LOCUS       NM_009183               5409 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 4 (St8sia4), transcript variant 1,
            mRNA.
ACCESSION   NM_009183
VERSION     NM_009183.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5409)
  AUTHORS   Humpfle,L., Hachem,N.E., Simon,P., Weinhold,B., Galuska,S.P. and
            Middendorff,R.
  TITLE     Knockout of the polysialyltransferases ST8SiaII and ST8SiaIV leads
            to a dilatation of rete testis during postnatal development
  JOURNAL   Front Physiol 14, 1240296 (2023)
   PUBMED   37520830
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5409)
  AUTHORS   Shinde,P., Kiepas,A., Zhang,L., Sudhir,S., Konstantopoulos,K. and
            Stamatos,N.M.
  TITLE     Polysialylation controls immune function of myeloid cells in murine
            model of pneumococcal pneumonia
  JOURNAL   Cell Rep 42 (6), 112648 (2023)
   PUBMED   37339052
REFERENCE   3  (bases 1 to 5409)
  AUTHORS   Varbanov,H., Jia,S., Kochlamazashvili,G., Bhattacharya,S.,
            Buabeid,M.A., El Tabbal,M., Hayani,H., Stoyanov,S., Sun,W.,
            Thiesler,H., Rockle,I., Hildebrandt,H., Senkov,O.,
            Suppiramaniam,V., Gerardy-Schahn,R. and Dityatev,A.
  TITLE     Rescue of synaptic and cognitive functions in polysialic
            acid-deficient mice and dementia models by short polysialic acid
            fragments
  JOURNAL   Neurobiol Dis 180, 106079 (2023)
   PUBMED   36918046
REFERENCE   4  (bases 1 to 5409)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5409)
  AUTHORS   Delgado,C., Bu,L., Zhang,J., Liu,F.Y., Sall,J., Liang,F.X.,
            Furley,A.J. and Fishman,G.I.
  TITLE     Neural cell adhesion molecule is required for ventricular
            conduction system development
  JOURNAL   Development 148 (11) (2021)
   PUBMED   34100064
REFERENCE   6  (bases 1 to 5409)
  AUTHORS   Kurosawa,N., Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Polysialic acid synthase (ST8Sia II/STX) mRNA expression in the
            developing mouse central nervous system
  JOURNAL   J Neurochem 69 (2), 494-503 (1997)
   PUBMED   9231707
REFERENCE   7  (bases 1 to 5409)
  AUTHORS   Angata,K., Nakayama,J., Fredette,B., Chong,K., Ranscht,B. and
            Fukuda,M.
  TITLE     Human STX polysialyltransferase forms the embryonic form of the
            neural cell adhesion molecule. Tissue-specific expression, neurite
            outgrowth, and chromosomal localization in comparison with another
            polysialyltransferase, PST
  JOURNAL   J Biol Chem 272 (11), 7182-7190 (1997)
   PUBMED   9054414
REFERENCE   8  (bases 1 to 5409)
  AUTHORS   Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Molecular cloning and characterization of a third type of N-glycan
            alpha 2,8-sialyltransferase from mouse lung
  JOURNAL   J Biochem 118 (3), 658-664 (1995)
   PUBMED   8690732
REFERENCE   9  (bases 1 to 5409)
  AUTHORS   Yoshida,Y., Kojima,N., Kurosawa,N., Hamamoto,T. and Tsuji,S.
  TITLE     Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha
            2,8-sialyltransferase from mouse brain
  JOURNAL   J Biol Chem 270 (24), 14628-14633 (1995)
   PUBMED   7782326
REFERENCE   10 (bases 1 to 5409)
  AUTHORS   Kuhn,R., Lohler,J., Rennick,D., Rajewsky,K. and Muller,W.
  TITLE     Interleukin-10-deficient mice develop chronic enterocolitis
  JOURNAL   Cell 75 (2), 263-274 (1993)
   PUBMED   8402911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104893.13 and AC102483.8.
