LOCUS       NM_001290713            5952 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus STAG2 cohesin complex component (Stag2), transcript
            variant 3, mRNA.
ACCESSION   NM_001290713 XM_006541453 XM_011250986
VERSION     NM_001290713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5952)
  AUTHORS   Li,X., Liu,Y., Liu,J., Qiang,W., Ma,J., Xie,J., Chen,P., Wang,Y.,
            Hou,P. and Ji,M.
  TITLE     STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant
            thyroid cancer cells
  JOURNAL   Cell Death Dis 14 (7), 454 (2023)
   PUBMED   37479689
  REMARK    GeneRIF: STAG2 inactivation reprograms glutamine metabolism of
            BRAF-mutant thyroid cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5952)
  AUTHORS   Cheng,N., Li,G., Kanchwala,M., Evers,B.M., Xing,C. and Yu,H.
  TITLE     STAG2 promotes the myelination transcriptional program in
            oligodendrocytes
  JOURNAL   Elife 11, e77848 (2022)
   PUBMED   35959892
  REMARK    GeneRIF: STAG2 promotes the myelination transcriptional program in
            oligodendrocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5952)
  AUTHORS   Bansal,K., Michelson,D.A., Ramirez,R.N., Viny,A.D., Levine,R.L.,
            Benoist,C. and Mathis,D.
  TITLE     Aire regulates chromatin looping by evicting CTCF from domain
            boundaries and favoring accumulation of cohesin on superenhancers
  JOURNAL   Proc Natl Acad Sci U S A 118 (38) (2021)
   PUBMED   34518235
REFERENCE   4  (bases 1 to 5952)
  AUTHORS   Cai,H., Chew,S.K., Li,C., Tsai,M.K., Andrejka,L., Murray,C.W.,
            Hughes,N.W., Shuldiner,E.G., Ashkin,E.L., Tang,R., Hung,K.L.,
            Chen,L.C., Lee,S.Y.C., Yousefi,M., Lin,W.Y., Kunder,C.A., Cong,L.,
            McFarland,C.D., Petrov,D.A., Swanton,C. and Winslow,M.M.
  TITLE     A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven
            Lung Cancer
  JOURNAL   Cancer Discov 11 (7), 1754-1773 (2021)
   PUBMED   33608386
REFERENCE   5  (bases 1 to 5952)
  AUTHORS   Ochi,Y.
  TITLE     [Molecular pathogenesis of myelodysplastic syndromes with
            concurrent mutations in cohesin STAG2 and transcription factor
            RUNX1]
  JOURNAL   Rinsho Ketsueki 62 (5), 352-359 (2021)
   PUBMED   34108313
  REMARK    GeneRIF: [Molecular pathogenesis of myelodysplastic syndromes with
            concurrent mutations in cohesin STAG2 and transcription factor
            RUNX1].
REFERENCE   6  (bases 1 to 5952)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   7  (bases 1 to 5952)
  AUTHORS   Lara-Pezzi,E., Pezzi,N., Prieto,I., Barthelemy,I., Carreiro,C.,
            Martinez,A., Maldonado-Rodriguez,A., Lopez-Cabrera,M. and
            Barbero,J.L.
  TITLE     Evidence of a transcriptional co-activator function of cohesin
            STAG/SA/Scc3
  JOURNAL   J Biol Chem 279 (8), 6553-6559 (2004)
   PUBMED   14660624
REFERENCE   8  (bases 1 to 5952)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 5952)
  AUTHORS   Prieto,I., Pezzi,N., Buesa,J.M., Kremer,L., Barthelemy,I.,
            Carreiro,C., Roncal,F., Martinez,A., Gomez,L., Fernandez,R.,
            Martinez-A,C. and Barbero,J.L.
  TITLE     STAG2 and Rad21 mammalian mitotic cohesins are implicated in
            meiosis
  JOURNAL   EMBO Rep 3 (6), 543-550 (2002)
   PUBMED   12034751
  REMARK    GeneRIF: a cohesin complex containing Rad21 and STAG2 cooperates
            with a STAG3-specific complex to maintain sister chromatid cohesion
            during the diplotene stage of meiosis
REFERENCE   10 (bases 1 to 5952)
  AUTHORS   Carramolino,L., Lee,B.C., Zaballos,A., Peled,A., Barthelemy,I.,
            Shav-Tal,Y., Prieto,I., Carmi,P., Gothelf,Y., Gonzalez de
            Buitrago,G., Aracil,M., Marquez,G., Barbero,J.L. and Zipori,D.
