LOCUS       NM_009182               6306 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Mus musculus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 3 (St8sia3), mRNA.
ACCESSION   NM_009182
VERSION     NM_009182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6306)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6306)
  AUTHORS   Lin,C.Y., Lai,H.L., Chen,H.M., Siew,J.J., Hsiao,C.T., Chang,H.C.,
            Liao,K.S., Tsai,S.C., Wu,C.Y., Kitajima,K., Sato,C., Khoo,K.H. and
            Chern,Y.
  TITLE     Functional roles of ST8SIA3-mediated sialylation of striatal
            dopamine D2 and adenosine A2A receptors
  JOURNAL   Transl Psychiatry 9 (1), 209 (2019)
   PUBMED   31455764
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6306)
  AUTHORS   Rinflerch,A.R., Burgos,V.L., Hidalgo,A.M., Loresi,M. and
            Argibay,P.F.
  TITLE     Differential expression of disialic acids in the cerebellum of
            senile mice
  JOURNAL   Glycobiology 22 (3), 411-416 (2012)
   PUBMED   22038478
  REMARK    GeneRIF: A significant decrease in ST8Sia III gene expression was
            found in the cerebellum of senile animals.
REFERENCE   4  (bases 1 to 6306)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   5  (bases 1 to 6306)
  AUTHORS   Ngamukote,S., Yanagisawa,M., Ariga,T., Ando,S. and Yu,R.K.
  TITLE     Developmental changes of glycosphingolipids and expression of
            glycogenes in mouse brains
  JOURNAL   J Neurochem 103 (6), 2327-2341 (2007)
   PUBMED   17883393
REFERENCE   6  (bases 1 to 6306)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   7  (bases 1 to 6306)
  AUTHORS   Zeng,G., Gao,L. and Yu,R.K.
  TITLE     Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8
            sialyltransferase
  JOURNAL   Gene 187 (1), 131-134 (1997)
   PUBMED   9073076
REFERENCE   8  (bases 1 to 6306)
  AUTHORS   Kono,M., Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Molecular cloning and expression of a fifth type of
            alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is
            similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and
            GT3
  JOURNAL   J Biol Chem 271 (46), 29366-29371 (1996)
   PUBMED   8910600
REFERENCE   9  (bases 1 to 6306)
  AUTHORS   Yoshida,Y., Kurosawa,N., Kanematsu,T., Taguchi,A., Arita,M.,
            Kojima,N. and Tsuji,S.
  TITLE     Unique genomic structure and expression of the mouse alpha
            2,8-sialyltransferase (ST8Sia III) gene
  JOURNAL   Glycobiology 6 (6), 573-580 (1996)
   PUBMED   8922952
REFERENCE   10 (bases 1 to 6306)
  AUTHORS   Yoshida,Y., Kojima,N., Kurosawa,N., Hamamoto,T. and Tsuji,S.
  TITLE     Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha
            2,8-sialyltransferase from mouse brain
  JOURNAL   J Biol Chem 270 (24), 14628-14633 (1995)
   PUBMED   7782326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB616760.1, AK015874.1 and BC075645.1.
