LOCUS       NM_177707               1829 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus SH3 and cysteine rich domain 3 (Stac3), transcript
            variant 1, mRNA.
ACCESSION   NM_177707
VERSION     NM_177707.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Bi,X., Liu,J., Xu,S., Wang,Y. and Wu,X.
  TITLE     Testicular STAC3 regulates Leydig cell steroidogenesis through
            potentiating mitochondrial membrane potential and StAR processing
  JOURNAL   Cell Tissue Res 384 (1), 195-209 (2021)
   PUBMED   33409656
  REMARK    GeneRIF: Testicular STAC3 regulates Leydig cell steroidogenesis
            through potentiating mitochondrial membrane potential and StAR
            processing.
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Campiglio,M., Kaplan,M.M. and Flucher,B.E.
  TITLE     STAC3 incorporation into skeletal muscle triads occurs independent
            of the dihydropyridine receptor
  JOURNAL   J Cell Physiol 233 (12), 9045-9051 (2018)
   PUBMED   30071129
  REMARK    GeneRIF: we provide evidence that endogenous STAC3 incorporates
            into triads in the absence of the DHPR in myotubes and muscle
            fibers of dysgenic mice. This finding demonstrates that STAC3
            interacts with additional triad proteins and is consistent with its
            proposed role in directly or indirectly linking the DHPR with the
            RyR1
REFERENCE   3  (bases 1 to 1829)
  AUTHORS   Polster,A., Nelson,B.R., Papadopoulos,S., Olson,E.N. and Beam,K.G.
  TITLE     Stac proteins associate with the critical domain for
            excitation-contraction coupling in the II-III loop of CaV1.1
  JOURNAL   J Gen Physiol 150 (4), 613-624 (2018)
   PUBMED   29467163
  REMARK    GeneRIF: RyR1 Ca2+ release by CaV1.1 depends on Stac3 being bound
            to critical domain residues in the II-III loop.
REFERENCE   4  (bases 1 to 1829)
  AUTHORS   Campiglio,M. and Flucher,B.E.
  TITLE     STAC3 stably interacts through its C1 domain with CaV1.1 in
            skeletal muscle triads
  JOURNAL   Sci Rep 7, 41003 (2017)
   PUBMED   28112192
  REMARK    GeneRIF: Thus, the C1 domain of STAC3 is responsible for its stable
            incorporation into the voltage-sensor (CaV1.1) of
            excitation-contraction-coupling complex, whereas the SH3 domain
            containing the Native American myopathy mutation site may be
            involved in low-affinity functional interactions in
            excitation-contraction-coupling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1829)
  AUTHORS   Polster,A., Nelson,B.R., Olson,E.N. and Beam,K.G.
  TITLE     Stac3 has a direct role in skeletal muscle-type
            excitation-contraction coupling that is disrupted by a
            myopathy-causing mutation
  JOURNAL   Proc Natl Acad Sci U S A 113 (39), 10986-10991 (2016)
   PUBMED   27621462
  REMARK    GeneRIF: Stac3 is directly involved in conformational coupling
            between CaV1.1 and RyR1.
REFERENCE   6  (bases 1 to 1829)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   7  (bases 1 to 1829)
  AUTHORS   Ge,X., Zhang,Y., Park,S., Cong,X., Gerrard,D.E. and Jiang,H.
  TITLE     Stac3 inhibits myoblast differentiation into myotubes
  JOURNAL   PLoS One 9 (4), e95926 (2014)
   PUBMED   24788338
  REMARK    GeneRIF: Stac3 may play a role in preventing precocious myoblast
            differentiation during skeletal muscle development
            Erratum:[PLoS One. 2014;9(8):e105240]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1829)
  AUTHORS   Nelson,B.R., Wu,F., Liu,Y., Anderson,D.M., McAnally,J., Lin,W.,
            Cannon,S.C., Bassel-Duby,R. and Olson,E.N.
  TITLE     Skeletal muscle-specific T-tubule protein STAC3 mediates
            voltage-induced Ca2+ release and contractility
  JOURNAL   Proc Natl Acad Sci U S A 110 (29), 11881-11886 (2013)
   PUBMED   23818578
  REMARK    GeneRIF: STAC3 mediates voltage-induced Ca2+ release and
            contractility in skeletal muscles.
REFERENCE   9  (bases 1 to 1829)
  AUTHORS   Reinholt,B.M., Ge,X., Cong,X., Gerrard,D.E. and Jiang,H.
  TITLE     Stac3 is a novel regulator of skeletal muscle development in mice
  JOURNAL   PLoS One 8 (4), e62760 (2013)
   PUBMED   23626854
  REMARK    GeneRIF: Stac3 gene plays a critical role in skeletal muscle
            development and function in mice.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1829)
  AUTHORS   Bower,N.I., de la Serrana,D.G., Cole,N.J., Hollway,G.E., Lee,H.T.,
            Assinder,S. and Johnston,I.A.
