LOCUS       NM_009176               2631 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 3
            (St3gal3), transcript variant 1, mRNA.
ACCESSION   NM_009176
VERSION     NM_009176.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Blazetic,S., Krajina,V., Labak,I., Viljetic,B., Pavic,V., Ivic,V.,
            Balog,M., Schnaar,R.L. and Heffer,M.
  TITLE     Sialyltransferase Mutations Alter the Expression of Calcium-Binding
            Interneurons in Mice Neocortex, Hippocampus and Striatum
  JOURNAL   Int J Mol Sci 24 (24), 17218 (2023)
   PUBMED   38139047
  REMARK    GeneRIF: Sialyltransferase Mutations Alter the Expression of
            Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and
            Striatum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Gonzalez-Gil,A., Porell,R.N., Fernandes,S.M., Maenpaa,E., Li,T.A.,
            Li,T., Wong,P.C., Aoki,K., Tiemeyer,M., Yu,Z.J., Orsburn,B.C.,
            Bumpus,N.N., Matthews,R.T. and Schnaar,R.L.
  TITLE     Human brain sialoglycan ligand for CD33, a microglial inhibitory
            Siglec implicated in Alzheimer's disease
  JOURNAL   J Biol Chem 298 (6), 101960 (2022)
   PUBMED   35452678
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Rivero,O., Alhama-Riba,J., Ku,H.P., Fischer,M., Ortega,G.,
            Almos,P., Diouf,D., van den Hove,D. and Lesch,K.P.
  TITLE     Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder
            Risk Gene St3gal3 in Mice Causes Alterations in Cognition and
            Expression of Genes Involved in Myelination and Sialylation
  JOURNAL   Front Genet 12, 688488 (2021)
   PUBMED   34650588
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Yoo,S.W., Motari,M.G., Susuki,K., Prendergast,J., Mountney,A.,
            Hurtado,A. and Schnaar,R.L.
  TITLE     Sialylation regulates brain structure and function
  JOURNAL   FASEB J 29 (7), 3040-3053 (2015)
   PUBMED   25846372
  REMARK    GeneRIF: St3gal2/3 double-null mice displayed dysmyelination marked
            by a reduction in major myelin proteins, fewer myelinated axons, a
            decrease in myelin thickness, possibly by dysregulation of
            ganglioside-mediated oligodendroglial precursor cell proliferation.
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Kiwamoto,T., Brummet,M.E., Wu,F., Motari,M.G., Smith,D.F.,
            Schnaar,R.L., Zhu,Z. and Bochner,B.S.
  TITLE     Mice deficient in the St3gal3 gene product alpha2,3
            sialyltransferase (ST3Gal-III) exhibit enhanced allergic
            eosinophilic airway inflammation
  JOURNAL   J Allergy Clin Immunol 133 (1), 240-7 (2014)
   PUBMED   23830412
  REMARK    GeneRIF: knock-out mice have enhanced allergic eosinophilic airway
            inflammation
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   Ellies,L.G., Sperandio,M., Underhill,G.H., Yousif,J., Smith,M.,
            Priatel,J.J., Kansas,G.S., Ley,K. and Marth,J.D.
  TITLE     Sialyltransferase specificity in selectin ligand formation
  JOURNAL   Blood 100 (10), 3618-3625 (2002)
   PUBMED   12393657
  REMARK    GeneRIF: was not found to play a role in regulating synthesis of
            selectin ligands nor in vitro rolling of marrow-derived neutrophils
            on E- or P-selectins presented by Chinese hamster ovary cells
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Takashima,S. and Tsuji,S.
  TITLE     Comparison of genomic structures of four members of
            beta-galactoside alpha2,3-sialyltransferase genes in the mouse
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 101-106 (2000)
   PUBMED   10894948
REFERENCE   8  (bases 1 to 2631)
  AUTHORS   Takashima,S., Tachida,Y., Nakagawa,T., Hamamoto,T. and Tsuji,S.
