LOCUS       NM_145933               4508 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus beta galactoside alpha 2,6 sialyltransferase 1
            (St6gal1), transcript variant 1, mRNA.
ACCESSION   NM_145933 NM_009175
VERSION     NM_145933.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4508)
  AUTHORS   Werner,A., Hanic,M., Zaitseva,O.O., Lauc,G., Lux,A., Nitschke,L.
            and Nimmerjahn,F.
  TITLE     IgG sialylation occurs in B cells pre antibody secretion
  JOURNAL   Front Immunol 15, 1402000 (2024)
   PUBMED   38827747
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4508)
  AUTHORS   Zhao,H., Wang,H., Qin,Y., Ling,S., Zhai,H., Jin,J., Fang,L.,
            Cao,Z., Jin,S., Yang,X. and Wang,J.
  TITLE     CCCTC-binding factor: the specific transcription factor of
            beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the
            sialylation of anti-citrullinated protein antibodies in rheumatoid
            arthritis
  JOURNAL   Rheumatology (Oxford) 63 (3), 826-836 (2024)
   PUBMED   37326830
  REMARK    GeneRIF: CCCTC-binding factor: the specific transcription factor of
            beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the
            sialylation of anti-citrullinated protein antibodies in rheumatoid
            arthritis.
REFERENCE   3  (bases 1 to 4508)
  AUTHORS   Ortigoza,M.B., Mobini,C.L., Rocha,H.L., Bartlett,S., Loomis,C.A.
            and Weiser,J.N.
  TITLE     Inhibiting influenza virus transmission using a broadly acting
            neuraminidase that targets host sialic acids in the upper
            respiratory tract
  JOURNAL   mBio 15 (2), e0220323 (2024)
   PUBMED   38206008
REFERENCE   4  (bases 1 to 4508)
  AUTHORS   Glendenning,L.M., Zhou,J.Y., Kukan,E.N., Gao,C., Cummings,R.D.,
            Joshi,S., Whiteheart,S.W. and Cobb,B.A.
  TITLE     Platelet-localized ST6Gal1 does not impact IgG sialylation
  JOURNAL   Glycobiology 33 (11), 943-953 (2023)
   PUBMED   37379323
  REMARK    GeneRIF: Platelet-localized ST6Gal1 does not impact IgG
            sialylation.
REFERENCE   5  (bases 1 to 4508)
  AUTHORS   Bhalerao,N., Chakraborty,A., Marciel,M.P., Hwang,J., Britain,C.M.,
            Silva,A.D., Eltoum,I.E., Jones,R.B., Alexander,K.L., Smythies,L.E.,
            Smith,P.D., Crossman,D.K., Crowley,M.R., Shin,B., Harrington,L.E.,
            Yan,Z., Bethea,M.M., Hunter,C.S., Klug,C.A., Buchsbaum,D.J. and
            Bellis,S.L.
  TITLE     ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and
            pancreatic cancer progression
  JOURNAL   JCI Insight 8 (19), e161563 (2023)
   PUBMED   37643018
  REMARK    GeneRIF: ST6GAL1 sialyltransferase promotes acinar to ductal
            metaplasia and pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4508)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   7  (bases 1 to 4508)
  AUTHORS   Sabile,A., Poras,I., Cherif,D., Goodfellow,P. and Avner,P.
  TITLE     Isolation of monochromosomal hybrids for mouse chromosomes 3, 6,
            10, 12, 14, and 18
  JOURNAL   Mamm Genome 8 (2), 81-85 (1997)
   PUBMED   9060403
REFERENCE   8  (bases 1 to 4508)
  AUTHORS   Kurosawa,N., Inoue,M., Yoshida,Y. and Tsuji,S.