  TITLE     Stac3 is required for myotube formation and myogenic
            differentiation in vertebrate skeletal muscle
  JOURNAL   J Biol Chem 287 (52), 43936-43949 (2012)
   PUBMED   23076145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036516.1 and BC067208.1.
            
            On Jan 13, 2018 this sequence version replaced NM_177707.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1790              AK036516.1         2-1791
            1791-1829           BC067208.1         1571-1609
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..1829
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /note="SH3 and cysteine rich domain 3"
                     /db_xref="GeneID:237611"
                     /db_xref="MGI:MGI:3606571"
     exon            1..268
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            269..436
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1453
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     3"
                     /protein_id="NP_808375.1"
                     /db_xref="CCDS:CCDS24242.1"
                     /db_xref="GeneID:237611"
                     /db_xref="MGI:MGI:3606571"
                     /translation="MTEKEVVESPQPPFPGETPQSGLQRLKQLFKKGSPETAEMEPPP
                     EPQANGEAVGAGGGPIYYIYEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFC
                     DVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFRRAYSSPLYSDQQ
                     YAVSAANRNDPVFETLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQD
                     GNNAEKDKKAEKKTPDDKNKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDS
                     NEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKG
                     DEAGGYVKVYTGRKVGLFPTDFLEEI"
     exon            437..701
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            702..799
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            800..860
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            861..958
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1025
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1078
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1164
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1216
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1354
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1793
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /note="hexamer: ATTAAA"
     polyA_site      1793
                     /gene="Stac3"
                     /gene_synonym="9830125E18"
                     /note="major polyA site"
ORIGIN      
        1 acttcagctc tgccaccacg gtgagaggct ccaaggccta cctactaata ctgtctgggt
       61 agctggtgtg ggtccagaag gtaccagaaa gggggcttac ctccctgaag gaagagggct
      121 agccctcccc agcagcacca tcaaggtctc agagacccct ttccacagtg aactgactta
      181 gggagtctgg aaagtaagtc gtctcttcat tatcctttca tttcttctaa cctgagtctg
      241 ttgggcttct tcgtctctct cctcacctgc tccccttcga gggccaccct actgtgtgca
      301 gcaggactgc tggaatagaa gaacagcaga cagagattag aactcatagc ggggcccaat
      361 ctcttgtaag atgacagaaa aggaagtggt ggagtcccct cagcccccct ttccaggaga
      421 gactccgcaa agtgggctac agcgactgaa gcagttattc aagaagggct ctccagagac
      481 agctgagatg gagcctcccc cagagcccca agccaatgga gaggcggtgg gggctggggg
      541 tgggcccatc tactatatct atgaggaaga agaggaggag gaggaagagg aggaaccacc
      601 cccagaacct cctaagctcg tcaacgacaa gccccacaag ttcaaagatc acttcttcaa
      661 gaagcccaag ttctgcgatg tctgtgcccg gatgattgtg ctcaataaca agtttggact
      721 ccgctgcaag aactgcaaaa ccaacatcca tgagcattgt cagtcctacg tggagatgca
      781 gagatgcttc ggcaagatcc cacctggttt ccgtcgggcc tatagctccc cactctacag
      841 cgaccaacag tacgctgtct ctgctgccaa tcgcaatgac cccgtgtttg aaaccctgcg
      901 cgtcggggtg atcatggcaa acaaggaacg gaagaagggg caggcagata agaaaaatcc
      961 tctggcagcc atgatggagg aggagccaga gtcagccagg ccagaggagg gcaagtcaca
     1021 ggatggaaac aatgcagaaa aggacaagaa ggccgagaag aaaactcctg atgacaaaaa
     1081 caagcagcct ggcttccagc agtctcatta ctttgtggct ctctatcggt tcaaagccct
     1141 ggagaaggac gacctggatt tcccgccagg ggagaagatc acagtcattg atgactccaa
     1201 tgaggagtgg tggcggggga aaatcggaga gaaagtcgga ttcttccctc caaacttcat
     1261 cattcgggtg cgggctggag aacgtgtgca ccgcgtgacc agatcgtttg tggggaaccg
     1321 cgagattgga cagatcactc tcaagaagga ccagatcgta gtgcagaaag gagatgaagc
     1381 tggtggttac gtcaaggtct acaccggccg caaggtgggg ctgtttccca ccgacttcct
     1441 ggaggagatt taagagtact ggtgcctgct ggcgggagac acccactcct cgttctgggc
     1501 ggggcccagt gcgagctggg gagggaaggg gcaaggggag ggagtactgg atgaggaggg
     1561 tcggaaaggc ccaccagagc ataatgacgt ttctggggag ggtctggttc ccacctctct
     1621 cccctgccta gggctccgga tacctggtgc gctgagcagc ctgcaccgat taggcccaca
     1681 cttcaggttc atccaacttt caagagcttg ggggtggggg tgggggagca tctccataag
     1741 gaggggcaga actgtcaaat gtttcgaatt tattaaagtt ttaacaaaag ttaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
