LOCUS       NM_009282               6202 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus stromal antigen 1 (Stag1), transcript variant 1, mRNA.
ACCESSION   NM_009282 XM_906584 XM_919934 XM_919945 XM_919958 XM_919969
            XM_919981 XM_919990 XM_920002 XM_920014 XM_920028
VERSION     NM_009282.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6202)
  AUTHORS   Akagawa R, Nabeshima YI and Kawauchi T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6202)
  AUTHORS   De Koninck M, Lapi E, Badia-Careaga C, Cossio I, Gimenez-Llorente
            D, Rodriguez-Corsino M, Andrada E, Hidalgo A, Manzanares M, Real FX
            and Losada A.
  TITLE     Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and
            Adult Tissue Homeostasis
  JOURNAL   Cell Rep 32 (6), 108014 (2020)
   PUBMED   32783938
REFERENCE   3  (bases 1 to 6202)
  AUTHORS   Arruda NL, Carico ZM, Justice M, Liu YF, Zhou J, Stefan HC and
            Dowen JM.
  TITLE     Distinct and overlapping roles of STAG1 and STAG2 in cohesin
            localization and gene expression in embryonic stem cells
  JOURNAL   Epigenetics Chromatin 13 (1), 32 (2020)
   PUBMED   32778134
  REMARK    GeneRIF: Distinct and overlapping roles of STAG1 and STAG2 in
            cohesin localization and gene expression in embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6202)
  AUTHORS   Viny AD, Bowman RL, Liu Y, Lavallee VP, Eisman SE, Xiao W, Durham
            BH, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS,
            Witkin M, Azizi E, Baslan T, Ott CJ, Pe'er D, Dekker J, Koche R and
            Levine RL.
  TITLE     Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin
            Accessibility and Topological Control of HSC Self-Renewal and
            Differentiation
  JOURNAL   Cell Stem Cell 25 (5), 682-696 (2019)
   PUBMED   31495782
REFERENCE   5  (bases 1 to 6202)
  AUTHORS   Cuadrado A, Remeseiro S, Grana O, Pisano DG and Losada A.
  TITLE     The contribution of cohesin-SA1 to gene expression and chromatin
            architecture in two murine tissues
  JOURNAL   Nucleic Acids Res 43 (6), 3056-3067 (2015)
   PUBMED   25735743
  REMARK    GeneRIF: reduced dosage of SA1 altered the architecture of the Reg
            locus and decreased the expression of Reg genes in the pancreas of
            SA1 heterozygous mice
REFERENCE   6  (bases 1 to 6202)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 6202)
  AUTHORS   Lemon WJ, Bernert H, Sun H, Wang Y and You M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   8  (bases 1 to 6202)
  AUTHORS   Prieto I, Pezzi N, Buesa JM, Kremer L, Barthelemy I, Carreiro C,
            Roncal F, Martinez A, Gomez L, Fernandez R, Martinez-A C and
            Barbero JL.
  TITLE     STAG2 and Rad21 mammalian mitotic cohesins are implicated in
            meiosis
  JOURNAL   EMBO Rep 3 (6), 543-550 (2002)
   PUBMED   12034751
REFERENCE   9  (bases 1 to 6202)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 6202)
  AUTHORS   Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal
            Y, Prieto I, Carmi P, Gothelf Y, Gonzalez de Buitrago G, Aracil M,
            Marquez G, Barbero JL and Zipori D.
  TITLE     SA-1, a nuclear protein encoded by one member of a novel gene
            family: molecular cloning and detection in hemopoietic organs
  JOURNAL   Gene 195 (2), 151-159 (1997)
   PUBMED   9305759
  REMARK    Erratum:[Gene 1998 Jan 12;206(2):283]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043215.1, BC062954.1 and AC134825.5.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_009282.5.
