca tattctcaga aggctctgct ataggacttg atgttcctct
     1861 tggtggcata tttccgctga atgccattga caatgttagg agattcatta acatcctaaa
     1921 atttgctttt cctcagctta taagagtcta tcttggtcaa gttcaaatac tcaagaaggt
     1981 agaactgtct tcaatttgca ctgaattttt agaggaatgc ctctaccctg aggaatgaaa
     2041 ctacttacaa catttatttc ctttcataat atgaagaatt gttacaagat tgttgttgtc
     2101 ttgtaaaatt acctggtctg cagcactcag aagatcaaca actgctgtgg ccaatgttat
     2161 ctgtacatgc attgacatgt aactttgtta gtgaccattg gaattgcagt ggtgatcatg
     2221 tgaatatatt taacaccgtg ttaaattaat ttacattgtt ttactttaat catgaacaag
     2281 tatgtttgct aatgtttggt gtaaatttaa gataagtaca ctatcttttt aagctacaag
     2341 agaactaaat tgtagcacac tgacctgaag gcattgtcct gttatagtgt cacattaaat
     2401 tgaacctttc ttttactaat tatgaacaaa ccatgtatgt tatatcttcc tgtagcttct
     2461 gccctctact ggttgtcacc ataccagcat acggtagcca cagttttggt gcaattagag
     2521 gagaataatg ttccttttaa acttttatat ttggcatgat gttccaggta ttgtggacca
     2581 tgagacaaaa attagtcttt gtattttatt ttgaaagaag taagggcatt ggtttccttt
     2641 gtcatagttg ccgtggtgat tagggattag gctttactgt gtttattggt agaagtgaca
     2701 ccaaagatac aggtgatgca catggagaat tttcaactgg aaagaaaatg aactaacact
     2761 acattttcag tctcctgtca tttttaggat ataaacaaaa tttgattcac ttgtcttacc
     2821 ccactagttt tttttaaaat gtcgttgata cattgtatct tgtaattctc attaaaatgg
     2881 atataaatag gtgtttcaaa gtaatttata ttctgatttt gtttaatagt ttatatattt
     2941 attgttaagt ttcaaaccgg agtcttaagt ttttcccttt gtctgtctct gtctcatttg
     3001 aaggtctaat agaattatct ttgcttattt aggagtaatt ttaatgaatt attttaattc
     3061 atacaaaaat tccactgaca ttttagacat aaatatttat aattcccctg attgtactat
     3121 tctattattt aaataaccta aaatttcagt atcacgttta ttagacctta gcttcccttc
     3181 tgtgaatgca tattacattt gcatttctga gacttgtgtg ttttcttttt gacaaatgac
     3241 ttcagctttg gcaaatagta ttgagggtga ttaactcatg ggttcatatt tacagccctt
     3301 ttttggtttt tcgagacagg gtttctctgt gtagccctgg ctgtcctgga actcactctg
     3361 tagaccaggc tggactactc agaaatctgc ctgcctctgc ctccaaagtt ctaggattaa
     3421 aggcgtgcac caccactgcc cagcatattt atagctcttt cactcttcag tttacttgag
     3481 tttaaagtat gtcactatca attagtaatg ttaagattta agtttttttt gataaaactt
     3541 cataagcagt tcgattataa ttttttatta cgatttaaat tttatggtat atgtgataga
     3601 cttttcttca agtcatactg tattttcctt gtatttttat aagtttctgt tttacaacta
     3661 tatttccatt ttaattttga taccttcatg tgaaaaaaaa aa
//
