LOCUS       NM_016853               2662 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus src homology three (SH3) and cysteine rich domain
            (Stac), transcript variant 1, mRNA.
ACCESSION   NM_016853
VERSION     NM_016853.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Li H, Jones KL, Hooper JE and Williams T.
  TITLE     The molecular anatomy of mammalian upper lip and primary palate
            fusion at single cell resolution
  JOURNAL   Development 146 (12) (2019)
   PUBMED   31118233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Polster A, Nelson BR, Papadopoulos S, Olson EN and Beam KG.
  TITLE     Stac proteins associate with the critical domain for
            excitation-contraction coupling in the II-III loop of CaV1.1
  JOURNAL   J Gen Physiol 150 (4), 613-624 (2018)
   PUBMED   29467163
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Rzhepetskyy Y, Lazniewska J, Proft J, Campiglio M, Flucher BE and
            Weiss N.
  TITLE     A Cav3.2/Stac1 molecular complex controls T-type channel expression
            at the plasma membrane
  JOURNAL   Channels (Austin) 10 (5), 346-354 (2016)
   PUBMED   27149520
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Nelson BR, Wu F, Liu Y, Anderson DM, McAnally J, Lin W, Cannon SC,
            Bassel-Duby R and Olson EN.
  TITLE     Skeletal muscle-specific T-tubule protein STAC3 mediates
            voltage-induced Ca2+ release and contractility
  JOURNAL   Proc Natl Acad Sci U S A 110 (29), 11881-11886 (2013)
   PUBMED   23818578
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   Tripathi P, Wang Y, Casey AM and Chen F.
  TITLE     Absence of canonical Smad signaling in ureteral and bladder
            mesenchyme causes ureteropelvic junction obstruction
  JOURNAL   J Am Soc Nephrol 23 (4), 618-628 (2012)
   PUBMED   22282597
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Legha W, Gaillard S, Gascon E, Malapert P, Hocine M, Alonso S and
            Moqrich A.
  TITLE     stac1 and stac2 genes define discrete and distinct subsets of
            dorsal root ganglia neurons
  JOURNAL   Gene Expr Patterns 10 (7-8), 368-375 (2010)
   PUBMED   20736085
  REMARK    GeneRIF: found STAC1 and STAC2 expressed in mutually exclusive
            fashion in adult DRG neurons; STAC1 marks peptidergic nociceptive
            neurons; STAC2 is expressed in subset of nonpeptidergic
            nociceptors, all trkB+ neurons and a subpopulation of
            proprioceptive neurons
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Fujimoto M, Oshima K, Shinkawa T, Wang BB, Inouye S, Hayashida N,
            Takii R and Nakai A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Mitchem KL, Hibbard E, Beyer LA, Bosom K, Dootz GA, Dolan DF,
            Johnson KR, Raphael Y and Kohrman DC.
  TITLE     Mutation of the novel gene Tmie results in sensory cell defects in
            the inner ear of spinner, a mouse model of human hearing loss DFNB6
  JOURNAL   Hum Mol Genet 11 (16), 1887-1898 (2002)
   PUBMED   12140191
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Kawai J, Suzuki H, Hara A, Hirose K and Watanabe S.
  TITLE     Human and mouse chromosomal mapping of Stac, a neuron-specific
            protein with an SH3 domain
  JOURNAL   Genomics 47 (1), 140-142 (1998)
   PUBMED   9465308
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Suzuki H, Kawai J, Taga C, Yaoi T, Hara A, Hirose K, Hayashizaki Y
            and Watanabe S.
  TITLE     Stac, a novel neuron-specific protein with cysteine-rich and SH3
            domains
  JOURNAL   Biochem Biophys Res Commun 229 (3), 902-909 (1996)
   PUBMED   8954993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ174720.1, AK143440.1, AK134777.1 and BQ174853.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_016853.4.