            
            On Oct 25, 2017 this sequence version replaced NM_009282.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062954.1, Z75332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AK043215.1         2-176
            176-5569            BC062954.1         1-5394
            5570-5672           BC062954.1         5396-5498
            5673-5673           AC134825.5         101943-101943       c
            5674-6202           BC062954.1         5500-6028
FEATURES             Location/Qualifiers
     source          1..6202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..6202
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /note="stromal antigen 1"
                     /db_xref="GeneID:20842"
                     /db_xref="MGI:MGI:1098658"
     exon            1..349
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..451
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..4199
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cohesin subunit SA-1; SCC3 homolog 1"
                     /codon_start=1
                     /product="cohesin subunit SA-1 isoform 1"
                     /protein_id="NP_033308.2"
                     /db_xref="CCDS:CCDS23441.1"
                     /db_xref="GeneID:20842"
                     /db_xref="MGI:MGI:1098658"
                     /translation="MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPP
                     STNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQQNGDGDPVTLFEVVKLGKSAMQSVV
                     DDWIELYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSG
                     DYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAF
                     RHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKE
                     LQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKY
                     VGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVE
                     AIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQAEEA
                     LAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLE
                     EPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNK
                     LTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVV
                     EKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEE
                     ADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQC
                     SHYSILWQLVKITDGSPSKEDLLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDL
                     LMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEA
                     NKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQI
                     DKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTRE
                     AVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFL
                     TEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRSKKGRPPLHRKR
                     VEDESLDNTWLNRTDTMIQTPGPLPTPQLTSTVLRENSRPMGEQIQEPESEHGSEPDF
                     LHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRAGVRHAVRGLMEEDAEPIFEDVMMS
                     SRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF"
     exon            452..554
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..719
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..816
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..893
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1098
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1250
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1324
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1448
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1547
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1627
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1735
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1850
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1968
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2072
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2165
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2255
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2459
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2530
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2618
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2699
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2792
