LOCUS       NM_001289624            2210 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus suppression of tumorigenicity 7 (St7), transcript
            variant 3, mRNA.
ACCESSION   NM_001289624 XM_006505153
VERSION     NM_001289624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2210)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2210)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2210)
  AUTHORS   Takeda,K., Ho,V.C., Takeda,H., Duan,L.J., Nagy,A. and Fong,G.H.
  TITLE     Placental but not heart defects are associated with elevated
            hypoxia-inducible factor alpha levels in mice lacking prolyl
            hydroxylase domain protein 2
  JOURNAL   Mol Cell Biol 26 (22), 8336-8346 (2006)
   PUBMED   16966370
REFERENCE   5  (bases 1 to 2210)
  AUTHORS   Yatsula,B., Galvao,C., McCrann,M. and Perkins,A.S.
  TITLE     Assessment of F-MuLV-induced tumorigenesis reveals new candidate
            tumor genes including Pecam1, St7, and Prim2
  JOURNAL   Leukemia 20 (1), 162-165 (2006)
   PUBMED   16307020
REFERENCE   6  (bases 1 to 2210)
  AUTHORS   Zaffaroni,D., Spinola,M., Galvan,A., Falvella,F.S., Pazzaglia,S.,
            Saran,A., Mancuso,M.T., Galbiati,F., Pignatiello,C., Cabrera,W.,
            Ibanez,O., Manenti,G. and Dragani,T.A.
  TITLE     Met proto-oncogene juxtamembrane rare variations in mouse and
            humans: differential effects of Arg and Cys alleles on mouse lung
            tumorigenesis
  JOURNAL   Oncogene 24 (6), 1084-1090 (2005)
   PUBMED   15592501
REFERENCE   7  (bases 1 to 2210)
  AUTHORS   Pal,S., Vishwanath,S.N., Erdjument-Bromage,H., Tempst,P. and Sif,S.
  TITLE     Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and
            negatively regulates expression of ST7 and NM23 tumor suppressor
            genes
  JOURNAL   Mol Cell Biol 24 (21), 9630-9645 (2004)
   PUBMED   15485929
  REMARK    GeneRIF: suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23
            (NM23) are direct targets of PRMT5-containing BRG1 and hBRM
            complexes
REFERENCE   8  (bases 1 to 2210)
  AUTHORS   Saitoh,T. and Katoh,M.
  TITLE     Molecular cloning and characterization of mouse St7r (St7-like,
            St7l)
  JOURNAL   Int J Mol Med 10 (1), 119-123 (2002)
   PUBMED   12060862
REFERENCE   9  (bases 1 to 2210)
  AUTHORS   Zenklusen,J.C., Conti,C.J. and Green,E.D.
  TITLE     Mutational and functional analyses reveal that ST7 is a highly
            conserved tumor-suppressor gene on human chromosome 7q31
  JOURNAL   Nat Genet 27 (4), 392-398 (2001)
   PUBMED   11279520
REFERENCE   10 (bases 1 to 2210)
  AUTHORS   Vincent,J.B., Herbrick,J.A., Gurling,H.M., Bolton,P.F., Roberts,W.
            and Scherer,S.W.
  TITLE     Identification of a novel gene on chromosome 7q31 that is
            interrupted by a translocation breakpoint in an autistic individual
  JOURNAL   Am J Hum Genet 67 (2), 510-514 (2000)
   PUBMED   10889047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153836.5 and AC068561.2.
            
            On Jan 24, 2014 this sequence version replaced XM_006505153.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (3) has a distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY007792.1, SRR7345562.2509775.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AC153836.5         21851-22219
            370-452             AC153836.5         147107-147189
            453-612             AC153836.5         162474-162633
            613-667             AC153836.5         172766-172820
            668-783             AC153836.5         174056-174171
            784-859             AC153836.5         175861-175936
            860-928             AC153836.5         178214-178282
            929-1083            AC153836.5         180115-180269
            1084-1181           AC153836.5         182788-182885
            1182-1296           AC153836.5         213861-213975
            1297-1369           AC068561.2         50624-50696
            1370-1472           AC068561.2         52135-52237
            1473-1623           AC068561.2         67716-67866
            1624-1716           AC068561.2         76493-76585
            1717-1856           AC068561.2         79846-79985
            1857-2210           AC068561.2         88397-88750
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.0 cM"
     gene            1..2210
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /note="suppression of tumorigenicity 7"
                     /db_xref="GeneID:64213"
                     /db_xref="MGI:MGI:1927450"
     exon            1..369
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1952
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /note="isoform 3 is encoded by transcript variant 3; 4low
                     density lipoprotein-related protein 12; suppressor of
                     tumorigenicity 7 protein; family with sequence similarity
                     4, subfamily A, member 2"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 7 protein isoform
