LOCUS       NM_009180               2033 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus ST6
            (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
            3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
            (St6galnac2), mRNA.
ACCESSION   NM_009180
VERSION     NM_009180.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Ye,C., Clements,S.A., Gu,W., Geurts,A.M., Mathews,C.E.,
            Serreze,D.V., Chen,Y.G. and Driver,J.P.
  TITLE     Deletion of Vbeta3+CD4+ T cells by endogenous mouse mammary tumor
            virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T
            cells
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2312039120 (2023)
   PUBMED   38015847
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Orr,S.L., Le,D., Long,J.M., Sobieszczuk,P., Ma,B., Tian,H.,
            Fang,X., Paulson,J.C., Marth,J.D. and Varki,N.
  TITLE     A phenotype survey of 36 mutant mouse strains with gene-targeted
            defects in glycosyltransferases or glycan-binding proteins
  JOURNAL   Glycobiology 23 (3), 363-380 (2013)
   PUBMED   23118208
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Platt,M.D., Salicioni,A.M., Hunt,D.F. and Visconti,P.E.
  TITLE     Use of differential isotopic labeling and mass spectrometry to
            analyze capacitation-associated changes in the phosphorylation
            status of mouse sperm proteins
  JOURNAL   J Proteome Res 8 (3), 1431-1440 (2009)
   PUBMED   19186949
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Kurosawa,N., Inoue,M., Yoshida,Y. and Tsuji,S.
  TITLE     Molecular cloning and genomic analysis of mouse Galbeta1,
            3GalNAc-specific GalNAc alpha2,6-sialyltransferase
  JOURNAL   J Biol Chem 271 (25), 15109-15116 (1996)
   PUBMED   8662927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK004613.1.
            
            [WARNING] On Feb 11, 2025 this sequence was replaced by
            NM_009180.4.
            
            On Sep 20, 2006 this sequence version replaced NM_009180.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004613.1, X93999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2033              AK004613.1         2-2034
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.49 cM"
     gene            1..2033
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /note="ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2"
                     /db_xref="GeneID:20446"
                     /db_xref="MGI:MGI:107553"
     exon            1..224
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1224
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /EC_number="2.4.3.3"
                     /note="sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde
                     alpha-2,6-sialyltransferase) B; Gal-beta-1,3-GalNAc
                     alpha-2,6-sialyltransferase; alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase II; SIAT7-B; ST6GalNAcII;
                     sialyltransferase 7B; galNAc alpha-2,6-sialyltransferase
                     II; ST6GalNAc II"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 2"
                     /protein_id="NP_033206.2"
                     /db_xref="CCDS:CCDS36379.1"
                     /db_xref="GeneID:20446"
                     /db_xref="MGI:MGI:107553"
                     /translation="MDLPRRWLFRMLLLVATSSGILLMLYSSAGQQSPETQVPARNMA
                     YPRAFFDPKPPNSENRKSRLCQHSLSLAIQKDRRFRSLFDLSTPVLLWEGLFTQELWN
                     NLSQHKVPYGWQGLSHEVIASTLRLLKSPESGELFGAPRKLPLSCIRCAVVGNGGILN