            
            On Oct 12, 2022 this sequence version replaced NM_009183.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060112.1, AJ223956.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               AC104893.13        22406-22847         c
            443-574             AC104893.13        16121-16252         c
            575-832             AC104893.13        8770-9027           c
            833-1126            AC102483.8         150596-150889       c
            1127-5409           AC102483.8         110771-115053       c
FEATURES             Location/Qualifiers
     source          1..5409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.76 cM"
     gene            1..5409
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 4"
                     /db_xref="GeneID:20452"
                     /db_xref="MGI:MGI:106018"
     exon            1..442
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1409
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /EC_number="2.4.99.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sialyltransferase 8 (alpha-2,
                     8-sialyltransferase) D;
                     CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase;
                     sialyltransferase 8D; polysialyltransferase-1;
                     sialytransferase St8Sia IV; alpha-2,8-sialyltransferase
                     8D; sialyltransferase St8Sia IV"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-poly-alpha-2,
                     8-sialyltransferase isoform 1 precursor"
                     /protein_id="NP_033209.1"
                     /db_xref="CCDS:CCDS15201.1"
                     /db_xref="GeneID:20452"
                     /db_xref="MGI:MGI:106018"
                     /translation="MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCL
                     SRSLVNSSDKIIRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSF
                     KPGDVIHYVLDRRRTLNISHNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEI
                     DSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSML
                     NDSVLWIPAFMVKGGEKHVEWVNALILKNKLQVRTAYPSLRLIHAVRGYWLTNKVPIK
                     RPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMP
                     LEFKTLNVLHNRGALKLTTGKCMKQ"
     exon            443..574
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            575..832
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1126
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..5409
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5384..5389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /note="hexamer: AATAAA"
     regulatory      5389..5394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /note="hexamer: ATTAAA"
     polyA_site      5406
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
     polyA_site      5409
                     /gene="St8sia4"
                     /gene_synonym="PST; PST-1; SIAT8-D; Siat8d; ST8SiaIV"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgccc ccgagcccag ctgcagaaga aaccgccacc tccaatgcac aaggtgtcac
       61 atttgaaaag aaacctgagc cccagggagg cggcgcagag cgacccgggc ccggtaagcg
      121 ctaactgcgc ggcagggagc tgggcagcgc tggagaaccg ggagagctcc accgctgaac
