LOCUS       NM_011371               2396 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ST6
            (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
            3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
            (St6galnac1), mRNA.
ACCESSION   NM_011371 XM_001005669
VERSION     NM_011371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Ye,C., Clements,S.A., Gu,W., Geurts,A.M., Mathews,C.E.,
            Serreze,D.V., Chen,Y.G. and Driver,J.P.
  TITLE     Deletion of Vbeta3+CD4+ T cells by endogenous mouse mammary tumor
            virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T
            cells
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2312039120 (2023)
   PUBMED   38015847
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Yao,Y., Kim,G., Shafer,S., Chen,Z., Kubo,S., Ji,Y., Luo,J.,
            Yang,W., Perner,S.P., Kanellopoulou,C., Park,A.Y., Jiang,P., Li,J.,
            Baris,S., Aydiner,E.K., Ertem,D., Mulder,D.J., Warner,N.,
            Griffiths,A.M., Topf-Olivestone,C., Kori,M., Werner,L., Ouahed,J.,
            Field,M., Liu,C., Schwarz,B., Bosio,C.M., Ganesan,S., Song,J.,
            Urlaub,H., Oellerich,T., Malaker,S.A., Zheng,L., Bertozzi,C.R.,
            Zhang,Y., Matthews,H., Montgomery,W., Shih,H.Y., Jiang,J.,
            Jones,M., Baras,A., Shuldiner,A., Gonzaga-Jauregui,C.,
            Snapper,S.B., Muise,A.M., Shouval,D.S., Ozen,A., Pan,K.T., Wu,C.
            and Lenardo,M.J.
  TITLE     Mucus sialylation determines intestinal host-commensal homeostasis
  JOURNAL   Cell 185 (7), 1172-1188 (2022)
   PUBMED   35303419
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Yu,X., Wu,Q., Wang,L., Zhao,Y., Zhang,Q., Meng,Q., Pawan and
            Wang,S.
  TITLE     Silencing of ST6GalNAc I suppresses the proliferation, migration
            and invasion of hepatocarcinoma cells through PI3K/AKT/NF-kappaB
            pathway
  JOURNAL   Tumour Biol 37 (9), 12213-12221 (2016)
   PUBMED   27235117
  REMARK    GeneRIF: Results suggest a role of ST6GalNAc I in promoting the
            growth and invasion of hepatocarcinoma cells through regulating
            PI3K/AKT/NF-kappa B signaling, and ST6GalNAc I might be a marker
            for the prognosis and therapy of hepatocarcinoma.
            Erratum:[Tumour Biol. 2021;43(1):75-76. doi: 10.3233/TUB-219003..
            PMID: 33935134]
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Ozaki,H., Matsuzaki,H., Ando,H., Kaji,H., Nakanishi,H., Ikehara,Y.
            and Narimatsu,H.
  TITLE     Enhancement of metastatic ability by ectopic expression of
            ST6GalNAcI on a gastric cancer cell line in a mouse model
  JOURNAL   Clin Exp Metastasis 29 (3), 229-238 (2012)
   PUBMED   22228572
  REMARK    GeneRIF: It was confirmed that MUC1 carries sialyl Tn also in human
            advanced gastric cancer tissues
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Clement,M., Rocher,J., Loirand,G. and Le Pendu,J.
  TITLE     Expression of sialyl-Tn epitopes on beta1 integrin alters
            epithelial cell phenotype, proliferation and haptotaxis
  JOURNAL   J Cell Sci 117 (Pt 21), 5059-5069 (2004)
   PUBMED   15383613
  REMARK    GeneRIF: ST6GalNAc I has a role in O-glycosylation of the integrin
            beta1 chain and integrin beta 1-mediated signalling
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Fu,G., Haywood,M.E. and Morley,B.J.
  TITLE     Representational difference analysis in a lupus-prone mouse strain
            results in the identification of an unstable region of the genome
            on chromosome 11
  JOURNAL   Nucleic Acids Res 30 (6), 1394-1400 (2002)
   PUBMED   11884638
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   Kurosawa,N., Takashima,S., Kono,M., Ikehara,Y., Inoue,M.,
            Tachida,Y., Narimatsu,H. and Tsuji,S.