            
            On Oct 23, 2009 this sequence version replaced NM_009182.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161482.1, AK015874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BB616760.1         2-18
            18-1807             AK015874.1         2-1791
            1808-4318           BC075645.1         1103-3613
            4319-6306           BC075645.1         3615-5602
FEATURES             Location/Qualifiers
     source          1..6306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 37.25 cM"
     gene            1..6306
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 3"
                     /db_xref="GeneID:20451"
                     /db_xref="MGI:MGI:106019"
     exon            1..333
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            334..410
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            411..968
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             790..1932
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /EC_number="2.4.3.8"
                     /note="sialyltransferase 8 (alpha-2, 8-sialyltransferase)
                     C; sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha
                     2,8-sialyltransferase; SIAT8-C; sialyltransferase 8C;
                     sialytransferase St8Sia III; alpha-2,8-sialyltransferase
                     8C; alpha-2,8-sialyltransferase III; sialyltransferase
                     St8Sia III; ganglioside GD3 synthase ST8SIA3; sia alpha
                     2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase"
                     /codon_start=1
                     /product="alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase ST8SIA3"
                     /protein_id="NP_033208.2"
                     /db_xref="CCDS:CCDS29301.1"
                     /db_xref="GeneID:20451"
                     /db_xref="MGI:MGI:106019"
                     /translation="MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKY
                     ASPGAPRMYMFHAGFRSQFALKFLDQSFVPITNSLTHELQEKPSKWTFNRTAFLHQRQ
                     EILQHVDVIKNFSLTKSSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKRYN
                     VCAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFHKDVGRKTNLTTFNPSILEKY
                     YNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLA
                     WPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDL
                     PYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA"
     exon            969..1091
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1649
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..6280
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="St8sia3"
                     /gene_synonym="Siat8c; ST8SiaIII"
                     /note="major polyA site"
ORIGIN      
        1 agattgttct acactgtgag ttccagggca gccctggcta catagagaga ccctgtctca
       61 aaaaggagga ggaagaggaa aaagaggagg gtttgatgga agccagaaat gttagagcat
      121 gataaagcag gaatgttacc aggtgaaagc tagactgaac tacagagatc ccccatctca
      181 acataaagaa gtgacacact tcctcctaca aggccacacc cccaatcatg ccactcctgg
      241 ggccatctac actcagaccg ctccactgtg gtagctccta agatgtagct tctgctctgc
      301 acagctgaca ctgcattgcc caagctcttg aaacaatttg aattcagagg gacaatatgg
      361 aaagatggat caagtcgcaa ctaggagttg acaggtgtct ggtaaccagt gcggcggtgg
      421 agatggcaac ctcgctggga acgcgctggg gagcctgagc ccgcagccgg agacgcactg
      481 ctccttgtgc tccaccgccc gccacgccgc cgcgcagacc ctccatcttc catttcagct
      541 ccgggccagg ctcgaccctg ccccggggtg gggtagggag cgggctcccg cttctctcgg