      181 atcctagcga cctgattctg ggatctcggc tccacgctcc cttcgcaatt ttcagatttc
      241 tcccccttga ttatcatccc aaaacggagc ctttatacca ggagaaggtg cctgagctgg
      301 gacaaccagg actttcccgg gcacccaaga tgcgctcaat tagaaaacgg tggaccatct
      361 gcactataag tctactcctg atcttttata agacaaaaga aatagccaga actgaggagc
      421 accaagagac gcaactcatc ggagatggtg aactgtgttt gagcagatca cttgtcaaca
      481 gctctgataa aatcatccgg aaggctggct ccaccatctt ccaacattct gtacaaggct
      541 ggaaaatcaa ttcttcttta gtcctggaga taaggaagaa cattcttcgt ttcttagatg
      601 cggaacgtga cgtatctgtg gtcaagagca gttttaagcc tggtgatgtc atacactatg
      661 tgctggacag acgccggaca ctaaatattt ctcacaatct gcatagcctc ctgcctgaag
      721 tttcaccaat gaaaaaccgc aggtttaaga cctgtgcagt tgttggaaat tccggcattc
      781 tgctagacag tggatgtgga aaggagattg acagccacaa ctttgtaata aggtgcaatc
      841 tagctcctgt ggtggagttc gctgctgatg tggggactaa atcagatttt attaccatga
      901 atccatcagt tgtgcaaaga gcatttggag gctttcggaa tgagagtgac agagaaaaat
      961 ttgtgcatag actctccatg ctgaatgaca gcgtcctttg gattcctgcc ttcatggtca
     1021 aaggaggaga gaagcacgtg gagtgggtta atgcattaat ccttaagaac aaactgcaag
     1081 tgcgaactgc ctatccatca cttagactta ttcatgcagt cagaggatac tggctgacta
     1141 acaaagttcc tatcaaaaga cctagcacag gtctcctcat gtatacactt gccaccagat
     1201 tctgtgatga aattcacctt tatggattct ggccatttcc caaggatctg aatggaaaag
     1261 ctgtcaaata tcattactat gatgacttaa aatatagata cttttccaac gccagtcctc
     1321 acaggatgcc attagaattt aaaacattga atgtgctaca caatagagga gctctaaaac
     1381 tgaccacagg aaagtgcatg aagcaataag gcacactttg gaggataaaa actgaacaca
     1441 gactttgttt ttttaagatg cttctggaga tttagaatca ggatccaaaa taaggctggg
     1501 attcagcatc caccacttga ctgagtagct gaaatggaag tctgtgtgaa ttcaccacca
     1561 gctgatgaaa aacctgcaaa gtgctctgac tacaacatat tctgacttca agggtcctag
     1621 taagtgccac ttccatgaag aatacagttt gaatgtatta tcagtagtgt ttacaagatt
     1681 caacagtgca ctcaacatca gttagcaaag caaacatgtt catcactgtg gggcagccac
     1741 tgtaatgcca agcacactgg aagaggaacc caggagcaca gctcagccct tgggacttga
     1801 aaacatcctt agtagaaatg aagaaggaga gagttcaagc agtgaaatcc atgacatgaa
     1861 gcaacttgag gaaacgcttt cagtcaggac actgagaatg gtcatgttta cgttttgctt
     1921 atatttcttg tttgtcttct gacatttatt ttggtttggg tttgggtgct tagaaattca
     1981 tttgagatac agaaatggga aacacatgtg aatgagaaaa acgaacatca aacagtcctt
     2041 tctaaagtcc ttatatattt ttaaacaaca gtcacaccaa acttatgctt gttcgtttgt
     2101 ttgtttgttt tactttgcac aactctaaat ctctggatta tagatcaatg gtgtagtggg
     2161 taccagccaa actataccac tcgatattag tagactatta tgaaggagtg atatttgaaa
     2221 aatggtaaaa atagcagaaa agtttcactc ttggtaccaa agattatatc atgttcctac
     2281 acagtaagcc actctcctgt tataaagaga atatattatt aacatgaaca catttatatg
     2341 aagttaatag gaaactcagc tctacacagt taaaaatttc aagttcaaac attactttta
     2401 atttacttct ttgacatttc atcataattt tgtggaaatc catggccagg tagattgttg
     2461 gattgaagta gctgaaatga gacttctcat tcagtaaaat cttcttggct attcaggtgc
     2521 agagatcaat atgaagcact tactattatt ttaaaatttc tctccacaaa ataagatgat
     2581 taactgagtg ttgttttcat aacaggtaat taattcaaag cagtttaaca ataacacatc
     2641 aacaatacgt caaatgaatt cagttaacaa ggatttttct gtagttaagt acagttccat
     2701 tatgactgca ttttttaaaa caacatgaac ttactcatag agtgacttac tgacttacat
     2761 acgtgactga attgactggt ggccaggctt tctgtttctt ttgaaagcag aactatattc