  TITLE     SA-1, a nuclear protein encoded by one member of a novel gene
            family: molecular cloning and detection in hemopoietic organs
  JOURNAL   Gene 195 (2), 151-159 (1997)
   PUBMED   9305759
  REMARK    Erratum:[Gene 1998 Jan 12;206(2):283]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672089.17, BC066041.1, CO434048.1, CN708963.1, AK161072.1 and
            AA461826.1.
            
            On or before Nov 23, 2017 this sequence version replaced
            XM_011250986.2, NM_001290713.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.21130.1,
                                           SRR10223969.19769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL672089.17        44890-45027
            139-394             BC066041.1         17-272
            395-1042            CO434048.1         78-725
            1043-3701           BC066041.1         920-3578
            3702-3812           CN708963.1         198-308
            3813-4929           BC066041.1         3579-4695
            4930-5930           AK161072.1         1421-2421
            5931-5952           AA461826.1         359-380
FEATURES             Location/Qualifiers
     source          1..5952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 23.19 cM"
     gene            1..5952
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /note="STAG2 cohesin complex component"
                     /db_xref="GeneID:20843"
                     /db_xref="MGI:MGI:1098583"
     exon            1..138
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            139..278
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..4041
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     cohesin subunit SA-2; SCC3 homolog 2; nuclear protein SA2;
                     stromal antigen 2"
                     /codon_start=1
                     /product="cohesin subunit SA-2 isoform 2"
                     /protein_id="NP_001277642.1"
                     /db_xref="CCDS:CCDS72371.1"
                     /db_xref="GeneID:20843"
                     /db_xref="MGI:MGI:1098583"
                     /translation="MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCK
                     KGKKGPAEKGKSGNGGGKPPSGSNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDW
                     IESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYP
                     LTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHT
                     STLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQE
                     NQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGW
                     TMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIK
                     LLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGLMKR
                     RGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLS
                     GEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTRITEL
                     FAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHT
                     DTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDED
                     DAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCAHYV
                     ILWQLAKITESTSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIF
                     SHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDSNSADGQQEDEASKIE
                     ALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQ
                     CAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAM
                     LHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQM
                     SLRREDVWLPLMSYRNSLLAGGDDDTMSVISGMSSRGSTVRSKKSKPSTGKRKVVEGM
                     QLALPEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQA
                     EHHQTPLDYNTQVTWMLAQRQQEEARQQQERAAMSYVKLRTNLQHAIRRGTSLMEDDE
                     EPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERTELKPDFFDPASIMDESV
                     LGVSMF"
     exon            279..357
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..522
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..619
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..696
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..901
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1053
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1127
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1251
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1350
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1430
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1538
