LOCUS       NM_146028               3049 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus SH3 and cysteine rich domain 2 (Stac2), mRNA.
ACCESSION   NM_146028
VERSION     NM_146028.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Zhao,X., Lin,S., Ren,H., Sun,S., Zheng,L., Chen,L.F. and Wang,Z.
  TITLE     The histone methyltransferase ASH1L protects against bone loss by
            inhibiting osteoclastogenesis
  JOURNAL   Cell Death Differ 31 (5), 605-617 (2024)
   PUBMED   38431690
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Jeong,E., Choi,H.K., Park,J.H. and Lee,S.Y.
  TITLE     STAC2 negatively regulates osteoclast formation by targeting the
            RANK signaling complex
  JOURNAL   Cell Death Differ 25 (8), 1364-1374 (2018)
   PUBMED   29348675
  REMARK    GeneRIF: STAC2 physically interacts with RANK and inhibits the
            formation of the RANK signaling complex, which contains
            Grb-2-associated binder 2 (Gab2) and phospholipase Cgamma2
            (PLCgamma2), thus leading to the suppression of RANK-mediated
            NF-kappaB and MAPK activation.
REFERENCE   6  (bases 1 to 3049)
  AUTHORS   Polster,A., Nelson,B.R., Papadopoulos,S., Olson,E.N. and Beam,K.G.
  TITLE     Stac proteins associate with the critical domain for
            excitation-contraction coupling in the II-III loop of CaV1.1
  JOURNAL   J Gen Physiol 150 (4), 613-624 (2018)
   PUBMED   29467163
REFERENCE   7  (bases 1 to 3049)
  AUTHORS   Caubit,X., Gubellini,P., Andrieux,J., Roubertoux,P.L., Metwaly,M.,
            Jacq,B., Fatmi,A., Had-Aissouni,L., Kwan,K.Y., Salin,P.,
            Carlier,M., Lieden,A., Rudd,E., Shinawi,M., Vincent-Delorme,C.,
            Cuisset,J.M., Lemaitre,M.P., Abderrehamane,F., Duban,B.,
            Lemaitre,J.F., Woolf,A.S., Bockenhauer,D., Severac,D., Dubois,E.,
            Zhu,Y., Sestan,N., Garratt,A.N., Lydia Kerkerian-Le,Goff. and
            Fasano,L.
  TITLE     TSHZ3 deletion causes an autism syndrome and defects in cortical
            projection neurons
  JOURNAL   Nat Genet 48 (11), 1359-1369 (2016)
   PUBMED   27668656
REFERENCE   8  (bases 1 to 3049)
  AUTHORS   Nelson,B.R., Wu,F., Liu,Y., Anderson,D.M., McAnally,J., Lin,W.,
            Cannon,S.C., Bassel-Duby,R. and Olson,E.N.
  TITLE     Skeletal muscle-specific T-tubule protein STAC3 mediates
            voltage-induced Ca2+ release and contractility
  JOURNAL   Proc Natl Acad Sci U S A 110 (29), 11881-11886 (2013)
   PUBMED   23818578
REFERENCE   9  (bases 1 to 3049)
  AUTHORS   Legha,W., Gaillard,S., Gascon,E., Malapert,P., Hocine,M., Alonso,S.
            and Moqrich,A.
  TITLE     stac1 and stac2 genes define discrete and distinct subsets of
            dorsal root ganglia neurons
  JOURNAL   Gene Expr Patterns 10 (7-8), 368-375 (2010)
   PUBMED   20736085
  REMARK    GeneRIF: found STAC1 and STAC2 expressed in mutually exclusive
            fashion in adult DRG neurons; STAC1 marks peptidergic nociceptive
            neurons; STAC2 is expressed in subset of nonpeptidergic
            nociceptors, all trkB+ neurons and a subpopulation of
            proprioceptive neurons
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL591209.17.
            
            On May 1, 2007 this sequence version replaced NM_146028.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078132.1, AK079357.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               AL591209.17        133614-134183       c
            571-877             AL591209.17        124201-124507       c
            878-975             AL591209.17        123478-123575       c
            976-1066            AL591209.17        123250-123340       c
            1067-1179           AL591209.17        122188-122300       c
            1180-1252           AL591209.17        122025-122097       c
            1253-1314           AL591209.17        121860-121921       c
            1315-1412           AL591209.17        121143-121240       c
            1413-1464           AL591209.17        120819-120870       c
            1465-1602           AL591209.17        120340-120477       c
            1603-3049           AL591209.17        117345-118791       c
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.58 cM"
     gene            1..3049
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="SH3 and cysteine rich domain 2"
                     /db_xref="GeneID:217154"
                     /db_xref="MGI:MGI:2144518"
     exon            1..570
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..1707
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /note="SRC homology 3 and cysteine-rich domain-containing
                     protein 2"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     2"
                     /protein_id="NP_666140.1"
                     /db_xref="CCDS:CCDS25338.1"
                     /db_xref="GeneID:217154"
                     /db_xref="MGI:MGI:2144518"
                     /translation="MTEMSEKENEPDDAATHTPPGTVSTLQETKLQRFKRSLSLKTIL