                     3"
                     /protein_id="NP_001276553.1"
                     /db_xref="CCDS:CCDS71728.1"
                     /db_xref="GeneID:64213"
                     /db_xref="MGI:MGI:1927450"
                     /translation="MAEAGAGFLEQLKSCIVWSWTYLWTVWFFLVLFLVYILRVPLRI
                     NDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLR
                     PLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPL
                     TYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSR
                     VEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQ
                     LQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNI
                     HENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASR
                     RGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLA
                     HWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYP
                     KKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESIL
                     PSSLWHQLTRI"
     exon            370..452
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            453..612
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            613..667
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            668..783
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            784..859
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            860..928
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1083
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1181
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1296
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1369
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1472
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1623
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1716
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1856
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2210
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /note="hexamer: AATAAA"
     polyA_site      2209
                     /gene="St7"
                     /gene_synonym="9430001H04Rik; Fam4a2; HELG; RAY1; SEN4;
                     TSG7"
                     /note="major polyA site"
ORIGIN      
        1 ccgggagagt gcagggaccg ggcccacgtg accgctccac gaaggccacc ggcgggggct
       61 cggagcgcag gccgcgcgct ttcccgccgc atccgggcgc cgggcgagct ccggggacgc
      121 cgggccctgg cggcggcggc ggctcgagcc gtgcctcggg cgggtgaatc atcccggccg
      181 acagcgagcg ccgcggcggc ccgtagcagc gccggaagat ggccgaggcg ggcgcgggct
      241 tcctggagca gctcaagtcc tgcatcgtgt ggtcgtggac ctatctgtgg accgtgtggt
      301 tcttcctcgt gctcttcctg gtctacatcc tgagggtgcc cctgaggatc aacgacaacc
      361 tgagcacagt gagcatgttt ttgaacacgt taaccccaaa gttctacgtg gccctgacag
      421 gcacttcctc gctaatatcg ggacttattt tgatatttga atggtggtat tttcgcaagt
      481 atggaacatc tttcattgaa caagtctccg taagccactt gcgccccctt ctgggagggg
      541 ttgacaacaa ctcttccaat aattctaatt ccagtaatgg agactcagat tccaacagac
      601 aaagtgtctc agaatgcaaa gtatggcgaa atccactgaa tctgtttagg ggtgcggaat
      661 ataatcggta cacttgggtc acaggacgag agcctctgac ctactatgac atgaacctct
      721 ctgcccagga ccaccagaca ttctttactt gtgattcaga tcatcttcgc cctgcagatg
      781 caataatgca aaaagcttgg agagaaagga accctcaagc caggatttct gcagctcatg
      841 aagccttgga gataaacgaa attaggtcca gagttgaagt tcccctaatt gcttcctcta
      901 ccatctggga gataaaattg ttaccaaagt gtgcaactgc gtacattctc ttggcggaag
      961 aagaagcgac aactattgct gaagcagaaa aactctttaa gcaggccctg aaggctggag
     1021 atggttgtta ccggcgctct cagcagctac aacatcatgg gtcccagtat gaagctcaac
     1081 acagacgaga caccaatgtc ttagtctata tcaaaagaag gctggcgatg tgtgcccgga
     1141 gacttggaag gaccagagaa gcagtgaaga tgatgagaga tttaatgaag gagtttcccc
     1201 tcctaagcat gttcaatatc catgagaacc ttctagaagc tcttctggaa ctccaagctt
     1261 atgctgatgt tcaggcagtc ttagcaaagt atgatgatat aagcttacca aagtcggcga
     1321 caatatgcta cacagccgcc ctgctcaaag caagagctgt ctctgacaaa ttctctccag
     1381 aggctgcgtc tcggaggggg ctgagcacag cagagatgaa tgcagtagaa gccatccaca
     1441 gagctgtgga atttaatcca cacgtgccaa aatatctact agaaatgaaa agcttaatcc
     1501 tcccaccaga acacatcctg aagagaggag acagtgaagc gatagcatat gcattctttc
     1561 atcttgcaca ctggaagagg gtggaagggg ctttgaatct cttgcattgt acgtgggaag
     1621 gcactttccg gatgatcccg tatcccctgg agaagggaca cctattttat ccatacccaa
     1681 tctgtacaga aacagctgac cgggagctgc ttccctcttt ccatgaagtc tcagtttacc
     1741 caaagaagga acttcccttc ttcatcctct tcactgctgg actgtgctcc ttcacagcca
     1801 tgctggccct cctgacacat cagtttccgg aacttatggg agtcttcgca aaagctttcc
     1861 tcagcacttt gtttgccccc ttgaactttg ttatggagaa agtggaaagc atcctcccct
     1921 ccagtttgtg gcatcagctg acacggatct gagggagcct cccatccttc actttccaca
     1981 ccatccacca tctcttctgt gccaacctct catggaccgc aagaaagcat gactttgaaa
     2041 aagggaaacc attctgagat tttaaactgc tcatggacta tcagttcctt attaaaggct
     2101 ggttttgttg tacaaaattt attgatgttc agttctattt tattttgcct tcaaaactga
     2161 ctgatcaaaa agtaaaaaaa ataaataaat aaacttttgt gtattgcaag
//
