LOCUS       NM_013666               2115 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 5 (St8sia5), transcript variant 1,
            mRNA.
ACCESSION   NM_013666
VERSION     NM_013666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Kwak,D.H., Jin,J.W., Ryu,J.S., Ko,K., Lee,S.D., Lee,J.W., Kim,J.S.,
            Jung,K.Y., Ko,K., Ma,J.Y., Hwang,K.A., Chang,K.T. and Choo,Y.K.
  TITLE     Regulatory roles of ganglioside GQ1b in neuronal cell
            differentiation of mouse embryonic stem cells
  JOURNAL   BMB Rep 44 (12), 799-804 (2011)
   PUBMED   22189683
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Kono,M., Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Molecular cloning and expression of a fifth type of
            alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is
            similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and
            GT3
  JOURNAL   J Biol Chem 271 (46), 29366-29371 (1996)
   PUBMED   8910600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157991.5.
            
            On Oct 25, 2022 this sequence version replaced NM_013666.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98014.1, SRR17784644.753208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AC157991.5         76497-76889         c
            394-501             AC157991.5         50959-51066         c
            502-594             AC157991.5         29837-29929         c
            595-681             AC157991.5         20532-20618         c
            682-826             AC157991.5         16511-16655         c
            827-939             AC157991.5         14173-14285         c
            940-1032            AC157991.5         9613-9705           c
            1033-2115           AC157991.5         7274-8356           c
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.13 cM"
     gene            1..2115
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 5"
                     /db_xref="GeneID:225742"
                     /db_xref="MGI:MGI:109243"
     exon            1..393
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1501
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /note="isoform long is encoded by transcript variant 1;
                     sialyltransferase 8 (alpha-2, 8-sialyltransferase) E;
                     alpha-2,8-sialyltransferase 8E; SIAT8-E; sialytransferase
                     St8Sia V; sialyltransferase St8Sia V"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8E isoform long"
                     /protein_id="NP_038694.2"
                     /db_xref="CCDS:CCDS50325.1"
                     /db_xref="GeneID:225742"
                     /db_xref="MGI:MGI:109243"
                     /translation="MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKR
                     GFQFGWQRGDQQANWTGLFNDSDSPTEQNITGSSSRYFEFYKEPLEFNSTRCLELRQE
                     ILEVKVLSMVKQSELFERWKSLQICKWAMDTAEASLFKSTLSRCCNAPSFLFTTQKNT
                     PVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEI
                     NSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYE
                     NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARR
                     ISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFT
                     FLRMHSRGILRVHTGTCNCC"
     exon            394..501
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            502..594
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            595..681
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            682..826
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            827..939
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1032
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2115
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /note="major polyA site"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
                     /note="hexamer: TATAAA"
     polyA_site      2115
                     /gene="St8sia5"
                     /gene_synonym="Siat8e; ST8SiaV"
ORIGIN      
        1 acgggcagat ccgcggctgc gggacaccgg ctcccagaag ccgcagcacg agagggcagg
       61 cctggggctc agaggatctc cacgcggccg gccctgtcct tttgctgccg cctccgggat
      121 tgcgcccgcg ggaaactttg ccccgccaag tcctctgccc tcttgaccac gcagttctcc
      181 taagggcccc cggggccccc gcatagcgcg cgtgattgct gccccgcccc gcacagtgcg
      241 tccgcggcgc cgggccgcca ggatgcgcta cgcagacccc tccgccaaca gagatttgtt
      301 ggggaatcga actttgctct ttatcttcat ctgcgccttt gccttggtga ccttgcttca
      361 gcagatcctg tacagcaaga gctacatcaa aagaggcttc cagtttggtt ggcagagggg
      421 cgaccaacag gccaattgga ctgggctctt taatgacagc gacagcccaa cagagcagaa
      481 catcactggc tccagctcca ggtacttcga gttttacaag gagcctttag agtttaactc
      541 cacgagatgc ctggagctga ggcaggagat cctggaggtg aaggtgctgt ccatggtgaa
      601 gcagtctgaa ctcttcgaaa ggtggaagag tctccagata tgcaaatggg caatggacac
      661 cgcggaagcc agcctcttca agtccacctt gtccaggtgc tgcaatgccc ccagctttct
      721 cttcaccacc cagaagaaca ccccggtgga gacgaatctc aggtatgagg tggaatccag
      781 cggcttatat cacatcgacc aggagatctt caaaatgttt cccaaggaaa tgccctacta
      841 ccgctctcag tttaagaagt gtgctgtggt gggcaatggc ggcatcttga agaacagcgg
      901 ctgcgggaag gagatcaaca gtgctgactt tgtcttccgg tgcaacctgc cccccatctc
      961 agggatatat accacagatg tgggagagaa gacagatgta gtcaccgtga atcccagcat
     1021 cataattgac aggttccaca agttggagaa gtggcggcgg cctttcttca gcgtgctgca
     1081 gaggtacgag aacgcctcag tgctgctgcc agcgttctac aacgtccgca acaccctggt
     1141 atccttccga gtcaaataca tgctggacga cttccagtcg cggcagccgg tctacttctt
     1201 ccacccgcag tacctgagca gtgtgtcgcg ctactggctc agcctgggtg tgcgcgcgcg
     1261 gcgtatcagc accggcctca tcctggtcac cgcggccctg gagctctgcg aggaggtgca
     1321 cctgttcggt ttctgggcct tccccatgaa cccctccggc ttcttcatca cgcaccatta
     1381 ctatgacaac gtcaagccca agccgggttt ccatgctatg ccctcggaga tcttcacctt
     1441 cctgcgcatg cacagccgcg gcatccttcg cgtgcacaca ggcacctgca attgctgctg
     1501 aaaaccaggc ctgccatggg tgtctcgact cctgtctttc tccctgaagg attccttgac
     1561 cttgccatta tggctgctgt cactccctaa ggatttaggg gttgtctttg ggtcttgggg
     1621 agggagacag ggaaacattc atttaacagg atagagcaca gatccaggtc tcactcagac
     1681 ctttggctgc ccaagtttta catggggaaa ctcagccatg aagcaccatc tagaatctca
     1741 caactcagag accatccctt ccaggggaca gtgtgagtgt cctggtcaca ccacctggct
     1801 gagctcaaaa gacttcaggg atatctaatc aaaacccccg tgttagcata tccccaagag
     1861 tccaggagct gagagccatg ccccttaaaa cagctcttgg acacacacag ccttggtgcc
     1921 tctaggttcc agcctgcatt taacctttga caacaaggaa ataaaccaga ccagccattt
     1981 gcactaagat cttcaagcca atgttatcga ctcaataagt gcttagcaat ttgcttcctg
     2041 ttctgtctcc ctattttcag ctccatttta atcaggagtt atttataaag atcggttcct
     2101 ctttatgtcc ctgaa
//