  TITLE     Molecular cloning and genomic analysis of mouse Galbeta1,
            3GalNAc-specific GalNAc alpha2,6-sialyltransferase
  JOURNAL   J Biol Chem 271 (25), 15109-15116 (1996)
   PUBMED   8662927
REFERENCE   9  (bases 1 to 4508)
  AUTHORS   Lee,Y.C., Kojima,N., Wada,E., Kurosawa,N., Nakaoka,T., Hamamoto,T.
            and Tsuji,S.
  TITLE     Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc
            alpha 2,3-sialyltransferase
  JOURNAL   J Biol Chem 269 (13), 10028-10033 (1994)
   PUBMED   8144500
REFERENCE   10 (bases 1 to 4508)
  AUTHORS   Hamamoto,T., Kawasaki,M., Kurosawa,N., Nakaoka,T., Lee,Y.C. and
            Tsuji,S.
  TITLE     Two step single primer mediated polymerase chain reaction.
            Application to cloning of putative mouse, beta-galactoside alpha
            2,6-sialyltransferase cDNA
  JOURNAL   Bioorg Med Chem 1 (2), 141-145 (1993)
   PUBMED   8081843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF898349.1, BC092222.1 and
            CJ238175.1.
            
            On Nov 17, 2011 this sequence version replaced NM_145933.3.
            
            Summary: This gene encodes a member of glycosyltransferase family
            29. The encoded protein is a type II membrane protein that
            catalyzes the transfer of sialic acid from CMP-sialic acid to
            galactose-containing substrates. The protein, which is normally
            found in the Golgi but can be proteolytically processed to a
            soluble form, is involved in the generation of the cell-surface
            carbohydrate determinants and differentiation antigens HB-6, CD75,
            and CD76. This gene has been incorrectly referred to as CD75.
            Alternatively spliced transcript variants have been observed for
            this gene, and a pseudogene of this gene is located on chromosome
            15. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092222.1, AK084124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CF898349.1         1-22
            23-4506             BC092222.1         1-4484
            4507-4508           CJ238175.1         694-695
FEATURES             Location/Qualifiers
     source          1..4508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 14.03 cM"
     gene            1..4508
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /note="beta galactoside alpha 2,6 sialyltransferase 1"
                     /db_xref="GeneID:20440"
                     /db_xref="MGI:MGI:108470"
     exon            1..490
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            491..633
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            634..768
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1414
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     CDS             817..2028
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /EC_number="2.4.3.1"
                     /note="alpha 2,6-ST 1;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     6-sialyltransferase 1; ST6Gal I"
                     /codon_start=1
                     /product="beta-galactoside alpha-2,6-sialyltransferase 1"
                     /protein_id="NP_666045.1"
                     /db_xref="CCDS:CCDS28077.1"
                     /db_xref="GeneID:20440"
                     /db_xref="MGI:MGI:108470"
                     /translation="MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQM
