LOCUS       NM_018784               2506 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 6
            (St3gal6), transcript variant 1, mRNA.
ACCESSION   NM_018784 XM_358853
VERSION     NM_018784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Li,X., Xiao,Y., Li,P., Zhu,Y., Guo,Y., Bian,H. and Li,Z.
  TITLE     Sialyltransferase ST3GAL6 silencing reduces alpha2,3-sialylated
            glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain
            with hepatic encephalopathy
  JOURNAL   J Zhejiang Univ Sci B 25 (6), 485-498 (2024)
   PUBMED   38910494
  REMARK    GeneRIF: Sialyltransferase ST3GAL6 silencing reduces
            alpha2,3-sialylated glycans to regulate autophagy by decreasing
            HSPB8-BAG3 in the brain with hepatic encephalopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2506)
  AUTHORS   Yang,W.H., Aziz,P.V., Heithoff,D.M., Kim,Y., Ko,J.Y., Cho,J.W.,
            Mahan,M.J., Sperandio,M. and Marth,J.D.
  TITLE     Innate mechanism of mucosal barrier erosion in the pathogenesis of
            acquired colitis
  JOURNAL   iScience 26 (10), 107883 (2023)
   PUBMED   37752945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2506)
  AUTHORS   Yang,W.H., Heithoff,D.M., Aziz,P.V., Haslund-Gourley,B.,
            Westman,J.S., Narisawa,S., Pinkerton,A.B., Millan,J.L., Nizet,V.,
            Mahan,M.J. and Marth,J.D.
  TITLE     Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes
            by Discrete Pathogens Fuels Sepsis
  JOURNAL   Cell Host Microbe 24 (4), 500-513 (2018)
   PUBMED   30308156
REFERENCE   4  (bases 1 to 2506)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 2506)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   6  (bases 1 to 2506)
  AUTHORS   Yang,W.H., Nussbaum,C., Grewal,P.K., Marth,J.D. and Sperandio,M.
  TITLE     Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in
            the synthesis of selectin ligands
  JOURNAL   Blood 120 (5), 1015-1026 (2012)
   PUBMED   22700726
  REMARK    GeneRIF: Coordinated participation of both ST3Gal-VI and ST3Gal-IV
            in the synthesis of functional selectin ligands.
REFERENCE   7  (bases 1 to 2506)
  AUTHORS   Takashima,S. and Tsuji,S.
  TITLE     Comparison of genomic structures of four members of
            beta-galactoside alpha2,3-sialyltransferase genes in the mouse
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 101-106 (2000)
   PUBMED   10894948
REFERENCE   8  (bases 1 to 2506)
  AUTHORS   Kapitonov,D., Bieberich,E. and Yu,R.K.
  TITLE     Combinatorial PCR approach to homology-based cloning: cloning and
            expression of mouse and human GM3-synthase
  JOURNAL   Glycoconj J 16 (7), 337-350 (1999)
   PUBMED   10619706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154764.2 and CT027564.7.
            
            On Oct 27, 2017 this sequence version replaced NM_018784.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048950.1, AF119390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AC154764.2         38295-38645         c
            352-518             AC154764.2         22667-22833         c
            519-700             CT027564.7         173042-173223       c
            701-778             CT027564.7         168266-168343       c
            779-882             CT027564.7         165757-165860       c
            883-946             CT027564.7         164125-164188       c
            947-1042            CT027564.7         155212-155307       c
            1043-1229           CT027564.7         153016-153202       c
            1230-1367           CT027564.7         152771-152908       c
            1368-1520           CT027564.7         151673-151825       c
            1521-2506           CT027564.7         149104-150089       c
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.58 cM"
     gene            1..2506
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 6"
                     /db_xref="GeneID:54613"
                     /db_xref="MGI:MGI:1888707"
     exon            1..351
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            352..518
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            519..700
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..1601
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /EC_number="2.4.3.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sialyltransferase 10 (alpha-2,3-sialyltransferase VI);
                     type 2 lactosamine alpha-2,3-sialyltransferase;
                     CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI;
                     ST3Gal VI"
                     /codon_start=1
                     /product="type 2 lactosamine alpha-2,3-sialyltransferase
                     isoform 1"
                     /protein_id="NP_061254.1"
                     /db_xref="CCDS:CCDS28230.1"
