LOCUS       NM_012028               2827 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus ST6
            (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
            3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
            (St6galnac5), mRNA.
ACCESSION   NM_012028
VERSION     NM_012028.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Paul,A., Crow,M., Raudales,R., He,M., Gillis,J. and Huang,Z.J.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   2  (bases 1 to 2827)
  AUTHORS   Tsuchida,A., Okajima,T., Furukawa,K., Ando,T., Ishida,H.,
            Yoshida,A., Nakamura,Y., Kannagi,R., Kiso,M. and Furukawa,K.
  TITLE     Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer
            cell lines by a sialyltransferase, ST6GalNAc VI, responsible for
            the synthesis of alpha-series gangliosides
  JOURNAL   J Biol Chem 278 (25), 22787-22794 (2003)
   PUBMED   12668675
REFERENCE   3  (bases 1 to 2827)
  AUTHORS   Ikehara,Y., Shimizu,N., Kono,M., Nishihara,S., Nakanishi,H.,
            Kitamura,T., Narimatsu,H., Tsuji,S. and Tatematsu,M.
  TITLE     A novel glycosyltransferase with a polyglutamine repeat; a new
            candidate for GD1alpha synthase (ST6GalNAc V)(1)
  JOURNAL   FEBS Lett 463 (1-2), 92-96 (1999)
   PUBMED   10601645
REFERENCE   4  (bases 1 to 2827)
  AUTHORS   Okajima,T., Fukumoto,S., Ito,H., Kiso,M., Hirabayashi,Y., Urano,T.
            and Furukawa,K.
  TITLE     Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V)
            containing CAG/Glutamine repeats
  JOURNAL   J Biol Chem 274 (43), 30557-30562 (1999)
   PUBMED   10521438
  REMARK    Erratum:[J Biol Chem 2000 Jan 14;275(2):1520]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125349.3 and AC162890.4.
            
            On Feb 20, 2019 this sequence version replaced NM_012028.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034387.1, AK038434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC125349.3         187230-187437       c
            209-451             AC125349.3         186285-186527       c
            452-861             AC162890.4         27864-28273
            862-969             AC162890.4         34283-34390
            970-2827            AC162890.4         52792-54649
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.16 cM"
     gene            1..2827
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5"
                     /db_xref="GeneID:26938"
                     /db_xref="MGI:MGI:1349471"
     exon            1..208
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1201
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialyltransferase) E; SIAT7-E; ST6GalNAcV; GD1
                     alpha synthase; sialyltransferase 7E; galNAc
                     alpha-2,6-sialyltransferase V; ST6GalNAc V"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 5"
                     /protein_id="NP_036158.3"
                     /db_xref="CCDS:CCDS38676.1"
                     /db_xref="GeneID:26938"
                     /db_xref="MGI:MGI:1349471"
                     /translation="MKTLMRHGLAVCLVLTTMCTSLLLVYSSLGSQKERPPQQQQQQQ
                     QQQQAATATGSTQLVESSPQPRRTAPAGPRQLEGYLGVADHKPLKMHCKDCALVTSSG
                     HLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLN
                     VSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQE
                     TGKDRKISNTWLSTGWFTMTIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGP
                     DECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESPAVNHAEGKPV
                     F"
     exon            209..451
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /inference="alignment:Splign:2.1.0"
     exon            452..861
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /inference="alignment:Splign:2.1.0"
     exon            862..969
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2827
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="hexamer: CATAAA"