                     PKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKL
                     NPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTT
                     EWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQ
                     DVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFE
                     TYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQ
                     VDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGK
                     ATLSGFRNNRC"
     exon            1415..1512
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1611
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1786
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..4508
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4486..4491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /note="hexamer: AATAAA"
     polyA_site      4506
                     /gene="St6gal1"
                     /gene_synonym="Siat1; St6gal; St6Gal-I; St6galI"
                     /note="major polyA site"
ORIGIN      
        1 ccaaaggctt gctctttgtg gacagactgc aagattccct gcattacggg gagccctaag
       61 caggcacctt taaccttgag cctgctcgct agcgacctcc agagggccag gatggtttgg
      121 gaccggtgtg atagagcact tttctagttt taacgactct atttgcataa cggagaccaa
      181 gcgtcctccc gccggtctgc cgtgcttttc ttccctcctt cccggtcctc tgtaccctca
      241 tctgtgctcc ctctctgctt cccagaagat ccgttctcaa ggggactcac tcggagcttg
      301 agtcccgggc tcttctccct cggcccggca agatccagag gcacctgggg gagtggagtt
      361 gagcgccagc ctgggttggg gagccgccct ggcactgccc gaccctaaca aagggaatcg
      421 gactgcgcgc cgtgcgagcg ctcggtgggc tcagcgaccg cagccgcctt cccgattgag
      481 agagctgcaa gcaggggtag agccagctgt gccaagctcc acagccagcg cccgagagag
      541 aagttatcag tgccccggaa gtcaactgaa atgaactggc ccccttgagc cttccccaaa
      601 tacctggtac ccactttcca gccggatgct gagatggttt ttgatcatcc tgtgaaaaat
      661 gagccttggc ctccagacct agtaaagtaa acctctttcc catggagaac agtgctggct
      721 cctgaggacc tggagggccc aagccccaga aggattagcc agaagcaggc ttggttcctg
      781 ctccgatcag tggctctcct gcccgtacca ttcattatga ttcataccaa cttgaagaga
      841 aagttcagct gctttgtcct ggtctttctc ctgtttgcca tcatctgcgt gtggaagaaa
      901 gggagcgact atgaggctct tacattgcaa gccaaggtat tccagatgcc gaagagccag
      961 gagaaagtgg ccgtggggcc tgctccccag gctgtgttct caaacagcaa acaagaccct
     1021 aaggaaggcg ttcagatcct cagttacccc agggtcacag ccaaggtcaa gccacagccc
     1081 tccttgcagg tgtgggacaa ggactccaca tactcaaaac ttaaccccag gctgctgaag
     1141 atctggagga actatctgaa catgaataaa tataaagtgt cctacaaggg gccgggacca
     1201 ggagtcaagt tcagcgtaga ggcgctgcgc tgccaccttc gagaccacgt gaatgtgtct
     1261 atgatagagg ccacagattt tcccttcaac accactgaat gggagggtta cctgcccaag
     1321 gagaacttca gaaccaaggc tgggccttgg cataagtgtg ccgtcgtgtc ttctgcagga
     1381 tctctgaaga actcccagct gggtcgagag attgataatc atgatgcggt cctgaggttt
     1441 aatggggcac ctacagacaa cttccaacag gatgtgggca caaaaactac catccgccta
     1501 gtgaactctc agttagtcac cacagaaaag cgcttcctga aggacagttt gtacaccgaa
     1561 ggaatcctga ttctgtggga cccatctgtg tatcatgcag acattccgca gtggtatcag
     1621 aagccagact acaacttctt cgaaacctat aagagttacc gaaggcttca ccccagccag
     1681 cctttttaca tcctcaagcc ccagatgcca tgggaactat gggacatcat tcaggaaatc
     1741 tctccagatc tgattcagcc gaatccccca tcctccggca tgctgggtat catcattatg
     1801 atgacgctgt gtgaccaagt tgatatttac gagttcctcc catccaagcg caagacagat
