LOCUS       NM_001410351            2507 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 5
            (St3gal5), transcript variant 5, mRNA.
ACCESSION   NM_001410351 XM_006505816
VERSION     NM_001410351.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Takeda,K., Kaifu,T., Michihata,R., Kinugawa,N., Fujioka,A.,
            Tateno,A., Toshima,K., Kanoh,H., Inamori,K.I., Kamijo,K.,
            Himeda,T., Ohara,Y., Inokuchi,J.I. and Nakamura,A.
  TITLE     Chronic encephalomyelitis virus exhibits cellular tropism and
            evades pDCs by binding to sialylated integrins as the cell surface
            receptors
  JOURNAL   Eur J Immunol 53 (10), e2350452 (2023)
   PUBMED   37565654
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Chowdhury,S., Kumar,R., Zepeda,E., DeFrees,S. and Ledeen,R.
  TITLE     Synthetic GM1 improves motor and memory dysfunctions in mice with
            monoallelic or biallelic disruption of GM3 synthase
  JOURNAL   FEBS Open Bio 13 (9), 1651-1657 (2023)
   PUBMED   37401916
  REMARK    GeneRIF: Synthetic GM1 improves motor and memory dysfunctions in
            mice with monoallelic or biallelic disruption of GM3 synthase.
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Bharathi,S.S., Zhang,B.B., Paul,E., Zhang,Y., Schmidt,A.V.,
            Fowler,B., Wu,Y., Tiemeyer,M., Inamori,K.I., Inokuchi,J.I. and
            Goetzman,E.S.
  TITLE     GM3 synthase deficiency increases brain glucose metabolism in mice
  JOURNAL   Mol Genet Metab 137 (4), 342-348 (2022)
   PUBMED   36335793
  REMARK    GeneRIF: GM3 synthase deficiency increases brain glucose metabolism
            in mice.
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Arends,M., Weber,M., Papan,C., Damm,M., Surma,M.A., Spiegel,C.,
            Djannatian,M., Li,S., Connell,L., Johannes,L., Schifferer,M.,
            Klose,C. and Simons,M.
  TITLE     Ganglioside lipidomics of CNS myelination using direct infusion
            shotgun mass spectrometry
  JOURNAL   iScience 25 (11), 105323 (2022)
   PUBMED   36310581
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Strekalova,T., Veniaminova,E., Svirin,E., Kopeikina,E.,
            Veremeyko,T., Yung,A.W.Y., Proshin,A., Tan,S.Z.K., Khairuddin,S.,
            Lim,L.W., Lesch,K.P., Walitza,S., Anthony,D.C. and Ponomarev,E.D.
  TITLE     Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and
            Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice
  JOURNAL   Biomolecules 11 (12), 1759 (2021)
   PUBMED   34944404
  REMARK    GeneRIF: Sex-Specific ADHD-like Behaviour, Altered Metabolic
            Functions, and Altered EEG Activity in Sialyltransferase
            ST3GAL5-Deficient Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Takashima,S. and Tsuji,S.
  TITLE     Comparison of genomic structures of four members of
            beta-galactoside alpha2,3-sialyltransferase genes in the mouse
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 101-106 (2000)
   PUBMED   10894948
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Kapitonov,D., Bieberich,E. and Yu,R.K.
  TITLE     Combinatorial PCR approach to homology-based cloning: cloning and
            expression of mouse and human GM3-synthase
  JOURNAL   Glycoconj J 16 (7), 337-350 (1999)
   PUBMED   10619706
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Fukumoto,S., Miyazaki,H., Goto,G., Urano,T., Furukawa,K. and
            Furukawa,K.
  TITLE     Expression cloning of mouse cDNA of CMP-NeuAc:Lactosylceramide
            alpha2,3-sialyltransferase, an enzyme that initiates the synthesis
            of gangliosides
  JOURNAL   J Biol Chem 274 (14), 9271-9276 (1999)
   PUBMED   10092602
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Kono,M., Takashima,S., Liu,H., Inoue,M., Kojima,N., Lee,Y.C.,
            Hamamoto,T. and Tsuji,S.
  TITLE     Molecular cloning and functional expression of a fifth-type alpha
            2,3-sialyltransferase (mST3Gal V: GM3 synthase)
  JOURNAL   Biochem Biophys Res Commun 253 (1), 170-175 (1998)
   PUBMED   9875239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127244.3.