      601 ggctccaggt cgttctccac ccccgggccc tctgcgactc aattgcctgg gtcccccctc
      661 ccccgccaca cacactcaca cgcgcccgcg agcacacacg cacgcacaca acacactcac
      721 acgccagcag gctgctggcc gctcaatgga ccgatttccc cggtttccct gaacccagcc
      781 tagcccggga tgagaaattg caaaatggcc cgagtcgcca gtgtgctagg gctggtcatg
      841 ctcagcgtgg ccctgctgat tttatcgctt atcagctacg tgtctctgaa aaaggagaac
      901 atcttcacca ctcccaagta cgccagcccg ggggcgcccc gaatgtacat gttccacgcg
      961 ggattccggt cacagtttgc actgaagttt ctagaccagt catttgtgcc cattacgaat
     1021 tctctcaccc atgaactcca agagaaacct tctaaatgga catttaatcg gacagcgttt
     1081 ttacatcaaa ggcaagaaat tcttcagcat gtcgatgtaa taaaaaattt ttctttgacc
     1141 aagagtagtg ttcggattgg acaactaatg cattatgatt attccagcca taaatatgtc
     1201 ttctcgatta gcaataactt ccggtccctg ctcccagatg tgtcgcccat tatgaataag
     1261 cgttataatg tttgtgctgt ggttggaaac agtggaatct tgacagggag tcagtgtgga
     1321 caagaaatag ataaatcaga ttttgttttt cgatgcaatt ttgccccgac agaggctttc
     1381 cacaaagatg ttggaaggaa aaccaacctc acaaccttca atccgagcat cttagagaaa
     1441 tattacaaca atcttttaac cattcaggac cgtaacaact tcttcctcag tttaaaaaag
     1501 cttgatgggg ccatactttg gatccctgca tttttcttcc acacttctgc aactgtaacg
     1561 agaacgctag tggatttttt tgttgagcac agaggtcagt taaaggtcca gttggcttgg
     1621 cctggaaata tcatgcaaca tgtcaacagg tactggaaaa acaaacacct gtcacccaaa
     1681 cgactgagca caggtatcct aatgtatact cttgcatctg caatatgtga agagatccac
     1741 ttgtacggtt tctggccctt tggatttgac cccaacacca gggaggatct gccctaccac
     1801 tactatgaca aaaaaggaac caaatttacc accaagtggc aggagtctca ccagctgcct
     1861 gctgagtttc agctgctcta tcgaatgcat ggggaagggc tcacgaagct cactctgtca
     1921 cactgtgcct aagaactcca aatggaaagt gccaaacggc tgattaaaaa gtgcccccac
     1981 ccccaaacca aattgaatag tctccagaac agaacccata gacaatctgg caaagcctgt
     2041 ctgccactta caaggaaaga cgccttctct tcctcttttg cactgctctt tgaatggtct
     2101 taacaaactt aggacaggtg cattgaagcc gtgtgattta gacttgattg ggaaaaggtt
     2161 atattgcatt tggaagtatg ctgcacagag aatagcttga aatagttcta agtttgtatt
     2221 ttaataataa accgactccc atgtgaatga ggaatgtgac tgtcatctcc tcctctctac
     2281 tttgatatag tcctcacaac cagggagctc tggccagctc cagcaggatc tctttagcca
     2341 aggggatcag aatcttcaaa ataaaaagta aaaaaactgg tttgcaggtt gcattctctc
     2401 tctctctctc tctctctctc tctctctctc tctcacacac acacacacac acacacacac
     2461 acacacacac acacttcctg ttgccctagt accaattagg aatacttctg ggctagcttt
     2521 gcttgtatgt gtttgcatct gtacccattg tgttcaaggc tctggataac ttggatgttt
     2581 cataacaaac tgagcaaatc ttaatgtctt cccccgtgaa gaattctata ggaaatgcct
     2641 cttattctta ctggtccata ttgttattct acagcatggt ggtctatttg agtagagtgg
     2701 cataagctac agtgtctctt ctttctgtca aaaagaaagc ccacagtgtg ggtagcattg
     2761 tgtctgttgg catgagcgaa gttgtggcag atcctgcaag ggctttctag tgtagccttc
     2821 aactatttaa tttcaagcgc taggctgggc actctctcag aaaaaaaaaa gagtcattgg
     2881 gttaatttaa accctaggga ctataaagaa aggggaagaa gagtgtttgc aggttgtata
     2941 ctctgcaaag aattgtgacc attggagaca ttggagaagc acaagagttg gtgtagaaga
     3001 caaactagag ctttggccag actggtccct gtgtgacgca tgttagcatt agtcatgtca
     3061 gatcctttct gtgacatctc caccaacaag gatctagaca tgcttgcttt ctttgaaaca
     3121 gttgaagata ttattctctg tttccaagtc tgtgtgccta tacattgagc atctcaaaaa
     3181 agaaaagcca ttatgcagtg ggaatacttg gtcctaagta acctttggga tttgagatca
     3241 gctggccatt gttctcactg cttcagctgt atccgtagaa atcacatcgc tcccatccca
     3301 ggcgtttaca ctgagcagca ctttgttctt gcaattcaac ccaaagtctg gccaagttga
     3361 tgttaaattt tcataagact ttcctcttta caagggccca tggagcacat ttgttatatg
     3421 ttccagtggg ttatcttgtt cttgtccaga aatctcatct agacagctta cagtgttgta
