LOCUS       NM_145838               3489 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 6 (St8sia6), mRNA.
ACCESSION   NM_145838
VERSION     NM_145838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3489)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3489)
  AUTHORS   Friedman,D.J., Kizerwetter,M., Belmonte,P., Rajcula,M.,
            Theodore,K., Kim Lee,H.S., Shapiro,M.J., Dong,H. and Shapiro,V.S.
  TITLE     Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice
  JOURNAL   J Immunol 208 (8), 1845-1850 (2022)
   PUBMED   35379746
  REMARK    GeneRIF: Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6
            Knockout Mice.
REFERENCE   3  (bases 1 to 3489)
  AUTHORS   Belmonte,P.J., Shapiro,M.J., Rajcula,M.J., McCue,S.A. and
            Shapiro,V.S.
  TITLE     Cutting Edge: ST8Sia6-Generated alpha-2,8-Disialic Acids Mitigate
            Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes
  JOURNAL   J Immunol 204 (12), 3071-3076 (2020)
   PUBMED   32350083
REFERENCE   4  (bases 1 to 3489)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3489)
  AUTHORS   Garaffo,G., Provero,P., Molineris,I., Pinciroli,P., Peano,C.,
            Battaglia,C., Tomaiuolo,D., Etzion,T., Gothilf,Y., Santoro,M. and
            Merlo,G.R.
  TITLE     Profiling, Bioinformatic, and Functional Data on the Developing
            Olfactory/GnRH System Reveal Cellular and Molecular Pathways
            Essential for This Process and Potentially Relevant for the
            Kallmann Syndrome
  JOURNAL   Front Endocrinol (Lausanne) 4, 203 (2013)
   PUBMED   24427155
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3489)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   7  (bases 1 to 3489)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3489)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3489)
  AUTHORS   Teintenier-Lelievre,M., Julien,S., Juliant,S., Guerardel,Y.,
            Duonor-Cerutti,M., Delannoy,P. and Harduin-Lepers,A.
  TITLE     Molecular cloning and expression of a human hST8Sia VI
            (alpha2,8-sialyltransferase) responsible for the synthesis of the
            diSia motif on O-glycosylproteins
  JOURNAL   Biochem J 392 (Pt 3), 665-674 (2005)
   PUBMED   16120058
  REMARK    Erratum:[Biochem J. 2007 Feb 1;401(3):763]
REFERENCE   10 (bases 1 to 3489)
  AUTHORS   Takashima,S., Ishida,H.K., Inazu,T., Ando,T., Ishida,H., Kiso,M.,
            Tsuji,S. and Tsujimoto,M.
  TITLE     Molecular cloning and expression of a sixth type of alpha
            2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans
  JOURNAL   J Biol Chem 277 (27), 24030-24038 (2002)
   PUBMED   11980897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928918.8 and AL772303.11.