            
            On Aug 4, 2022 this sequence version replaced XM_006505816.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1068831.1,
                                           SRR13422592.92127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AC127244.3         89481-89867
            388-448             AC127244.3         90790-90850
            449-572             AC127244.3         120137-120260
            573-684             AC127244.3         123925-124036
            685-1028            AC127244.3         134013-134356
            1029-1215           AC127244.3         138942-139128
            1216-1374           AC127244.3         140892-141050
            1375-2507           AC127244.3         145304-146436
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.24 cM"
     gene            1..2507
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 5"
                     /db_xref="GeneID:20454"
                     /db_xref="MGI:MGI:1339963"
     exon            1..387
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1614
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /EC_number="2.4.3.9"
                     /note="isoform c is encoded by transcript variant 5;
                     sialyltransferase 9 (CMP-NeuAc:lactosylceramide
                     alpha-2,3-sialyltransferase); ST3GalV; ganglioside GM3
                     synthase; mST3Gal V; GM3-specific sialytransferase"
                     /codon_start=1
                     /product="lactosylceramide alpha-2,3-sialyltransferase
                     isoform c"
                     /protein_id="NP_001397280.1"
                     /db_xref="GeneID:20454"
                     /db_xref="MGI:MGI:1339963"
                     /translation="MHTEAVGGAARRPQKLRSQAAAPACRGTWRSPQSAERTPGSPDS
                     GDPPLRYPRPSGSSPALRRRTRLLGDTGGGSRPLAAYMGAPGAACAGVDAALRPYANA
                     GPEKRDLSAERKDQKTMPSEFTSAKLRSDCSRTSLQWYTRTQHKMRRPSLLIKDICKC
                     TLVAFGVWLLYILILNYTAEECDMKRMHYVDPDRIKRAQSYAQEVLQKECRPRYAKTA
                     MALLFEDRYSINLEPFVQKVPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEH
                     LRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTY
                     PEGAPLSDVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQ
                     PKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATHLCDEVSLAG
                     FGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKLLKEGVVEDLSGGIH"
     exon            388..448
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..572
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..684
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1028
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1215
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1374
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2507
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2465
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /note="major polyA site"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /note="hexamer: AATAAA"
     polyA_site      2507
                     /gene="St3gal5"
                     /gene_synonym="3S-T; Siat9; [a]2"
                     /note="major polyA site"
ORIGIN      
        1 ggactgtccg gggctgaatt ggcgcgagcg cggcgccggg ggctggctgg ggcgcggggc
       61 cccgggctgg cggcttgcca gcgctccctc cctagcatgc acacagaggc ggtgggcggc
      121 gcggcgcgga ggccccagaa gctgcgaagc caagcagcgg cacctgcctg ccgaggtacg
      181 tggcgcagcc cccagtcggc agagcggaca ccggggagcc cagatagcgg cgatccgcct
      241 ttgcgatacc ccaggcccag cggctcctcc ccagccctgc gacgccggac gcgcctgcta
      301 ggggacacgg gcggagggtc gcggcccctg gctgcctaca tgggcgcccc cggcgcagcc
      361 tgcgcaggtg tggacgcggc gctgcggccc tacgcaaatg ctgggcctga gaagagggat
      421 ttgtctgctg aaagaaagga ccagaaaaca atgccaagtg agttcacctc tgcaaagctg
      481 agaagtgatt gctcaaggac ctccctgcaa tggtacaccc gaacccagca caagatgaga
      541 agacccagct tgttaataaa agacatctgc aagtgcacgt tggttgcatt tggagtctgg
      601 ctcctgtaca tcctcatttt gaattacacc gctgaagaat gtgacatgaa aagaatgcac
      661 tatgtggacc ctgaccggat aaagagagct cagagctatg ctcaggaagt cttgcagaag
      721 gaatgtcggc ccaggtacgc gaagacggct atggctctgt tatttgagga caggtacagc
      781 atcaacttgg agccttttgt gcagaaggtc cccacggcca gtgaagctga gctcaagtat
      841 gacccgcctt ttggattccg gaagttctcc agtaaagtcc agagcctctt ggatatgctg
      901 cccgaacatg actttcctga acacttgaga gccaaggcct gcaagcgctg tgtggttgtt
      961 gggaacgggg gcatcctgca cggactagag ctgggtcacg ccctcaacca gttcgatgtg
     1021 gtaataaggt tgaacagtgc gccagttgag ggttactctg aacacgttgg gaataaaact
     1081 actataagga tgacttaccc agagggtgcg ccactgtcgg acgttgaata ctacgccaat
     1141 gatttgttcg ttactgtttt atttaagagt gttgatttca agtggcttca agcaatggta
     1201 aaaaatgaaa gcctgccctt ttgggttcgc ctcttctttt ggaagcaagt ggcagaaaaa
     1261 gtcccactcc agccaaagca cttcaggatt ttgaacccag ttatcatcaa agaaactgcc
     1321 ttcgacatcc ttcagtactc agagcctcag tcaagattct ggggccatga taagaacatc
     1381 cccacgatcg gcgtcattgc cgttgtcttg gctacacatc tgtgtgatga agtcagcctg
     1441 gcaggctttg gctacgacct cagtcaaccc aggacccctc tgcactactt tgacagtcag
     1501 tgcatgggcg ccatgcactg gcaggtcatg cacaatgtga ccacagagac caagttcctc
     1561 ctgaagctcc tcaaggaggg cgtggtggag gacctcagcg gcggcatcca ctgagaactc
     1621 ggaacacggc aaacctcacc cagcaccgca gctgagagcg tggtgagcag cctccacagg
     1681 gacttcaccc tgcagctgct tcgatgtgca gctagtgttt tcaaactcca catttttttt
     1741 aaaaaaggaa aagaaagaac aacagcaaca acaaaagctc tgctctgtgc acctcttcgt
     1801 cctatttatt tgaagtcagt gttggatttt gcacagtttt gtaagttaat cttaagaatg
     1861 ggattggaag gacttttcaa agagaattgt atagtttatt gttttttaag gaagtaattt
     1921 aatttgcaga aactgtacac acgtactctg ctcaggtgtt gaggtgggag gagaggggct
     1981 tctggcccct ggatgatggc tgtgatgccc gatactgggg tctgctgctc tgtttggtag
     2041 aactgatggc agagaaactt cctgcctcca ggataaaggg cttactcatc acctctggca
     2101 gctgctagac aagttcataa cccctttctg ctagtccatc tgccagctgg ctcgcaggac
     2161 tcaggcaggg cagctgtccc ggaggctgct ggttggtgag ccactgtcag ctgagcgccg
     2221 tgatgttgcc ccagggtgga agaagccaca cttcctacac tgtcagggca cttttaaact
     2281 tctggagggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2341 tgttcattct gcccttccaa atcatctaag tgttatttaa ggcactctgc tgtttgtatg
     2401 agatggttca tagaaattat gacaaagcct ttgttatcca ggccatggga agaggaaaaa
     2461 gaaaagaaag aaagaaaaga ataaaagctt ttgaggagcc cctgtga
//
