LOCUS       NM_009178               2097 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 4
            (St3gal4), mRNA.
ACCESSION   NM_009178
VERSION     NM_009178.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Immler,R., Nussbaumer,K., Doerner,A., El Bounkari,O., Huber,S.,
            Abisch,J., Napoli,M., Schmidt,S., Margraf,A., Pruenster,M.,
            Rohwedder,I., Lange-Sperandio,B., Mall,M.A., de Jong,R.,
            Ohnmacht,C., Bernhagen,J., Voehringer,D., Marth,J.D., Frommhold,D.
            and Sperandio,M.
  TITLE     CCR3-dependent eosinophil recruitment is regulated by
            sialyltransferase ST3Gal-IV
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2319057121 (2024)
   PUBMED   38687790
  REMARK    GeneRIF: CCR3-dependent eosinophil recruitment is regulated by
            sialyltransferase ST3Gal-IV.
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Pisa,E., Traversa,A., Caputo,V., Ottomana,A.M., Hauser,J. and
            Macri,S.
  TITLE     Long-term consequences of reduced availability and compensatory
            supplementation of sialylated HMOs on cognitive capabilities
  JOURNAL   Front Cell Neurosci 17, 1091890 (2023)
   PUBMED   36794260
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Gonzalez-Gil,A., Porell,R.N., Fernandes,S.M., Maenpaa,E., Li,T.A.,
            Li,T., Wong,P.C., Aoki,K., Tiemeyer,M., Yu,Z.J., Orsburn,B.C.,
            Bumpus,N.N., Matthews,R.T. and Schnaar,R.L.
  TITLE     Human brain sialoglycan ligand for CD33, a microglial inhibitory
            Siglec implicated in Alzheimer's disease
  JOURNAL   J Biol Chem 298 (6), 101960 (2022)
   PUBMED   35452678
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Chen,X., Wang,L., Wu,Y., Zhang,H., Dong,W., Yu,X., Huang,C., Li,Y.,
            Wang,S. and Zhang,J.
  TITLE     Caveolin-1 knockout mice have altered serum N-glycan profile and
            sialyltransferase tissue expression
  JOURNAL   J Physiol Biochem 78 (1), 73-83 (2022)
   PUBMED   34462883
  REMARK    GeneRIF: Caveolin-1 knockout mice have altered serum N-glycan
            profile and sialyltransferase tissue expression.
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Pisa,E., Martire,A., Chiodi,V., Traversa,A., Caputo,V., Hauser,J.
            and Macri,S.
  TITLE     Exposure to 3'Sialyllactose-Poor Milk during Lactation Impairs
            Cognitive Capabilities in Adulthood
  JOURNAL   Nutrients 13 (12), 4191 (2021)
   PUBMED   34959743
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Ellies,L.G., Ditto,D., Levy,G.G., Wahrenbrock,M., Ginsburg,D.,
            Varki,A., Le,D.T. and Marth,J.D.
  TITLE     Sialyltransferase ST3Gal-IV operates as a dominant modifier of
            hemostasis by concealing asialoglycoprotein receptor ligands
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 10042-10047 (2002)
   PUBMED   12097641
  REMARK    GeneRIF: operates as a dominant modifier of hemostasis by
            concealing asialoglycoprotein receptor ligands
REFERENCE   7  (bases 1 to 2097)
  AUTHORS   Takashima,S. and Tsuji,S.
  TITLE     Comparison of genomic structures of four members of
            beta-galactoside alpha2,3-sialyltransferase genes in the mouse
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 101-106 (2000)
   PUBMED   10894948
REFERENCE   8  (bases 1 to 2097)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 2097)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   10 (bases 1 to 2097)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140448.3, BC050773.1 and AI385650.1.