  TITLE     Quantitative analysis of expression of mouse sialyltransferase
            genes by competitive PCR
  JOURNAL   Biochem Biophys Res Commun 260 (1), 23-27 (1999)
   PUBMED   10381338
REFERENCE   9  (bases 1 to 2631)
  AUTHORS   Ji,M.Y., Lee,Y.C., Kim,K.S., Cho,J.W., Jung,K.Y., Kim,C.H. and
            Choo,Y.K.
  TITLE     Developmental patterns of GalBeta1,3(4)GlcNAc
            alpha2,3-sialyltransferase (ST3Gal III) expression in the mouse: in
            situ hybridization using DIG-labeled RNA probes
  JOURNAL   Arch Pharm Res 22 (3), 243-248 (1999)
   PUBMED   10403125
REFERENCE   10 (bases 1 to 2631)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868500.1, AK136442.1, AK005053.1, AL611952.9 and BF472945.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_009176.6.
            
            On Oct 22, 2013 this sequence version replaced NM_009176.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2 and 3
            all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005053.1, X84234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB868500.1         2-51
            51-529              AK136442.1         2-480
            530-1256            AK005053.1         475-1201
            1257-1257           AL611952.9         16242-16242         c
            1258-2605           AK005053.1         1203-2550
            2606-2631           BF472945.1         443-468
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.84 cM"
     gene            1..2631
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 3"
                     /db_xref="GeneID:20441"
                     /db_xref="MGI:MGI:1316659"
     exon            1..557
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            558..702
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     CDS             588..1712
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /EC_number="2.4.3.6"
                     /note="isoform a is encoded by transcript variant 1;
                     sialyltransferase 6 (N-acetyllacosaminide alpha
                     2,3-sialyltransferase);
                     CMP-N-acetylneuraminate-beta-1,4-galactoside
                     alpha-2,3-sialyltransferase; alpha 2,3-ST 3;
                     beta-galactoside alpha-2,3-sialyltransferase 3;
                     N-acetyllactosaminide alpha-2,3-sialyltransferase; gal
                     beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-1,4-galactoside
                     alpha-2,3-sialyltransferase isoform a"
                     /protein_id="NP_033202.3"
                     /db_xref="CCDS:CCDS18544.1"
                     /db_xref="GeneID:20441"
                     /db_xref="MGI:MGI:1316659"
                     /translation="MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEDSNSLLLS
                     LDSAGQTLGTEYDRLGFLLKLDSKLPAELATKYANFSEGACKPGYASAMMTAIFPRFS
                     KPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLHCRRCI
                     IVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQ
                     YERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFI
                     QEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHY
                     YETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI"
     exon            703..750
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            751..793
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            794..886
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            887..981
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1045
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1141
