LOCUS       NM_001347403            6250 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus beta galactoside alpha 2,6 sialyltransferase 2
            (St6gal2), mRNA.
ACCESSION   NM_001347403 XM_006524266
VERSION     NM_001347403.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6250)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6250)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   3  (bases 1 to 6250)
  AUTHORS   Ohmi,Y., Nishikaze,T., Kitaura,Y., Ito,T., Yamamoto,S.,
            Sugiyama,F., Matsuyama,M., Takahashi,Y., Takeda,A., Kawahara,T.,
            Okajima,T., Furukawa,K. and Furukawa,K.
  TITLE     Majority of alpha2,6-sialylated glycans in the adult mouse brain
            exist in O-glycans: SALSA-MS analysis for knockout mice of
            alpha2,6-sialyltransferase genes
  JOURNAL   Glycobiology 31 (5), 557-570 (2021)
   PUBMED   33242079
  REMARK    GeneRIF: Majority of alpha2,6-sialylated glycans in the adult mouse
            brain exist in O-glycans: SALSA-MS analysis for knockout mice of
            alpha2,6-sialyltransferase genes.
REFERENCE   4  (bases 1 to 6250)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6250)
  AUTHORS   Takashima,S., Tsuji,S. and Tsujimoto,M.
  TITLE     Comparison of the enzymatic properties of mouse beta-galactoside
            alpha2,6-sialyltransferases, ST6Gal I and II
  JOURNAL   J Biochem 134 (2), 287-296 (2003)
   PUBMED   12966079
REFERENCE   6  (bases 1 to 6250)
  AUTHORS   Krzewinski-Recchi,M.A., Julien,S., Juliant,S.,
            Teintenier-Lelievre,M., Samyn-Petit,B., Montiel,M.D., Mir,A.M.,
            Cerutti,M., Harduin-Lepers,A. and Delannoy,P.
  TITLE     Identification and functional expression of a second human
            beta-galactoside alpha2,6-sialyltransferase, ST6Gal II
  JOURNAL   Eur J Biochem 270 (5), 950-961 (2003)
   PUBMED   12603328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009635.18 and BE991433.1.
            
            On Nov 24, 2016 this sequence version replaced XM_006524266.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.88586.1,
                                           SRR1660821.138209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               CT009635.18        90304-90731         c
            429-1418            CT009635.18        53219-54208         c
            1419-1516           CT009635.18        45073-45170         c
            1517-1618           CT009635.18        39720-39821         c
            1619-1793           CT009635.18        37707-37881         c
            1794-5934           CT009635.18        21832-25972         c
            5935-6250           BE991433.1         1-316               c
FEATURES             Location/Qualifiers
     source          1..6250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 28.82 cM"
     gene            1..6250
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /note="beta galactoside alpha 2,6 sialyltransferase 2"
                     /db_xref="GeneID:240119"
                     /db_xref="MGI:MGI:2445190"
     exon            1..428
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1418
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2065
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /EC_number="2.4.3.1"