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2967
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3107
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3209
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3358
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3487
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3693
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3868
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3979
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4094
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4175
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..6185
                     /gene="Stag1"
                     /gene_synonym="SA-1; Scc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgtgcgc gccccccgga ggcgagcgat ggcgcgcggc cccgtccgag ggcccctgct
       61 cgcgcctcag ctccctcccc tttccgggca ggcccgtcct gtcagcggag cagtgagcag
      121 cgcggccagc agagggcggt cgggacccga gtctgcagcg gcgccattgg cgtgtggaaa
      181 atgccaccag atggcgggtt aggattgcag ctccgttgaa ggcgcggccc ccgctcccga
      241 acccccggcg accaccccgt aaccaccccc ccacctcggg aataacacac cggagacttt
      301 tggggggaaa ctaggtcgac ggccgacagc gcccggatgg gcagctgagg tgtgactttg
      361 aggttgaata accagtttga attatacaga aatttctgta ctgtggaata gcttctccag
      421 caatgattac ttcagagtta ccagtgttac aggattcaac taatgaaact actgcccact
      481 ctgatgctgg cagcgaactt gaagaaacag aggtcaaagg aaaaagaaaa aggggtcgtc
      541 ctggccggcc tccatcaaca aataagaaac ctcgaaaatc tccaggagaa aagagcagaa
      601 ttgaagctgg aattcgagga gcaggtcgtg gaagagccaa tgggcacccc caacagaacg
      661 gcgacgggga tcctgtcacc ttatttgagg tggtgaagct ggggaagagt gcaatgcagt
      721 ccgtggtgga tgactggatt gaattatata aacaagacag ggacatcgca cttctggatt
      781 taatcaactt ttttatccag tgttcaggat gtcgaggtac ggtcagaata gagatgtttc
      841 gaaatatgca gaacgcagaa ataatcagaa aaatgactga agaatttgat gaggacagtg
      901 gtgactaccc ccttacaatg cctggtcctc agtggaaaaa atttcgttcc aatttttgtg
      961 aatttattgg agtcctgatt cgacagtgtc aatatagcat aatttatgat gaatatatga
     1021 tggacaccgt aatttccctt ttgactggtt tgtcagactc ccaagtcaga gcttttaggc
     1081 atacaagtac ccttgctgca atgaagctga tgactgctct ggtgaatgtt gctttaaacc
     1141 tcagtattca tcaagataat acacagaggc aatatgaagc tgagagaaat aaaatgattg
     1201 ggaagagagc caatgaaaga ctggagttac tacttcagaa acgtaaagag ctacaagaaa
     1261 atcaagatga aattgaaaat atgatgaact ctatctttaa gggtatattt gttcatcgat
     1321 accgtgatgc aattgctgaa attcgagcca tctgtattga agaaattgga gtgtggatga
     1381 aaatgtatag cgatgccttc ctaaatgaca gttacttgaa atatgtagga tggactcttc
     1441 acgataggca aggggaagtc agactgaagt gtttgaaagc tctacaaagc ctgtatacca
     1501 atagagaatt attccccaaa ttggagctat ttacaaatcg attcaaggat cgcattgtat
     1561 caatgactct tgacaaagaa tatgatgttg ctgtggaagc aatccgattg gttactctga
     1621 tccttcatgg cagtgaagaa gctctttcca acgaagactg tgaaaatgtt taccatttgg
     1681 tgtattcagc acatcgccct gttgctgtgg cagctggaga gttcctacac aaaaagctgt
     1741 tcagcagaca tgacccacaa gcagaggaag cgttagcgaa gaggagagga aggaacagtc
     1801 caaacgggaa cctcattagg atgcttgttc ttttctttct ggaaagtgag ttacatgaac
     1861 atgcagccta cttggtggac agcttgtggg agagctctca agaactgttg aaagactggg
     1921 aatgtatgac agagttacta ttagaagaac ctgttcaagg agaagaagca atgtctgacc
     1981 gtcaagagag tgctcttata gagctaatgg tctgtacaat tcgtcaggca gctgaggcac
     2041 atcctccagt gggaaggggt actggcaaga gagtgctaac agccaaagaa aggaaaactc
     2101 aaattgatga taggaacaaa ttaactgaac attttatcat tacacttcct atgttactat
     2161 caaagtattc tgcagatgct gagaaggtag caaacttgct gcaaattcca cagtattttg
     2221 atctagaaat ctacagcaca ggtcggatgg aaaagcacct ggatgcttta ttaaaacaaa
     2281 ttaagtttgt tgtagagaaa catgtagaat cagatgtcct agaagcctgc agtaaaacct
     2341 acagcatttt atgcagtgaa gagtatacca ttcagaatcg agttgatatt gctcggagcc
     2401 aactgattga tgaatttgta gatcgattca atcattctgt agaagacctg ttgcaagagg
     2461 gtgaagaagc tgacgatgat gatatctaca atgttctttc caccttaaag cgtttaactt
     2521 cttttcacaa tgctcatgat ctcactaaat gggatctatt tggtaattgc tacagactat
     2581 tgaagactgg aattgaacat ggagctatgc cagaacagat agtcgtacaa gcactgcagt
     2641 gttcccatta ctcaattctg tggcagttgg tgaaaattac tgacggatct ccttccaaag
     2701 aggatttgtt ggtattgagg aaaacagtga agtcttttct ggctgtttgc caacagtgcc
     2761 tatctaatgt taatactcca gttaaggaac aggctttcat gctgctctgt gatcttttaa