     3481 aatattttta aaagcccttg ctatagttca ggcatcagtg tactggccct ttttgggaaa
     3541 aaacaaaacc aaccattcct aaaaagaagt ggagtaagga catgcactgt tcttgtgtag
     3601 cgcctggtcc tggagctgca ctggtctttt cgaggagata aatcgacccc agataaatct
     3661 agtgaaagaa agccactcag atccaaacac aatgccaact gtggcacatc ttaccctttg
     3721 tgaatgccag ccacttagat agaggagagg aactaggggc taaatatttc aaaataagaa
     3781 gcatttacta tgcacaggat agtaagaaaa ttaaaattat aaggtatttt taaaaacact
     3841 ttagaattca aggacaattt catgggcatg aaaattatac catggctgtg ccctgtcaca
     3901 gtaagccaca ccatggctgt gccctgtcac tttaaagagt gcaggacacc atgctgctac
     3961 tctggatggg tgtgggtcat ggagacttga cagaattgca gcagttatca tcaggactga
     4021 aaagcctagc tattcctaag cccttagctc atttggttgc agctaagtta ttccaatgct
     4081 aacattatcc aggccagatt ctgactcgaa agctttaatt tcagtgtgcc catcaggtct
     4141 tactaaatat aaacttggac tctttacact aagcaagaca aaatactcaa agactagaag
     4201 atccccaaag ctagttgaat gttgtggtgt tttttgttat tttttttaat gcacctttta
     4261 acctcagttg tatcctggac ctgctgttct gaccaactga ttctacaatt ttttttttct
     4321 gtttcccaaa actatttcaa catgtaaacc aatgcaacag ctttcatggc aggaagattt
     4381 tcttattaga aaagcagcca gagtttgttg gctctcccac agtccccagg cttgtaggct
     4441 caaatgcagt ggacagagca gagggaccat tgagtttcct gtttatgcag ctacacgctc
     4501 ataccccacc cttctatgtt ggctccactt ggttggatct gggttagtac attcttttct
     4561 tagaaacata ctcatttttt tcggctacct agagctgagt acaccatcag ctatgtgaat
     4621 aaatttcact ataatgctcc caaggctgtc tgaaaataac tacttactta gcagagaaga
     4681 caaggaaatt tacaaactcc tggcagcatg agtcaaaagg tggttgccat gacttcctcc
     4741 cacacccgga aatttggggt ctgtgtgtga gtctatggag ctggtgatcc aacccaggac
     4801 cttgctcatg gtagacaaat actctaccat tgatctccat tcccagactg tgttctcatg
     4861 ctaagcaact ttaaccgtta tttttaaaaa tgcagtctat ctagtagtac tgtgtgtctg
     4921 ccaatgctga atatgaccac tgaaccatct gtctctgacc tgaatatcag acatgggcta
     4981 tagcaaggat atacaaagga agaccccgtt cattcaccta accttctggt accaaggctg
     5041 tcagtgccaa tggatatgag tgtccagaca aaactaatat atcagagaat tcaatgaata
     5101 tgagtccatg ctatctcacc tcaagcaagg ccccaaacac tcagacaata attcatgagc
     5161 cccagagaag caggaacaat agaaagggag aagtcattga gttttctaac ccatgttggc
     5221 tttacaaata ttaaggttga gatacagata gactaataga ttttccccaa aattttacat
     5281 agataattat tgacgttatg atttcacata ttaatcttat cagaatcaaa gatcaggtca
     5341 aaggaaagca acttaactct ggaatatttg gagcgtaaac ataatggaga ggggccgtaa
     5401 gggaagaagg ggaaaagact actaaatgca cttgcctggg tacacagcag taggggagat
     5461 acctgcccag tacacagcag cctgctgaaa accacccact ctcccctaaa atgagagaga
     5521 aacctgttaa tccttgactg ataagtccca gttctgttat tgatggtaca cagctgacag
     5581 atgaaattgt acctgatagt atattcatct caataaaatc atgtgtgcat gatttagaat
     5641 ttgaaggcta aaagtggctg tgtacttctc cttgtatata aaactttcag caagggcccc
     5701 ttgagttaag aaacattttc catcatgtaa gtaatcgaga caacagcctt tgaactattg
     5761 tattcgttca tttcactaag attgtacaaa gcatagtgga aaactttggt ggttcttcat
     5821 tttttcaaaa gacattctga gatcttgtct gtgtcgttct gggtctttaa gcccctcttc
     5881 tcataactgt ttgaatgtat cagacaaata tttgcttagc ttctactact tccccactgt
     5941 gtataactga ccttgtgacc agagttggga ctgtgtatgt gtgactgaag agctctaatg
     6001 gaacaccatg ggttccggga atcgaaggca tttcaccagt cagtctaagc cgcttaatcc
     6061 gtggaccttt taaccgaggc caccaatgaa ttgataccaa ggaccaaaat gacgaatcct
     6121 gcctccctca cactctgact gctttgccac ataaatagaa catttcaaat gggaaatgtt
     6181 ttcgaatgtt atggtttgtt atgtgatatt tgttgagcat ttatttttat tgtaatgatt
     6241 tgttaaagac atgtgtggtt gaatagatgt tttaatcctt aaaaaaaaaa aaaaaaaaaa
     6301 aaaaaa
//