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1328
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1475
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1622
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..2606
                     /gene="St3gal3"
                     /gene_synonym="Siat3; Siat6; ST3GalIII; ST3N"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgatgccc gacccccggc gcggccgccg aggcggaccg caggattggt ggtcccgccg
       61 ctgcgtcccc accatggcgg cgcccgtgca gcttgccgcg tcctgggctc cctctggggt
      121 cccctcggct gtccccgcta ttcgcgctgc aattgcctcc gcgctctgcg tgcgccctgg
      181 cgccacccgc ccccggcctc cctctctgct gcggtaaggc ctgccctgcg tccccgaagc
      241 agctctcggc cgccgcgccc ctcccccggc cagaccggcc cgagccgcgc tggggaccaa
      301 agcccgggcc cgggtggggg ccaggcctgc cagagggccg cgcgagccgg gccgagcgcg
      361 ccgaggtcac ctgtgtgcag tgtcccaggc gcgcgagtct gagcgcaaag gagggtcacg
      421 gtcacccggg acccgctgtg ggacaagcgc aagaaagtcc ggggaaagcc tagcgggagt
      481 caccaagagt agcggttgtc atctctgcct tccccggggc cagatcctcc tcggagcgac
      541 cgggtcagtt tatcaaagtc atgtaggaaa ttgtgagtca tgtgaagatg ggactcttgg
      601 tatttgtgcg caatctgctg ctagccctct gcctcttcct ggtcctggga tttttgtatt
      661 attctgcctg gaagctacac ttactccaat gggaagactc caattcattg cttctttccc
      721 ttgactccgc tggacaaacc ctaggcacag agtatgatag gctgggcttc ctcctgaagc
      781 tggactctaa actgcctgcc gagctagcca ccaagtacgc aaacttttcc gagggagctt
      841 gcaaacccgg ctacgcttca gccatgatga ctgccatctt ccccaggttc tccaagccag
      901 cacccatgtt cctggatgac tcctttcgca agtgggctag gatccgggag tttgtgccac
      961 cttttgggat caaaggtcaa gacaatctga tcaaagccat cttgtcagtc accaaagaat
     1021 accgcctgac ccctgccttg gacagcctcc actgccgccg ctgcatcatt gtaggcaatg
     1081 gaggggtcct cgccaacaag tctctggggt cacggattga cgactatgac attgtgatca
     1141 gactgaactc agcacctgtg aagggctttg agagggacgt gggcagcaag accaccctac
     1201 gcatcaccta ccctgagggc gccatgcagc gacctgagca atatgaacga gactctctct
     1261 ttgtcctcgc tggcttcaag tggcaggact tcaagtggct gaagtacatc gtctacaagg
     1321 agagagtgag tgcatctgat ggcttctgga agtccgtggc cacccgagtg cccaaggagc
     1381 cccctgagat ccgcatcctc aacccatact tcatccagga ggctgccttc actctcattg
     1441 gactgccctt caacaacggc ctcatgggca gagggaacat cccaaccctt ggcagtgtgg
     1501 cagtgaccat ggcactacac ggctgtgatg aagtggcagt cgcgggcttt ggctatgaca
     1561 tgaacacacc caatgcaccc ctgcactact atgaaactgt gcgcatggca gccatcaaag
     1621 agtcctggac acacaacatc cagcgagaga aagagtttct gcggaagcta gtgaaggcac
     1681 gtgtcatcac tgacttaagc agcggtatct gagtgggccg gacaccaggc cagagaggct
     1741 cacgccagga ccaagcagct gccacctgca caggagcctt cccacccaga gagggacagt
     1801 gccaagagac ccgagggcca gtgaggcctt ggcaaggcaa ccagagctgt gcccactgca
     1861 ggccagcttc agagaccagc accctgcctt gctgcctggg tccatgaagc cagagggcca
     1921 ggaggccact ggctgtggcc agcaggccca gcatgcagga ggtgggacat ttggtagcaa
     1981 gaatgctacc agaatcattt ctctaatcag tgtttggtgt attatcattt tgtgaatttg
     2041 ggtatgggga ggggagggat aatttatttt taaattagat gtcacatttg gtccacttgt
     2101 tgtgcagaaa gaggcccact agagggccca tcagacagtg gtaccagtga actccctgaa
     2161 ggatggaggt gtggtgacca tgcttcaggg accgggaggt ggatagcatc tcatgtcagc
     2221 catctccagc tcacgacact ctttggcctt ccttggggag aagatgaagt actccctctc
     2281 accagccacc agtgtcccac aggggaaccc cagagccatc cctttaaagc caacaggaca
     2341 gctcttggac aagagcagag agaactcagg aggcaaggcc cagcccagcc tgacgggaat
     2401 gaatggctcc gtccatagct gtccctaatc catggggcag taatccttcc tgaactgtca
     2461 gatggtctgg gtttcttgct gggactgcca gctccatggg tcctacccag gaccagaggg
     2521 aagtgaggct ccaggacctc acccaggctg ccgcagccag ccggggcagc tctcacggaa
     2581 gcaataaagc tctcctctga atctggaaaa aaaaaaaaaa aaaaaaaaaa a
//
