LOCUS       NM_011372               2961 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ST6
            (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
            3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
            (St6galnac3), transcript variant 1, mRNA.
ACCESSION   NM_011372
VERSION     NM_011372.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Fuseya,S., Izumi,H., Hamano,A., Murakami,Y., Suzuki,R., Koiwai,R.,
            Hayashi,T., Kuno,A., Takahashi,S. and Kudo,T.
  TITLE     Reduction in disialyl-T antigen levels in mice deficient for both
            St6galnac3 and St6galnac4 results in blood filling of lymph nodes
  JOURNAL   Sci Rep 13 (1), 10582 (2023)
   PUBMED   37386100
  REMARK    GeneRIF: Reduction in disialyl-T antigen levels in mice deficient
            for both St6galnac3 and St6galnac4 results in blood filling of
            lymph nodes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Spies,N., Smith,C.L., Rodriguez,J.M., Baker,J.C., Batzoglou,S. and
            Sidow,A.
  TITLE     Constraint and divergence of global gene expression in the
            mammalian embryo
  JOURNAL   Elife 4, e05538 (2015)
   PUBMED   25871848
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Lee,Y.C., Kaufmann,M., Kitazume-Kawaguchi,S., Kono,M.,
            Takashima,S., Kurosawa,N., Liu,H., Pircher,H. and Tsuji,S.
  TITLE     Molecular cloning and functional expression of two members of mouse
            NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase
            family, ST6GalNAc III and IV
  JOURNAL   J Biol Chem 274 (17), 11958-11967 (1999)
   PUBMED   10207017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121914.3, AC103637.11, AC133943.3 and AC163209.2.
            
            On Mar 7, 2023 this sequence version replaced NM_011372.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058387.1, Y11342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC121914.3         99313-99435
            124-318             AC103637.11        42377-42571
            319-728             AC133943.3         81259-81668
            729-836             AC163209.2         133583-133690       c
            837-2961            AC163209.2         130432-132556       c
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.82 cM"
     gene            1..2961
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /note="ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3"
                     /db_xref="GeneID:20447"
                     /db_xref="MGI:MGI:1341828"
     exon            1..123
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1023
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /EC_number="2.4.3.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialyltransferase) C;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     3; STY; SIAT7-C; ST6GalNAcIII; sialyltransferase 7C;
                     galNAc alpha-2,6-sialyltransferase III; ST6GalNAc III"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 3 isoform 1"
                     /protein_id="NP_035502.1"
                     /db_xref="CCDS:CCDS38677.1"
                     /db_xref="GeneID:20447"
                     /db_xref="MGI:MGI:1341828"
                     /translation="MACILKRKPVLVVSFIALCILLLAMRLVNDATFPLLLNCFGQPK
                     TKWIPLPYTFRQPLRTHYGYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHAS
                     CIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWGPFRN
                     MRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTG
                     WFTFILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGG
                     HRFITEKKVFAKWAKKHRIVFTHPNWTLS"
     exon            124..318
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            319..728
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            729..836
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            837..2961