            
            On Sep 28, 2022 this sequence version replaced NM_145838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB059554.1, AK156557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AL928918.8         24810-25314         c
            506-604             AL928918.8         24220-24318         c
            605-694             AL772303.11        196647-196736       c
            695-781             AL772303.11        170032-170118       c
            782-926             AL772303.11        145687-145831       c
            927-1039            AL772303.11        141989-142101       c
            1040-1132           AL772303.11        138624-138716       c
            1133-3489           AL772303.11        128138-130494       c
FEATURES             Location/Qualifiers
     source          1..3489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 10.09 cM"
     gene            1..3489
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 6"
                     /db_xref="GeneID:241230"
                     /db_xref="MGI:MGI:2386797"
     exon            1..505
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1601
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /note="sialyltransferase 8 (alpha-2, 8-sialyltransferase)
                     F; SIAT8-F; sialyltransferase 8F; sialytransferase St8Sia
                     VI; ST8Sia VI; alpha2,8-sialyltransferase VI;
                     sialyltransferase St8Sia VI"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8F"
                     /protein_id="NP_665837.1"
                     /db_xref="CCDS:CCDS15697.1"
                     /db_xref="GeneID:241230"
                     /db_xref="MGI:MGI:2386797"
                     /translation="MRSGGTLFALIGSLMLLLLLRMLWCPADAPARSRLLMEGSREDT
                     SGTSAALKTLWSPTTPVPRTRNSTYLDEKTTQITEKCKDLQYSLNSLSNKTRRYSEDD
                     YLQTITNIQRCPWNRQAEEYDNFRAKLASCCDAIQDFVVSQNNTPVGTNMSYEVESKK
                     HIPIRENIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGAEIDKSDFVFRCNLPPI
                     TGSASKDVGSKTNLVTVNPSIITLKYQNLKEKKAQFLEDISTYGDAFLLLPAFSYRAN
                     TGISFKVYQTLKESKMRQKVLFFHPRYLRHLALFWRTKGVTAYRLSTGLMIASVAVEL
                     CENVKLYGFWPFSKTIEDTPLSHHYYDNMLPKHGFHQMPKEYSQMLQLHMRGILKLQF
                     SKCETA"
     exon            506..604
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            605..694
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            695..781
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            782..926
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1039
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1132
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..3489
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /note="hexamer: CATAAA"
     polyA_site      2319
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /note="major polyA site"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="St8sia6"
                     /gene_synonym="1700007J08Rik; Siat8f; ST8SiaVI"
ORIGIN      
        1 gtggcggcgg cggcagcagt aggcagaggc agcggcggct gcagcgacca gagcccgcag
       61 cggctccgag cgcctccggg aggacaagcg acgagcttgg agaatcgtca tccgctagct
      121 gtccgccagc ttcgccagct tcggcggccg gggctggctt ggaagaagcg agcgagcccg
      181 aacgcggctt cttcggctcg gtgcccagca acactgttgc aggctgggct ctgggcagcc
      241 cccagagtgc gggcccgcgc caccgccttt gaacgctggg ggtgtgcgtg gcagcggccg
      301 cggtggcggc ggcggcgaag gcggtgaccg gagcggcgag tcggtgccgc ccgggctgcg
      361 cttcgccccg gcagctttgg cggcgaggac gcccgtggct caggatgaga tcggggggca
      421 cgctgttcgc cctcataggc agcctgatgc tgctgctcct cctgcgtatg ctctggtgcc
      481 cagccgacgc gcctgcccgc tccaggctgt tgatggaggg aagcagagag gacaccagtg