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1650
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1768
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1872
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1965
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2055
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2259
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2330
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2418
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2499
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2592
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2767
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2907
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3009
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3158
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3287
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3511
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3701
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3812
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3939
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4017
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..5941
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5914..5919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /note="hexamer: AATAAA"
     polyA_site      5934
                     /gene="Stag2"
                     /gene_synonym="9230105L23Rik; B230112I07Rik; SA-2; SAP2"
                     /note="major polyA site"
ORIGIN      
        1 gggtggccca aaatggagaa cgcgcagcgg cgcaagatgg aggctcggcg cctccgcgta
       61 gcctgctcgc tcgcttcctc tcctcccggg gcctcttaag cagcccgtgg agggggacga
      121 gagcccccca gactggagga actgtctttc ttagaggaag cacactgtca ttttactcac
      181 ataaatatat gaatatattt ctgacattgg ggtgatccag aagatgataa agaaatgata
      241 gcagctccag aaataccaac tgattttaat ctactgcagg agtcagagac acacttttct
      301 tctgacacag attttgaaga cattgaagga aaaaatcaga agcaaggcaa aggcaaaact
      361 tgtaaaaaag gcaaaaaggg tccagcagaa aagggtaaaa gtggaaatgg aggaggaaaa
      421 cctccttctg gctcaaaccg aatgaacggt catcatcaac agaatggagt tgaaaacatg
      481 atgttgttcg aagttgttaa aatgggcaag agtgctatgc agtcggtggt agatgactgg
      541 atcgagtcct acaagcatga ccgggacata gcgcttcttg accttatcaa tttctttatt
      601 cagtgctcag gctgcaaagg agtcgtcaca gcagagatgt tcagacatat gcagaactct
      661 gagataattc gaaaaatgac agaagaattt gacgaggata gtggggatta cccacttacc
      721 atggctggtc ctcagtggaa gaagttcaag tccagcttct gtgagttcat tggtgtgtta
      781 gtacggcagt gtcaatacag tatcatatat gatgagtaca tgatggatac tgtcatttca
      841 cttcttactg gattgtctga ctcccaagtc agagcatttc gacatacaag caccctggca
      901 gctatgaagt tgatgactgc tttggtaaat gtggcactaa atcttagcat taatatggat
      961 aacacacaaa gacagtacga ggcagaacgg aataaaatga ttggaaaacg agctaacgaa
     1021 aggctagaac tcctgttaca aaagcgtaaa gagcttcagg aaaatcaaga tgagatagaa
     1081 aatatgatga atgcaatatt taaaggagtg tttgtacata gatacaggga tgcaatagct
     1141 gaaatcagag ctatatgcat tgaagagatt ggcatttgga tgaagatgta tagtgatgcc
     1201 ttccttaatg acagctattt aaaatatgtt ggttggacta tgcatgataa gcaaggtgaa
     1261 gtcagactca aatgtcttac tgctttacaa gggctttact ataacaaaga acttaattcc
     1321 aaactggaac tctttaccag tcgattcaag gatagaattg tgtctatgac ccttgacaaa
     1381 gaatatgatg ttgcagtaca agcaataaag ttactcactc ttgttttaca gagtagtgaa
     1441 gaagttctaa ctgcagaaga ttgtgaaaat gtctatcatc tggtttattc agctcaccgg
     1501 ccagtagcag ttgcagctgg agaatttctc tacaaaaagc tcttcagccg cagagaccca
     1561 gaagaggatg ggctgatgaa aagaagggga aggcaaggcc cgaatgccaa ccttgtgaag
     1621 actttggtgt ttttcttttt ggaaagtgag ttacacgagc atgcagctta ccttgtggac
     1681 agcatgtggg attgtgctac tgagctcctg aaagactggg aatgtatgaa tagcttgtta
     1741 ttagaagagc ctcttagtgg agaggaagct ctaacagaca gacaagagag tgctttgatt
     1801 gaaataatgc tttgtactat tagacaagca gctgaatgtc atcctcccgt gggaagaggg
     1861 acaggaaaaa gggtgctgac agcaaaggag aagaagacac agttggatga cagaacaaga
     1921 atcactgagc tgtttgctgt ggcccttccg cagttattag ctaaatactc tgtagatgca
     1981 gaaaaggtga ccaatttgtt gcagttacct cagtactttg atttggagat atacaccact
     2041 ggacgattag aaaagcattt ggatgcctta ttgcgccaga tccgaaatat tgtagagaag
     2101 cacacagaca cagatgtttt ggaagcatgt tctaaaactt accatgcatt atgtaacgaa
     2161 gagttcacca tcttcaacag agtagatatt tcaagaagtc agctgattga tgaactggca
     2221 gataaattta accggcttct tgaagatttt ctgcaagagg gagaagaacc tgatgaagat
     2281 gacgcatatc aggtattgtc aacattgaag aggatcactg cttttcataa tgctcatgat
