LOCUS       NM_011373               3986 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Mus musculus ST6
            (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
            3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
            (St6galnac4), transcript variant 1, mRNA.
ACCESSION   NM_011373
VERSION     NM_011373.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3986)
  AUTHORS   Fuseya,S., Izumi,H., Hamano,A., Murakami,Y., Suzuki,R., Koiwai,R.,
            Hayashi,T., Kuno,A., Takahashi,S. and Kudo,T.
  TITLE     Reduction in disialyl-T antigen levels in mice deficient for both
            St6galnac3 and St6galnac4 results in blood filling of lymph nodes
  JOURNAL   Sci Rep 13 (1), 10582 (2023)
   PUBMED   37386100
  REMARK    GeneRIF: Reduction in disialyl-T antigen levels in mice deficient
            for both St6galnac3 and St6galnac4 results in blood filling of
            lymph nodes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3986)
  AUTHORS   Ciobanu,D.C., Lu,L., Mozhui,K., Wang,X., Jagalur,M., Morris,J.A.,
            Taylor,W.L., Dietz,K., Simon,P. and Williams,R.W.
  TITLE     Detection, validation, and downstream analysis of allelic variation
            in gene expression
  JOURNAL   Genetics 184 (1), 119-128 (2010)
   PUBMED   19884314
REFERENCE   3  (bases 1 to 3986)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   4  (bases 1 to 3986)
  AUTHORS   Harduin-Lepers,A., Stokes,D.C., Steelant,W.F., Samyn-Petit,B.,
            Krzewinski-Recchi,M.A., Vallejo-Ruiz,V., Zanetta,J.P., Auge,C. and
            Delannoy,P.
  TITLE     Cloning, expression and gene organization of a human Neu5Ac alpha
            2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV
  JOURNAL   Biochem J 352 Pt 1 (Pt 1), 37-48 (2000)
   PUBMED   11062056
REFERENCE   5  (bases 1 to 3986)
  AUTHORS   Takashima,S., Kurosawa,N., Tachida,Y., Inoue,M. and Tsuji,S.
  TITLE     Comparative analysis of the genomic structures and promoter
            activities of mouse Siaalpha2,3Galbeta1,3GalNAc GalNAcalpha2,
            6-sialyltransferase genes (ST6GalNAc III and IV): characterization
            of their Sp1 binding sites
  JOURNAL   J Biochem 127 (3), 399-409 (2000)
   PUBMED   10731711
REFERENCE   6  (bases 1 to 3986)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   7  (bases 1 to 3986)
  AUTHORS   Lee,Y.C., Kaufmann,M., Kitazume-Kawaguchi,S., Kono,M.,
            Takashima,S., Kurosawa,N., Liu,H., Pircher,H. and Tsuji,S.
  TITLE     Molecular cloning and functional expression of two members of mouse
            NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase
            family, ST6GalNAc III and IV
  JOURNAL   J Biol Chem 274 (17), 11958-11967 (1999)
   PUBMED   10207017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928710.6 and AL772271.11.