            
            On Jan 24, 2017 this sequence version replaced NM_009178.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050773.1, D28941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC140448.3         110819-110872
            55-2083             BC050773.1         1-2029
            2084-2097           AI385650.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 19.36 cM"
     gene            1..2097
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 4"
                     /db_xref="GeneID:20443"
                     /db_xref="MGI:MGI:1316743"
     exon            1..167
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            168..243
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            244..328
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            329..409
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            410..507
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            508..568
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            569..664
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            665..854
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            855..998
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1142
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..2086
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2058..2063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /note="hexamer: ATTAAA"
     polyA_site      2086
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; Siat4c; ST3Gal IV; ST3GalIV"
                     /note="major polyA site"
ORIGIN      
        1 cgcctcccct tcaggcggac ttgcccgctc ccaggccggc cccgctcccg ggacagggac
       61 cgggccgagc ggagccactg cgccagtgct gccccgccag tcggggcgcc taacggatcg
      121 gagctgcgcg cggatttacc tcgccccgcc ccgctccacc cgcgagggtg gcccgaggca
      181 gccgggatga cacttctccc caggaaccct gctatctgct gagaaacatg accagcaaat
      241 ctcactggaa gctcctggcc ctggctctgg tccttgttgt tgtcatggtg tggtattcca
      301 tctcccgaga agataggtac attgagttct tttattttcc catctcagag aagaaagagc
      361 catgcttcca gggtgaggca gagagacagg cctctaagat ttttggcaac cgttctaggg
      421 aacagcccat ctttctgcag cttaaggatt atttttgggt aaagacgcca tccacctatg
      481 agctgccctt tgggactaaa ggaagtgaag accttcttct ccgggtgctg gccatcacta
      541 gctattctat acctgagagc ataaagagcc tcgagtgtcg tcgctgtgtt gtggtgggaa
      601 atgggcaccg gttgcggaac agctcgctgg gcggtgtcat caacaagtac gacgtggtca
      661 tcagattgaa caatgctcct gtggctggct acgagggaga tgtgggctcc aagaccacca
      721 tacgtctctt ctatcctgag tcggcccact ttgaccctaa aatagaaaac aacccagaca
      781 cgctcttggt cctggtagct ttcaaggcga tggacttcca ctggattgag accatcttga
      841 gtgataagaa gcgggtgcga aaaggcttct ggaaacagcc tcccctcatc tgggatgtca
      901 accccaaaca ggtccggatt ctaaacccct tctttatgga gattgcagca gacaagctcc
      961 tgagcctgcc catacaacag cctcgaaaga tcaagcagaa gccaaccacg ggtctgctag
     1021 ccatcacctt ggctctacac ctctgcgact tagtgcacat tgctggcttt ggctatccag
     1081 atgcctccaa caagaagcag accatccact actatgaaca gatcacactt aagtctatgg
     1141 cgggatcagg ccataatgtc tcccaagagg ctatcgccat caagcggatg ctagagatgg
     1201 gagctgtcaa gaacctcaca tacttctgac ttggatggga gctgtaacac cttggttccc
     1261 tactttgcca tctgagtagg ccctgtctac agcttagagg ttcctggtgc cagtacaatc
     1321 caattgaact caccctcaat ggagagggtg ttctggggct gtccaggtct ccagagaggc
     1381 tatgcccctg cctactttgg tggatttcaa atccagacag ggtagtcaca ccgaggctac
     1441 aggagcctgg ctaaaggggg gggggggggt gctgttactg tggcatcccc tctctcagcc
     1501 agcacaaaga gctgttttgt tttgttttgt tttgtttcgt tttgttttgt cttgtattgt
     1561 tggtggtggt tggttgggtt ttgtttgttt gtttgttttt gtttgctttg ttttgttctt
     1621 gagacagggt ctgactgtga aaccctggct aatctggaac tcactatgta gaccagactg
     1681 gtcttgaact cacagagatc caactgcctt tgcctcccaa gtgttgggat gaaaggcatg
     1741 tactacgcct ggccccaaca ccaagagatt atttaacatt ctatttaatt aaggggtagg
     1801 aaaatgaatg ggctggtccc aggatgttca tgaaagggac acaatacagt gttctgccca
     1861 ctttttaata aaatttacat gtgattggcc tgttaaggcc caattctaga gctggcctcc
     1921 cagaaagatg gaggcatcaa gagtgggagg gtgtcctcca gagagaggtt gctacttccc
     1981 agcaggcatg gggggagcat tgacaagggg gttccaccta gaaggggcct caccttgaaa
     2041 agaggttgta aaagaccatt aaaatatttt tttttctaaa atggaaaaaa aaaaaaa
//