     2821 tgatttttag ccaccaatta atgacaggtg gcagagaggg ccttcagcct ttggtgttta
     2881 atccagatac tggactccag tctgaactcc tcagttttgt gatggatcat gttttcattg
     2941 accaagatga ggaaaaccaa agcatggagg gtgatgagga agatgaagct aataaaattg
     3001 aagccttaca taaaaggagg aacctgcttg ctgccttcag caaacttatc atttatgata
     3061 ttgttgacat gcacgcagct gcagacatct ttaaacacta catgaagtat tacaatgact
     3121 atggtgatat tattaaggaa acactgagta agaccaggca gattgataaa attcagtgtg
     3181 ctaagactct cattctcagt ctgcaacagt tgtttaatga acttgttcaa gaacaaggtc
     3241 ctaatctgga taggacatct gcccacgtca gtgggattaa agaactggca cgtcgttttg
     3301 cccttacatt tggattggac cagatcaaga cccgagaagc tgttgccaca cttcacaagg
     3361 atggaataga gtttgccttt aaataccaga atcagaaagg acaagaatac ccacccccta
     3421 atctggcttt tctagaagta ctaagtgaat tttcttctaa actccttcga caggacaaga
     3481 aaactgttca ttcgtatctt gaaaaattcc tcaccgagca gatgatggaa aggagggagg
     3541 atgtgtggct tccactcatc tcgtatagaa actcattagt cactggaggt gaagatgaca
     3601 ggatgtctgt gaacagtgga agtagcagca gtaaaacgtc ctcagtaagg agtaagaaag
     3661 gaagaccccc actgcacaga aaacgagtag aagatgaaag tctggataac acatggctaa
     3721 ataggactga cacgatgatt cagactcctg gacccttgcc aaccccacag ctcacctcca
     3781 cggtacttag agaaaacagc cgtcccatgg gagagcagat tcaggaacct gagtctgagc
     3841 atggctctga accagacttt ttacataatc cccagatgca gatctcttgg ttaggccagc
     3901 cgaagttaga agacttgaat cggaaggaca gaacagggat gaactacatg aaagtaagag
     3961 ctggagtccg gcacgccgtt cggggtctaa tggaggaaga tgctgagccc atctttgaag
     4021 atgtgatgat gtcatcacgg agccagttag aagacatgaa tgaagaattt gaagacacca
     4081 tggttattga tttgccccca tcaagaaatc gccgagagag agctgagcta aggccagact
     4141 tctttgactc tgcagctatc atagaagatg attcaggatt tggaatgcct atgttctgaa
     4201 gtctgaagaa aatttacaaa tctggaactc tattatttag agctagaggc ctatatactg
     4261 tgatagcttg tatgggggaa gaaacgcttt tgatgtgatc gggtttgttt tgtaatcaaa
     4321 tgattaaagg ttggtccctt ttgcagtgac agagcagcat gtcagtcacc catggaaatg
     4381 ttggtgaatg tcacctcgga aagactgacc aaaaaaatca tttgtactct aatgttggac
     4441 ttatctcagt acagatgtgt gtgtgttttt ctgaaaggag gaagatattt taaattttta
     4501 aaacagctgt caaaataaac actgttatac acctgtttta tgaaaatcag cattgagtaa
     4561 aaaaaatatt tttaacttta ttttcctgtt gtacaattta aaaaccgttt taacattttg
     4621 cctttttatg ttttaaaagc taaccatttt tattaaacta tgagtaagca gctcgttcta
     4681 atcgccgaag agtgtttttg gagctcgctg ggttttgttg accttgtaaa gcagacattg
     4741 aaggaacaga gcatggacaa gctaaaatag agttctaaca tcgtgcatct ctgccaaaaa
     4801 ccacacgccc tctgtggatg gatgggaatc cccagatttt atatactctt gaataaaaag
     4861 gtttattttt atttataagt gggcataaga taagtgccca tgcagccatt tttccaacag
     4921 atgctgtaca ccgttcattt tctatagaat agtgagattc aaatacagtg cattttctat
     4981 tggtctttgt tctgtgcatt tttagcaact tctaccagca aataaactat tctcagtaaa
     5041 acaaaaatgg ttctcaagtt atcagtctca ctgttgttaa cacttgtttc atgccctgcc
     5101 aaagtcacgt tacacagact tccgttttct tatagtcatg aaattttcct ttgccattca
     5161 gaagtaattt taagatgtgt aacgtaactg tcttcccatg cactcagtat cccctcaacc
     5221 cactaatgtt gtgaaatgtt taccaatcat agatgtatgt gctgcataga agtctgtgct
     5281 tagaaggtgg cgttctaagc ttaccgtgaa acacagctac atttcagtgt taagtgtgca
     5341 tattaagaaa aattcttttg gagaaagaaa ttctgaatct tcgggacagt cttcagtggc
     5401 ttagagttac aatcagctta cttttatgac ttgctattat tttaaaaatc cacatagctt
     5461 tccctgattt tagtgtaggc ttccaaattt ccaaaccagt ctgtccacag ctgtttctgg
     5521 gctggttttt taaaatagct gcaacagaat tgagaggctt tcccttttta ccaaaaatga
     5581 acatttttta aaagtatatg aactctatga ttatcttttg tgtgggaaaa taaaatacga
     5641 ttttattcat ccttttagta gacaagattt ttctcaacat ttgtacagtt cagagattta
     5701 aaaaaaaaaa attcttggtc accaaaaatg ttttacctac taactcagca agtcctaggc
     5761 tccagttaaa acatctgggg ccttgctctc tcctagaaat gtgggcttca ctggaactca
     5821 aggggcagga atgaatggac tgcacacctc agccctgcct cactatagtt cttggccagg
     5881 gacccagctt tgaggaaccc tggaataagc acagataatt ctttgcctga cgatctcctg
     5941 tgaacaccac atgctgattt aagggttaca gactaccatg caacaacaaa ggcggcttaa
     6001 tctctactcc agtgggtttc caagttcagt ttaaagtcaa tcaaattttt gtattttcag
     6061 tgtctccttg attggttttg ctagtaattc tgtaaattgt acatttgcaa aatgatggtt
     6121 ttttttcctt ttgtacaatt tgaaactgat gcttcacctt tcctttaata aactattcaa
     6181 aatcaaaaaa aaaaaaaaaa aa
//