                     /note="beta-galactoside alpha-2,6-sialyltransferase II;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     6-sialyltransferase 2"
                     /codon_start=1
                     /product="beta-galactoside alpha-2,6-sialyltransferase 2"
                     /protein_id="NP_001334332.1"
                     /db_xref="CCDS:CCDS84324.1"
                     /db_xref="GeneID:240119"
                     /db_xref="MGI:MGI:2445190"
                     /translation="MKPHLKQWRQRMLFGIFVWGLLFLAIFIYFTNSNPAAPMPSSFS
                     FLERRGLLPLQGKQRVIMGALQEPSLPRSLDASKVLLDSHPENPFHPWPGDPQKWDQA
                     PNGFDNGDEFFTSQVGRKSQSAFYPEEDSYFFVADQPELYHHRQGALELPSPGETSWR
                     SGPVQPKQKLLHPRRGSLPEEAYDSDMLSASMSRAFLYRLWKGAVSSKMLNPRLQKAM
                     RYYMSFNKHGVRFRRRGRREATRTGPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVP
                     GVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKT
                     TVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQH
                     RRKYPTQPFYILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYE
                     YIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNTGTQADLHHKGKVVLPG
                     FQTLRCPVTSPNNTHS"
     exon            1419..1516
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1618
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1793
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..6234
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3224..3229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /note="hexamer: ATTAAA"
     polyA_site      3253
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
     regulatory      6210..6215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /note="hexamer: AATAAA"
     polyA_site      6234
                     /gene="St6gal2"
                     /gene_synonym="C230064G14Rik; mKIAA1877; St6galII"
                     /note="major polyA site"
ORIGIN      
        1 acactccacc cagctgcctg gcgcgcaggt agcccggctt ttgctctgtc tacagagggc
       61 tgtgtgttcg aagccagcac acaaagactc acttcctccc ggccagcttc ccagaccgcc
      121 ctgcccacca ccggcggccg gtggcattcc agaggccacc accgggacat tcctgtgccc
      181 gggtgccagg tacttggagc agaagccatt cggggagccc ttggagccgc tcagctggtg
      241 aaggtggcgg ctgggattag cacgcctttt taggcagccg cgccgcccca cgcagcggag
      301 tctgcaatcg ctgtacgaca ggcaggctct gcgtcgccag agcgtccccg cctgcgctgg
      361 ccgcggggca agctgcgggc cggagcgctc gcgggaggcc gatcaactcc ccagcgccta
      421 gccagcaggt tttgtccacc tcgtagtgct ttagaacccc aaggtgaagt gctggcccca
      481 aagatctgca atgaaaccac acttgaagca atggcgacaa cgaatgctct ttggaatatt
      541 tgtttggggg ctcctctttt tggcaatttt catctacttc accaacagca atcctgcggc
      601 acctatgccc agctcctttt ccttcctgga gagacgtggg ctcctgcctc tacagggcaa
      661 gcagcgggtc atcatgggcg ctttgcagga accctctttg cccagaagtt tggatgcaag
      721 caaagtgctg ctggacagcc accctgagaa ccctttccac ccttggcctg gggacccaca
      781 gaaatgggat caggccccaa atggctttga caatggggat gagtttttta catcccaggt
      841 tgggaggaaa tcacaaagcg ctttctatcc cgaggaagat agctattttt ttgttgcgga
      901 tcagcctgag ttgtaccacc acaggcaggg tgcactggag ctgccatctc caggggagac
      961 atcatggcga tcaggacctg ttcagcccaa gcagaagctg ctccacccaa ggcgaggcag