  TITLE     Molecular cloning and genomic analysis of mouse GalNAc alpha2,
            6-sialyltransferase (ST6GalNAc I)
  JOURNAL   J Biochem 127 (5), 845-854 (2000)
   PUBMED   10788794
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   9  (bases 1 to 2396)
  AUTHORS   Lee,Y.C., Kaufmann,M., Kitazume-Kawaguchi,S., Kono,M.,
            Takashima,S., Kurosawa,N., Liu,H., Pircher,H. and Tsuji,S.
  TITLE     Molecular cloning and functional expression of two members of mouse
            NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase
            family, ST6GalNAc III and IV
  JOURNAL   J Biol Chem 274 (17), 11958-11967 (1999)
   PUBMED   10207017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y11274.1, AL645542.13 and BE847090.1.
            
            On Feb 23, 2007 this sequence version replaced NM_011371.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11274.1, BC141095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               Y11274.1           1-222
            223-511             AL645542.13        51277-51565         c
            512-1236            Y11274.1           512-1236
            1237-1237           AL645542.13        48802-48802         c
            1238-1336           Y11274.1           1238-1336
            1337-1737           BE847090.1         1-401
            1738-1970           Y11274.1           1738-1970
            1971-2243           AL645542.13        47371-47643         c
            2244-2396           Y11274.1           2248-2400
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.49 cM"
     gene            1..2396
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /note="ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1"
                     /db_xref="GeneID:20445"
                     /db_xref="MGI:MGI:1341826"
     exon            1..221
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1686
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /EC_number="2.4.3.3"
                     /note="sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde
                     alpha-2,6-sialyltransferase) A; SIAT7-A; ST6GalNAcI;
                     sialyltransferase 7A; ST6GalNAc I"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 1"
                     /protein_id="NP_035501.2"
                     /db_xref="CCDS:CCDS36380.1"
                     /db_xref="GeneID:20445"
                     /db_xref="MGI:MGI:1341826"
                     /translation="MTRYCRGLSQRQAFLLLTVLALLFILLFVVKDPRAKDSRCQFIW
                     KNDASAQENQQKAEPQVPIMTLSPRVHNKETTSVSSKDLKKQEREAVQGEQAEGKEKR
                     KLETIRPAPENPQSKAEPAAKTPVSEHLDKLPRAPGALSTRKTPMATGAVPAKKKVVQ
                     ATKSPASSPHPTTRRRQRLKASEFKSEPRWDFEEEYSLDMSSLQTNCSASVKIKASKS
                     PWLQNIFLPNITLFLDSGRFTQSEWNRLEHFAPPFGFMELNQSLVQKVVTRFPPVRQQ
                     QLLLASLPTGYSKCITCAVVGNGGILNDSRVGREIDSHDYVFRLSGAVIKGYEQDVGT
                     RTSFYGFTAFSLTQSILILGRRGFQHVPLGKDVRYLHFLEGTRDYEWLEAMFLNQTLA
                     KTHLSWFRHRPQEAFRNALDLDRYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYRPTTG
                     ALLLLTALHLCDKVSAYGFITEGHQRFSDHYYDTSWKRLIFYINHDFRLERMVWKRLH
                     DEGIIWLYQRPQSDKAKN"
     exon            222..720
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            721..889
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1061
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1200