                     RSKSVENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPASTDRGLPTPTPSPCPVPRPL
                     APLKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQ
                     CPGKTSTSFRRNFSSPLLVHAPPPACAMNKESPPTGTSGKVDPVYETLRYGTSLALMN
                     RSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSVFTAPAESEGSGPEEKSPG
                     QQPPKLPLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDR
                     VGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVSRSKDSDGFIRVS
                     SGKKRGLVPADSLAEI"
     exon            571..877
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..975
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1066
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1179
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1252
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1314
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1412
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1464
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1602
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3049
                     /gene="Stac2"
                     /gene_synonym="24b2; 24b2/STAC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgacctc ctaaatcaaa gttgggaggc taggactggg cggaggggcc gccgggtgca
       61 aggctggggc cggcgcgggg agggggaggg agatgggggg cgggcgcaga ggacggcgga
      121 gccggccgga ctcggacagc tcggtcgttc cctggctttg cacatccgcg catccctact
      181 tccctcctcc tcccgcggag cgcagcatcc tctgcagacc cttggtcctc acaccccggg
      241 tcgtccagct tccgcggctc ggggtaattg cctccctctc ccctgccaca ccgacaactt
      301 tctcccctgg tgcctggggt tagggggctg ctttgcctgg gagggtttct cctggggtca
      361 ctgaagagct gcccctggag aaaggcttga gagtcccaaa gagacgcccg ccactcacag
      421 cctgacccca gcgggcctgc cgtcgggtct ccgcaccctc tcttccttta taccccaacc
      481 atgaccgaaa tgagcgagaa ggagaatgaa ccggatgacg cggccaccca taccccccca
      541 gggaccgtct ccaccctcca agaaaccaag ctccagcgat ttaagcgctc cctctccctc
      601 aaaaccatcc ttcgaagtaa gagcgtagag aacttcttcc tccgctcggg ctctgagctc
      661 aagtgcccaa cagaggtgct gctgacaccg ccaaccccac tgcctccccc ttctccacca
      721 cctgcatcca cagacagggg tctacccacc ccaacaccct ccccgtgccc agtccctcgc
      781 cccttggcac cgctcaaacc agtgaggctg cacagtttcc aggaacatgt cttcaagaga
      841 gccagcccgt gtgaactgtg ccaccagctc attgtgggaa actccaaaca gggcttgcga
      901 tgtaagactt gcaaagtcag cgttcacctc tggtgctccg aggagatctc ccaccagcaa
      961 tgcccgggca agacatccac atcttttcga cgcaacttca gctccccact cctggtgcat
     1021 gcgccaccac cagcctgtgc catgaacaag gagtccccac ctactgggac cagcgggaag
     1081 gtggacccag tttatgagac gctgcgctat ggcacctccc tggcactgat gaaccgttcc
     1141 agcttcagca gcacatctga gtcccccaca cggagcctga gtgagcgtga cgagctaaca
     1201 gaagacgggg aaggcagcat ccgcagctca gaagaggggc ctggggacag tgtattcaca
     1261 gctccagcag aaagtgaagg ctccggacca gaggagaaga gccctggaca gcagccccca
     1321 aagctgcccc tgcggaagga cgtggggccc atgtactcct acgtcgccct ctacaagttc
     1381 ctgcctcagg agaacaatga cctggctctg cagcctggag atcggatcat gctggtggat
     1441 gactctaacg aagactggtg gaagggcaag attggcgacc gagttggctt cttcccagcc
     1501 aatttcgtgc agcgggtgag gccaggagag aatgtttggc gatgctgtca gcctttctct
     1561 ggaaacaagg agcagggtta catgagcctc aaggagaacc agatctgcgt aggcgtgagc
     1621 agaagcaagg atagcgatgg cttcatccgc gtcagcagtg gcaagaagcg gggtttggtg
     1681 ccagccgact ccttggcaga gatctgacag aaaccgagag aacccagatg ctacccctgc
     1741 ccatgcctgg ctcttgcttc tggcctgaga aggaagcggg catcctggcc acacccttcc
     1801 tctcccagtc tctctcctaa gcatcacccg cccccactta ggagccttct gcactgagga
     1861 aggtttattt cttggttggg gtatcctgaa tggggcttgg gaaagggagt caaaagtggg
     1921 aagaaacgag gaagttacag gtaggaccac ccggagccca agcaccacct agtcgggttg
     1981 ccatagtgag gcccacccta gggagtcgtc tgctgtcttc cagagactac ccgctcatac
     2041 tgccttgcat gcctgactcc tctctgccca cagcctttgc ttgggtctgt gtatccaccc
     2101 tctgcaagtg gggccttgag agaggacctg ttggtgtccc ttagccctcc cctctggctt
     2161 gagaagacgc tgaggactat gggagagccc taagttaacc acctgtcacc ccttcaactc
     2221 tcaggaaagt tcaggaatct ttccaattac ttgaaacctg ggcgacagag cagggtcagg
     2281 actgaggtct gcaagggatt gtaacacgta ggagtctgtt ccttgaaggc agtcctcaca
     2341 gaacagtctc attctccttt gtctactaga aatcggtagc caagagcagc ctggacaaag
     2401 acccaggtgg agaacaagac gctggccctt gcttggtcaa aacatttcac tgttaggact
     2461 ccagaaatcc ctaccaccag aagcagacag ctaggggagt ctgaggttgt gaggtctggt
     2521 ttctctaaaa gccctgtcct cagatggacc aaacttacct tcttaccgtt tgggctctat
     2581 agggcccatc cctgggaagg ataccttggc agattgagga aggctatgga aagttctttt
     2641 ggccaccatc aaatgatgct ctaggagccc ttagccctcc tggcaggaca aaggacctct
     2701 tcctcaagag gctgcttctt ctttttcctg gtgccagcac ctgcccctcc ttccaagctc
     2761 agatcctcct tttaagccct gatcctgtca gccaatgcca cccccctcag ttctgggcac
     2821 agtcttgcct tccatacaac gagaggacac tgattctcta cccaacacac cttgccccat
     2881 tttcccccta aaaggggtct aaagccacac tgccctgttt gctgccatga gggccccccc
     2941 cagcaaaatc cccggggcgg gcccaatgcc cactgtacat gaggctgcat gacgggtctg
     3001 cgggggcgtt gctgagcccc caggcccata attaaatgtt tcttgtctc
//