     1021 cttgcctgag gaagcctatg acagcgacat gctgtcagcc tccatgtcga gagccttcct
     1081 gtaccggctc tggaaggggg ccgtgtcctc taagatgttg aacccgcgcc tgcagaaggc
     1141 catgcgttac tacatgtcct tcaacaagca tggtgtgcgc ttccgcaggc ggggtcggcg
     1201 tgaagctaca cgtacagggc cggagctgct gtgtgagatg cgcagacgtg tgcgtgtgcg
     1261 cacgttggac ggcagagagg cgcccttctc ggggctgggc tggcggcctc tggtaccagg
     1321 tgtacctctg agccagttgc acccgcgcgg tctgagcagc tgcgcagttg tcatgtctgc
     1381 cggtgccatc ctgaactcct ccttggggga ggaaatcgat tctcatgatg cagttttgag
     1441 atttaactct gcccctacac gtggctatga gaaagatgtc ggaaataaaa ccacagtacg
     1501 catcattaat tctcagattc tggccaaccc cagccatcac ttcattgaca gtgctttata
     1561 taaagatgtt atcctggtag cctgggatcc tgctccttat tctgccaatc ttaacctgtg
     1621 gtataagaag ccagattaca accttttcac tccatatatc cagcatcgcc ggaaataccc
     1681 gactcagcca ttttacattc ttcaccccaa gttcatatgg cagctttggg acattatcca
     1741 ggagaataca agggagaaga tacagcccaa cccaccatct tctggtttta ttggaatcct
     1801 catcatgatg tccatgtgta aagaggtgca cgtgtatgag tacatcccat ctgttcgaca
     1861 gacagagctt tgccactacc atgagctgta ctacgacgca gcctgcacct tgggggccta
     1921 ccacccactg ctctatgaaa agctactggt gcagcgcctt aacactggca cccaggcaga
     1981 cttgcatcac aagggcaagg tagtcttgcc aggcttccag acccttcggt gtccagtaac
     2041 cagccccaac aatacacact cttaaaatgg aactcttggg aactgatgtg caataaggta
     2101 ctactgttgt cctcaaagtc acacacacac acacacacac acacacacac acacacaaaa
     2161 tacttgaaga tagatttaga caatgtattg tctttaactg taacttagtg cccatgagaa
     2221 ttctttctag tctaagccat tgggtaacta ttactgctat gaatatagaa atgaaacttt
     2281 aaaaccacac aagaaagaag ccaaaataag atgtatagaa aacagatttt tactcatggg
     2341 catgatacct ctaaacatgt taacctctac agcagggata ctttttatca cagttggttc
     2401 cagccacaag ttgggatgat actactgatg atacagtttc catctagaaa tatccaagtt
     2461 gaggtcctgt aactagcagt cacgtatacc tccatttctc attatgcgtc ctagaatctg
     2521 tgatgaatgt ctgatttctc actcagatgt gtttgacgtt tcttcacata tactgtcagg
     2581 cacaggattt tcaacaacag cttcgcagtt ttgcttccca gtgttctctg aatgttacag
     2641 ctgagaacca agctacactt acaaaagtac aaaccatccc taccacacaa tctaagaagt
     2701 caaacgaaac atctgccaac agtgaagaac agcacctttg tctgcctgca gcatactcta
     2761 cctagccaac aacatgtagc acacacaggt ggtacaggtg gtgtatgcag ggttatgact
     2821 ggtcaggtgt ccctaacctg gcttttcaac attatattcc tagctttcca atcactctgt
     2881 agctctcaga tagccagtga cttactgggc agtagcatcc ttgcaggtca gcccggggac
     2941 acccttgttc ctttcaagct ataaagaata gcttggaagc atgcactctg agctgcgtgg
     3001 gatgcacact tccctgtcac ttctattgga agctcttgta ggcttttctc aactatcaca
     3061 aacttgatct ccttgctctg aatgttgttc agttttaagc ataaacagct agaaatccac
     3121 ctttgttttt gcaggcatgt tttatgttaa gaatgtgatg gaaccacaaa attgtttttt
     3181 aacaattaag ttaaaacttt ttgaaaatga cgatatcagt ttaattaaat gtaccagcct
     3241 accccttgca aaatgtgtgg ctttcaaagt attgtggggg aaaaaaatgt ttcactatgt
     3301 ttgttctgga atgctctact gattacttcc tgaggaagca aggttttcag agaccaccag
     3361 tttttgtttg ggtattgccc cctgcagagc tcaagcagga ctgcagatgt cctcagtggc
     3421 ttgctacagc agtgaagtga gagaacttga gctttcagtt atgagataat ctgctggcat
     3481 cccattctga gtgacagagt atcatcttct gcttagcctg gtccaaccat gtaatctcat
     3541 gagagttcaa ccttgtcacc atgctgacat gtctaatcat ctcggtaact ctagaggagg
     3601 cattgttcat gttgtatgaa ttttctccag tggtccttgg agctttctag atcttccagc