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1304
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1394
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2392
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /note="hexamer: AATAAA"
     polyA_site      2392
                     /gene="St6galnac1"
                     /gene_synonym="Siat7a"
                     /note="major polyA site"
ORIGIN      
        1 aaagggcagg gctccctcgc tctcacctga aggagcaggc gatctgactg ctgctttaag
       61 aagcttgctc tcatcataca tgctgttagg gaccagccat ccaccatgac gagatattgc
      121 agaggacttt cccagaggca agctttcctg cttctgactg tgttggcatt gctctttatt
      181 ctgctcttcg ttgttaagga tccaagggca aaagattcca ggtgccagtt catatggaag
      241 aatgacgcaa gtgcccagga gaatcaacaa aaggctgagc cccaagtacc catcatgaca
      301 ctgtcaccca gagttcacaa caaggagaca acctctgtca gttcaaagga cctgaagaaa
      361 caggagagag aggcagtcca aggagagcaa gctgagggga aggagaagag gaagttggag
      421 accataaggc cagcaccaga gaatcctcag agcaaggcag agcctgctgc aaagacgcct
      481 gtgtcagaac acctggacaa actacccaga gctccaggag cactgtcaac aaggaagaca
      541 ccaatggcca caggagctgt cccagctaag aagaaagtgg tccaggctac caaatcccct
      601 gcctcttccc cacaccccac cacacgaaga aggcaaaggc tgaaggcctc tgagttcaag
      661 tctgagcctc ggtgggattt tgaggaggaa tatagcttgg atatgagcag cctgcagacg
      721 aactgctctg cttctgtgaa gatcaaggcc tccaagtcac catggctaca gaatatcttt
      781 ctgcccaaca tcactctgtt cctggactct ggacgcttca cccagagcga gtggaaccgt
      841 ctagagcact tcgctcctcc ctttggcttc atggaactca atcagtccct ggtacagaag
      901 gtggtgaccc gcttccctcc agttcgccag cagcagctcc tcctggccag cctccctact
      961 gggtactcca agtgtatcac ctgtgctgta gtgggcaacg ggggcatcct gaatgattca
     1021 cgtgttggcc gggagataga cagccatgac tatgttttcc gactgagtgg agccgttatt
     1081 aaaggatatg aacaggatgt ggggacccgg acatccttct atggcttcac tgctttctct
     1141 ctgacccagt ctatcctcat tttgggtaga cgaggcttcc agcatgtgcc tctgggaaag
     1201 gacgtccgat atctacactt cctggaaggc acccgggact atgagtggct ggaagctatg
     1261 tttttgaatc agaccttggc aaaaacccac ctttcctggt tcaggcatag gcctcaggaa
     1321 gccttccgga atgccttgga cttggatcga tacttgctgc tgcacccaga ctttctccgt
     1381 tacatgaaga acaggtttct gaggtcaaag accctggaca ctgcccattg gagaatatac
     1441 cgccccacca ctggtgccct cctgctgctc acagcccttc atctctgtga caaggtcagc
     1501 gcctatggct tcatcaccga gggccaccag cgcttctctg accactacta tgatacatcg
     1561 tggaaaaggt tgatctttta tatcaaccat gacttcaggt tagagagaat ggtgtggaag
     1621 cggttgcatg atgaaggcat catctggctc taccagcgtc cacaaagtga caaagcaaag
     1681 aactgaccag ggcccagatc agggtgttcc cctcgaccac ttacaacaca gaatgcaagg
     1741 gctcctcaaa tgctcctacc tgtgtctctg gaatcagacc tgctccacac ctttcaagag
     1801 tctagatcta cagagtaagt tcactgtctg acagagctac acagagaaac cctctccaaa
     1861 acaaaacaaa agaaaacaac aacaaaagca aacaggaaaa tcactgaaaa gtaacattga
     1921 cagtaatgtt ttactttaaa ataaataaaa tcagtcaagt tacttccccc aggaataggg
     1981 agagatcccc aaagtgtcag caccacccac aaggcattga cttcaacctc acagtgtgct
     2041 cacctgacat tttgggtgag tagactgaac acattcaagg tacggcagga tttcagagtg
     2101 agccctctgt gccactgaat gcttgtaatc ttattgagag agagagaggg agagagagag
     2161 agagagagag agagagagag tatgtgtgtg tgtacatctg tgtaaatgta caggtttaca
     2221 cattttcagg agttcaaggc tagcattggc tacacagcaa gttcaaggtc agcctgggtt
     2281 acaggaagac tctgtctcac atcaaagaac ttcccagagt ggaattttgt gttaattcag
     2341 agccatgatg gggcaccatg agctgccatt gaataaaggg actaccctct gaaaaa
//