     2341 ctttcaaagt gggatttgtt cgcttgtaat tacaaactct tgaaaaccgg aatcgaaaat
     2401 ggagatatgc ctgagcagat tgttattcac gcactgcagt gtgctcacta tgtaatcctt
     2461 tggcagcttg ctaagatcac tgaaagcacg tctacaaagg aggacttact gcgcttaaag
     2521 aaacagatga gggtattttg ccagatatgt cagcattact tgaccaacgt gaatactact
     2581 gttaaagaac aggccttcac tattctgtgt gacattttga tgatcttcag tcaccagatt
     2641 atgtctggag ggcgtgacat gttagagcca ttagtttata ctcctgattc ttcattgcag
     2701 tctgagttgc tcagctttat tttggatcat gtcttcattg aacaggatga tgatagtaat
     2761 agtgcagatg gtcagcaaga ggatgaagcc agcaaaattg aagctttgca caagaggaga
     2821 aatttacttg cagcattttg taagctaatt gtatataccg tggtggagat gaacacagct
     2881 gcagatatct tcaagcagta tatgaagtat tataatgatt atggcgatat catcaaagaa
     2941 acaatgagta aaacaaggca gattgacaaa attcagtgtg ctaagaccct tattctcagt
     3001 ttgcagcagc tttttaatga gatgatacaa gagaatggct ataattttga tagatcatcc
     3061 tcaacattta gtggcataaa agaacttgct cggcgttttg ctttaacttt tggacttgat
     3121 caattgaaaa ccagagaagc cattgccatg ctccacaaag atggtataga atttgctttt
     3181 aaggagccta atccacaagg ggagagccat ccacctttaa acttggcatt tcttgatatt
     3241 ctcagtgaat tttcttctaa actgctccga caggataaaa gaacagtgta tgtttatttg
     3301 gaaaagttca tgacctttca gatgtcactc cgaagagaag atgtatggct tcctctgatg
     3361 tcttaccgaa attctttgct agctggtggt gatgatgata ctatgtcagt cattagtgga
     3421 atgagcagtc ggggatcaac tgtacggagt aaaaaatcaa aaccatctac aggaaagcgg
     3481 aaagtggttg aaggcatgca actagcactc cctgaagaaa gcagtagcag tgacagtatg
     3541 tggttgagca gagagcaaac actgcacacc cctgtcatga tgcagacacc acagctcacc
     3601 tccactatta tgagagaacc gaaaaggtta cggcctgaag atagcttcat gagtgtctat
     3661 ccgatgcagg cagaacacca tcaaacgcct ctggattata acacgcaggt aacatggatg
     3721 ttagctcaaa gacaacaaga ggaagcaagg caacagcagg agagagcagc aatgagctat
     3781 gttaaactgc gaactaatct tcagcatgcc attcggcgtg gtacaagcct aatggaagat
     3841 gatgaagagc caattgttga agatgttatg atgtcctcag aaggaaggat tgaggatctt
     3901 aatgagggaa tggactttga caccatggat atagacttgc caccatcaaa gaatagaaga
     3961 gagagaacag aactgaagcc cgatttcttt gatccagctt caattatgga tgaatcagtt
     4021 cttggggtgt caatgtttta atcccagtac acatttaaat ctgtggtgaa gtcgttttct
     4081 aagtggaaga ggaaatttga aaataaagtg tggtagatac agtgaaattc tgtacagatt
     4141 tttctctaag gagaatataa catgcttatg cttaccaaga tgaagtgcat tgaggggcag
     4201 ttttgtttgc ctgaaaaaat aaaggacaag taaacaattt gatgataagc tacagttttt
     4261 cttagaaagt aaatatttta tttatgcgct gttagttggc ttttaaagga attatttcat
     4321 gcttttttaa aaaatataac aatctgaaga agtatttggt acagataaga atcttctcac
     4381 atttatttac tggttgtact aaataatgat gacctctgct ggatttctgt ttacatccac
     4441 gaaacaaaag ttaaggatgg atttattccc cgaccctgaa attgtaggat agaattgttt
     4501 ttagcattct aaatttaaat gcttaaaaca tcaatcaaca aaactttgtt ttaaatgttg
     4561 taattgtgga aaaaaagtta aacttataag cagaactttt acaatttttt catctaaaat
     4621 gtattttaag atatttttaa aatccaagag cttctgtata cttttcagaa atatccagat
     4681 gcagtgaact gccagaaggt aaccagtctt gaacatgctt atcccatagc agccctgaac
     4741 gtttgcttgt cctttaagat aaaaatgtaa cgttgtgata ttccttccag tagtgccact
     4801 gtattttgtc tccaaataaa agaagcttat tgtagtatgt ttgcagaaaa tttaaacaaa
     4861 aattatacag cttattagag tgtgggaata gggatctaaa ttttaaataa aattatatat
     4921 atatataaat tggtgctgat tttataattg cgcagtttgt ttagtttttt cttactttta
     4981 aattccaact taaaattatg aggtttcaga aatatattga aagtttaaca atgtttaaaa
     5041 atagaaaagc atgactgttc atgctttaaa atgattttta aatttgtatt ttatattgtt
     5101 ttatctatct gtctttgcaa gcagtcttca ggttaaagat acttctaaca ggttacagta
     5161 catttcctct gtatgtaaat tagatgggat aatagaattc ataacccata atattctttg
     5221 aaagctaagc tttaaacttc attttatgtc ctttcacaag tgaattagtt taaaacagaa
     5281 agtggccact tgccattttg acatcgactc attttgcgag gcttaggcag ctagacatcg
     5341 tttaaaacaa aatattaact tatattacat gtatatctat cttttgtcag tcgtctctca
     5401 gttcttgagg tatattattt taatcattcc atgccttaat atgcttgcaa tacaagaata
     5461 tcttcagatg tgtgaatacc aaaaggtttc tggtttttcg agtcaggaaa tcaacaagca
     5521 ttgggctgtg gtagccaaaa aaccataggt taaatgaacg accacaacat acatttgttt
     5581 tattaattaa tggttaacaa ataaaaccag acttgtctaa catactttcc atcaacaacc
     5641 attgttacgt gcaaacatat tgcatatgtt ccttcacaca ccactgcatt tcctagaact
     5701 gctgagagga ctgtatatat gatttgaaac ctaggttgat ttcttttctc actcttgaaa
     5761 ggagtatttc tttgtgaaag cagttcttcc agctttgttt tgaaccagct aaactgtttt
     5821 ctatattact ctaacctgtt gtcctccaca ttctattgtc ctaattgtac tgtttgctga
     5881 tttgtattta tgtcttgaga cagtaacttt ttgaataaaa ataaacctac cgtgtgttgt
     5941 aaaaaaaaaa aa
//