                     /db_xref="GeneID:54613"
                     /db_xref="MGI:MGI:1888707"
                     /translation="MKGYLVAIFLSSIFLYYVLYCILWGTNGYWFPAEEMRTRNNVNN
                     CFKKPAFANLLRFPQLYPFLCRADFIKVAAMSGTNNFPLPYGIKTFETYFSSALSKLQ
                     SCDLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTR
                     TTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQDLRWLVEILLGKKINTQGFWKTPALK
                     LIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSEVHL
                     AGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDIIKKKMVINLT"
     exon            701..778
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            779..882
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            883..946
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1042
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1229
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1367
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1520
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2506
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="hexamer: AATATA"
     polyA_site      1707
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="major polyA site"
     polyA_site      2038
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="hexamer: AAGAAA"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="hexamer: AGTAAA"
     polyA_site      2495
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
     polyA_site      2506
                     /gene="St3gal6"
                     /gene_synonym="1700023B24Rik; Siat10; St3galVI"
                     /note="major polyA site"
ORIGIN      
        1 caggaacttg ggggcggcgg ccaccgagca tctggcgcca gcaataagga ggagcttccc
       61 gcggcgtagc acacagccgc cgggggaccc agagtccggc gctgagagct gtaaggggaa
      121 cgttggcggt ctcagcctcc gggccacact gcgcctcgct ccgctctgct ccttcgccac
      181 atcgggggta ggggtggagg gaagggatcg cgttcttgtc accccgctag ctcaggcttc
      241 cgctcgccgc ctgctcggga cccgatgctg cagacgccac gggacagaca gaagcgcgct
      301 gcggagagcc ctgtgcatgc ctctgcggtg gccgagctcg ggcctcggca gcacgcacac
      361 gtgaagcaac aacaaagccc ctcatcttgg attatttcca gcatcaagac ctccacatgt
      421 caacagcagg ctcctgaggc agtccatcct cctccaactc tcctcactac attcttcaga
      481 aagagagggt cttcaggaaa cacaccccaa aagcgcagat ttatttacta attcatgtat
      541 ttgaaccatc gtggaagacc tctgcatatt catctcccct cactttggac tctgtttcag
      601 gcaggccagc catgaaaggg tatctggtgg ccatattcct gagttccatc ttcctctatt
      661 atgtactata ctgtatactg tggggaacaa atggctattg gttcccagct gaagaaatga
      721 ggactagaaa caatgtcaat aattgtttta aaaagccagc tttcgccaat cttctgagat
      781 ttcctcagct ttacccattt ctgtgcagag ctgactttat aaaggttgct gccatgtccg
      841 gtaccaataa ttttccgttg ccctatggaa taaagacctt cgagacatat ttcagctcgg
      901 ccctttcaaa actgcagagt tgtgatctct ttgacgagtt tgacagagtg ccatgtaaaa
      961 ggtgtgtggt ggttggtaat ggaggagtgt tgaagaataa gacattagga gcaacaattg
     1021 actcctatga tgtaataata agaatgaaca acggtcctgt cttaggccat gaagaggaag
     1081 ttgggacaag aacaaccttc aggctttttt atccagagtc tgtcttttca gactccagtc
     1141 actatgaccc caatactaca gcggttctcg tcgtctttaa gccacaggat ttaaggtggc
     1201 tggtggaaat actgctaggt aaaaaaataa atactcaagg gttttggaag acaccagcct
     1261 taaaactgat ctataaacaa taccaaatca gaatattaga tccatatatc accagcgaag
     1321 cagcttttca aatgcttcgt tttcccagag tatttcccaa ggatcagaaa cccaaacacc
     1381 ctacaacagg aattattgcc atcacaatgg cctttcacat atgcagtgaa gtgcacctcg
     1441 ctggttttaa gtacaacttt tacagcccca acagtccttt acactactac gggaatgcca
     1501 ccatgtcttt gatgaagcag aatgcatatc acaatctgac tgcagagcag ctctttttaa
     1561 acgacattat aaagaaaaaa atggtgatca acttgactta aaattgaccc tatggatcca
     1621 aaagatgatg atgctaaaca gtattagttt tatttttgta ctgcaaattt tagtttattt
     1681 ttaaatatat tggatgaact tatcaaatta tgtgtattaa gtctgttgct gcctggtgac
     1741 ttgtaaccac cggctaaagt tctgtgaata tatttatgaa aaaacaagaa gatttttagt
     1801 taagatatca gggaaaaatg tgaagttttg attatgttgt tttaaaatgt gatcttttta
     1861 gtgctctgag gtgttttaaa ataccttctc atagttcctt catcttaaag agttctagga
     1921 gatttagtgg acttcgcccg tgctgatagt cacgtatcac tttgaactgc tgatttagat
     1981 tgcttactca tgggcatgtg actgggagcc aggtgcagaa cacgagaatc acctgtaagt
     2041 ccgtggtgtc cattgtggtt tcattaagtt ctctttacaa ttaattaaac cagtaataat
     2101 gtaataattt gctgtgaggg aggaaaaaat agccttctgc atgcttggaa agcgcgctct
     2161 tctaacgagc atcctgagac tttgatttgg aaggggtggg gggaggggca gcttcttact
     2221 atgtagcctg ggctaggctc gaccttggtt ttcttgcctc agcttcccaa gtactgggat
     2281 tacagctatg tgccaattgc tgcaccctct agcatcattt ttcaaaacta caaagttttt
     2341 gttgttcgtt ttagacaggg tctatgtagt gctggatggc ctagaactac aatgtagtgc
     2401 agactagact tgagctcaga ggtgagccta cctgtgggaa gaagaaaacc ttaaatgttt
     2461 ctatgaagaa aatcttaaga gtaaaacaat gcaagtaaaa ccttaa
//