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2937..2942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /note="hexamer: AATAAT"
     polyA_site      2961
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcgcag ctcccgcggc ccggctcgct ctgcgggaat gtgggctgga gtggtccagc
       61 tgcggggccg aggtgcagcg agccacaggg tcgatccata gcgccatggc ctgcatcctc
      121 aagaggaagc ccgtgcttgt ggtgagcttc atagccctgt gcatcttgct gctagccatg
      181 cgccttgtca atgatgcgac tttccctttg ctcctgaact gctttggaca gcctaagacc
      241 aaatggatcc ctttgcccta cacattcagg cagcctcttc gaactcacta tggatacata
      301 aatgtgagga cccaagagcc tttgcaactg aactgtaacc actgtgccat cgtgtcaaat
      361 tcaggtcaaa tggtcgggca gaaggtgggg gaagagatag accatgcatc ctgcatctgg
      421 agaatgaaca acgccccaac caagggcttt gaggaagatg tcggctacat gacaatggtc
      481 cgagttgtgt cacataccag tgtccctctc ttgctgaaaa atcctgacta ttttttcaaa
      541 gaagcaagca ggaccattta tgttatctgg ggccctttcc gcaacatgag gaaggatggt
      601 aatggcatcg tgtacaacat gttaaagaag acagttgatg cctatccaga tgcgcagatc
      661 tacgtgacca cagagcagca gatgactcac tgcgatagag tgtttaagga tgagactgga
      721 aaggacagag tccagtctgg ctcctacctc agcactggct ggtttacctt tatcctggct
      781 atggatgcct gctacagtat ccacgtctac gggatgataa atgaaaccta ctgcaagaca
      841 gaagggtata gaaaagtccc ctatcactac tatgaacaag ggaaagatga gtgtaacgaa
      901 tatcttctcc atgaacatgc cccgtatggg ggacacaggt tcatcaccga gaagaaagtg
      961 tttgccaagt gggccaagaa gcacagaata gtattcacac acccgaactg gacgctgtcc
     1021 tgatgccgtg cttcccgacc atgacactgc agctgtggtg aagagaggct gatggtgctg
     1081 acggtgtagg caggatgttc agggtgtgac catggccctg gacattctct ggtgtggata
     1141 ctgactctgt tagtaatttg aacttggcgt tccatgggag gcggtcatgt tcattctgat
     1201 ctttctggtg gttcggccct atcaattgca ctttaaaact tacctacggt tgaaatgaag
     1261 gccagtgacc tgatggctgt gactaaagaa aacacgaaga ttacctttca agatagctgc
     1321 tcagaattct tcaagaggct tccagaagtg acgacttctg cctgctcagg caagcttact
     1381 gagtgcacgg gctgctcccc atcttggaaa atggtggact atcaaacact gtcccaagtc
     1441 atccttcagg gtatagatgt catgccacag ttaccagtca gcctgataga ggggaggtat
     1501 ctctttctga tatgccatct tccttccata tgtctctcag cgaaagcctc aggccaccta
     1561 cctaaatgta gcaatgaagg cattctgtaa ttcctgcgta ccaggattac tggactatct
     1621 cagagactta attcaaaatg tatcaagtag caaatattga caaattttca ctcagacagc
     1681 tgtgctctca ctactcaaaa caatataact aaacatatta ttacagttac ctacgttaat
     1741 gtttagttat ttttggttga gtgctaagta ttaacatgtt agatatactt caacactgta
     1801 ataacacata ctgtgaaagc atttcttgag cataaccaaa gggtttctct ctctgcttca
     1861 gcactcagta ccaacaaatg agatgctttt tgaatcacaa aacagggaaa gcaagacata
     1921 tttttgcatc aatttgtatc ctatcatatt cataatatat atttttaaat tcaaatttct
     1981 attttataag ctgaaagggt atctttccat atacattatc aatgccaagt gccaaacact
     2041 ctttatacca tcaaacccag gctgagcttt tgccttcatg gggttgacca tcccttaggt
     2101 tatcagatgt tctgctagga cagtaaaatg gtgacgagct tacttcccaa agtgcttcgc
     2161 tatgcttcac atatgctgtg tgccatgtga cacccacggc cgcctcactg gatgattgcc
     2221 ggcacattct gccaccccca gcagctgatc tgcattgtta gctgtgttcc tgtgtcccaa
     2281 gttgctctgc ctcagaatat atgtatagag tagcatttgt gtaaattagt atatgattga
     2341 gttctctgcc aaatacagca gagattatac aagatgacca caaggatggc tgtgtcatag
     2401 atcagtaccc tataagctta gatactttta atgtttttgt ttctgtcagt ggctctgttc
     2461 cagggctcgg ggacaatgga taggaatgga agcagagaaa tacagttccc tggtctaggc
     2521 ctgagacggc ttccttctcc gtagatcaat ggtccttaaa tattagaagt tggttttctg
     2581 agacactacc aagcatctat aaatatcttg gcacaacaat tcaaaagcta aaaccaggct
     2641 gcatttaatg ttttagagct ggaaataaca atacacctca gctgtagaac cttgacaggg
     2701 ctaggactaa aggccatgtg acgtgtgacg tcattaagat gtgcatcttt cctaccctac
     2761 actgtcacac tgatagacat cccacaccca cacccacaag agttacccag ccccagcctc
     2821 atccctggga ggagtggtta ttctattgtt tgcttatgtg actttttttt tttagttcta
     2881 tgaatgttag attttagagc tgatagtgat tcaagatgcc cacttaaagg aaaataaata
     2941 atagcaatgt taaaatttca a
//