     2821 ttacttctgc ttttgcctgc agcaatttaa catgacttcc tgtttcttgg ggaaggcaat
     2881 cagaagaaag cagaaatggc atgaaaaatg tgtatgtttt gtttttctaa gtcaggcaat
     2941 ctaaaatgaa tgaagagcac agcaaaggta tacatatata ttatatatgt attcatattc
     3001 tggacaagga tagtcatgta gtacagttac caaattttta atattagctg cagtgttttt
     3061 taaaacagtg atagaatctc aggataaaaa taacagtttc tgagaatcca tgtatctatc
     3121 agaaaggaaa agagaatgga tatgggcatt tcataaccag tatatacctt tatcattaaa
     3181 tttcattttt atttcgcaat tcaatacatt taataaaaag tgttaaatat gtgttatgta
     3241 gatgttaaat tgaaagtcta atacactgga tgtgtgatca ttggataata tataaaactt
     3301 attttgaact ctatgcagat ctgtgttccc accaacagct aacatgaatt ccttagaaat
     3361 ccagaggttg caagtaaatt ctggcaagta aattctatct tggcactcat tcaaagtatg
     3421 tatctgaaag cagcagcata ccatcttgac tgaaatttta agaagggaaa aaaagatgtg
     3481 tttaaacaac attttggcca cagcaagcac agcttagcca ttcacttttg catgcattga
     3541 tgtctatctc ttacatgcat tgagtagtgc cttttaatgt ctttgcattg attcttcacc
     3601 ctctgctttg tgtttcctaa atgcttgccc agttagagaa atgttcagta tcaaaagggc
     3661 ttcagatttg agagataact acttttgttc atctcaggga actttcagta cataagaatg
     3721 gattcaatta aagacattta gcactcaaag aggaaatatt gtgtgagatt atttcatcct
     3781 cacacacaca ccctttcatt tgccatcact gctcaatccc tatcacggct ttcttacagg
     3841 aggaaggcaa ggagagaatt gaagactaac agtagagaaa agagttagga cttaacacac
     3901 atgatggcat aaggaatcat aacaaaatca aattataagc atatacttga actatctgtg
     3961 atttccttaa tatggtatgc taacagcttt atttgtttta tttccttttt ctaatgtttt
     4021 aatcatgcac ttgggaatac ccaggtagct gactgtgaaa tatcccagtc actgagctaa
     4081 catgattgct actgtgcttt tgacatgaac agaccatgga aatattttca tcattgctac
     4141 tcagcataaa ctatacttaa taaaaagttg ttgaaagaaa acatgaatca ataatagatt
     4201 ttcagagcaa atctagtgat tcagcccaca ggaccaatga aagtactgtg gaagctttcc
     4261 tcacttagag aaggtgctgg gcattcaaat gtcttcatgt gttgtatttc atatgagctg
     4321 tatatcaatt gttaatgaaa atctccacat atatccttac agaaatgctt tattcaagaa
     4381 atgctaaggg tagtgtacag acaagtgatt tactcagtta ctattcaaga aagggtaagc
     4441 aaagtaattt atttatagtt gtgccagtta gtcataatac atattatgtg atatttggtt
     4501 cacagagttg ttttcatgtg attattatga ggactatcta tagttgtgga agggggatgg
     4561 aaaagttgtg tatagttagc tggtatctct acaagtttga gagtttcccc attaaatgtt
     4621 atcaatatac caaggtttta ataaaaacaa gtaaggttaa ttatttgtat ttgataaaca
     4681 aactccaaat acaacccatc tagaaataga tattttatta tatatgtgct ataaatatat
     4741 ctatatagta caaatagaaa tgtgtgatgc atatatacca tgttatatat gtatatctgt
     4801 gtgtacacac tgattctgta atatgtgcac aactagatgt gtgttatatt gatatcttca
     4861 gggtctgcac tgtgaactgc cctggagatc atggccactt taaaaacaga agttcttttg
     4921 aaacttcatt tactactctg ctttaagaaa gacctacttt gtagctgaat tatatgttct
     4981 ttcctagagt aatagtaagc agctagtatg ttcaaatctt tcaaaacaaa agtcaaggaa
     5041 aaaatatctt caagctggca atgtatttat ttaaattgcg gttttttgat tgttggtcta
     5101 ggttgtgtgt ttctctttta tgtagcgcct tttaagaaat actggggttt ttttgtgtgt
     5161 gtgtgtcggt gaaagcacaa gtgtttttga tgtatatagc aagaagagaa aaaagtttcc
     5221 agatagcttt gctgcatagg ataattgcta ctgagccttt cttataccat ctgtggaaag
     5281 gaaggatgaa gcttactctg taggttcatt ctgatcaaca atatcttctg ttgtttgtgc
     5341 atagcaatgg actattactg ctttatcatt tgtacaattg taaaataaat taaattactt
     5401 gtttttcaa
//