     1861 gtgtgctact atcaccagaa gttctttgac agcgcctgca cgatgggtgc ctaccatccg
     1921 ctcctcttcg agaagaatat ggtgaagcat ctcaatgagg gaacagatga agacatttat
     1981 ttgtttggga aagctaccct gtctggcttc cggaacaatc gctgttgagc caggcatcct
     2041 catccttctc cataagtcat tttatggctg ctctcctggt taccactgct tgaaggagtg
     2101 tttttattca acaggcccag cctgcttctt gcactctagg gaattttgtt ggcgagggtt
     2161 ctggggcctc cagtgtctga tggcaaggag gcagacccag ccttccctgc aggcacagag
     2221 tatgggagcc cagattcttg ccgtacacat ttctcctgac aacatcctcc tctcctttca
     2281 catgagtagg ggaaagagcc acatttctca ccagggttgc caaaactaga ctttgttttt
     2341 tccaactgaa tgatgtcatc ctaacaaagg agcaccttcc gtggcttaaa tctctcccta
     2401 ggtggtgatt tcacatctcc cagatcatga tttgtgtcag atgcagggtg gcttcaggga
     2461 ggggaggcaa ataattggga cacggtgggg aagcctactc agttactcta gagtaaagtt
     2521 gttcccaagg gtagtccctt ttgatcctta atcctgggtg cttatgatct tgcaaaggat
     2581 cttgggtagc tcacttccca ctctccatgg agacagaagg tacaaaacct cccatctgtc
     2641 cccaacctga tcagagttga gtaaaagaga gagacaccca acaggcagct agaatgcaaa
     2701 cattccgtgc gctcagtgat ttgggctcct ctctgagagc gtgctgtctg tacacccagc
     2761 aggggccagt tctactgtgt tcttgttgag caagagcact ggggaagctc ttagaggaag
     2821 aagagaaaca caccgtcttc ttcagaagaa gttttcactt tcccctttat cactgatgtt
     2881 agaacatgga aacccaaggt atttttgtta gaaagtccct acccacattg gcaccaagtg
     2941 ctgccccaca ggagacagca gattagtcag ataggctggg gctcttttat tttattttat
     3001 tgttttagct gtctactccc taaccttctc ctaattgcta tcattactct cccttacagc
     3061 aggcttccct cccaaattac ttttaatcat tttctgtttt gcaattaccc caactttcgc
     3121 tgaccttatg ggcccccccg ccccccatga aaggtctctc agggcatggg gaatatggtt
     3181 tctgggactt aggttagaat cttaatcata actgattctc acaaggggtg aggtgtgtga
     3241 tcacagattg ccctgctccc cctgcaaggg agtagcattg gtctctgggc agggaggacc
     3301 caccctgttt ggcaagcata ctctcacaag gattttctga gacctctcta cctggtggga
     3361 aaccacagca gcccactcag cccctggtgt ggagtggttc agtgacttac agatcagaat
     3421 taatgctatt gaatcaaggt cactgagaca cagtctactg gattcccaag gctgtgctca
     3481 cagggcttcg gtgtttcgag ctgcagaccc acagtctcag agctcagaaa cttgtttact
     3541 gctgaccccc ttgccttatg cgggcaatag aaagcccgga gtgaaaagcc ctggctttcc
     3601 aggttgaccc ccacttcctc actgtgccac tttgtttcca tatctgtaaa atgggggtga
     3661 caatcctacc tcacaaggct gtgtggggac cgcaggaaaa catatatctg ggctgtgtga
     3721 ggaccactgg aaagcacgtg gctgggctgt gtccacggtg cataggaagt aggtaccctg
     3781 atgtctttcc ttgtttcctt atggagggtc acacccatac tgggccttgc tgcaggagag
     3841 ggcagtagag aaaagcaggg catcctttct gttgtgaggc atctgcatca tttgcaacgt
     3901 gcaggagcct acctgtcttg ctgcctgcac ctcagggtgt gcagagcatt gggctgcttg
     3961 gccgctgtgg gggttaggtc tagggaattc ctggctcatt ataaggcatc aggactgtgg
     4021 atagagtgcc caggaagctg atgttccttc aagaggtcag caagaggtac attagagatg
     4081 gagactacac tgggtagatt ctagttttta gttcttatta atgtggggga gtaaattaat
     4141 aagtgtaata tgattctgat gtctgttaga ctttctctgt gctctgtaaa tgtggatact
     4201 tgagtaaagt ggactacgga gtggatgtgg gcgtcactgt tagtctgatg aggtatttag
     4261 tatttgcgac aggtagttta aaatctgtga ctgagtgcta taggaaagtg tctttctacg
     4321 tgggcactga cgtcactagc catctatgca tcctaaatgc aggatcctct tgattccttc
     4381 tgccaatcaa atctctcatt gctcttggtt tccgggtttg tgtcagaaac ttttaaaaca
     4441 tacctgttaa ttctaaatta tccaaagatt atgtgcaaat tttaaaataa atatcttttt
     4501 cagaaatc
//