            
            On Jan 7, 2022 this sequence version replaced NM_011373.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159712.1, BC086784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL928710.6         180698-180748
            52-594              AL772271.11        2001-2543
            595-780             AL772271.11        4307-4492
            781-1193            AL772271.11        8852-9264
            1194-1301           AL772271.11        10556-10663
            1302-3986           AL772271.11        11876-14560
FEATURES             Location/Qualifiers
     source          1..3986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3986
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /note="ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4"
                     /db_xref="GeneID:20448"
                     /db_xref="MGI:MGI:1341894"
     exon            1..594
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             583..1491
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /EC_number="2.4.3.7"
                     /note="sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialyltransferase) D;
                     Sia-alpha-2-3-Gal-beta-1-3-GalNAc
                     GalNAc-alpha-2,6-sialyltransferase; GalNAc
                     alpha-2,6-sialyltransferase; ST6
                     neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4;
                     sialyltransferase 7D;
                     neuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,
                     6-sialyltransferase"
                     /codon_start=1
                     /product="alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase"
                     /protein_id="NP_035503.1"
                     /db_xref="CCDS:CCDS15921.1"
                     /db_xref="GeneID:20448"
                     /db_xref="MGI:MGI:1341894"
                     /translation="MKAPGRLLLLTLCILTFSAVCVFLCCWACLPLCLATCLDRHLPA
                     APRSTVPGPLHFSGYSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLR
                     MNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWGQGRHMDRV
                     LGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTM
                     ILALELCEEIVVYGMVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPRSAHRF
                     ITEKAVFSRWAKKRPIVFAHPSWRAK"
     exon            595..780
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1193
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1301
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3986
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1990
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /note="major polyA site"
     regulatory      3964..3969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
                     /note="hexamer: AATAAA"
     polyA_site      3986
                     /gene="St6galnac4"
                     /gene_synonym="SIAT7-D; Siat7d; ST6GalNAcIV"
ORIGIN      
        1 agcttcaggc ttcagaagct gcggccgcag caccgcctcc tacccggggc ccggttccag
       61 cccctctggc ccggcgcact ggacatggag ctccgagcag cgcatcctga gcccccagcg
      121 cactccaatc cgctcgttcg gttagcgccc agcttgggga ggggacggtg gaagctagcc
      181 gggtgaaaac ctcacatcct gcccgcccca ggcctctcca tcaccccgcg gtagagagtt
      241 gggatggatg ggaacgatgt tctcctggct cctggctttc tttgcctgcc tccgaccgaa
      301 tggatgacct tgagccgaga gcgtctcctc tttgcctctc cttccccatc tgcacaatgg
      361 gaattggttt ggcaaggtct ctgaactcac ggcctttaga atgggacacg ttgtcacatg
      421 cttggagact taaaggcttt tggttcctgg gcccgttttt cttgatctgg atttgtctct
      481 tcccttgcct cagtttctct catatcctgg gaccagcttc cagcctttct catcccaagc
      541 actggagaca gcagcctcca gactgctaag agcagagaca gcatgaaggc cccgggccgc
      601 cttctgctcc tcacactgtg catcttgaca ttctctgctg tctgtgtctt cctgtgctgc
      661 tgggcctgcc tgccgctctg cctggcaacc tgcctggacc gccacctccc tgcggccccc
      721 agatccactg tgccagggcc cctgcacttc agtggctaca gcagcgtgcc agacgggaag
      781 cctcttatcc gagaactgtg ccacagctgt gcggtggtgt ccagctctgg ccagatgctg