            
            On May 13, 2016 this sequence version replaced NM_016853.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143440.1, D86639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               CJ174720.1         1-100
            101-1537            AK143440.1         2-1438
            1538-2027           AK134777.1         1138-1627
            2028-2643           AK134777.1         1629-2244
            2644-2662           BQ174853.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 61.81 cM"
     gene            1..2662
                     /gene="Stac"
                     /note="src homology three (SH3) and cysteine rich domain"
                     /db_xref="GeneID:20840"
                     /db_xref="MGI:MGI:1201400"
     exon            1..351
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1452
                     /gene="Stac"
                     /note="isoform 1 is encoded by transcript variant 1; SH3
                     and cysteine-rich domain-containing protein; SRC homology
                     3 and cysteine-rich domain-containing protein"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     isoform 1"
                     /protein_id="NP_058549.1"
                     /db_xref="CCDS:CCDS23586.1"
                     /db_xref="GeneID:20840"
                     /db_xref="MGI:MGI:1201400"
                     /translation="MIPPSGAREDSGDGLTGEATGTEQPPSPASTSSLESKLQKLKRS
                     LSFKTKSLRSKSADNFFPRTNSDVKPQADLLAKASPGPSPIAIPGSPASMPTKAGLHP
                     GSNSKLHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLRCGACKMSIHHKCADGLAPQRC
                     MGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYEALRFGTSLAQRTKKGG
                     SGSGSDSPPRTSTSELVDVPEEADGPGDGSDMRTRSNSVFTYPENGMDDFRDQMKTTN
                     HQGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGF
                     FPANFVQRVEEHEKIYRCVRTFIGCKDQGQITLKENQICVTSEEEQDGFIRVLSGKKR
                     GLVPLDVLVDV"
     exon            352..631
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            632..732
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            733..814
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            815..930
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1009
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1074
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1163
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1215
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1353
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..2644
                     /gene="Stac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgctgcg gtgggcggca gtcacgacta gaggcgcgcg atctccagtg aggtggctgc
       61 gggcgctgcg cggggcgggg cggaggccgg ggaggtgggc aggacctggt caggcgaggc
      121 cccagggcac acgccgccgc ctggcgcgat ggacatcccg gggacccggc ggcactgagc
      181 gatcaagcac gagcctgcgg ttcccccaga agcccaacac agttcccgcg gccggccacg
      241 atgattcctc caagtggcgc ccgcgaggac agcggagacg gactgaccgg ggaggcaacg
      301 ggcacagagc agccgccctc tcctgcgtcc accagcagcc tggaatccaa gctccagaaa
      361 ctaaaacggt cactttcttt caagaccaag agcttgcgga gcaaaagtgc tgacaacttc
      421 ttcccaagaa ccaacagtga tgtgaaaccg caagcagacc tgctggccaa ggccagccca
      481 ggccccagcc caatagccat ccctggaagc ccagcgtcca tgcccaccaa ggctggcctg
      541 caccccggca gcaacagcaa gctccacgcc tttcaggagc atgtctttaa gaagcccacc
      601 ttctgtgatg tctgcaacca catgatcgtg ggaacacatg ctaagcacgg actgcgctgc
      661 ggagcctgta agatgagcat ccaccacaag tgtgcagatg gcctggcgcc ccagcggtgc
      721 atgggcaagt tgccaaaggg atttcggcgt tactacagct cccccttgct cattcacgaa
      781 cagtttggat gcattaaaga agttatgccc attgcgtgtg gcaataaagt ggaccccgtg
      841 tatgaggccc tccggttcgg cacgtccctg gcccagagaa cgaagaaggg cggctcaggc
      901 agtggttctg actcaccgcc cagaacctcg acttcagagc ttgtagacgt ccctgaagag
      961 gccgatgggc caggagatgg atctgacatg aggacacgga gcaacagtgt gtttacatat
     1021 ccagaaaacg gtatggatga cttcagagat caaatgaaga ccacaaacca ccagggacct
     1081 ctttccaaag acccattaca gatgaacacc tacgttgcct tgtacagatt tataccacag
     1141 gagaatgaag acttggaaat gaggccagga gacatgatca ctctcctaga agactccaat
     1201 gaagactggt ggaaaggaaa gattcaggac agggttggtt tctttccagc caactttgtt
     1261 cagagagtag aagagcatga gaagatttat aggtgtgttc gaaccttcat tggctgcaag
     1321 gaccaggggc agataacact gaaagagaac cagatatgcg tgacctctga ggaagaacag
     1381 gacggcttca tcagagtcct cagtgggaag aagagaggcc tcgtcccact ggatgtactg
     1441 gtagacgtgt gactgtagca gtcccttccc aagcaggagg ccagcgctgc tgatctctct
     1501 gtgtccaccc agaggagcag ctgcacggat gggtgcccag aaaacaggga gacttgaaga
     1561 gctgagactg tgctaggaat ctggaagcag gcccactgca cagcacatca aggcgtcctg
     1621 agagcagcat cccagcgctg aggggagccg ggggcagtaa gtgggctgta gctaaggctg
     1681 cccaggactc agctcccttc ctgcccacct gtgcaaggct ggagtctgct ccaggtcatg
     1741 gtgtggtcct agtgagaagt ttggagctgc cgagtagcca agtttctctg attctggata
     1801 actgttccca gggctggcca atcagcctca gcatgattcc tgcagagaat caagaaggtc
     1861 aaccttccgg ctcccaacac cccagggttc actccagctc ctgctcagtt tgtgtctcag
     1921 tttggctggc aggattgttc tttctttctc ttcagcagca catcctaggc agggccgaac
     1981 cagcatggta ccaagtgcaa agatccgact tacctacaga tcgagaacga gggcgtcctt
     2041 gctattccag tggctccgaa gtggcagggc aaggtccaag gcacagagtc cagcagcagc
     2101 aaggagaagc gggagtgggg acaaggaagg agcccttatg tattgggatc ggacagccct
     2161 ttcagttggg gtgggttttt ttcccaaagc aggtgaggct gggaatggga agtagggaag
     2221 agtctccatt ttcattccat cccctcttta tcaggagcac cacttcttcc tgtggaggat
     2281 gatccaggga caggggagca ccactgagaa aaacatctta gaataaatgt agccaactta
     2341 gaatccattc ttctctaggg caacgttttc agctccagca gctgtgaagt ggaacggacc
     2401 gggtcatgct tcatctctgt gcaaacagag gaagctgggg cttagctcac accacctggg
     2461 gatattgctc tctacctgta ccgatgttta caagaacata ccacactgcg atgccttcct
     2521 cccaagcccc gtcccagcat tcagacctgc ttcctagcag tcactgacat gtttaaatgt
     2581 gactttggga ttattgttgc ttcaatttat tttgccactg agcaataaaa tcattagaac
     2641 catcaaaaaa aaaaaaaaaa aa
//