                     GSRQGQKIDAHDYVFRLNGAITEGFERDVGTKTSFYGFTVNTMKNSLISYAKLGFTSV
                     PQGQNLRYIFIPSSIRDYLMLRSAILGVPVPEGPDKGDRPHTYFGPETSASKFKLLHP
                     DFISYLTERFLKSKLINTRFGDMYMPSTGALMLLTALHTCDQVSAYGFITNNYQKYSD
                     HYFEREKKPLIFYANHDLSLEASLWRDLHNAGILWLYQR"
     exon            225..285
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            286..460
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            461..629
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            630..768
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            769..872
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            873..956
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1056
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..2033
                     /gene="St6galnac2"
                     /gene_synonym="II; Siat7; Siat7b; ST6GalNAc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagggc cgccgcctcc gcgggtccca ctgggacggt cctctccggc cgggggctcg
       61 gtgagcaggg cggcagacgg ggcgcacccc ggccaggctc acatggacct cccgcgccgc
      121 tggctctttc ggatgttgtt gctcgttgcc accagctctg ggatcctcct catgctgtac
      181 tcctcggcgg ggcagcagtc ccctgagacc caggttcccg ccaggaacat ggcgtaccca
      241 cgagcattct ttgaccccaa accaccgaat tcggaaaaca gaaagagccg actttgccaa
      301 cactcgctgt ccctggccat tcagaaggac cgtcgcttcc gcagcctgtt tgacctctcc
      361 accccggtgc tgctgtggga gggcctcttc actcaggaac tctggaataa tctgagccag
      421 cacaaagtcc cctacggatg gcaggggctc tcccacgaag tcattgcctc taccctgaga
      481 cttctgaaaa gcccggagag cggggagctg tttggtgccc ccaggaaact acctctaagc
      541 tgtattcgct gtgccgtggt gggtaacgga ggtattctga atgggtcccg gcagggccag
      601 aaaatcgatg ctcatgacta tgtcttcaga ctcaatggcg ccataaccga aggctttgag
      661 cgcgacgtgg gcactaagac ctccttctac ggtttcaccg tgaacaccat gaagaactcg
      721 ctcatctcct acgccaaact gggcttcacc tctgtgccac aagggcagaa cctgcgctac
      781 atcttcatcc cctccagcat ccgtgactac ctgatgctga gatccgccat cctgggtgtg
      841 cctgttccag aaggtcctga taaaggggac aggcctcaca cctattttgg accggaaacc
      901 tctgccagta aattcaagct cctgcaccca gacttcatca gctacctgac agagaggttt
      961 ctgaaatcca agctgattaa cacacgattt ggagacatgt atatgcctag cacgggagcg
     1021 ctcatgctgc tgacagcctt gcacacctgt gaccaggtca gtgcctacgg attcatcaca
     1081 aacaactacc agaaatactc agaccactat ttcgaacgag aaaagaaacc actgatattc
     1141 tacgcaaacc acgacctgtc cctggaagct tcgctatggc gagacctgca caacgccggc
     1201 atcctttggc tgtaccaacg ctgaccccaa agtaccggat ttctgtgcct caaaagcact
     1261 ttttttgacc tttcaacttc tggaagaggc aacactcccc ttggccctct acttcccaac
     1321 agagggtatt gagacaagac ccgtcacata ataccagagc ctgttcaatg cacgacactg
     1381 tcacaggtca agacaactct tctgaggctt agccgaggga gggaagactg ctttgtagga
     1441 ttcgttttaa aactgaacat taaatgagac aatgatgctc accagcaaac aggcgggcag
     1501 gcacatctca gagctaagta gtccaaagcc agcacctggc cctgggcaac tagaaacatt
     1561 gatggaacca ctcagggcta tccaggaacc tcgatcgagc agagctgaaa ccaatggcat
     1621 gttgagtccc aaatgccaaa gccattcaac ctagaacacc ttaggcatta taggaacagg
     1681 acacttctgc ctcctgatag aggatgagaa acagaggcag aatgtagttt gaagctagat
     1741 aatagggtgt gatggatgac cattttgtct tttttgtgtt ggtagagtag aagacacaaa
     1801 ctccaaggtg gtgtgtctgg agggaagggg tgtggcggca ctcaggacag agtttggtgg
     1861 cacctgcacc gaggttcagg ctaggagtac ctagcaccaa agagacaaac tttgtgtaag
     1921 tcgccaccac tgacgagtct cactggagag gcacatcagt ccttgtcacc aacaggaaac
     1981 tgagtgatgg accctcactt cacagcttca ataaacagca cctgatgcag tcc
//