      541 gtacctcagc tgcactgaag acactctgga gcccgacaac cccggtacca cgcaccagga
      601 acagcacata tctggatgag aagacaaccc aaataacaga gaaatgcaaa gatctgcaat
      661 atagcttgaa ctctttatct aacaaaacga gacggtactc tgaggatgac tacctccaga
      721 ccatcacaaa catacagaga tgcccatgga accggcaagc agaagaatat gacaatttta
      781 gagcaaaact ggcttcctgt tgcgatgcca ttcaagactt cgtggtttcc cagaacaaca
      841 ctccagtggg gactaacatg agctacgagg tggaaagcaa gaaacacatc cccattcgag
      901 agaacatttt ccacatgttt ccagtgtcgc agccttttgt ggactatccc tataaccagt
      961 gtgcagtggt tggtaatggg ggaattctca acaagtctct ctgcggagca gaaattgata
     1021 aatctgactt cgtcttcagg tgtaacctcc ccccaatcac agggagcgct agtaaagatg
     1081 ttggaagcaa aacaaatctt gtgactgtca atcccagcat tataaccctg aagtaccaga
     1141 atttgaagga gaagaaagca cagtttttgg aggacatctc cacctatgga gatgcattcc
     1201 tcctcctgcc agcattttcc tatcgggcca acacaggcat ctcttttaaa gtctaccaaa
     1261 cactcaaaga gtcaaaaatg aggcaaaagg ttctcttctt ccatcccagg tacctgagac
     1321 acctcgctct tttctggaga actaaagggg tgactgcata ccgcttgtcc acaggcttga
     1381 tgattgcaag tgtcgctgtg gaactgtgtg aaaacgtgaa gctctacgga ttctggcctt
     1441 tctctaagac tatcgaagac accccactca gtcaccacta ctatgataac atgttaccta
     1501 agcatggttt ccaccagatg cctaaagaat acagccaaat gctccagctc catatgagag
     1561 gaatcctcaa actgcaattc agcaaatgtg aaacggctta acgtttctta gaaggagaat
     1621 aatttcagga ggtggagtgg atgtgtcaca gcatctccaa aaagccaata gaagaaggca
     1681 cagagaaagc atgaattaca aaggcgctct cccacttgtc tagaccaaag ccacccgccc
     1741 ccactcactt tgcagcctcc acgagtcact cattctcacc ttcaacgttc tttctctgag
     1801 aatagagacc aaaacatcag acttggataa gtaaaatgag ataatttttc aaatcatcat
     1861 agaatttgat ttgagccagg gtctctcaga atgcttcctt gttcctatcc atgatagcca
     1921 ttcccacctt tatcagagtg gtaatgaaac tgtgcaattg tgccaaagac cctttctgaa
     1981 gagaatgtct gaatcatgcg ccgagttttt acacacagct cttcctttat aaataaatcc
     2041 ttcccattct ccctcctagt agagtacaga aacaaaatac ccttgatgat tcaggaagaa
     2101 aagtcttttt tacttagcaa tgtgcctgct tctgattcag ttcgcttgtg acattaagct
     2161 gggttggggt tttggttgga tttggggcgt ttcttcactt cttttgtcta tattttcctt
     2221 acctttatca gtttgtattc gagcttcctg ctttgggatt ctgcaattct ctctcccact
     2281 gacaggatca actcaatgac ataaagtagt tcaaacatcc attgcttctc acatgtttta
     2341 tccataaagt tactcatctg attttattta aaatagtgaa catctacttg atatcagacc
     2401 cgaggaccat cctccattgg agaatatgaa gatattgtca ctggcagaaa agcaggtgtg
     2461 tgccattaat tgataagata ccacaagcat catcatgcca gttatgaaca cagtgctgaa
     2521 aggatcatag acaggggtgg ttaaatctga tcccagtaga ataaacttca gtgtacctat
     2581 ttcagggaag agttaatttc acaattaaaa ctagtaaatg aaccaattct taggcacatt
     2641 aagtggattc tgagtaaaag aaagggaaca gcaggagaaa gctgttcgct tggttctgat
     2701 tacccaaatg agcatgctgg aaggaggttg tgaggctacg ctaaaacctc tgcgtaggga
     2761 gagagtacag tgcatgagtg tggcggcttt tgtccacact cgtgaagggt gagtaattca
     2821 gagccaatca catcacaagg atggacacac ctaactcatc acttcagggg gagatgaatg
     2881 ctttcatgag aaattacact cataagctaa gcatcagttt tgagtaaaat ttgagtagat
     2941 gttaaatatg aacattttat acctcttact aatgtcccac cgacaccttt taatgtaagc
     3001 acatttattt attaagttac ttgacattaa atgcttatgt ctgtatattc tgttcatcca
     3061 tcgattttcc caaaaagtaa gagcatagga gatgaggcct acatgccaag aaaactataa
     3121 attttactct ttaattctta cttgagccag cttgttgttt atcaagtgct tttttgaaga
     3181 gacagcaccc tgtgaattct tcattctgat acagtgtcac cttgtattta acatttgtaa
     3241 tgttgtttca agtttacatc tctttcattc ttttatagca aatcaaacgt attagcttca
     3301 gaaatttatc agaagttcat atataaatat tttgcaaagg gtaaaaggct tttttgttaa
     3361 ataaaataaa atttattatt ttcttctgat gaatagaggc tcttttatgc tgctgctaat
     3421 gaacctaatt agctttaaat tatctcctag caacattggt cacgtttcaa tcatgctatt
     3481 agcaaaaaa
//