     polyA_site      1958
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="major polyA site"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="hexamer: AACAAA"
     polyA_site      2003
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="major polyA site"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="St6galnac5"
                     /gene_synonym="Siat7e"
ORIGIN      
        1 agttttaatt ctcctctaat ctctgcaaca gcagcgcttc ccggtcccgc ggctcctgct
       61 cccgctcagc tgccgtcact gccaggtgag catctgagca gcctccgccc catcacccac
      121 catggacaac ctccaagaaa aagtggctcc ggacgcgctt gcctgagaat tccgcacaaa
      181 agaggagccc aaaatgaaga ccctgatgcg ccatggtctg gcagtgtgtt tagtgctcac
      241 taccatgtgc accagcttgt tgctcgtgta cagcagcctc ggcagccaga aggagcggcc
      301 cccgcagcag cagcagcagc agcagcagca gcagcaggcg gcaaccgcga ctggcagcac
      361 gcagcttgtg gagagcagtc cccagccacg tagaaccgcc cccgcaggac cccggcagct
      421 cgaaggatac ctcggtgtag cagaccacaa gcccctgaaa atgcattgca aggattgcgc
      481 cctggtgacc agctcagggc atctgctgcg tagtcagcag ggcccccaca tcgaccagac
      541 agagtgtgtt atccgcatga atgatgcccc cacccgaggc tatgggcttg acgtgggcaa
      601 ccgcacgagc ctgcgggtca tcgcacattc cagcatccag aggatcctcc gcaaccgcca
      661 tgacctgctc aatgtgagcc agggcaccgt gttcatcttc tggggcccca gcagctacat
      721 gcgccgggat ggcaagggcc aggcgtacaa caacctacag ctccttagcc aagtgctgcc
      781 tcggctgaag gccttcatga tcacgcgcca caggatgctg cagttcgatg agctcttcaa
      841 gcaggagact ggcaaagaca ggaagatctc caacacttgg ctgagcactg gctggttcac
      901 catgacaatt gctctggagc tgtgtgacag gatcgatgtt tacggcatgg tgcccccaga
      961 cttctgcagg gacccaaagc atccttccgt accctatcat tactatgagc cttcaggacc
     1021 cgatgaatgt acaatgtacc tctctcacga gcgaggacgc aagggcagtc atcaccgttt
     1081 cattacagag aaacgggtgt ttaagaactg ggcacggaca ttcaacattc actttttcca
     1141 accagactgg aaaccagaat cacccgctgt gaatcatgcc gagggtaagc ctgtgttctg
     1201 aggggtgaac atggtggaca gcggtgtcca cgctgtgtgg caggagagga aggacttaaa
     1261 ctctaggcag ggaaacggga actgaatggg tgaccgagaa gagcggcgtc cttcagcacc
     1321 atggacagat cccagcggcc agagaacatt ccagaacgct tacatgctaa tgagtgttgt
     1381 ctcttggaaa gagcaactga agccttgatt cagtgacact gccatggcta ggaacacccc
     1441 aggtctctgg gagtattgcc ttcgaaactg aaccgggagc agcccgccac ttttagttgc
     1501 atttctttac agatacccac gtcaaaagac ttttttatca gaaacctaac ctgacctata
     1561 gtctctgtca tttgtcagac tttgtgattt gtaaaaggcc tgaaagtatg gacatgcttc
     1621 cgaagagcac atctccaatg attttcataa agcaaatgtc tgctatttat ttattgagag
     1681 ttttttagtg tactctaggc agtattttta tagattatga ttatgtggca atgtattctt
     1741 cctgactctt taatcctgaa tggtggttgg tatgggctag gatcgggctg atgagttact
     1801 gaattcacaa tgcccattac tagcttgaaa tcagtatttg atgtggaaat gtgcaacatt
     1861 gtttgaacct ctctgcttca ggcaatttgc tgtttcataa caaaaacagc tataacactt
     1921 tctaatgtac ataaatgtcc aaaagaacaa aattgaaacc caaaaactgt gttattaaaa
     1981 caaaaagatg ctaatgagag aaatttaaag atacccttac tttttcttca gtagcaactg
     2041 ataatacaag ctatttctct ttgagttcta cttccccttt ccttagaatg taggataaag
     2101 tcccgagttc ctcttgcaaa tctaagatag tcagagcctc tcgtttatag gaggactaga
     2161 cacttggatt gatgtggggc tgacagtagg aggaaacttc cagtcagggt agagatgtca
     2221 gggtcctctg ggtagacatc acgcctcctc ctggggctct cttgcctaac tactatccct
     2281 agattcttta agaaagtgag aaattggggg cagggggtgg aggcagtgcc aagagctgcc
     2341 catgttttga gaacacagaa cagttccacc ccaccggctg caagtcttgg aatatgaagg
     2401 actcctctct ccattcaaat ccacgatcaa gtagtactat agactttcat tttagaaact
     2461 tgtatcgctc agaagagtaa gaaatactag actcttcttt acatcgtgcc aaagggactt
     2521 tagtgtgtct aatgacaggc ttgagggcag cagctaatgt cgtgagggaa caggcattct
     2581 ctacaaacag gacaggactt gtgaataaag tgtctcatac caccagttct ttcccatctt
     2641 tttaattagt gataatgtcc catgcccttt cattaagtag aactattcat tatgcagggc
     2701 gccattgtgg agctgcagat acagtccagg tattcagaca gcaaagacaa agtgttattg
     2761 tggtgtggct tgagttattt aaagtcagta aaaaagaaaa agaaaaaaat taaatggctg
     2821 tccaaga
//