     3661 ttttgcaatt ttaaatgatc ataaccagta agtttctttt tatagcctgg aataggattc
     3721 acttagaggc ataattagta tccatgacaa tgcccttaga tggcctgaga acttgattaa
     3781 agaataactt attgaggtca gtgtaaatat tcaaattcga aagctccaca aaacacatca
     3841 aaggttgtta aatatcattc tgtttttgca catgtatttt taaaaggttt ctctcagttt
     3901 tacacggggt tacaaggaat ctgaagagca taaaggaaat gtaattaatt ttttgaattt
     3961 attatggccc taaagacttg tgggaatcag tctgttaaat attcagaaaa tatggcacac
     4021 atatgaatat gctattggct agtcactctt gtatttcaaa gtttaaatag cttagcagat
     4081 gctcacacaa tgattgctaa tatggtggct gcttcttgta ttaacaaaat gtgtcccaac
     4141 aggcaatatt ttgccagata gtgattaaat acttccaccc cacatttact atccttaagt
     4201 gacccaacag tacctgtgaa acagcaacac taactatcct cccacctcat tttttcctgg
     4261 atctgactct agctcttcca gaaccttctg acctcttctg tgaaaggact ctggttagat
     4321 cctcatggtg gcaccaaaag ccacccggtg ctgtttgttc cctgaagact aacagatgtc
     4381 atagtccttt gtgttttgag aaaaatatct ctatttctta ttgttattat tgttgttcct
     4441 attacaaaga tactagtgtt gtccaaaaat gataattcag tcactccaag attctctcga
     4501 atatgtgtct ctagctgctc acatgaggca agtggtagtg tataatgaac atgctaacta
     4561 cagacaactc agtgcaataa tagggccatg tggttgacta tgcctgccac attatctgtt
     4621 gcaaattctg gaaagacagt ggtaatcaaa cacaagttac ttgtaagcat ataagatgtg
     4681 atttaatgga caaatttggg gcttgagtac atctgaattg ctgtgtttac ctggtctctg
     4741 agctcaaggt gttttgattt agaaatggca ctttgcatgt gtcttgacct cttggtccct
     4801 tagtcactca acatggactt ttcagtagtc ctctgtcatt ggagctataa tatctgagca
     4861 aaagtagtgc tgcagtggtc attagtactt tttttagact caaatgtcaa agggcctggc
     4921 ttactctgtt atgtttatga accaatacat ctgttggaac agagttcagc ctgtgttgcc
     4981 agctcaccat actcatatag tctggattta ttgggcactg tttgggtgcg tcaagtagaa
     5041 tcagtctccc acaagttatg acgtgataaa agactttggt atacataggc agcttgatca
     5101 agtttcacca gattttctta gaatacatgt agaatagtct ccagatctgt cccatcacac
     5161 tgccaatttc tgtttgactt tctgatagtc aaatattacc ccatggctac atgactgatc
     5221 aaggcagctc tgtttagaca taattaagtt aggtaaatca tgcctgcatt ccagcaaact
     5281 ttttatatca ggacatttcc attgtgagat ttttccacat ttctgtctct tggtatgttt
     5341 agatactcag tgaatgtgta gcagttctct agcagctcaa gaaaataaaa tgcaaattct
     5401 tagttcttgt ttcgttaaat gaatggagcc ttcaataaga aaagaaacag catattcttt
     5461 acaaggttag ggtagtgaca tttaagaatt cttattctta acataaaagt gtgcatgtag
     5521 atagttatat aattgtatat atacttatct acacacatgg ttgattttat tgtctttttc
     5581 agtcatcttt ataatgagag ctttacaaca aattttattt tagttatgca aacactaatt
     5641 tttttaagag aaggaagtaa atattttatg tccttctgcg aaaaataagt cagtcttctg
     5701 ccctcactac agacacactc atattctaca tatcttggcc atattaacaa acaataacca
     5761 aaatattgaa aggtaccatt cacagaacca ttcctcaagt gtattattag tcagaagcat
     5821 gatatagctc tgaaaattga agagtttgtt gattatccat ggcttatata agattaaagg
     5881 aagaaacatt tgttggttgt cgggaaaata gatttcaaca aaacaagtgc aacagtagca
     5941 ttaaaatcta agtttacaat acacccctgt taggctctag ataaatatgt atagaatctt
     6001 tccactggaa accagtgaag ttttttaaag gctttgggaa tttttttgta tgataatttt
     6061 taaaacaaaa tgtgttctct tcaaactaat taatggcttg aggttttcca agaagcgcat
     6121 tttagacgtg tttgtacaca ttttaacact tgaatatttt gtattttgtt tttgtatatt
     6181 tttatgtgta cacagtgtac agacttgtaa ataaaacatg ttttcattta tctaaaaaaa
     6241 aaaaaaaaaa
//