      841 ggttcaggcc tgggtgccca gatcgatggc gcagagtgcg tgctacgcat gaaccaggca
      901 cccaccgtgg gctttgagga ggacgtgggc cagcgcagca ctctgcgcgt gatctctcac
      961 acaagtgtgc cattgcttct gcgcaactac tcacactatt tccagcatgc ccgagacacg
     1021 ctctacgtgg tgtggggcca gggcaggcac atggacaggg tgctgggcgg ccgcacctac
     1081 cgaacgttgc tgcagctcac cagaatgtat ccaggcctgc aagtgtacac cttcactgaa
     1141 cgcatgatgg cctactgtga ccagatcttc caagatgaga caggcaagaa ccggagacaa
     1201 tcaggctcct ttctcagcac cggttggttc accatgattc tggccctgga gctgtgcgag
     1261 gagatcgtgg tctacgggat ggtcagcgat agttactgca gcgagaagag tccccgctcc
     1321 gtgccctacc actactttga gaagggccgg ctagatgagt gtcagatgta ccgtttgcat
     1381 gagcaggctc caaggagcgc ccatcgcttc attaccgaga aggctgtgtt ctcccgctgg
     1441 gccaagaagc gacccatcgt gttcgcccac ccgtcctgga gggccaagta gttcctgttg
     1501 ccagtgactg ccaggcctca gccaggcctg tgacccattc caggccaaca cggctctaat
     1561 gtgagcattt atgactcacc ttctacctga caccaggtag aacatgaagt ctctattacc
     1621 caacactggg tacactcgga ggaacctcag gccttgtgac ttgaagagga gtcgagaaga
     1681 tgccatttac accacccctg cttccagaag aatccacatc ttcatcttgg ggtttgtccc
     1741 actgccaggt tgtttaagtg acctttgccc tgggtccgtc gatggcccca cctcaccagc
     1801 attatggctt tataccagtc ttgaaccttt cctctacctg gctccagcca catggtgcca
     1861 cattctcagg ctggtggccc tggttggtgc accctggaac ttgggatttg atggatgtga
     1921 gggcctttga gcctcagcct ctcaggactg actgtcttgg gagtgtgctg gtaaaggcag
     1981 attttctgga cactgtgtct ctgtggtaac ggatgtggga tgggggttag ttaggacaag
     2041 gcctgtagcc tgttccctgg agggctgact gagccttcca gcccttctct aggcccacaa
     2101 ctgtcctgct cttcccgcat tgtctggaca tcagccctac agtctcctgc cccagcatcc
     2161 cacaagcctg accttctgat ggtctgacca caggactgtg ctggcccagg acagccaccc
     2221 tgccctcact caacaggcac agagcggggc ctgggaggac tcggggtgag gaagaaattc
     2281 cacccaacgc cactttcctg cctcatgagt cagattccaa agtctttgcc agtcaggctg
     2341 tctcttaact gtgggacatg attcctttgt aaaacagagg gcagaacgaa ctcagcgcgg
     2401 ggagggtgct gaccagaaag gagtggtctc ggggccagcc ctttctctga gttttgcttt
     2461 tcagtactaa aacacagcca ccacctagct gttaaggagg gtgtgaggcc accctgcgga
     2521 gggagctggt gctcattaca gatgatatag cccaggctag ctttcaggag gtgtctgaac
     2581 taggatgctg gcagccttga gagctcacta cccaggctct gcctccttcc ccctttggaa
     2641 gactgaagaa tggcaccctg ggctttagct ctctgcttca gagttcggga ccctctgggt
     2701 gtaacctgcg cggtccccag agtcccgtgc ttagtttaac ctctcctgct acaaacttga
     2761 aattccttat tttaggtctt ggtttgaaac aaggaacctc tcagtttcct taccggatcc
     2821 cacaaagggc agaacccgtc atgctaaggg ctctggtggc ctagcccact ctccctccta
     2881 cccattttcc caggagtgac tagagacctg gcacctggcc cacaacactg cccttgtccc
     2941 tgtccagtgc caggtggacc ggaagcctca tatgtgggag gggaagcaga gagggaaatc
     3001 tctgagccag ggttacaggc gggaagccaa accgtttccg caggcctgga ggggctgagg
     3061 ggctgagtgt agggataggc catgagtggg tcgtgggtga gacgaagggt cctggcatca
     3121 ggcctgaccc catgttccca ggcaataaag acagtagagt agttcctgcc tcaccagatt
     3181 gtatgagctc agagatgctg gggtgcccct tggggcttac ttagaacaca cttggctctc
     3241 agtattcaga agccaccatt taaatagggt ggccctctgc ctgactgatc ctgttccacc
     3301 ctggcatagg tggcatcagt gcaaaataat aataataata atgatgatgt tctcatccta
     3361 atgagaatag tgtcttctgg tgccattttg agtgactgtg actcaggaac agagatgtat
     3421 gttaccccga attccatgtt ccgttgcgga aacagtttca tgaagtttta tagttttgcg
     3481 gaacataaag tcctaagtcc aggcaagtct aaaatacatt ggtggggaca tcagaaaggt
     3541 gggtacggca agctggggag gactttccta taaggtctga gaggttgaga gctttgggtt
     3601 ggtagaagct atgttctgac aaaggtagtc aggaaatggc tgtgtgaagc tacagctagc
     3661 ccaagatctg ctgattttgg cctctgggcc atctccggag gcctggtttc tttctaggac
     3721 tttttgctca tggtagagag ctggctctcc atcccattag aagtctccgc acctgtgccc
     3781 ttctccgtgc atgtccaggg tcaagagact ccctggtcct ggtgggatct agactactcc
     3841 tttctgagag tcagtcttcc tgctttcagc cataaggaaa tgctgaccca acccttagac
     3901 aaggcacaca gagatgcttc tgtcctggct tctgggtgag gtgtttactg ctgggttggc
     3961 ctgaataaat tgtatttctc agggaa
//
